Research Topics
| Demetris YannopoulosSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
Intra-cardiopulmonary resuscitation hypothermia with and without volume loading in an ischemic model of cardiac arrestDemetris Yannopoulos
Cardiology Division, University of Minnesota, Mayo Mail Code 508, 420 Delaware St SE, Minneapolis, MN 55455, USA
Circulation 120:1426-35. 2009..We investigated the effects of intra-cardiopulmonary resuscitation (CPR) hypothermia with and without volume loading on return to spontaneous circulation and infarction size in an ischemic model of cardiac arrest...
Controlled pauses at the initiation of sodium nitroprusside-enhanced cardiopulmonary resuscitation facilitate neurological and cardiac recovery after 15 mins of untreated ventricular fibrillationDemetris Yannopoulos
Cardiovascular Division, Department of Emergency Medicine, University of Minnesota, Minneapolis, MN, USA
Crit Care Med 40:1562-9. 2012..The primary study end point was 24-hr survival with favorable neurologic function after 15 mins of untreated ventricular fibrillation...
Cardiac arrest, mild therapeutic hypothermia, and unanticipated cerebral recoveryDemetris Yannopoulos
Department of Medicine, Cardiovascular Division, University of Minnesota, Minneapolis, Minnesota 55455, USA
Neurologist 13:369-75. 2007....- Acute management of sudden cardiac death in adults based upon the new CPR guidelinesDemetris Yannopoulos
Department of Medicine, Division of Cardiology, University of Minnesota, 2800 Hamline Avenue North No 211, Roseville, MN 55113, USA
Europace 9:2-9. 2007..CONCLUSION: The new guidelines for CPR have focused on early defibrillation, uninterrupted compressions, complete decompression, fewer ventilations, and simplification and uniformity of the process... - Sodium nitroprusside enhanced cardiopulmonary resuscitation improves survival with good neurological function in a porcine model of prolonged cardiac arrestDemetris Yannopoulos
Department of Medicine, University of Minnesota, Minneapolis St Paul, MN, USA
Crit Care Med 39:1269-74. 2011..The combination of active compression-decompression CPR+ITD+AB without SNP will be called "enhanced" or eCPR... - Subacute gastric perforation caused by a left ventricular assist deviceDemetris Yannopoulos
Division of Cardiology, University of Minnesota, MN, Mail Code 508, 420 Delaware St, SE Minneapolis, MN 55455, United States
World J Gastroenterol 13:3253-4. 2007..Gastric acid related erosions were present on the metallic surface suggesting prolonged exposure. This is the second case report of this rare complication and the first case report of a subacute course... - Advances in cardiopulmonary resuscitationDemetris Yannopoulos
Department of Medicine, Interventional Cardiology, University of Minnesota, 420 Delaware Street, MMC 508, Minneapolis, MN 55455, USA
Heart Fail Clin 7:251-68, ix. 2011..Special emphasis is given to the basic simple ways to improve circulation, vital organ perfusion pressures, and the grave prognosis of sudden cardiac death... - Effects of incomplete chest wall decompression during cardiopulmonary resuscitation on coronary and cerebral perfusion pressures in a porcine model of cardiac arrestDemetris Yannopoulos
Minneapolis Medical Research Foundation, 914 South 8th St, 3rd Floor, Minneapolis, MN 55404, USA
Resuscitation 64:363-72. 2005..1, p = 0.045. CONCLUSIONS: Incomplete chest wall recoil during the decompression phase of CPR increases endotracheal pressure, impedes venous return and decreases mean arterial pressure, and coronary and cerebral perfusion pressures... - No assisted ventilation cardiopulmonary resuscitation and 24-hour neurological outcomes in a porcine model of cardiac arrestDemetris Yannopoulos
Division of Cardiology, University of Minnesota, Minneapolis, MN, USA
Crit Care Med 38:254-60. 2010..To evaluate the effect of no assisted ventilation cardiopulmonary resuscitation on neurologically intact survival compared with ten positive pressure ventilations/minute cardiopulmonary resuscitation in a pig model of cardiac arrest... - Sodium nitroprusside enhanced cardiopulmonary resuscitation (SNPeCPR) improves vital organ perfusion pressures and carotid blood flow in a porcine model of cardiac arrestJason Schultz
Department of Medicine, University of Minnesota, Minneapolis, MN, USA
Resuscitation 83:374-7. 2012.... - Ischemic postconditioning at the initiation of cardiopulmonary resuscitation facilitates functional cardiac and cerebral recovery after prolonged untreated ventricular fibrillationNicolas Segal
Cardiovascular Division, University of Minnesota, Minneapolis 55455 0341, USA
Resuscitation 83:1397-403. 2012..We hypothesized that four 20-s pauses during the first 3 min of standard CPR would improve post resuscitation cardiac and neurological function, in a porcine model of prolonged untreated cardiac arrest... - Sodium nitroprusside-enhanced cardiopulmonary resuscitation improves resuscitation rates after prolonged untreated cardiac arrest in two porcine modelsJason C Schultz
Department of Medicine, Division of Cardiology, University of Minnesota, Minneapolis, MN, USA
Crit Care Med 39:2705-10. 2011.... - Sodium nitroprusside enhanced cardiopulmonary resuscitation prevents post-resuscitation left ventricular dysfunction and improves 24-hour survival and neurological function in a porcine model of prolonged untreated ventricular fibrillationJason Schultz
Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, MN 55455 0341, USA
Resuscitation 82:S35-40. 2011..We hypothesize that SNPeCPR will improve post resuscitation left ventricular function and neurological function compared to standard (S) CPR after 15 min of untreated ventricular fibrillation in a porcine model of cardiac arrest... - Comparison of a 10-breaths-per-minute versus a 2-breaths-per-minute strategy during cardiopulmonary resuscitation in a porcine model of cardiac arrestKeith G Lurie
Department of Emergency Medicine, University of Minnesota, Minneapolis, Minnesota, USA
Respir Care 53:862-70. 2008..Hyperventilation during cardiopulmonary resuscitation (CPR) is harmful... - Incomplete chest wall decompression: a clinical evaluation of CPR performance by trained laypersons and an assessment of alternative manual chest compression-decompression techniquesTom P Aufderheide
Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Resuscitation 71:341-51. 2006..Complete chest wall recoil improves hemodynamics during CPR by generating relatively negative intrathoracic pressure, which draws venous blood back to the heart, providing cardiac preload prior to the next chest compression... - Hemodynamic and respiratory effects of negative tracheal pressure during CPR in pigsDemetris Yannopoulos
Department of Cardiology, Cardiac Arrhythmia Center, University of Minnesota, Minneapolis, MN, USA
Resuscitation 69:487-94. 2006..The beneficial hemodynamic effects of ITPR-CPR were sustained at least 15 min without any compromise in oxygenation... - From laboratory science to six emergency medical services systems: New understanding of the physiology of cardiopulmonary resuscitation increases survival rates after cardiac arrestTom P Aufderheide
Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
Crit Care Med 36:S397-404. 2008.... - Clinical and hemodynamic comparison of 15:2 and 30:2 compression-to-ventilation ratios for cardiopulmonary resuscitationDemetris Yannopoulos
University of Minnesota, Minneapolis, MN, USA
Crit Care Med 34:1444-9. 2006..CONCLUSIONS: These data strongly support the contention that a ratio of 30:2 is superior to 15:2 during manual CPR and that the ITD further enhances circulation with both C:V ratios... - Incomplete chest wall decompression: a clinical evaluation of CPR performance by EMS personnel and assessment of alternative manual chest compression-decompression techniquesTom P Aufderheide
Department of Emergency Medicine, Medical College of Wisconsin, 9200W. Wisconsin Avenue, FEH Room 1870, Milwaukee, WI 53226, USA
Resuscitation 64:353-62. 2005..These data support development and testing of more effective means to deliver manual as well as mechanical CPR... - Intrathoracic pressure regulation improves vital organ perfusion pressures in normovolemic and hypovolemic pigsDemetris Yannopoulos
University of Minnesota, Division of Cardiology, MN, USA
Resuscitation 70:445-53. 2006..The decrease in ICP was directly proportional to the reduction in intrathoracic pressure. The effects were more pronounced in severe hypovolemic and hypotensive states with more negative ETP pressure... - Inspiratory impedance threshold device effects on hypotension in heat-stroked swineWolfgang G Voelckel
Minneapolis Medical Research Foundation, Cardiac Arrhythmia Center, Department of Emergency Medicine, Minneapolis, MN, USA
Aviat Space Environ Med 79:743-8. 2008.... - Improved cerebral perfusion pressures and 24-hr neurological survival in a porcine model of cardiac arrest with active compression-decompression cardiopulmonary resuscitation and augmentation of negative intrathoracic pressureAnja K Metzger
Department of Emergency Medicine, University of Minnesota, Minneapolis, MN, USA
Crit Care Med 40:1851-6. 2012.... - Reducing ventilation frequency combined with an inspiratory impedance device improves CPR efficiency in swine model of cardiac arrestDemetris Yannopoulos
Department of Medicine, University of Minnesota (DY, Minneapolis, MN 55455, USA
Resuscitation 61:75-82. 2004..CONCLUSION: CPR efficiency can be optimized by changing the compression: ventilation ratio from 5:1 to 10:1 and with concurrent use of the inspiratory threshold device... - Intrathoracic pressure regulation improves 24-hour survival in a pediatric porcine model of hemorrhagic shockAnja Metzger
Department of Emergency Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
Pediatr Res 70:267-71. 2011..01). IPR survival rates were significantly improved with IPR [9/9 (IPR) versus 5/11 (controls); p < 0.02]. In this piglet model of hemorrhagic shock, IPR treatment safely and significantly improved MAP, CI, and 24-h survival rates... - Intrathoracic pressure regulation for intracranial pressure management in normovolemic and hypovolemic pigsDemetris Yannopoulos
Department of Cardiology, University of Minnesota, Minneapolis, Minnesota, USA
Crit Care Med 34:S495-500. 2006..The effect was most pronounced in the hypovolemic animals... - Improving microcirculation with therapeutic intrathoracic pressure regulation in a porcine model of hemorrhageNicolas Segal
Department of Emergency Medicine, University of Minnesota Medical Center, Minneapolis, MN, USA
Resuscitation 82:S16-22. 2011..This therapy augments cardiac output and lowers intracranial pressure, thereby providing greater circulation to the heart and brain. The effects of IPR on microcirculation remain unknown... - Implementing the 2005 American Heart Association Guidelines improves outcomes after out-of-hospital cardiac arrestTom P Aufderheide
Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Heart Rhythm 7:1357-62. 2010..The purpose of the study was to determine whether applying highly recommended changes in the 2005 American Heart Association (AHA) Guidelines would improve outcomes after out-of-hospital cardiac arrest... - Intrathoracic pressure regulation improves 24-hour survival in a porcine model of hypovolemic shockDemetris Yannopoulos
Department of Cardiology, University of Minnesota, Minneapolis, Minnesota, USA
Anesth Analg 104:157-62. 2007..We hypothesized that application of intermittent negative intrathoracic pressure in a pig model of severe hypovolemic hypotension would increase 24-h neurological intact survival rates... - Hyperventilation-induced hypotension during cardiopulmonary resuscitationTom P Aufderheide
Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, USA
Circulation 109:1960-5. 2004..Subsequent animal studies demonstrated that similar excessive ventilation rates resulted in significantly increased intrathoracic pressure and markedly decreased coronary perfusion pressures and survival rates... - Take Heart America: A comprehensive, community-wide, systems-based approach to the treatment of cardiac arrestCharles J Lick
Allina Medical Transportation, St Paul, MN, USA
Crit Care Med 39:26-33. 2011.... - Standard cardiopulmonary resuscitation versus active compression-decompression cardiopulmonary resuscitation with augmentation of negative intrathoracic pressure for out-of-hospital cardiac arrest: a randomised trialTom P Aufderheide
Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Lancet 377:301-11. 2011..We aimed to assess effectiveness and safety of this intervention on survival with favourable neurological function after out-of-hospital cardiac arrest... - Effects of an inspiratory impedance threshold device on blood pressure and short term survival in spontaneously breathing hypovolemic pigsGardar Sigurdsson
Hennepin County Medical Center, Minneapolis, MN, USA
Resuscitation 68:399-404. 2006..Arterial oxygenation was not compromised in the ITD group. CONCLUSIONS: Use of an ITD improved blood pressure and short-term survival rates in a spontaneously breathing porcine model of hypovolemic hypotension... - Treatment of hypotension in pigs with an inspiratory impedance threshold device: a feasibility studyKeith G Lurie
Cardiac Arrhythmia Center at the University of Minnesota, Minneapolis, MN 55455, USA
Crit Care Med 32:1555-62. 2004..An inspiratory impedance threshold device was evaluated in spontaneously breathing animals with hypotension to determine whether it could help improve systemic arterial pressures when fluid replacement was not immediately available... - Intrathoracic pressure regulator during continuous-chest-compression advanced cardiac resuscitation improves vital organ perfusion pressures in a porcine model of cardiac arrestDemetris Yannopoulos
Department of Cardiology, Cardiac Arrhythmia Center, University of Minnesota, Minneapolis, MN, USA
Circulation 112:803-11. 2005..CONCLUSIONS: Compared with STD-CPR, use of ITPR-CPR improved hemodynamics and short-term survival rates after cardiac arrest... - Impairment of carotid artery blood flow by supraglottic airway use in a swine model of cardiac arrestNicolas Segal
Department of Emergency Medicine, University of Minnesota Medical Center, Minneapolis, MN 55455, USA
Resuscitation 83:1025-30. 2012..These devices utilize pressurized balloons to direct air to the trachea and prevent esophagus insufflation. We hypothesize that the use of a SGD will compress the carotid artery and decrease carotid blood flow (CBF) during CPR in pigs... - Cardiorespiratory interactions and blood flow generation during cardiac arrest and other states of low blood flowGardar Sigurdsson
Cardiac Arrhythmia Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
Curr Opin Crit Care 9:183-8. 2003.... - Reduced atrial tachyarrhythmia susceptibility after upgrade of conventional implanted pulse generator to cardiac resynchronization therapy in patients with heart failureDemetris Yannopoulos
Cardiac Arrhythmia Center, Department of Medicine, Cardiovascular Division, University of Minnesota Medical School, the University of Minnesota Medical Center Fairview, Minneapolis, Minnesota, USA
J Am Coll Cardiol 50:1246-51. 2007.... - Intrathoracic pressure regulation during cardiopulmonary resuscitation: a feasibility case-seriesNicolas Segal
Department of Emergency Medicine, University of Minnesota, Minneapolis, MN, USA
Resuscitation 84:450-3. 2013..In this first feasibility case-series, we tested the hypothesis that IPR improves End tidal (ET) CO2 during cardiopulmonary resuscitation (CPR). ETCO2 was used as a surrogate measure for circulation... - Spontaneous breathing through an inspiratory impedance threshold device augments cardiac index and stroke volume index in a pediatric porcine model of hemorrhagic hypovolemiaBradley S Marino
Cardiac Center at the Children's Hospital of Philadelphia and the Department of Pediatrics, University of Pennsylvania School of Medicine, USA
Crit Care Med 32:S398-405. 2004..These beneficial effects of ITD-assisted breathing are not changed by the addition of positive end-expiratory pressures of 3 cm H2O... - A dose-response curve for the negative bias pressure of an intrathoracic pressure regulator during CPRCharles F Babbs
Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47907 1246, USA
Resuscitation 71:365-8. 2006..Perfusion pressure increases approximately 50% as baseline airway pressure falls from zero to -10 cm H2O. Thereafter perfusion pressure plateaus. Negative bias pressures exceeding -10 cm H2O are not needed in ITPR-CPR... - Rapid induction of cerebral hypothermia is enhanced with active compression-decompression plus inspiratory impedance threshold device cardiopulmonary resusitation in a porcine model of cardiac arrestVijay Srinivasan
Department of Anesthesia and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
J Am Coll Cardiol 47:835-41. 2006..3 +/- 2) than S-CPR pigs (17.4 +/- 3, p < 0.01). CONCLUSIONS: A rapid ice-cold saline infusion combined with ACD + ITD CPR during cardiac arrest induces cerebral hypothermia more rapidly immediately after ROSC than with S-CPR... - Reducing ventilation frequency during cardiopulmonary resuscitation in a porcine model of cardiac arrestDemetris Yannopoulos
Minneapolis Medical Research Foundation, 914 South 8th Street, 3rd Floor, Minneapolis MN 55404, USA
Respir Care 50:628-35. 2005.... - Use of the Impedance Threshold Device (ITD)Demetris Yannopoulos
Resuscitation 75:192-3; author reply 193-4. 2007 - Spontaneous gasping decreases intracranial pressure and improves cerebral perfusion in a pig model of ventricular fibrillationVijay Srinivasan
Department of Anesthesia and Critical Care Medicine, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, PA 19104, USA
Resuscitation 69:329-34. 2006..The potential beneficial effect of gasping on cerebral perfusion may underlie the observed survival benefit, but mechanisms remain unknown...