Affiliation: University of Rochester
- Statistical estimation & inference of cell counts from ELISPOT limiting dilution assaysHongmei Yang
Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Biopharm Stat 23:921-36. 2013..Thus, the t -test or the Wilcoxon Rank Sum test can be applied to detect group differences. These methods are compared through simulations and application to real data. ..
- B cell responses to H5 influenza HA in human subjects vaccinated with a drifted variantJane Baer
David H Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical Sciences, Department of Microbiology and Immunology, Rochester, NY, USA
Vaccine 28:907-15. 2010..These observations suggest prior vaccination against H5 influenza HA induces cellular immune responses that cross-react among drifted variants, without precluding a response to new, or existing HA strains...
- High-resolution temporal response patterns to influenza vaccine reveal a distinct human plasma cell gene signatureAlicia D Henn
Department of Medicine, Division of Nephrology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Sci Rep 3:2327. 2013..With robust statistical methods, time-varying response characteristics of individual subjects were effectively captured along with a shared plasma cell gene signature. ..
- Increase in IFNγ(-)IL-2(+) cells in recent human CD4 T cell responses to 2009 pandemic H1N1 influenzaJason M Weaver
David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America
PLoS ONE 8:e57275. 2013....
- Host differences in influenza-specific CD4 T cell and B cell responses are modulated by viral strain and route of immunizationAarthi Sundararajan
David H Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America
PLoS ONE 7:e34377. 2012..Our findings emphasize the importance of immunization strategy for demonstrating inherent host differences in CD4 T cell and B cell responses...
- B cell response and hemagglutinin stalk-reactive antibody production in different age cohorts following 2009 H1N1 influenza virus vaccinationMark Y Sangster
David H Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA
Clin Vaccine Immunol 20:867-76. 2013..They also emphasize the need to clarify how the level of circulating stalk-reactive Abs relates to resistance to influenza...
- CD4+ T-cell expansion predicts neutralizing antibody responses to monovalent, inactivated 2009 pandemic influenza A(H1N1) virus subtype H1N1 vaccineJennifer L Nayak
Department of Pediatrics, Department of Pediatrics, Division of Infectious Diseases, University of Rochester Medical Center, Rochester, NY 14642, USA
J Infect Dis 207:297-305. 2013....
- Frequencies of human influenza-specific antibody secreting cells or plasmablasts post vaccination from fresh and frozen peripheral blood mononuclear cellsShuya Y Kyu
Division of Pulmonary and Critical Care Medicine, NY 14642, USA
J Immunol Methods 340:42-7. 2009..43, 0.28, 0.28 respectively). These results demonstrate feasibility of testing whether antigen-specific ASC from frozen PBMC are an early biomarker of long-term antibody responses in multi-center vaccine trials...
- Anergic responses characterize a large fraction of human autoreactive naive B cells expressing low levels of surface IgMTâm D Quách
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
J Immunol 186:4640-8. 2011....