P J Yao

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Reduced O-glycosylated clathrin assembly protein AP180: implication for synaptic vesicle recycling dysfunction in Alzheimer's disease
    P J Yao
    Department of Neurobiology and Anatomy, University of Rochester Medical Center, NY 14642, USA
    Neurosci Lett 252:33-6. 1998
  2. ncbi request reprint Changes in synaptic expression of clathrin assembly protein AP180 in Alzheimer's disease analysed by immunohistochemistry
    P J Yao
    Department of Neurobiology and Anatomy, University of Rochester Medical Center, NY 14642, USA
    Neuroscience 94:389-94. 1999
  3. ncbi request reprint Synaptic distribution of the endocytic accessory proteins AP180 and CALM
    Pamela J Yao
    Laboratory of Neurosciences, National Institute on Aging National Institutes of Health, Baltimore, Maryland 21224, USA
    J Comp Neurol 481:58-69. 2005
  4. ncbi request reprint Clathrin assembly protein AP-2 is detected in both neurons and glia, and its reduction is prominent in layer II of frontal cortex in Alzheimer's disease
    P J Yao
    Center for Aging and Developmental Biology, University of Rochester Medical Center, Box 645, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Neurobiol Aging 21:921-9. 2000
  5. ncbi request reprint High-resolution localization of clathrin assembly protein AP180 in the presynaptic terminals of mammalian neurons
    Pamela J Yao
    Department of Neurobiology and Anatomy and Center for Aging and Developmental Biology, University of Rochester, Rochester, New York 14642, USA
    J Comp Neurol 447:152-62. 2002
  6. ncbi request reprint Immunohistochemical characterization of clathrin assembly protein AP180 and synaptophysin in human brain
    Pamela J Yao
    Department of Neurobiology and Anatomy, University of Rochester, Rochester, NY 14642, USA
    Neurobiol Aging 24:173-8. 2003
  7. ncbi request reprint AP180 and CALM in the developing hippocampus: expression at the nascent synapse and localization to trafficking organelles
    Ronald S Petralia
    Laboratory of Neurochemistry, NIDCD NIH, Bethesda, Maryland 20892, USA
    J Comp Neurol 504:314-27. 2007
  8. ncbi request reprint Partially overlapping distribution of epsin1 and HIP1 at the synapse: analysis by immunoelectron microscopy
    Pamela J Yao
    Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Comp Neurol 494:368-79. 2006
  9. ncbi request reprint Preserved synaptic vesicle recycling in hippocampal neurons in a mouse Alzheimer's disease model
    Pamela J Yao
    Laboratory of Neurosciences, NIA NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Biochem Biophys Res Commun 330:34-8. 2005
  10. pmc Involvement of Notch signaling in hippocampal synaptic plasticity
    Yue Wang
    Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 101:9458-62. 2004

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Reduced O-glycosylated clathrin assembly protein AP180: implication for synaptic vesicle recycling dysfunction in Alzheimer's disease
    P J Yao
    Department of Neurobiology and Anatomy, University of Rochester Medical Center, NY 14642, USA
    Neurosci Lett 252:33-6. 1998
    ..Our findings suggest that synaptic vesicle recycling dysfunction may be involved in the pathology of synapse loss in AD...
  2. ncbi request reprint Changes in synaptic expression of clathrin assembly protein AP180 in Alzheimer's disease analysed by immunohistochemistry
    P J Yao
    Department of Neurobiology and Anatomy, University of Rochester Medical Center, NY 14642, USA
    Neuroscience 94:389-94. 1999
    ..The variations in altered AP180 immunoreactivity in different brain regions of Alzheimer's disease may underlie the dysfunction of the corresponding synapses...
  3. ncbi request reprint Synaptic distribution of the endocytic accessory proteins AP180 and CALM
    Pamela J Yao
    Laboratory of Neurosciences, National Institute on Aging National Institutes of Health, Baltimore, Maryland 21224, USA
    J Comp Neurol 481:58-69. 2005
    ..We propose that both AP180 and CALM function as endocytic accessory proteins at synapses, but each may regulate distinct clathrin pathways...
  4. ncbi request reprint Clathrin assembly protein AP-2 is detected in both neurons and glia, and its reduction is prominent in layer II of frontal cortex in Alzheimer's disease
    P J Yao
    Center for Aging and Developmental Biology, University of Rochester Medical Center, Box 645, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Neurobiol Aging 21:921-9. 2000
    ..In contrast to AP180, we have found that AP-2 is expressed by both neurons and glia. Furthermore, the only noticeable change of AP-2 in AD is a loss of its immunoreactivity in layer II of the superior frontal gyrus...
  5. ncbi request reprint High-resolution localization of clathrin assembly protein AP180 in the presynaptic terminals of mammalian neurons
    Pamela J Yao
    Department of Neurobiology and Anatomy and Center for Aging and Developmental Biology, University of Rochester, Rochester, New York 14642, USA
    J Comp Neurol 447:152-62. 2002
    ....
  6. ncbi request reprint Immunohistochemical characterization of clathrin assembly protein AP180 and synaptophysin in human brain
    Pamela J Yao
    Department of Neurobiology and Anatomy, University of Rochester, Rochester, NY 14642, USA
    Neurobiol Aging 24:173-8. 2003
    ..Although we found that AP180 had an overall expression similar to synaptophysin, the immunoreactivity for the two proteins did not always co-localize...
  7. ncbi request reprint AP180 and CALM in the developing hippocampus: expression at the nascent synapse and localization to trafficking organelles
    Ronald S Petralia
    Laboratory of Neurochemistry, NIDCD NIH, Bethesda, Maryland 20892, USA
    J Comp Neurol 504:314-27. 2007
    ..Our observations link AP180 and CALM to multiple vesicular organelles and raise the possibility that these proteins may play additional roles in developing neurons...
  8. ncbi request reprint Partially overlapping distribution of epsin1 and HIP1 at the synapse: analysis by immunoelectron microscopy
    Pamela J Yao
    Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Comp Neurol 494:368-79. 2006
    ..Our results suggest a dual role for epsin1 and HIP1 in the synapse: as broadly required factors for promoting clathrin assembly and as adaptors for specific endocytic pathways...
  9. ncbi request reprint Preserved synaptic vesicle recycling in hippocampal neurons in a mouse Alzheimer's disease model
    Pamela J Yao
    Laboratory of Neurosciences, NIA NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Biochem Biophys Res Commun 330:34-8. 2005
    ..These data suggest that the synaptic deficits observed in the 3xTg neurons may not arise from the preserved synaptic vesicle recycling...
  10. pmc Involvement of Notch signaling in hippocampal synaptic plasticity
    Yue Wang
    Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 101:9458-62. 2004
    ..These findings suggest an important role for Notch signaling in a form of synaptic plasticity known to be associated with learning and memory processes...
  11. ncbi request reprint Synaptic frailty and clathrin-mediated synaptic vesicle trafficking in Alzheimer's disease
    Pamela J Yao
    Laboratory of Neurosciences, National Institute on Aging NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Trends Neurosci 27:24-9. 2004
  12. ncbi request reprint Synaptic slaughter in Alzheimer's disease
    Paul D Coleman
    Univesity of Rochester, Center for Aging and Developmental Biology, Rochester, NY 14642, USA
    Neurobiol Aging 24:1023-7. 2003
    ..We also provide evidence indicating that in addition to loss of synapses, synaptic function is also affected in AD by decrements in transcript species related to synaptic vesicle trafficking...
  13. ncbi request reprint Defects in expression of genes related to synaptic vesicle trafficking in frontal cortex of Alzheimer's disease
    Pamela J Yao
    Department of Neurobiology and Anatomy, Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
    Neurobiol Dis 12:97-109. 2003
    ..The results suggest a link among SV vesicle-trafficking pathways, synaptic malfunction, and AD pathogenesis...
  14. pmc Clathrin assembly protein AP180 and CALM differentially control axogenesis and dendrite outgrowth in embryonic hippocampal neurons
    Ittai Bushlin
    Laboratory of Neurosciences, National Institute on Aging National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 28:10257-71. 2008
    ..Additionally, CALM-deficient neurons show disrupted secretory transport. Our data demonstrate previously unknown functions for AP180 and CALM in intracellular trafficking that are essential in the growth of neurons...
  15. ncbi request reprint Plasma membrane ion permeability induced by mutant alpha-synuclein contributes to the degeneration of neural cells
    Katsutoshi Furukawa
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    J Neurochem 97:1071-7. 2006
    ..These findings suggest that the high membrane ion permeability caused by mutant alpha-synuclein may contribute to the degeneration of neurons in PD...
  16. doi request reprint Evidence for CALM in directing VAMP2 trafficking
    Asaff Harel
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Traffic 9:417-29. 2008
    ..Thus, our results reveal a role for CALM in directing VAMP2 trafficking during endocytosis...