Jian Yang

Summary

Affiliation: University of South Alabama
Country: USA

Publications

  1. doi request reprint AMP-activated protein kinase suppresses LXR-dependent sterol regulatory element-binding protein-1c transcription in rat hepatoma McA-RH7777 cells
    Jian Yang
    Department of Physiology, University of South Alabama College of Medicine, Mobile, Alabama 36688, USA
    J Cell Biochem 106:414-26. 2009
  2. pmc Mechanism of AMPK suppression of LXR-dependent Srebp-1c transcription
    Fuichi Yap
    Department of Physiology, University of South Alabama College of Medicine, Mobile, Alabama 36688, USA
    Int J Biol Sci 7:645-50. 2011
  3. pmc The size of large adipose cells is a predictor of insulin resistance in first-degree relatives of type 2 diabetic patients
    Jian Yang
    NIDDK Diabetes Branch, National Institutes of Health, Bethesda, Maryland, USA
    Obesity (Silver Spring) 20:932-8. 2012
  4. doi request reprint Chronic activation of AMP-activated protein kinase-alpha1 in liver leads to decreased adiposity in mice
    Jian Yang
    Department of Physiology, The University of South Alabama College of Medicine, MSB 3074, 307 University Boulevard, Mobile, AL 36688 0002, USA
    Biochem Biophys Res Commun 370:248-53. 2008
  5. doi request reprint Compensatory increase in lipogenic gene expression in adipose tissue of transgenic mice expressing constitutively active AMP-activated protein kinase-alpha1 in liver
    Christi Knowles
    Department of Physiology, University of South Alabama College of Medicine, Mobile, AL 36688, USA
    Biochem Biophys Res Commun 412:249-52. 2011
  6. pmc Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
    Sonja I Berndt
    US Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 45:501-12. 2013
  7. ncbi request reprint Increase in DPP-IV in the intestine, liver and kidney of the rat treated with high fat diet and streptozotocin
    Jian Yang
    Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China
    Life Sci 81:272-9. 2007
  8. ncbi request reprint Mercury and its relation with selenium in the liver of Dall's porpoises (Phocoenoides dalli) off the Sanriku coast of Japan
    Jian Yang
    Key Laboratory of Ecological Environment and Resources of Inland Fisheries, Freshwater Fisheries Research Center, Chinese Academy of Fishery Science, Qitang Road No 1, Wuxi City, Jiangsu 214081, China
    Environ Pollut 148:669-73. 2007
  9. ncbi request reprint Treatment with total alkaloids from Radix Linderae reduces inflammation and joint destruction in type II collagen-induced model for rheumatoid arthritis
    Chan Wang
    Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, 1 Shennong Road, Nanjing 210038, China
    J Ethnopharmacol 111:322-8. 2007
  10. ncbi request reprint Investigation of health and nutrition status of middle-aged and old residents in the urban district of Chongqing
    Bao quan Jiang
    Nutrition Department, Daping Hospital, The Third Military Medical University, 10 Chang Jiang Zhi Lu, Chongqing 400042, China
    Asia Pac J Clin Nutr 16:17-21. 2007

Detail Information

Publications31

  1. doi request reprint AMP-activated protein kinase suppresses LXR-dependent sterol regulatory element-binding protein-1c transcription in rat hepatoma McA-RH7777 cells
    Jian Yang
    Department of Physiology, University of South Alabama College of Medicine, Mobile, Alabama 36688, USA
    J Cell Biochem 106:414-26. 2009
    ..We conclude that AMPK suppresses hepatic SREBP-1c mRNA expression by inhibiting LXR-dependent SREBP-1c transcription via inhibition of endogenous LXR ligand production and by inhibiting SREBP-1c processing in McA-RH7777 cells...
  2. pmc Mechanism of AMPK suppression of LXR-dependent Srebp-1c transcription
    Fuichi Yap
    Department of Physiology, University of South Alabama College of Medicine, Mobile, Alabama 36688, USA
    Int J Biol Sci 7:645-50. 2011
    ..Furthermore, AMPK activation attenuates induction of endogenous SREBP-1c mRNA by T0901317. These results indicate that AMPK directly inhibits ligand-induced LXR activity in addition to blocking production of endogenous LXR ligands...
  3. pmc The size of large adipose cells is a predictor of insulin resistance in first-degree relatives of type 2 diabetic patients
    Jian Yang
    NIDDK Diabetes Branch, National Institutes of Health, Bethesda, Maryland, USA
    Obesity (Silver Spring) 20:932-8. 2012
    ....
  4. doi request reprint Chronic activation of AMP-activated protein kinase-alpha1 in liver leads to decreased adiposity in mice
    Jian Yang
    Department of Physiology, The University of South Alabama College of Medicine, MSB 3074, 307 University Boulevard, Mobile, AL 36688 0002, USA
    Biochem Biophys Res Commun 370:248-53. 2008
    ....
  5. doi request reprint Compensatory increase in lipogenic gene expression in adipose tissue of transgenic mice expressing constitutively active AMP-activated protein kinase-alpha1 in liver
    Christi Knowles
    Department of Physiology, University of South Alabama College of Medicine, Mobile, AL 36688, USA
    Biochem Biophys Res Commun 412:249-52. 2011
    ....
  6. pmc Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
    Sonja I Berndt
    US Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 45:501-12. 2013
    ..Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups...
  7. ncbi request reprint Increase in DPP-IV in the intestine, liver and kidney of the rat treated with high fat diet and streptozotocin
    Jian Yang
    Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China
    Life Sci 81:272-9. 2007
    ..Since both high fat diet and insulin deficiency are closely linked with etiology of Type II diabetes, the evidence in this study suggests a role of DPP-IV in development of Type II diabetes...
  8. ncbi request reprint Mercury and its relation with selenium in the liver of Dall's porpoises (Phocoenoides dalli) off the Sanriku coast of Japan
    Jian Yang
    Key Laboratory of Ecological Environment and Resources of Inland Fisheries, Freshwater Fisheries Research Center, Chinese Academy of Fishery Science, Qitang Road No 1, Wuxi City, Jiangsu 214081, China
    Environ Pollut 148:669-73. 2007
    ....
  9. ncbi request reprint Treatment with total alkaloids from Radix Linderae reduces inflammation and joint destruction in type II collagen-induced model for rheumatoid arthritis
    Chan Wang
    Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, 1 Shennong Road, Nanjing 210038, China
    J Ethnopharmacol 111:322-8. 2007
    ..These data suggest that TARL is a potential therapeutic agent for rheumatoid arthritis that suppresses inflammation and protects joints from destruction...
  10. ncbi request reprint Investigation of health and nutrition status of middle-aged and old residents in the urban district of Chongqing
    Bao quan Jiang
    Nutrition Department, Daping Hospital, The Third Military Medical University, 10 Chang Jiang Zhi Lu, Chongqing 400042, China
    Asia Pac J Clin Nutr 16:17-21. 2007
    ..To investigate the health and nutrition status in middle-aged and old people in the urban district of Chongqing City, China in order to provide a rational diet construction for the population...
  11. ncbi request reprint Mapping the genetic architecture of complex traits in experimental populations
    Jian Yang
    Institute of Bioinformatics, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, PR China
    Bioinformatics 23:1527-36. 2007
    ..Two real-world phenotypes (BXD mouse olfactory bulb weight data and rice yield data) are used as exemplars to demonstrate our methods. AVAILABILITY: A software package is freely available at http://ibi.zju.edu.cn/software/qtlnetwork..
  12. ncbi request reprint MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation
    Ruirui Ji
    Cardiovascular Research Laboratory, Vascular Biology Center and Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Circ Res 100:1579-88. 2007
    ..MiRNAs may be a new therapeutic target for proliferative vascular diseases such as atherosclerosis, postangioplasty restenosis, transplantation arteriopathy, and stroke...
  13. pmc Genetic analysis for brix weight per stool and its component traits in sugarcane (Saccharum officinarum)
    Gui fu Liu
    College of Agriculture, South China Agricultural University, Guangzhou, China
    J Zhejiang Univ Sci B 8:860-6. 2007
    ..1%(85.5%. These determinants might be helpful in sugarcane breeding and provide valuable information for multiple-trait improvement of BW...
  14. ncbi request reprint Transgenic tools for analysis of the haematopoietic system: knock-in CD45 reporter and deletor mice
    Jian Yang
    Ontogeny of Haematopoietic Stem Cells Group, MRC JDRF Centre Development in Stem Cell Biology, Institute for Stem Cell Research, Scottish Centre for Regenerative Medicine, University of Edinburgh, Scotland, EH9 3JQ, United Kingdom
    J Immunol Methods 337:81-7. 2008
    ..These mouse models will be useful for the direct visualisation of haematopoietic cells, especially at the periphery, and for gene knockout studies, in the haematopoietic system...
  15. ncbi request reprint Recombinant M. smegmatis vaccine targeted delivering IL-12/GLS into macrophages can induce specific cellular immunity against M. tuberculosis in BALB/c mice
    Zhengjun Yi
    Department of Immunology, Chongqing University of Medical Sciences, Chongqing 400016, China
    Vaccine 25:638-48. 2007
    ..tuberculosis in BALB/c mice and has no obviously harmfulness to the host simultaneously, the recombinant vaccine might be a potential candidate therapeutic vaccine against tuberculosis...
  16. ncbi request reprint Novel model of inflammatory neointima formation reveals a potential role of myeloperoxidase in neointimal hyperplasia
    Jian Yang
    Vascular Biology Center and Dept of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Am J Physiol Heart Circ Physiol 291:H3087-93. 2006
    ..The results suggest that MPO may be a mediator for pathological neointima growth. This novel neointimal model could be useful for studying inflammation and atherosclerosis...
  17. ncbi request reprint The -822G/A polymorphism in the promoter region of the MAP4K5 gene is associated with reduced risk of type 2 diabetes in Chinese Hans from Shanghai
    Yanyun Gu
    School of Medicine, Ruijin Hospital, Endocrine and Metabolic Disease Deparment, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Jiaotong University, People s Republic China
    J Hum Genet 51:605-10. 2006
    ..Therefore, the G allele may be a factor that does not protect central-obesity cases from developing into diabetes...
  18. ncbi request reprint Substrate specificity of protein tyrosine phosphatase: differential behavior of SHP-1 and SHP-2 towards signal regulation protein SIRPalpha1
    Ashwini K Mishra
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, USA
    J Cell Biochem 84:840-6. 2002
    ....
  19. ncbi request reprint Dual regulation of voltage-gated calcium channels by PtdIns(4,5)P2
    Li Wu
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nature 419:947-52. 2002
    ..The dual actions of PtdIns(4,5)P2 and the crosstalk between PtdIns(4,5)P2 and protein kinase A set up a dynamic mechanism through which the activity of VGCCs can be finely tuned by various neurotransmitters, hormones and trophic factors...
  20. ncbi request reprint Total and subcellular distribution of trace elements in the liver of a mother-fetus pair of Dall's porpoises (Phocoenoides dalli)
    Jian Yang
    Freshwater Fisheries Research Center, Chinese Academy of Fishery Science, Wuxi City, Jiangsu, China
    Mar Pollut Bull 48:1122-9. 2004
    ..8 min for the mother, and for the fetus the peak elemental ion intensities occurred at a retention time of 4.3 min, suggesting that different MT isoforms may be involved in elemental accumulation in maternal and fetal hepatocytosols...
  21. ncbi request reprint Pulmonary functional MRI: an animal model study of oxygen-enhanced ventilation combined with Gd-DTPA-enhanced perfusion
    Jian Yang
    Department of Biomedical Engineering, School of Life Science and Technology, Xi an Jiaotong University, China
    Chin Med J (Engl) 117:1489-96. 2004
    ..In this study, we evaluated the usefulness of oxygen-enhanced ventilation in combination with first-pass Gd-DTPA-enhanced perfusion MRI in a canine model of pulmonary embolism and airway obstruction...
  22. ncbi request reprint Leukocyte-derived myeloperoxidase amplifies high-glucose--induced endothelial dysfunction through interaction with high-glucose--stimulated, vascular non--leukocyte-derived reactive oxygen species
    Chunxiang Zhang
    Vascular Biology Center of Excellence, Department of Medicine, University of Tennessee Health Science Center, 956 Court Ave, Coleman Bldg, H300, Memphis, TN 38163, USA
    Diabetes 53:2950-9. 2004
    ..MPO/H(2)O(2)/HOCL/chlorinating species may represent an important pathway in diabetes complications and a new mechanism in phagocyte- and systemic infection-induced exacerbation of diabetic vascular diseases...
  23. ncbi request reprint [An experimental study on the repair mechanism after pulmonary embolism]
    You min Guo
    Imaging Center, First Hospital of Xi an Jiaotong University, Xi an 710061, China
    Zhonghua Jie He He Hu Xi Za Zhi 27:723-6. 2004
    ..To study the role of basic fibroblast growth factor (bFGF) and small vascular density in the repair mechanism after pulmonary embolism (PE)...
  24. ncbi request reprint Spectroscopic approaches to elucidating novel iron-sulfur chemistry in the "radical-Sam" protein superfamily
    Charles J Walsby
    Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA
    Inorg Chem 44:727-41. 2005
    ..New ENDOR data supporting coordination of the methionine moiety of SAM to the unique site of the [4Fe-4S]2+/+ cluster are presented...
  25. ncbi request reprint [Effects of enalapril on plasma Ang II level and the expression of AT1 in blood vessel and kidney of type 2 diabetic rats]
    Jian Yang
    Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China
    Yao Xue Xue Bao 40:208-12. 2005
    ....
  26. ncbi request reprint Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action
    Brigitte Ganter
    Iconix Pharmaceuticals, 325 E Middlefield Road, Mountain View, CA 94043, USA
    J Biotechnol 119:219-44. 2005
    ..We will demonstrate that gene expression events monitored in the liver can be used to predict pathological events occurring in that tissue as well as in hematopoietic tissues...
  27. ncbi request reprint Effects of iptakalim on extracellular glutamate and dopamine levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats: a microdialysis study
    Jian Yang
    Department of Pharmacology and Neurobiology, Nanjing Medical University, Nanjing 210029, PR China
    Life Sci 78:1940-4. 2006
    ....
  28. ncbi request reprint Trace elements and butyltins in a Dall's porpoise (Phocoenoides dalli) from the Sanriku coast of Japan
    Jian Yang
    Freshwater Fisheries Research Center, Chinese Academy of Fishery Science, Qitang Road No 1, Wuxi City, Jiangsu 214081, China
    Chemosphere 63:449-57. 2006
    ....
  29. ncbi request reprint Placental transfer of arsenic to fetus of Dall's porpoises (Phocoenoides dalli)
    Reiji Kubota
    Center for Marine Environmental Studies CMES, Ehime University, Bunkyo cho 2 5, Matsuyama 790 8577, Japan
    Mar Pollut Bull 51:845-9. 2005
    ..To our knowledge, this is the first report on placental transfer of arsenic compounds to fetus in marine mammals...
  30. ncbi request reprint Biomechanical properties of the layered oesophagus and its remodelling in experimental type-1 diabetes
    Jian Yang
    Centre of Excellence in Visceral Biomechanics and Pain, Aalborg Hospital and Centre of Sensory Motor Interaction, Aalborg University, DK 9100 Aalborg, Nord Jylland, Denmark
    J Biomech 39:894-904. 2006
    ..Thus, the mechanical properties differed between layers as well as in different directions. Morphological and biomechanical remodelling is prominent in the diabetic oesophagus...
  31. ncbi request reprint Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c
    Guosheng Liang
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 277:9520-8. 2002
    ..Moreover, these mRNAs, as well as multiple other lipogenic mRNAs, showed a markedly blunted response to the LXR agonist T090137, indicating an essential role of SREBP-1c in the LXR response...