- The identification of an internal ribosomal entry site in the 5'-untranslated region of p53 mRNA provides a novel mechanism for the regulation of its translation following DNA damageD Q Yang
Division of Basic Biomedical Sciences, University of South Dakota, Sanford School of Medicine, Vermillion, SD 57069, USA
Oncogene 25:4613-9. 2006..Moreover, we found that the activity of the IRES element increases in response to etoposide-induced DNA damage in MCF-7 cells. These findings provide a novel mechanism for the regulation of p53 translation in response to DNA damage...