Qinglin Yang

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Carnitine palmitoyltransferase-1b deficiency aggravates pressure overload-induced cardiac hypertrophy caused by lipotoxicity
    Lan He
    Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Blvd, Webb 435, Birmingham, AL 35294 3360, USA
    Circulation 126:1705-16. 2012
  2. pmc Peroxisome proliferator-activated receptor {delta} is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart
    Peiyong Wang
    Department of Nutrition Sciences, University of Alabama at Birmingham, Webb 435, 1675 University Blvd, Birmingham, AL 35242, USA
    Circ Res 106:911-9. 2010
  3. pmc Peroxisome proliferator-activated receptor β/δ activation in adult hearts facilitates mitochondrial function and cardiac performance under pressure-overload condition
    Jian Liu
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
    Hypertension 57:223-30. 2011
  4. pmc Peroxisome proliferator-activated receptor delta regulates mitofusin 2 expression in the heart
    Yuquan Li
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
    J Mol Cell Cardiol 46:876-82. 2009
  5. pmc Hypoxia induces downregulation of PPAR-γ in isolated pulmonary arterial smooth muscle cells and in rat lung via transforming growth factor-β signaling
    Kaizheng Gong
    Vascular Biology and Hypertension Program, Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Am J Physiol Lung Cell Mol Physiol 301:L899-907. 2011
  6. pmc Cardiomyocyte-Restricted Deletion of PPARβ/δ in PPARα-Null Mice Causes Impaired Mitochondrial Biogenesis and Defense, but No Further Depression of Myocardial Fatty Acid Oxidation
    Jian Liu
    Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Boulevard, Birmingham, AL 35294 3360, USA
    PPAR Res 2011:372854. 2011
  7. pmc Generation of an inducible, cardiomyocyte-specific transgenic mouse model with PPAR β/δ overexpression
    Teayoun Kim
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA
    Methods Mol Biol 952:57-65. 2013
  8. pmc Cardiac hypertrophy in mice with long-chain acyl-CoA dehydrogenase or very long-chain acyl-CoA dehydrogenase deficiency
    Keith B Cox
    Department of Genetics, University of Alabama at Birmingham, USA
    Lab Invest 89:1348-54. 2009
  9. pmc Transforming growth factor-β inhibits myocardial PPARγ expression in pressure overload-induced cardiac fibrosis and remodeling in mice
    Kaizheng Gong
    Vascular Biology and Hypertension Program, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Hypertens 29:1810-9. 2011
  10. pmc Macrophage adiponectin expression improves insulin sensitivity and protects against inflammation and atherosclerosis
    Nanlan Luo
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Diabetes 59:791-9. 2010

Collaborators

Detail Information

Publications13

  1. pmc Carnitine palmitoyltransferase-1b deficiency aggravates pressure overload-induced cardiac hypertrophy caused by lipotoxicity
    Lan He
    Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Blvd, Webb 435, Birmingham, AL 35294 3360, USA
    Circulation 126:1705-16. 2012
    ..Preclinical studies using genetically modified animal models should provide a better understanding of targeting CPT1 to evaluate it as a safe and effective therapeutic approach...
  2. pmc Peroxisome proliferator-activated receptor {delta} is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart
    Peiyong Wang
    Department of Nutrition Sciences, University of Alabama at Birmingham, Webb 435, 1675 University Blvd, Birmingham, AL 35242, USA
    Circ Res 106:911-9. 2010
    ..Long-term cardiomyocyte-restricted PPARdelta deficiency in mice leads to depressed myocardial fatty acid oxidation, bioenergetics, and premature death with lipotoxic cardiomyopathy...
  3. pmc Peroxisome proliferator-activated receptor β/δ activation in adult hearts facilitates mitochondrial function and cardiac performance under pressure-overload condition
    Jian Liu
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
    Hypertension 57:223-30. 2011
    ....
  4. pmc Peroxisome proliferator-activated receptor delta regulates mitofusin 2 expression in the heart
    Yuquan Li
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
    J Mol Cell Cardiol 46:876-82. 2009
    ..We conclude that Mfn2 is a PPARdelta-selective target, which may play an important role in regulating myocardial energy homeostasis...
  5. pmc Hypoxia induces downregulation of PPAR-γ in isolated pulmonary arterial smooth muscle cells and in rat lung via transforming growth factor-β signaling
    Kaizheng Gong
    Vascular Biology and Hypertension Program, Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Am J Physiol Lung Cell Mol Physiol 301:L899-907. 2011
    ..These data provide strong evidence that activation of TGF-β/Smad signaling, via transcriptional suppression of PPAR-γ expression, mediates chronic hypoxia-induced downregulation of PPAR-γ expression in lung...
  6. pmc Cardiomyocyte-Restricted Deletion of PPARβ/δ in PPARα-Null Mice Causes Impaired Mitochondrial Biogenesis and Defense, but No Further Depression of Myocardial Fatty Acid Oxidation
    Jian Liu
    Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Boulevard, Birmingham, AL 35294 3360, USA
    PPAR Res 2011:372854. 2011
    ..Therefore, PPARβ/δ is essential for maintaining mitochondrial biogenesis and defense in cardiomyocytes independent of PPARα...
  7. pmc Generation of an inducible, cardiomyocyte-specific transgenic mouse model with PPAR β/δ overexpression
    Teayoun Kim
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA
    Methods Mol Biol 952:57-65. 2013
    ..In this chapter, we describe the methodology for a more efficient generation of transgenic mouse models with a constitutively active form of PPARβ/δ in different tissues...
  8. pmc Cardiac hypertrophy in mice with long-chain acyl-CoA dehydrogenase or very long-chain acyl-CoA dehydrogenase deficiency
    Keith B Cox
    Department of Genetics, University of Alabama at Birmingham, USA
    Lab Invest 89:1348-54. 2009
    ....
  9. pmc Transforming growth factor-β inhibits myocardial PPARγ expression in pressure overload-induced cardiac fibrosis and remodeling in mice
    Kaizheng Gong
    Vascular Biology and Hypertension Program, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Hypertens 29:1810-9. 2011
    ..This study tested the hypothesis that there is a functional interaction between transforming growth factor-β (TGF-β) signaling and endogenous PPARγ expression in cardiac fibroblasts and pressure overloaded heart...
  10. pmc Macrophage adiponectin expression improves insulin sensitivity and protects against inflammation and atherosclerosis
    Nanlan Luo
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Diabetes 59:791-9. 2010
    ....
  11. pmc Glucose deprivation-induced increase in protein O-GlcNAcylation in cardiomyocytes is calcium-dependent
    LuYun Zou
    Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    J Biol Chem 287:34419-31. 2012
    ..These results suggest that increased intracellular calcium and subsequent activation of CaMKII play a key role in regulating the stress-induced increase in cellular O-GlcNAc levels...
  12. pmc High-fat feeding in cardiomyocyte-restricted PPARdelta knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes
    Yuquan Li
    Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Blvd, Birmingham, AL 35294 3360, USA
    J Mol Cell Cardiol 47:536-43. 2009
    ..Increased lipid intake activates cardiac expression of FAO genes via PPARalpha/PGC-1alpha pathway, albeit it is not sufficient to improve cardiac pathology due to PPARdelta deficiency...
  13. pmc Peroxisome-proliferator-activated receptors regulate redox signaling in the cardiovascular system
    Teayoun Kim
    Teayoun Kim, Qinglin Yang, Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, United States
    World J Cardiol 5:164-74. 2013
    ..The purpose of the review is to summarize the effects of each PPAR on regulating redox and the underlying mechanisms, as well as to discuss the implications in the cardiovascular system. ..

Research Grants8