B Yang

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions
    B Yang
    Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Cell Death Differ 17:68-77. 2010
  2. ncbi request reprint Reduced severity of experimental autoimmune encephalomyelitis in GMF-deficient mice
    Asgar Zaheer
    Veterans Affair Medical Center, Iowa City, IA, USA
    Neurochem Res 32:39-47. 2007
  3. pmc Diminished cytokine and chemokine expression in the central nervous system of GMF-deficient mice with experimental autoimmune encephalomyelitis
    Asgar Zaheer
    Veterans Affair Medical Center, Iowa City, IA 52242, USA
    Brain Res 1144:239-47. 2007
  4. ncbi request reprint GMF-knockout mice are unable to induce brain-derived neurotrophic factor after exercise
    Asgar Zaheer
    Department of Neurology Division of Neurochemistry and Neurobiology, Veterans Affairs Medical Center and University of Iowa College of Medicine, Iowa City, 52242, USA
    Neurochem Res 31:579-84. 2006
  5. ncbi request reprint Glia maturation factor regulation of STAT expression: a novel mechanism in experimental autoimmune encephalomyelitis
    Smita Zaheer
    Veterans Affairs Medical Center, Iowa City, IA, USA
    Neurochem Res 32:2123-31. 2007
  6. pmc Glia maturation factor overexpression in neuroblastoma cells activates glycogen synthase kinase-3beta and caspase-3
    Asgar Zaheer
    Veterans Affair Medical Center, Iowa City, IA, USA
    Brain Res 1190:206-14. 2008
  7. ncbi request reprint Impaired motor performance and learning in glia maturation factor-knockout mice
    Ramon Lim
    Department of Neurology Division of Neurochemistry and Neurobiology, Veterans Affairs Medical Center and University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Brain Res 1024:225-32. 2004
  8. pmc Glia maturation factor modulates beta-amyloid-induced glial activation, inflammatory cytokine/chemokine production and neuronal damage
    Asgar Zaheer
    Veterans Affair Medical Center, and Division of Neurochemistry and Neurobiology, Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
    Brain Res 1208:192-203. 2008
  9. pmc Targeting the GA binding protein beta1L isoform does not perturb lymphocyte development and function
    Hai Hui Xue
    Department of Microbiology, University of Iowa, 51 Newton Road, BSB 3 710, Iowa City, IA 52246, USA
    Mol Cell Biol 28:4300-9. 2008
  10. ncbi request reprint Decreased copper-zinc superoxide dismutase activity and increased resistance to oxidative stress in glia maturation factor-null astrocytes
    Asgar Zaheer
    Department of Neurology Division of Neurochemistry and Neurobiology, Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA
    Neurochem Res 29:1473-80. 2004

Collaborators

Detail Information

Publications34

  1. pmc Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions
    B Yang
    Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Cell Death Differ 17:68-77. 2010
    ..In this article we focus on the biology and emerging functions of Nedd4 and Nedd4-2, and review recent in vivo studies on these E3s...
  2. ncbi request reprint Reduced severity of experimental autoimmune encephalomyelitis in GMF-deficient mice
    Asgar Zaheer
    Veterans Affair Medical Center, Iowa City, IA, USA
    Neurochem Res 32:39-47. 2007
    ..Our results show a significant decrease in incidence, delay in onset, and reduced severity of EAE in GMF-deficient mice, and support the hypothesis that GMF plays a major role in the pathogenesis of disease...
  3. pmc Diminished cytokine and chemokine expression in the central nervous system of GMF-deficient mice with experimental autoimmune encephalomyelitis
    Asgar Zaheer
    Veterans Affair Medical Center, Iowa City, IA 52242, USA
    Brain Res 1144:239-47. 2007
    ..Our results demonstrate significantly low levels of pro-inflammatory cytokines/chemokines in the CNS of GMF-KO mice and increased expression in Wt mice with EAE. Our data suggest that GMF play a critical role in CNS inflammation...
  4. ncbi request reprint GMF-knockout mice are unable to induce brain-derived neurotrophic factor after exercise
    Asgar Zaheer
    Department of Neurology Division of Neurochemistry and Neurobiology, Veterans Affairs Medical Center and University of Iowa College of Medicine, Iowa City, 52242, USA
    Neurochem Res 31:579-84. 2006
    ..The results are consistent with the hypothesis that GMF is necessary for exercise-induction of BDNF, and that GMF may promote neuroprotection through BDNF production...
  5. ncbi request reprint Glia maturation factor regulation of STAT expression: a novel mechanism in experimental autoimmune encephalomyelitis
    Smita Zaheer
    Veterans Affairs Medical Center, Iowa City, IA, USA
    Neurochem Res 32:2123-31. 2007
    ..The results are consistent with the diminished development of EAE in the GMF-knockout mice. A significant suppression of STATs expression in GMF-knockout mice suggests GMF as an upstream effector of JAK/STAT signaling...
  6. pmc Glia maturation factor overexpression in neuroblastoma cells activates glycogen synthase kinase-3beta and caspase-3
    Asgar Zaheer
    Veterans Affair Medical Center, Iowa City, IA, USA
    Brain Res 1190:206-14. 2008
    ....
  7. ncbi request reprint Impaired motor performance and learning in glia maturation factor-knockout mice
    Ramon Lim
    Department of Neurology Division of Neurochemistry and Neurobiology, Veterans Affairs Medical Center and University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Brain Res 1024:225-32. 2004
    ..The structural abnormality in GMF-null mice explained their impaired ability for both motor performance and motor learning...
  8. pmc Glia maturation factor modulates beta-amyloid-induced glial activation, inflammatory cytokine/chemokine production and neuronal damage
    Asgar Zaheer
    Veterans Affair Medical Center, and Division of Neurochemistry and Neurobiology, Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
    Brain Res 1208:192-203. 2008
    ..Taken together, our results indicate a novel mediatory role of GMF in the neuro-inflammatory pathway of Abeta and its pro-inflammatory functions...
  9. pmc Targeting the GA binding protein beta1L isoform does not perturb lymphocyte development and function
    Hai Hui Xue
    Department of Microbiology, University of Iowa, 51 Newton Road, BSB 3 710, Iowa City, IA 52246, USA
    Mol Cell Biol 28:4300-9. 2008
    ..Our findings argue against such a possibility and rather suggest that GABPbeta1S has a critical role in maintaining the transcriptional activity of the GABPalpha/beta complex...
  10. ncbi request reprint Decreased copper-zinc superoxide dismutase activity and increased resistance to oxidative stress in glia maturation factor-null astrocytes
    Asgar Zaheer
    Department of Neurology Division of Neurochemistry and Neurobiology, Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA
    Neurochem Res 29:1473-80. 2004
    ..By regulating the redox state of the cell, GMF may be involved in a wide spectrum of cellular events ranging from survival, proliferation, differentiation, to death...
  11. ncbi request reprint Selective cochlear degeneration in mice lacking the F-box protein, Fbx2, a glycoprotein-specific ubiquitin ligase subunit
    Rick F Nelson
    Medical Scientist Training Program, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Neurosci 27:5163-71. 2007
    ..Our findings demonstrate that components of protein quality control are essential for inner ear homeostasis and implicate Fbx2 and Skp1 as potential genetic modifiers in age-related hearing loss...
  12. pmc Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells
    Baoli Yang
    Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Nat Immunol 9:1356-63. 2008
    ..Our data demonstrate that Nedd4 promotes the conversion of naive T cells into activated T cells. We propose that Nedd4 and Itch ubiquitinate distinct target proteins in vivo...
  13. pmc Essential roles of an intercalated disc protein, mXinbeta, in postnatal heart growth and survival
    Qinchuan Wang
    Department of Biology, University of Iowa, Iowa City, IA 52242 1324, USA
    Circ Res 106:1468-78. 2010
    ..Ablation of mXinalpha results in adult late-onset cardiomyopathy with conduction defects. An upregulation of the mXinbeta in mXinalpha-deficient hearts suggests a partial compensation...
  14. ncbi request reprint De-differentiation of mouse interfollicular keratinocytes by the embryonic transcription factor Oct-4
    Katie L Grinnell
    Department of Anatomy and Cell Biology, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Invest Dermatol 127:372-80. 2007
    ..The latter finding has great implications for therapeutic cell-replacement applications using cells from easily accessible adult tissues, such as the skin...
  15. pmc A common disease-associated missense mutation in alpha-sarcoglycan fails to cause muscular dystrophy in mice
    Kazuhiro Kobuke
    Howard Hughes Medical Institute, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    Hum Mol Genet 17:1201-13. 2008
    ..Our study presents an unexpected difference in the behavior of a missense-mutated protein in mice versus human patients, and emphasizes the need to understand species-specific protein quality control systems...
  16. ncbi request reprint Altered GABAergic function accompanies hippocampal degeneration in mice lacking ClC-3 voltage-gated chloride channels
    Linda W Dickerson
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Brain Res 958:227-50. 2002
    ..The increase in GABA(A) receptor density may represent a compensatory response either to chronic excessive excitatory stimuli or reduced inhibitory input from local GABAergic interneurons within the dentate gyrus...
  17. pmc Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2
    Peijun P Shi
    Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City, USA
    Am J Physiol Renal Physiol 295:F462-70. 2008
    ..The absence of this gene is sufficient to produce salt-sensitive hypertension. This model provides an opportunity to further investigate mechanisms and consequences of this common disorder...
  18. pmc Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs
    Ping Xie
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Immunity 27:253-67. 2007
    ..These findings indicate that TRAF3 is a critical regulator of peripheral B cell homeostasis and may be implicated in the regulation of peripheral self-tolerance induction...
  19. pmc Mice defective in Trpm6 show embryonic mortality and neural tube defects
    Roxanne Y Walder
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Hum Mol Genet 18:4367-75. 2009
    ..This genetic defect produces one of very few mouse models of spina bifida occulta. These results point to a critical role of Trpm6 in development and suggest an important role in neural tube closure...
  20. pmc Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin
    Di Xu
    Interdisciplinary Genetics Program, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hypertension 54:1240-7. 2009
    ....
  21. pmc Identification and functional analysis of the vision-specific BBS3 (ARL6) long isoform
    Pamela R Pretorius
    Department of Biology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS Genet 6:e1000884. 2010
    ..Bbs3L-null mice lack key features of previously published Bbs-null mice, including obesity. These data demonstrate that the BBS3L transcript is required for proper retinal function and organization...
  22. pmc Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6)
    Christopher R Ingraham
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Nat Genet 38:1335-40. 2006
    ..Histological and gene expression analyses indicate that the primary defect is in keratinocyte differentiation and proliferation. This study describes a new role for an IRF family member in epidermal development...
  23. pmc Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin
    Darryl Y Nishimura
    Department of Pediatrics, Division of Medical Genetics, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 101:16588-93. 2004
    ..The evaluation of Bbs2(-/-) mice indicates additional phenotypes that should be evaluated in human patients, including deficits in social interaction and infertility...
  24. pmc Disruption of the beta subunit of the epithelial Na+ channel in mice: hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype
    F J McDonald
    Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 96:1727-31. 1999
    ..The phenotype of the betaENaC-deficient mice is similar to that of humans with pseudohypoaldosteronism type 1 and may provide a useful model to study the pathogenesis and treatment of this disorder...
  25. ncbi request reprint Physiological significance of two common haplotypes of human angiotensinogen using gene targeting in the mouse
    Branimir Cvetkovic
    Molecular Biology Interdisciplinary Program, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Physiol Genomics 11:253-62. 2002
    ..Our findings suggest that the AT and GM haplotypes of the hAGT gene have no effect on gene expression, but may affect the cardiovascular system and the regulation of BP differently...
  26. pmc Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects
    Elisabeth A Gustafson-Wagner
    Department of Biological Sciences, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 293:H2680-92. 2007
    ..The mXinalpha-knockout mouse line provides a novel model of cardiac hypertrophy and cardiomyopathy with conduction defects...
  27. pmc Nedd4 controls animal growth by regulating IGF-1 signaling
    Xiao R Cao
    Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Sci Signal 1:ra5. 2008
    ..Thus, in vivo, Nedd4 appears to positively control IGF-1 and insulin signaling partly through the regulation of Grb10 function...
  28. pmc Mice heterozygous for beta-ENaC deletion have defective potassium excretion
    X Renee Cao
    Department of Obstetrics and Gynecology, Carver College of Medicine, 463 MRF, University of Iowa, and Veterans Affairs Medical Center, Iowa City, IA 52242, USA
    Am J Physiol Renal Physiol 291:F107-15. 2006
    ..These experiments demonstrate that mice heterozygous for beta-ENaC have a small but detectable defect in their ability to conserve Na+ and a more readily apparent defect in the ability to secrete K+...
  29. ncbi request reprint Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome
    Melissa A Fath
    Department of Pediatrics, Division of Medcal Genetics, University of Iowa, Iowa City, IA 52242, USA
    Hum Mol Genet 14:1109-18. 2005
    ..These observations suggest that the complete absence of MKKS leads to BBS while the MKS phenotype is likely to be due to specific mutations...
  30. pmc Diminished degradation of myelin basic protein by anti-sulfatide antibody and interferon-gamma in myelin from glia maturation factor-deficient mice
    Krishnakumar Menon
    Veterans Affair Medical Center, Iowa City, IA, United States
    Neurosci Res 58:156-63. 2007
    ..Taken together, our data suggests a role for GMF in the biochemical organization of myelin and thereby its effect on MBP degradation induced by RmAb and IFN-gamma...
  31. pmc Bardet-Biedl syndrome type 4 (BBS4)-null mice implicate Bbs4 in flagella formation but not global cilia assembly
    Kirk Mykytyn
    Department of Pharmacology and Division of Human Genetics, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 101:8664-9. 2004
    ..To further evaluate an association between cilia and BBS, we performed homology comparisons of BBS proteins in model organisms and find that BBS proteins are specifically conserved in ciliated organisms...
  32. pmc Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation
    Paula M Oliver
    Howard Hughes Medical Institute, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Immunity 25:929-40. 2006
    ..Thus, in the absence of Ndfip1, Itch is inactive and JunB accumulates. As a result, T cells produce Th2 cytokines and promote Th2-mediated inflammatory disease...
  33. pmc Secretion and cell volume regulation by salivary acinar cells from mice lacking expression of the Clcn3 Cl- channel gene
    Jorge Arreola
    Center for Oral Biology, Aab Institute of Biomedical Sciences, Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Physiol 545:207-16. 2002
    ..Our results demonstrate that the ClC-3 Cl(-) channel is not a major regulator of acinar cell volume, nor is it essential for determining the secretion rate and composition of saliva...
  34. pmc Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice
    Yanling Zhang
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Proc Natl Acad Sci U S A 104:17518-23. 2007
    ..This report, along with a recent report on a mouse with a null mutation in Fig4, presents the unexpected finding that the housekeeping lipid, PI(3,5)P(2), is critical for the survival of neural cells...