Liu Yang

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor
    Liu Yang
    Medical Research Service, VA Puget Sound Health Care System, University of Washington, Seattle, Washington, WA 98108, USA
    Oncogene 21:148-52. 2002
  2. pmc An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B
    Liu Yang
    Department of Orthopedics, University of Washington School of Medicine, Seattle, WA 98195, USA
    Biochem J 369:651-7. 2003
  3. doi request reprint EWS/FLI1 suppresses retinoblastoma protein function and senescence in Ewing's sarcoma cells
    Hsien Ming Hu
    Department of Orthopedics and Sports Medicine, School of Medicine, University of Washington, 1660 S Columbian Way, ORT112, Seattle, Washington 98108, USA
    J Orthop Res 26:886-93. 2008
  4. pmc ESET histone methyltransferase is essential to hypertrophic differentiation of growth plate chondrocytes and formation of epiphyseal plates
    Liu Yang
    Department of Orthopedics and Sports Medicine, University of Washington, United States
    Dev Biol 380:99-110. 2013
  5. pmc FOXO1 is a direct target of EWS-Fli1 oncogenic fusion protein in Ewing's sarcoma cells
    Liu Yang
    Department of Orthopedics, University of Washington, Seattle, WA 98195, United States
    Biochem Biophys Res Commun 402:129-34. 2010
  6. doi request reprint TLS-ERG leukemia fusion protein deregulates cyclin-dependent kinase 1 and blocks terminal differentiation of myeloid progenitor cells
    Jing Pan
    Departments of Orthopedics and Medicine Hematology, University of Washington, 1660 South Columbian Way, GMR 151, Seattle, WA 98108
    Mol Cancer Res 6:862-72. 2008
  7. doi request reprint Proper expression of helix-loop-helix protein Id2 is important to chondrogenic differentiation of ATDC5 cells
    Liu Yang
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, U S A
    Biochem J 419:635-43. 2009
  8. pmc The oncogenic TLS-ERG fusion protein exerts different effects in hematopoietic cells and fibroblasts
    Junhui Zou
    Department of Orthopedics, University of Washington, Seattle 98195, USA
    Mol Cell Biol 25:6235-46. 2005
  9. ncbi request reprint Survival motor neuron (SMN) protein interacts with transcription corepressor mSin3A
    Junhui Zou
    Departments of Orthopedics and Sports Medicine and Medicine Hematology, University of Washington, Seattle, Washington 98195 USA
    J Biol Chem 279:14922-8. 2004
  10. pmc TASR-1 regulates alternative splicing of collagen genes in chondrogenic cells
    Hiroshi Matsushita
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Biochem Biophys Res Commun 356:411-7. 2007

Research Grants

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor
    Liu Yang
    Medical Research Service, VA Puget Sound Health Care System, University of Washington, Seattle, Washington, WA 98108, USA
    Oncogene 21:148-52. 2002
    ..Together, these findings raise the possibility that transcription factor ERG may participate in transcriptional regulation through ESET-mediated histone methylation...
  2. pmc An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B
    Liu Yang
    Department of Orthopedics, University of Washington School of Medicine, Seattle, WA 98195, USA
    Biochem J 369:651-7. 2003
    ..Taken together, these data suggest that ESET histone methyltransferase can form a large, multi-protein complex(es) with mSin3A/B co-repressors and HDAC1/2 that participates in multiple pathways of transcriptional repression...
  3. doi request reprint EWS/FLI1 suppresses retinoblastoma protein function and senescence in Ewing's sarcoma cells
    Hsien Ming Hu
    Department of Orthopedics and Sports Medicine, School of Medicine, University of Washington, 1660 S Columbian Way, ORT112, Seattle, Washington 98108, USA
    J Orthop Res 26:886-93. 2008
    ..Together, these results support the role of EWS/LI1 as an inhibitor of cellular senescence and implicate the retinoblastoma family of proteins as key mediators of this inhibition...
  4. pmc ESET histone methyltransferase is essential to hypertrophic differentiation of growth plate chondrocytes and formation of epiphyseal plates
    Liu Yang
    Department of Orthopedics and Sports Medicine, University of Washington, United States
    Dev Biol 380:99-110. 2013
    ..Together, these results provide clear evidence that ESET controls hypertrophic differentiation of growth plate chondrocytes and endochondral ossification during embryogenesis and postnatal development...
  5. pmc FOXO1 is a direct target of EWS-Fli1 oncogenic fusion protein in Ewing's sarcoma cells
    Liu Yang
    Department of Orthopedics, University of Washington, Seattle, WA 98195, United States
    Biochem Biophys Res Commun 402:129-34. 2010
    ..Together, these results suggest that suppression of FOXO1 function by EWS-Fli1 fusion protein may contribute to cellular transformation in Ewing's family tumors...
  6. doi request reprint TLS-ERG leukemia fusion protein deregulates cyclin-dependent kinase 1 and blocks terminal differentiation of myeloid progenitor cells
    Jing Pan
    Departments of Orthopedics and Medicine Hematology, University of Washington, 1660 South Columbian Way, GMR 151, Seattle, WA 98108
    Mol Cancer Res 6:862-72. 2008
    ....
  7. doi request reprint Proper expression of helix-loop-helix protein Id2 is important to chondrogenic differentiation of ATDC5 cells
    Liu Yang
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, U S A
    Biochem J 419:635-43. 2009
    ..Our results suggest that proper expression of Id2 is important to achieving a fine balance between growth and differentiation during chondrogenesis...
  8. pmc The oncogenic TLS-ERG fusion protein exerts different effects in hematopoietic cells and fibroblasts
    Junhui Zou
    Department of Orthopedics, University of Washington, Seattle 98195, USA
    Mol Cell Biol 25:6235-46. 2005
    ..Taken together, these results suggest that the oncogenic TLS-ERG fusion protein transforms hematopoietic cells and fibroblasts via different pathways...
  9. ncbi request reprint Survival motor neuron (SMN) protein interacts with transcription corepressor mSin3A
    Junhui Zou
    Departments of Orthopedics and Sports Medicine and Medicine Hematology, University of Washington, Seattle, Washington 98195 USA
    J Biol Chem 279:14922-8. 2004
    ..Together, these findings provide a potential mechanism by which lack of fully functional SMN protein is detrimental to motor neuron survival...
  10. pmc TASR-1 regulates alternative splicing of collagen genes in chondrogenic cells
    Hiroshi Matsushita
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Biochem Biophys Res Commun 356:411-7. 2007
    ..Immunohistostaining demonstrated that TASR-1 protein is more abundantly expressed than TASR-2 in mouse articular chondrocytes, raising the possibility that TASR-1 might be involved in phenotype maintenance of articular chondrocytes...
  11. ncbi request reprint Genomic structure and expression of the mouse ESET gene encoding an ERG-associated histone methyltransferase with a SET domain
    Michael L Blackburn
    Department of Orthopedics and Sports Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Biochim Biophys Acta 1629:8-14. 2003
    ..Full-length ESET transcript appears to be ubiquitously expressed. While the SET domain-deficient splicing variant is present in immortalized cell lines, it is undetectable by RT-PCR in the majority of normal mouse tissues...
  12. ncbi request reprint COL11A2 collagen gene transcription is differentially regulated by EWS/ERG sarcoma fusion protein and wild-type ERG
    Yoshito Matsui
    Department of Orthopedics and Sports Medicine, University of Washington School of Medicine, Seattle, Washington 98195 6500, USA
    J Biol Chem 278:11369-75. 2003
    ..Taken together, these findings indicate that the COL11A2 gene is regulated both by potential ERG association with a histone deacetylase complex and by direct EWS/ERG recruitment of RNA polymerase II...
  13. pmc Mesenchyme-specific knockout of ESET histone methyltransferase causes ectopic hypertrophy and terminal differentiation of articular chondrocytes
    Kevin A Lawson
    From the Department of Orthopedics and Sports Medicine, University of Washington, Seattle, Washington 98108 and
    J Biol Chem 288:32119-25. 2013
    ....
  14. pmc ESET histone methyltransferase regulates osteoblastic differentiation of mesenchymal stem cells during postnatal bone development
    Kevin A Lawson
    Department of Orthopedics and Sports Medicine, University of Washington, Seattle, WA 98195, United States
    FEBS Lett 587:3961-7. 2013
    ..As the bone phenotype in ESET-null mice is 100% penetrant, these results support ESET as a critical regulator of osteoblast differentiation during bone development...
  15. doi request reprint Rab23 regulates differentiation of ATDC5 chondroprogenitor cells
    Liu Yang
    Department of Orthopedics and Sports Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 283:10649-57. 2008
    ..Because the phenotypes of Rab23 mutations in mice and humans include defects in cartilage and bone development, our study suggests that Rab23 is involved in the control of Sox9 expression via Gli1 protein...
  16. ncbi request reprint Targeting of EWS/FLI-1 by RNA interference attenuates the tumor phenotype of Ewing's sarcoma cells in vitro
    Howard A Chansky
    Department of Orthopedics and Sports Medicine, School of Medicine, University of Washington, 1660 S Columbian Way, ORT112, Seattle, WA 98108, USA
    J Orthop Res 22:910-7. 2004
    ..These experiments suggest that targeted silencing of the EWS/FLI-1 fusion gene by siRNA represents a promising strategy to study the loss of EWS/FLI-1 protein in Ewing's sarcoma cells of otherwise identical genetic background...
  17. ncbi request reprint RNA splicing mediated by YB-1 is inhibited by TLS/CHOP in human myxoid liposarcoma cells
    Timothy B Rapp
    Department of Orthopaedics and Sports Medicine, School of Medicine, University of Washington, Seattle 98108, USA
    J Orthop Res 20:723-9. 2002
    ..When considered in conjunction with studies on other sarcoma fusion proteins, these data suggest that aberrant RNA splicing may be a common feature of human sarcomas...
  18. ncbi request reprint Characterization and expression of the human gene encoding two translocation liposarcoma protein-associated serine-arginine (TASR) proteins
    Jeremiah M Clinton
    Department of Orthopedics and Sports Medicine, University of Washington School of Medicine, 1660 South Columbian Way, GMR 151, Seattle, WA 98108, USA
    Gene 284:141-7. 2002
    ..Northern blot analysis showed that at least five different TASR-1 and -2 transcripts are expressed in a broad range of human tissues...
  19. pmc ESET methylates UBF at K232/254 and regulates nucleolar heterochromatin plasticity and rDNA transcription
    Yu Jin Hwang
    Department of Biomedical Sciences, World Class University Neurocytomics Group, Seoul National University College of Medicine, Seoul 110 799, South Korea, Medical Engineering, Seoul National University College of Medicine, Seoul 110 799, South Korea, Center for Neuro medicine, Brain Science Institute, Korea Institute of Science and Technology KIST, Seoul 136 791, South Korea, VA Boston Healthcare System, Boston, MA 02130, USA, Boston University Alzheimer s Disease Center and Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA, Department of Orthopedics and Division of Hematology, University of Washington School of Medicine, Seattle, WA 98195, USA and Medical Research Service, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Nucleic Acids Res 42:1628-43. 2014
    ..Together, our findings show that a novel epigenetic modification of UBF is linked to impaired rDNA transcription and nucleolar chromatin remodeling, which may play key roles in the pathogenesis of neurodegeneration. ..
  20. ncbi request reprint Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells
    Tomohiro Goto
    Department of Orthopaedics, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    J Bone Miner Res 21:661-73. 2006
    ..The findings indicate both ubiquitous and osteoblast-specific mechanisms of collagen gene regulation...
  21. ncbi request reprint [Effect of Tribulus terrestris L decoction of different concentrations on tyrosinase activity and the proliferation of melanocytes]
    Yan Deng
    Department of Traditional Chinese Medicine, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 22:1017-9. 2002
    ..To study the effects of the decoction of Tribulus terrestris L on tyrosinase activity and melanogenesis...
  22. ncbi request reprint DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells
    Yutaka Yata
    Department of Medicine, The University of North Carolina at Chapel Hill, 27599, USA
    Hepatology 37:267-76. 2003
    ..The collagen-GFP transgenic mice provide a convenient and reliable model system to investigate the molecular mechanisms controlling increased collagen expression during fibrosis...
  23. ncbi request reprint Polyphenols from Camellia sinenesis attenuate experimental cholestasis-induced liver fibrosis in rats
    Zhi Zhong
    Dept of Cell and Developmental Biology, CB 7090, Univ of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7090, USA
    Am J Physiol Gastrointest Liver Physiol 285:G1004-13. 2003
    ..Polyphenols from C. sinenesis scavenge oxygen radicals and prevent activation of stellate cells, thereby minimizing liver fibrosis...
  24. ncbi request reprint Immortalization of human articular chondrocytes and induction of their phenotype
    Qingyi He
    Department of Orthopedics, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China
    Chin Med J (Engl) 116:1351-6. 2003
    ..To immortalize human articular chondrocytes (HACs) using gene transfection and to maintain stable phenotype of transformed HACs after induction...
  25. ncbi request reprint Purification and characterization of an isoflavone-conjugates-hydrolyzing beta-glucosidase from endophytic bacterium
    Liu Yang
    The State Key Laboratory for Biocontrol, Sun Yet Sen University, Guangzhou, 510275, PR China
    J Agric Food Chem 52:1940-4. 2004
    ....
  26. ncbi request reprint Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis speciosa
    Yoichi Nakao
    Department of Chemistry, University of Hawaii at Manoa, 2545 The Mall, Honolulu, Hawaii 96822 2275, USA
    J Nat Prod 67:1332-40. 2004
    ..Kulokekahilide-2 showed potent cytotoxicity against several cell lines (P388, SK-OV-3, MDA-MB-435, and A-10 with IC50 values ranging from 4.2 to 59.1 nM) indicating cancer cell selectivity...
  27. ncbi request reprint [In vivo MR imaging tracking of supermagnetic iron-oxide nanoparticle-labeled bone marrow mesenchymal stem cells injected into intra-articular space of knee joints: experiment with rabbit]
    Xu hong Jin
    Center of Joint Surgery, Southwest Hospital, Third Military Medical University, Chongqing, China
    Zhonghua Yi Xue Za Zhi 87:3213-8. 2007
    ..5T system tracking of the survival, migration and differentiation of magnetically labeled seed cells-bone marrow-derived mesenchymal stem cells (MSCs) injected into the articular cavity...
  28. doi request reprint Synthesis of novel derivatives of bispodophyllotoxin as potential antineoplastic agents--part XVI
    Ying Qian Liu
    School of Pharmacy, Lanzhou University, Lanzhou, PR China
    Nat Prod Res 22:285-91. 2008
    ....
  29. pmc Excess FGF-7 in corneal epithelium causes corneal intraepithelial neoplasia in young mice and epithelium hyperplasia in adult mice
    Taiichiro Chikama
    Department of Ophthalmology, University of Cincinnati Medical Center, 3223 Eden Ave, Suite 350, Cincinnati, OH 45267 0527, USA
    Am J Pathol 172:638-49. 2008
    ..Taken together, Krt12-rtTA/tet-O-FGF-7 mice may be a suitable animal model for the study of the molecular and cellular mechanisms of human OSSN...
  30. pmc Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in dictyostelium cells
    Lan Ma
    Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Biophys J 87:3764-74. 2004
    ..Finally, we use the model to predict the response of a cell where only a fraction is stimulated by a saturating dose of chemoattractant...
  31. ncbi request reprint NF-kappaB activation in Kupffer cells after partial hepatectomy
    Liu Yang
    Dept of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Am J Physiol Gastrointest Liver Physiol 289:G530-8. 2005
    ..During liver regeneration, EGFP expression was detected within 12 h and was primarily located in Kupffer cells. Our data demonstrate that activation of NF-kappaB initially occurs in Kupffer cells after partial hepatectomy in mice...
  32. pmc Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells
    Liu Yang
    Gastroenterology and Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Hepatol 48:98-106. 2008
    ..The hedgehog (Hh) pathway regulates remodeling of other injured tissues. This study evaluates the hypothesis that autocrine production of Sonic hedgehog (Shh) promotes MFB growth...
  33. ncbi request reprint Constructing plasma protein binding model based on a combination of cluster analysis and 4D-fingerprint molecular similarity analyses
    Jianzhong Liu
    Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA
    Bioorg Med Chem 14:611-21. 2006
    ..Moreover, these three IPE/IPE type similarity measures are very similar to one another for the particular training and test sets investigated. The 4D-fingerprints have relatively high predictivity for this particular dataset...
  34. ncbi request reprint Cloning, expression, purification, and characterization of a novel epoxide hydrolase from Aspergillus niger SQ-6
    Yanbin Liu
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China
    Protein Expr Purif 53:239-46. 2007
    ..It may be an industrial biocatalyst for the preparation of enantiopure epoxides or vicinal diols...
  35. ncbi request reprint Regulation of peroxisome proliferator-activated receptor-gamma in liver fibrosis
    Liu Yang
    Department of Cell Biology, Duke University Medical Center, Durham, NC, USA
    Am J Physiol Gastrointest Liver Physiol 291:G902-11. 2006
    ..The data highlight a critical role for PPARgamma during in vivo fibrogenesis and emphasize the importance of the PPARgamma pathway in stellate cells during liver injury...
  36. ncbi request reprint Prediction of plasma protein binding of drugs using Kier-Hall valence connectivity indices and 4D-fingerprint molecular similarity analyses
    Jianzhong Liu
    Department of Chemistry and Biochemistry, University of Delaware, Newark, DE, 19716, USA
    J Comput Aided Mol Des 19:567-83. 2005
    ..Both the Kier-Hall valence connectivity indices similarity measures and the 4D-fingerprints have nearly same predictivity for this particular dataset...

Research Grants9

  1. TLS and TLS Fusion Proteins in Leukemia
    Liu Yang; Fiscal Year: 2005
    ..It is envisioned that successful completion of this project will unveil potential therapeutic targets in the treatment of human leukemias characterized by the t(16;21) translocation. ..
  2. TLS and TLS Fusion Proteins in Leukemia
    Liu Yang; Fiscal Year: 2002
    ..It is envisioned that successful completion of this project will unveil potential therapeutic targets in the treatment of human leukemias characterized by the t(16;21) translocation. ..
  3. TLS and TLS Fusion Proteins in Leukemia
    Liu Yang; Fiscal Year: 2003
    ..It is envisioned that successful completion of this project will unveil potential therapeutic targets in the treatment of human leukemias characterized by the t(16;21) translocation. ..
  4. TLS and TLS Fusion Proteins in Leukemia
    Liu Yang; Fiscal Year: 2004
    ..It is envisioned that successful completion of this project will unveil potential therapeutic targets in the treatment of human leukemias characterized by the t(16;21) translocation. ..
  5. CHONDROGENESIS AND HISTONE MODIFICATION ENZYMES
    Liu Yang; Fiscal Year: 2004
    ....
  6. TLS and TLS Fusion Proteins in Leukemia
    Liu Yang; Fiscal Year: 2005
    ..It is envisioned that successful completion of this project will unveil potential therapeutic targets in the treatment of human leukemias characterized by the t(16;21) translocation. ..
  7. CHONDROGENESIS AND HISTONE MODIFICATION ENZYMES
    Liu Yang; Fiscal Year: 2005
    ....
  8. CHONDROGENESIS AND HISTONE MODIFICATION ENZYMES
    Liu Yang; Fiscal Year: 2007
    ....
  9. CHONDROGENESIS AND HISTONE MODIFICATION ENZYMES
    Liu Yang; Fiscal Year: 2006
    ....