Honghong Yao

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. pmc Platelet-derived growth factor-BB restores human immunodeficiency virus Tat-cocaine-mediated impairment of neurogenesis: role of TRPC1 channels
    Honghong Yao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Neurosci 32:9835-47. 2012
  2. pmc Platelet-derived growth factor (PDGF)-BB-mediated induction of monocyte chemoattractant protein 1 in human astrocytes: implications for HIV-associated neuroinflammation
    Crystal Bethel-Brown
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Neuroinflammation 9:262. 2012
  3. pmc Cocaine and HIV-1 interplay in CNS: cellular and molecular mechanisms
    Shilpa Buch
    Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Curr HIV Res 10:425-8. 2012
  4. pmc Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration
    Honghong Yao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Blood 115:4951-62. 2010
  5. pmc Platelet-derived growth factor B chain is a novel target gene of cocaine-mediated Notch1 signaling: implications for HIV-associated neurological disorders
    Honghong Yao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Neurosci 31:12449-54. 2011
  6. pmc Cocaine hijacks σ1 receptor to initiate induction of activated leukocyte cell adhesion molecule: implication for increased monocyte adhesion and migration in the CNS
    Honghong Yao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Neurosci 31:5942-55. 2011
  7. pmc Nonmuscle myosin light-chain kinase mediates microglial migration induced by HIV Tat: involvement of β1 integrins
    Honghong Yao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    FASEB J 27:1532-48. 2013
  8. pmc Cocaine and HIV-1 interplay: molecular mechanisms of action and addiction
    Shilpa Buch
    Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center DRC 8011, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 6:503-15. 2011
  9. pmc HIV Tat induces expression of ICAM-1 in HUVECs: implications for miR-221/-222 in HIV-associated cardiomyopathy
    Ming Duan
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA
    PLoS ONE 8:e60170. 2013
  10. pmc Platelet-derived growth factor CC-mediated neuroprotection against HIV Tat involves TRPC-mediated inactivation of GSK 3beta
    Fuwang Peng
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e47572. 2012

Collaborators

Detail Information

Publications18

  1. pmc Platelet-derived growth factor-BB restores human immunodeficiency virus Tat-cocaine-mediated impairment of neurogenesis: role of TRPC1 channels
    Honghong Yao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Neurosci 32:9835-47. 2012
    ....
  2. pmc Platelet-derived growth factor (PDGF)-BB-mediated induction of monocyte chemoattractant protein 1 in human astrocytes: implications for HIV-associated neuroinflammation
    Crystal Bethel-Brown
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Neuroinflammation 9:262. 2012
    ..These results suggest that astrocyte activation by PDGF-BB exaggerates monocyte recruitment into the brain via MCP-1 and underscores the critical role astrocytes play in HAND...
  3. pmc Cocaine and HIV-1 interplay in CNS: cellular and molecular mechanisms
    Shilpa Buch
    Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Curr HIV Res 10:425-8. 2012
    ..This review summarizes previous studies on the mechanism(s) underlying the interplay of cocaine and HIV as it relates to the CNS...
  4. pmc Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration
    Honghong Yao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Blood 115:4951-62. 2010
    ..Understanding the regulation of MCP-1 expression and functional changes by cocaine/sigma receptor system may provide insights into the development of potential therapeutic targets for HIV-1-associated neurocognitive disorders...
  5. pmc Platelet-derived growth factor B chain is a novel target gene of cocaine-mediated Notch1 signaling: implications for HIV-associated neurological disorders
    Honghong Yao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Neurosci 31:12449-54. 2011
    ..This is the first evidence of involvement of Notch1 activation in cocaine-mediated regulation of PDGF-B expression...
  6. pmc Cocaine hijacks σ1 receptor to initiate induction of activated leukocyte cell adhesion molecule: implication for increased monocyte adhesion and migration in the CNS
    Honghong Yao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Neurosci 31:5942-55. 2011
    ..Neutralizing antibody to ALCAM ameliorated this effect. Together, these findings implicate cocaine-mediated induction of ALCAM as a mediator of increased monocyte adhesion/transmigration into the CNS...
  7. pmc Nonmuscle myosin light-chain kinase mediates microglial migration induced by HIV Tat: involvement of β1 integrins
    Honghong Yao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    FASEB J 27:1532-48. 2013
    ..nmMYLK is thus critical for eliciting microglial migration during the innate immune response...
  8. pmc Cocaine and HIV-1 interplay: molecular mechanisms of action and addiction
    Shilpa Buch
    Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center DRC 8011, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 6:503-15. 2011
    ..In this review, recent findings on the interplay of HIV infection and cocaine abuse and their possible implications in mode of action and/or addiction will be discussed...
  9. pmc HIV Tat induces expression of ICAM-1 in HUVECs: implications for miR-221/-222 in HIV-associated cardiomyopathy
    Ming Duan
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA
    PLoS ONE 8:e60170. 2013
    ..Taken together, these findings implicate that Tat-mediated induction of ICAM-1 expression plays a critical role in monocyte adhesion observed in HIV-1-associated cardiomyopathies...
  10. pmc Platelet-derived growth factor CC-mediated neuroprotection against HIV Tat involves TRPC-mediated inactivation of GSK 3beta
    Fuwang Peng
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e47572. 2012
    ..Taken together our findings lead to the suggestion that PDGF-CC could be developed as a therapeutic target to reverse Tat-mediated neurotoxicity with implications for HAD...
  11. pmc Morphine induces expression of platelet-derived growth factor in human brain microvascular endothelial cells: implication for vascular permeability
    Hongxiu Wen
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 6:e21707. 2011
    ..Understanding the regulation of PDGF expression may provide insights into the development of potential therapeutic targets for intervention of morphine-mediated neuroinflammation...
  12. pmc Role of endoplasmic reticulum (ER) stress in cocaine-induced microglial cell death
    Blaise Mathias Costa
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 8:705-14. 2013
    ..Understanding the link between ER stress, oxidative stress and apoptosis could lead to the development of therapeutic strategies targeting cocaine-mediated microglial death/dysfunction...
  13. pmc Yin and Yang of PDGF-mediated signaling pathway in the context of HIV infection and drug abuse
    Honghong Yao
    Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center DRC 8011, University of Nebraska Medical Center, Omaha, NE, 68198 5880, USA
    J Neuroimmune Pharmacol 9:161-7. 2014
    ..Herein, we review the opposing roles of PDGF in the context of HIV-associated neurodegenerative disorder (HAND). ..
  14. pmc Cocaine-mediated induction of platelet-derived growth factor: implication for increased vascular permeability
    Honghong Yao
    Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska MedicalCenter, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Blood 117:2538-47. 2011
    ..Understanding the regulation of PDGF-BB expression may provide insights into the development of potential therapeutic targets for neuroinflammation associated with HIV infection and drug abuse...
  15. pmc Platelet-derived growth factor-mediated induction of the synaptic plasticity gene Arc/Arg3.1
    Fuwang Peng
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Biol Chem 285:21615-24. 2010
    ..Chromatin immunoprecipitation assays demonstrated the binding of Egr-1, but not Egr-3, to the Arc promoter. These findings for the first time, thus, suggest an additional role of PDGF, that of induction of Arc...
  16. doi Platelet-derived growth factor-BB restores HIV Tat -mediated impairment of neurogenesis: role of GSK-3β/β-catenin
    Jie Chao
    Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center DRC 8011, University of Nebraska Medical Center, Omaha, NE, 68198 5880, USA
    J Neuroimmune Pharmacol 9:259-68. 2014
    ..Together these data underpin the role of GSK-3β/β-catenin as a novel target that regulates NPC proliferation mediated by PDGF-BB with implications for therapeutic intervention for reversal of impaired neurogenesis inflicted by Tat. ..
  17. doi Rodent models of HAND and drug abuse: exogenous administration of viral protein(s) and cocaine
    Honghong Yao
    Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 7:341-51. 2012
    ..Such a model system recapitulates aspects of HAND in the context of drug abuse...
  18. pmc Cocaine potentiates astrocyte toxicity mediated by human immunodeficiency virus (HIV-1) protein gp120
    Yanjing Yang
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 5:e13427. 2010
    ..Our results demonstrated that cocaine-mediated potentiation of gp120 toxicity involved regulation of oxidative stress, mitochondrial membrane potential and MAPK signaling pathways...