Jing Yang

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Exploring a new twist on tumor metastasis
    Jing Yang
    Whitehead Institute for Biomedical Research, Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cancer Res 66:4549-52. 2006
  2. ncbi request reprint Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma
    Toshiyuki Horikawa
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Res 67:1970-8. 2007
  3. pmc Targeting invadopodia to block breast cancer metastasis
    Mark A Eckert
    Department of Pharmacology
    Oncotarget 2:562-8. 2011
  4. doi request reprint Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis
    Jing Yang
    Department of Pharmacology and Pediatrics, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Dev Cell 14:818-29. 2008
  5. ncbi request reprint Exploring the molecular basis of tumor metastasis by microarray analysis
    Jing Yang
    Department of Pharmacology, University of California, San Diego, School of Medicine, La Jolla, CA 92093 0636, USA
    Assay Drug Dev Technol 4:483-8. 2006
  6. doi request reprint Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer
    Ying Li
    Department of Pharmacology, School of Medicine, Wuhan University, Wuhan 430071, China
    Toxicol Appl Pharmacol 272:37-48. 2013
  7. pmc Twist1-induced invadopodia formation promotes tumor metastasis
    Mark A Eckert
    Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Cancer Cell 19:372-86. 2011
  8. pmc Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
    Jeff H Tsai
    Department of Pharmacology, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Cancer Cell 22:725-36. 2012
  9. pmc Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer
    Wei Yu
    Department of Pharmacology, School of Medicine, Wuhan University, Wuhan 430071, China
    Toxicol Appl Pharmacol 264:73-83. 2012
  10. pmc Quantitative changes in gene transcription during induction of differentiation in porcine neural progenitor cells
    Jing Yang
    Gavin Herbert Eye Institute, University of California, Irvine, CA 92697 1705, USA
    Mol Vis 18:1484-504. 2012

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Exploring a new twist on tumor metastasis
    Jing Yang
    Whitehead Institute for Biomedical Research, Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cancer Res 66:4549-52. 2006
    ..Here, we review the Twist signaling pathway during normal development and discuss how the transcription factor Twist and the epithelial-mesenchymal transition program impinge their biological functions during tumor metastasis...
  2. ncbi request reprint Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma
    Toshiyuki Horikawa
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Res 67:1970-8. 2007
    ..These results suggest that induction of Twist by a human viral oncoprotein LMP1 directly contributes to the metastatic nature of NPC...
  3. pmc Targeting invadopodia to block breast cancer metastasis
    Mark A Eckert
    Department of Pharmacology
    Oncotarget 2:562-8. 2011
    ..Here, we provide an overview of clinically-relevant targets for intervention in invadopodia, including Src signaling, PDGFR signaling, and metalloprotease activity...
  4. doi request reprint Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis
    Jing Yang
    Department of Pharmacology and Pediatrics, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Dev Cell 14:818-29. 2008
    ..Studies in both fields are critical for our molecular understanding of cell migration and morphogenesis...
  5. ncbi request reprint Exploring the molecular basis of tumor metastasis by microarray analysis
    Jing Yang
    Department of Pharmacology, University of California, San Diego, School of Medicine, La Jolla, CA 92093 0636, USA
    Assay Drug Dev Technol 4:483-8. 2006
    ..Also highlighted are the pros and cons for each system. In particular, I will describe our experience of using microarray technology to identify the transcription factor Twist as an essential player in tumor metastasis...
  6. doi request reprint Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer
    Ying Li
    Department of Pharmacology, School of Medicine, Wuhan University, Wuhan 430071, China
    Toxicol Appl Pharmacol 272:37-48. 2013
    ..Collectively, these data suggest that isoliquiritigenin induces growth inhibition and apoptosis through downregulating AA metabolic network and the deactivation of PI3K/Akt in human breast cancer. ..
  7. pmc Twist1-induced invadopodia formation promotes tumor metastasis
    Mark A Eckert
    Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Cancer Cell 19:372-86. 2011
    ..Therefore, invadopodia-mediated matrix degradation is a key function of Twist1 in promoting tumor metastasis...
  8. pmc Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
    Jeff H Tsai
    Department of Pharmacology, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Cancer Cell 22:725-36. 2012
    ..Our study demonstrates in vivo the requirement of "reversible EMT" in tumor metastasis and may resolve the controversy on the importance of EMT in carcinoma metastasis...
  9. pmc Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer
    Wei Yu
    Department of Pharmacology, School of Medicine, Wuhan University, Wuhan 430071, China
    Toxicol Appl Pharmacol 264:73-83. 2012
    ..Collectively, these data suggest that increased CYP4Z1 expression promotes tumor angiogenesis and growth in breast cancer partly via PI3K/Akt and ERK1/2 activation...
  10. pmc Quantitative changes in gene transcription during induction of differentiation in porcine neural progenitor cells
    Jing Yang
    Gavin Herbert Eye Institute, University of California, Irvine, CA 92697 1705, USA
    Mol Vis 18:1484-504. 2012
    ..Differentiation of neural stem/progenitor cells involves changes in the gene expression of these cells. Less clear is the extent to which incremental changes occur and the time course of such changes, particularly in non-rodents...
  11. pmc Feline Neural Progenitor Cells I: Long-Term Expansion under Defined Culture Conditions
    Jing Yang
    Department of Ophthalmology, Ophthalmology Research Laboratories, The Gavin Herbert Eye Institute, University of California, Irvine, CA 92697, USA
    Stem Cells Int 2012:108340. 2012
    ..Importantly, later passage cNPCs did not develop chromosomal aberrations...
  12. pmc 20-HETE regulates the angiogenic functions of human endothelial progenitor cells and contributes to angiogenesis in vivo
    Li Chen
    Department of Pharmacology, School of Medicine, Wuhan University, Wuhan, PR China L C, J Y, A M G Department of Pharmacology, New York Medical College, Valhalla, New York L C, R A, M S, K H G, M L S, A M G Department of Obstetrics and Gynecology, Westchester Medical Center, Valhalla, New York M K Obstetrics and Gynecology, Phelps Memorial Hospital Center, Sleepy Hollow, New York L G M University of Texas Southwestern Medical Center, Dallas, Texas J R F and Henry Ford Hospital, Detroit, Michigan A S A, A G S
    J Pharmacol Exp Ther 348:442-51. 2014
    ..These results strengthened the notion that 20-HETE regulates the angiogenic functions of EPC in vitro and EPC-mediated angiogenesis in vivo...
  13. pmc Twist1 induces CCL2 and recruits macrophages to promote angiogenesis
    Janine M Low-Marchelli
    Biomedical Sciences Program, Department of Pharmacology, University of California, San Diego, CA 92093, USA
    Cancer Res 73:662-71. 2013
    ..As Twist1 expression has been associated with poor survival in many human cancers, this finding suggests that anti-CCL2 therapy may offer a rational strategy to treat Twist1-positive metastatic cancers...
  14. ncbi request reprint Ovol proteins: guardians against EMT during epithelial differentiation
    Shan Li
    Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA
    Dev Cell 29:1-2. 2014
    ..In this issue of Developmental Cell, Lee et al. (2014) and Watanabe et al. (2014) uncover a critical role of Ovol proteins in safeguarding this intricate process...
  15. pmc Feline Neural Progenitor Cells II: Use of Novel Plasmid Vector and Hybrid Promoter to Drive Expression of Glial Cell Line-Derived Neurotrophic Factor Transgene
    X Joann You
    The Gavin Herbert Eye Institute, School of Medicine, University of California, Irvine, Hewitt Hall, Rm 2014, 843 Health Sciences Road, Irvine, CA 92697 1705, USA
    Stem Cells Int 2012:604982. 2012
    ..These genetically modified cells appear suitable for use in allogeneic models of cell-based delivery of GDNF in the cat and may find veterinary applications should such strategies prove clinically beneficial...
  16. pmc Effects of glial cell line-derived neurotrophic factor on cultured murine retinal progenitor cells
    Jinmei Wang
    Gavin Herbert Eye Institute and Stem Cell Research Center, University of California, Irvine, CA 92697 1705, USA
    Mol Vis 16:2850-66. 2010
    ....
  17. pmc Visualizing extravasation dynamics of metastatic tumor cells
    Konstantin Stoletov
    Department of Pathology and Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, MC0612, La Jolla, CA 92093, USA
    J Cell Sci 123:2332-41. 2010
    ..Our results demonstrate that extravasation of tumor cells is a highly dynamic process influenced by metastatic genes that target adhesion and intravascular migration of tumor cells, and induce endothelial remodeling...
  18. pmc Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis
    Esmeralda Casas
    Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, California 92093 0636, USA
    Cancer Res 71:245-54. 2011
    ..Together, our results show that Twist1 needs to induce Snail2 to suppress the epithelial branch of the EMT program and that Twist1 and Snail2 act together to promote EMT and tumor metastasis...
  19. doi request reprint Antitumor and immunostimulatory activity of a polysaccharide-protein complex from Scolopendra subspinipes mutilans L. Koch in tumor-bearing mice
    Haixia Zhao
    Department of Pharmacology, School of Medicine, Wuhan University, Wuhan 430071, China
    Food Chem Toxicol 50:2648-55. 2012
    ....
  20. pmc Derivation of neural progenitors and retinal pigment epithelium from common marmoset and human pluripotent stem cells
    Laughing Bear Torrez
    Stem Cell Center, Department of Cell Biology and Neuroscience, University of California, Riverside, Riverside, CA 92521, USA
    Stem Cells Int 2012:417865. 2012
    ....
  21. pmc Sequential changes in the gene expression profile of murine retinal progenitor cells during the induction of differentiation
    Ping Gu
    Gavin Herbert Eye Institute, Department of Ophthalmology, School of Medicine, University of California, Irvine, Orange, CA 92868, USA
    Mol Vis 15:2111-22. 2009
    ..In vitro analysis of cultured RPCs allows detailed examination of marker gene expression during the initial phase of differentiation and can provide insight into the variables influencing this process...
  22. pmc Imatinib-resistant CML cells have low ENT activity but maintain sensitivity to gemcitabine
    Andrea V Leisewitz
    Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599, USA
    Nucleosides Nucleotides Nucleic Acids 27:779-86. 2008
    ..Although, imatinib-resistant cells showed decreased levels of both ENT1 and ENT2 activity and expression, these cells remained sensitive to gemcitabine, suggesting that nucleoside analogs can be used as adjunctive therapy...
  23. pmc Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers
    Sendurai A Mani
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 104:10069-74. 2007
    ..These observations indicate that FOXC2 plays a central role in promoting invasion and metastasis and that it may prove to be a highly specific molecular marker for human basal-like breast cancers...
  24. doi request reprint Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
    Tamer T Onder
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Cancer Res 68:3645-54. 2008
    ..These findings indicate that E-cadherin loss in tumors contributes to metastatic dissemination by inducing wide-ranging transcriptional and functional changes...
  25. ncbi request reprint Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    Jing Yang
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 117:927-39. 2004
    ..These results establish a mechanistic link between Twist, EMT, and tumor metastasis...
  26. ncbi request reprint Identification of differentially expressed genes contributing to radioresistance in lung cancer cells using microarray analysis
    Wan feng Guo
    Beijing Institute of Radiation Medicine, Beijing 100850, China
    Radiat Res 164:27-35. 2005
    ..This list of genes may be useful in attempts to sensitize the radioresistant lung cancer cells...
  27. ncbi request reprint [Research advances on inhibitor of apoptosis, survivin]
    Jing Yang
    Pathology Institute, Southwest Hospital, The Third Military Medical University, Chongqing, 400038, PR China
    Ai Zheng 22:771-4. 2003
    ..These results suggest that survivin may has the potential function as a new target for the diagnosis and treatment of cancer...
  28. ncbi request reprint Cells in G2/M phase increased in human nasopharyngeal carcinoma cell line by EBV-LMP1 through activation of NF-kappaB and AP-1
    Lin Deng
    Cancer Research Institute, Xiangya School of Medicine, Central South University, Xiangya Road 88, Changsha, Hunan 410078, China
    Cell Res 13:187-94. 2003
    ..This study provided some significant evidence for further elucidating the molecular mechanisms that LMP1 had effects on the surveillance mechanism of cell cycle and promoting the survival of transformed cells and tumorigenesis...
  29. ncbi request reprint Triptolide inhibits the growth and metastasis of solid tumors
    Shanmin Yang
    Department of Oncology, Georgetown University Medical Center, Washington, DC 20007, USA
    Mol Cancer Ther 2:65-72. 2003
    ..Taken together, these results suggest that TPL has several attractive features as a new antitumor agent...
  30. ncbi request reprint Ginsenoside Rg1-induced alterations in gene expression in TNF-alpha stimulated endothelial cells
    Jun ping Lu
    Department of Pathophysiology, West China Medical Center, Sichuan University, Chengdu 610041, China
    Chin Med J (Engl) 117:871-6. 2004
    ....
  31. ncbi request reprint Epstein-Barr virus induces human nasopharyngeal epithelial cells to escape from the replicative senescence
    Jing Yang
    Cancer Research Institute, Hunan Medical University, Changsha 410078, China
    Chin Med J (Engl) 115:803-9. 2002
    ..To observe the biological changes of primary human nasopharyngeal epithelial cells in the early stage of immortalization...
  32. ncbi request reprint [Epstein-Barr virus inhibits P16INK4a expression in human fetal nasopharyngeal epithelial cells escaping from the replicative senenscence]
    Jing Yang
    Cancer Research Institute, Xiangya Medical School, Central South University, Changsha, Hunan 410078, China
    Shi Yan Sheng Wu Xue Bao 36:215-20. 2003
    ..These data will be helpful for further studying the carcinogenesis of nasopharyngeal carcinoma...
  33. ncbi request reprint Gene-chip analysis of the effect of tripeptide tyroservatide (YSV) on gene-expression in human hepatocarcinoma BEL-7402 tumors transplanted to nude mice
    Jing Jia
    Department of Immunology, Tianjin Medical University, Tianjin, China
    Mol Carcinog 45:197-203. 2006
    ..Probably, YSV exhibits a significant antitumor activity by inhibiting the expression of tumor cells histone genes, then damaging tumor cell chromosome and killing tumor cells...
  34. ncbi request reprint Repression through a distal TCF-3 binding site restricts Xenopus myf-5 expression in gastrula mesoderm
    Jing Yang
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, PR China
    Mech Dev 115:79-89. 2002
    ..The element for ventral mesoderm activation responds to Activin. Together, these results describe a regulatory mosaic of repression and activation, which defines the myf-5 expression profile in the frog gastrula...
  35. ncbi request reprint Microarray analysis of differentially expressed genes in mouse bone marrow tissues after ionizing radiation
    Jin Ming Dai
    Beijing Institute of Radiation Medicine, Beijing, China
    Int J Radiat Biol 82:511-21. 2006
    ..To identify differentially expressed genes in mouse bone marrow involved in radiation-induced injury...
  36. ncbi request reprint Markov Chain Monte Carlo Algorithm based metabolic flux distribution analysis on Corynebacterium glutamicum
    Visakan Kadirkamanathan
    Signal Processing and Complex Systems Research Group, Department of Automatic Control and Systems Engineering, University of Sheffield Sheffield, S1 3JD, UK
    Bioinformatics 22:2681-7. 2006
    ..The flux distributions under such a framework can be freely obtained with various system noise and uncertainty models...
  37. pmc Dickkopf-1 (DKK1) is a widely expressed and potent tumor-associated antigen in multiple myeloma
    Jianfei Qian
    Department of Lymphoma and Myeloma, Division of Cancer Medicine, and the Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 110:1587-94. 2007
    ..Hence, our study identifies DKK1 as a potentially important antigen for immunotherapy in MM...
  38. ncbi request reprint [Advance on study in anti-tumor mechamism of bererine (Ber)]
    Jing Yang
    Union Hospital, Fujian Medical University, Fuzhou 350001, China
    Zhongguo Zhong Yao Za Zhi 32:881-3, 934. 2007
    ..In addition, Ber could induce tumor cells to differentiate to antagonize tumor...
  39. ncbi request reprint Male germ cell-specific expression of a novel Patched-domain containing gene Ptchd3
    Jun Fan
    Department of Biological Sciences, Marshall University, Huntington, WV, USA
    Biochem Biophys Res Commun 363:757-61. 2007
    ..Collectively, these results indicate that Ptchd3 is a novel male germ cell-specific gene and may be involved in the Hh signaling to regulate sperm development and/or sperm function...
  40. ncbi request reprint Characterization of GPR56 protein and its suppressed expression in human pancreatic cancer cells
    Yue Huang
    Biomedical Science Graduate Program, Joan C Edwards School of Medicine, Marshall University, Huntington, WV 25704, USA
    Mol Cell Biochem 308:133-9. 2008
    ..Taken together, these results define the biochemical properties of GPR56 protein, and suggest that the expression of GPR56 protein is suppressed in human pancreatic cancer cells...
  41. ncbi request reprint Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
    Jing Yang
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 132:387-96. 2008
    ..Identification of GOAT will facilitate the search for inhibitors that reduce appetite and diminish obesity in humans...
  42. pmc The epithelial-mesenchymal transition generates cells with properties of stem cells
    Sendurai A Mani
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 133:704-15. 2008
    ..These findings illustrate a direct link between the EMT and the gain of epithelial stem cell properties...