Research Topics
| C W YancySummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Detail Information
Publications
b-Blocker therapy for congestive heart failure: Clinical considerationsSandeep A Kamath
Dallas, TX 75390 9047, USA
Postgrad Med 118:12-20. 2005....
Summary: Cardiovascular disease in African AmericansClyde W Yancy
University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9047, USA
Congest Heart Fail 10:44. 2004
Improving outcomes in the post-myocardial infarction settingClyde W Yancy
University of Texas Southwestern Medical Center, Department of Internal Medicine Cardiology Division, CS7 102, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Clin Hypertens (Greenwich) 6:34-41. 2004....
Cardiovascular disease in African AmericansClyde W Yancy
University of Texas Southwestern Medical Center, Department of Internal Medicine/Cardiology Division, CS7-102, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Clin Hypertens (Greenwich) 6:54-6. 2004
Special considerations for carvedilol use in heart failureClyde W Yancy
University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Am J Cardiol 93:64B-8B. 2004....
The prevention of heart failure in minority communities and discrepancies in health care delivery systemsClyde W Yancy
The University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
Med Clin North Am 88:1347-68, xii-xiii. 2004..Treatment regimens should be individualized based on the disease presentation, associated comorbidity, and disease severity and not on something as arbitrary as race...
Safety and feasibility of using serial infusions of nesiritide for heart failure in an outpatient setting (from the FUSION I trial)Clyde W Yancy
University of Texas Southwestern Medical Center, Dallas, Texas, USA
Am J Cardiol 94:595-601. 2004..Additional studies are needed to determine the effect of outpatient serial infusions of nesiritide on rates of morbidity and mortality in advanced heart failure...
Decompensated heart failure: is there a role for the outpatient use of nesiritide?Clyde W Yancy
University of Texas Southwestern Medical Center, Department of Internal Medicine Cardiology Division, CS7 102, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA
Congest Heart Fail 10:230-6. 2004..Such an approach, once validated, should be integrated into an evidence-based HF disease management program...
Treatment with B-type natriuretic peptide for chronic decompensated heart failure: insights learned from the follow-up serial infusion of nesiritide (FUSION) trialClyde W Yancy
University of Texas Southwestern Medical Center, Dallas, TX, USA
Heart Fail Rev 9:209-16. 2004..If positive data emerge from FUSION II that either confirm or strengthen the data in FUSION I, a new therapeutic option may be available for patients with chronic decompensated heart failure...
Quality of care and outcomes in acute decompensated heart failure: The ADHERE RegistryClyde W Yancy
University of Texas Southwestern Medical Center, Division of Cardiology, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Curr Heart Fail Rep 1:121-8. 2004..These patient data have been reviewed and reveal important findings regarding acute decompensated heart failure and potential opportunities to improve the quality of care...
Heart failure in African AmericansClyde W Yancy
Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9047, USA
Am J Cardiol 96:3i-12i. 2005..This review discusses the unique characteristics of CVD in African Americans and addresses the need for targeted treatments to reduce the excess burden found in this population...
Clinical presentation, management, and in-hospital outcomes of patients admitted with acute decompensated heart failure with preserved systolic function: a report from the Acute Decompensated Heart Failure National Registry (ADHERE) DatabaseClyde W Yancy
Division of Cardiology, Department of Medicine, University of Texas Southwest Medical Center, Dallas, Texas 75390 9047, USA
J Am Coll Cardiol 47:76-84. 2006..Medical treatment strategies for patients with preserved systolic function are inconsistent and reflect the need for efficacious evidence-based treatment regimens...
Potential applications of outpatient nesiritide infusions in patients with advanced heart failure and concomitant renal insufficiency (from the Follow-Up Serial Infusions of Nesiritide [FUSION I] trial)Clyde W Yancy
Department of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, and Renal Division, Brigham and Women s Hospital, Boston, MA, USA
Am J Cardiol 98:226-9. 2006..Further study is warranted to test the validity of this finding...
The natural history, epidemiology, and prognosis of heart failure in African AmericansClyde W Yancy
University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Congest Heart Fail 10:15-8; quiz 21-2. 2004..An increased awareness of the risk of hypertension followed by early and effective intervention may reduce the risk of heart failure in this population...
Introduction: heart failure in African AmericansClyde W Yancy
University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Congest Heart Fail 10:12. 2004
Heart failure in blacks: etiologic and epidemiologic differencesC W Yancy
Heart Failure Cardiac Transplantation, University of Texas Southwestern Medical School, Dallas, TX 75390, USA
Curr Cardiol Rep 3:191-7. 2001..It is quite possible that unique pertubations in the neurohormonal environment may explain differences in the natural history of heart failure in blacks and yield new targets of therapy...
Cardiology patient page. Online program aids heart patients and their doctorsClyde Yancy
University of Texas Southwestern Medical Center, Dallas, USA
Circulation 106:2299-300. 2002
The use of beta-adrenergic receptor antagonists in the treatment of African Americans with heart failureClyde W Yancy
University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9047, USA
Congest Heart Fail 10:34-7. 2004..The first prospective trial in African Americans with heart failure, the African American Heart Failure Trial (A-HeFT), is ongoing and provides additional insight into the best treatment strategies for this patient population...
Noninvasive hemodynamic monitoring in heart failure: utilization of impedance cardiographyClyde Yancy
Department of Internal Medicine, Cardiology Division, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
Congest Heart Fail 9:241-50. 2003..ICG is a viable, noninvasive technique in early- and late-stage heart failure that provides assistance in diagnostic evaluation, longitudinal prognostication, and therapeutic decisions...
The role of race in heart failure therapyClyde W Yancy
Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Curr Cardiol Rep 4:218-25. 2002..Certain genetic polymorphisms may exist that explain the observed differences...
Practical considerations for BNP useClyde W Yancy
UT Southwestern Medical Center, Dallas, TX 75390 9047, USA
Heart Fail Rev 8:369-73. 2003..New biomarkers for heart failure similar to BNP are on the horizon but their clinical niche has yet to be determined...
Race and the response to adrenergic blockade with carvedilol in patients with chronic heart failureC W Yancy
University of Texas Southwestern Medical Center, Dallas 75390 9047, USA
N Engl J Med 344:1358-65. 2001....
Tailored therapy using dobutamine and nitroglycerin in advanced heart failureM H Drazner
Division of Cardiology, University of Texas Southwestern Medical Center, Dallas 75235 9047, USA
Am J Cardiol 84:941-3, A7. 1999..In the 23 patients who were weaned from inodilator therapy, significant improvements in hemodynamic parameters and a low 90-day hospital readmission rate were documented...
Clinical trials of beta-blockers in heart failure: a class reviewC W Yancy
Division of Cardiology, Congestive Heart Failure Program, The University of Texas Southwestern Medical Center, Dallas, Texas 75235-9047, USA
Am J Med 110:7S-10S. 2001..Questions still remain regarding the ideal use of beta blockers in heart failure, and ongoing trials will attempt to clarify those points...
Outcomes after emergency department discharge with a primary diagnosis of heart failureJ E Rame
Donald W. Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9034, USA
Am Heart J 142:714-9. 2001..Increased respiratory rate on presentation to the ED may be associated with adverse outcomes after ED discharge for CHF...
Influence of a performance-improvement initiative on quality of care for patients hospitalized with heart failure: results of the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients With Heart Failure (OPTIMIZE-HF)Gregg C Fonarow
Department of Medicine, University of California Los Angeles Medical Center, 10833 LeConte Ave, Room 47 123 CHS, Los Angeles, CA 90095 1679, USA
Arch Intern Med 167:1493-502. 2007..We sought to evaluate the effect of a national hospital-based initiative on quality of care in patients hospitalized with HF...
Improving the use of evidence-based heart failure therapies in the outpatient setting: the IMPROVE HF performance improvement registryGregg C Fonarow
Department of Medicine, Ahmanson UCLA Cardiomyopathy Center, Los Angeles, CA 90095 1679, USA
Am Heart J 154:12-38. 2007..Deidentified clinical data from the medical records of a planned 43,000 patients from 160 US cardiology practices will be included in this study...
2007 Focused Update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: developed in collaboratElliott M Antman
Circulation 117:296-329. 2008
Prospective evaluation of beta-blocker use at the time of hospital discharge as a heart failure performance measure: results from OPTIMIZE-HFGregg C Fonarow
Department of Medicine, University of California Los Angeles Medical Center, Los Angeles, California 90095 1679, USA
J Card Fail 13:722-31. 2007..The objective of this study was to prospectively evaluate beta-blocker use at hospital discharge as an indicator of quality of care and outcomes in patients with heart failure (HF)...
Influence of diabetes on characteristics and outcomes in patients hospitalized with heart failure: a report from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF)Barry H Greenberg
University of California San Diego Medical Center, San Diego, CA 92103 8411, USA
Am Heart J 154:277.e1-8. 2007..Whether diabetes mellitus (DM) influences characteristics and outcomes in patients hospitalized with HF has not been well studied...
Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure: a report from the OPTIMIZE-HF RegistryGregg C Fonarow
Ahmanson UCLA Cardiomyopathy Center, Department of Medicine, UCLA Medical Center, Los Angeles, California 90095 1679, USA
J Am Coll Cardiol 50:768-77. 2007..We sought to evaluate the characteristics, treatments, and outcomes of patients with preserved and reduced systolic function heart failure (HF)...
The safety of intravenous diuretics alone versus diuretics plus parenteral vasoactive therapies in hospitalized patients with acutely decompensated heart failure: a propensity score and instrumental variable analysis using the Acutely Decompensated Heart Maria Rosa Costanzo
Midwest Heart Foundation, Lombard, IL, USA
Am Heart J 154:267-77. 2007..Significant concerns have been expressed regarding risks and benefits of individual therapies, especially nesiritide (NES), but few studies have compared the relative safety of varied intravenous therapies on clinical outcomes...
Antibodies against donor human leukocyte antigens and the outcome of cardiac allografts in adults and childrenPeter Stastny
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8886, USA
Transplantation 84:738-45. 2007..Antibodies against human leukocyte antigen (HLA) are known to appear in the serum of heart transplant recipients...
Relation of low hemoglobin and anemia to morbidity and mortality in patients hospitalized with heart failure (insight from the OPTIMIZE-HF registry)James B Young
Department of Cardiovascular Medicine, Heart Failure Section, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Am J Cardiol 101:223-30. 2008..Lower hemoglobin is associated with higher morbidity and mortality in hospitalized patients with HF...
Treatment of ventricular dysrhythmias and sudden cardiac death: a guideline-based approach for patients with chronic left ventricular dysfunctionAyesha Hasan
Division of Cardiovascular Medicine, Heart Failure Devices Clinic, Ohio State University College of Medicine, Columbus, OH 43210 1252, USA
Congest Heart Fail 13:228-35. 2007..In addition, the authors review current guidelines for electrophysiology testing in chronic left ventricular dysfunction and the emerging role of microvolt T-wave alternans as a means of risk stratification...
Preventing tomorrow's sudden cardiac death today: dissemination of effective therapies for sudden cardiac death preventionSana M Al-Khatib
The Duke Clinical Research Institute, Durham, NC 27715, USA
Am Heart J 156:613-22. 2008..Although the meeting was funded by industry participants, this article summarizing the presentations and discussions that occurred at the meeting presents the expert opinion of the authors...
Use of cardiac resynchronization therapy in patients hospitalized with heart failureJonathan P Piccini
Duke Clinical Research Institute, Durham, NC 27715, USA
Circulation 118:926-33. 2008....
Race-based therapeuticsClyde W Yancy
3500 Gaston Avenue, Suite H 030, Dallas, TX 75246, USA
Curr Hypertens Rep 10:276-85. 2008..As more physiologic markers of disease and drug responsiveness become available, the need for racial designations in medicine may lessen, and therapies can be optimized for all patients without regard to race or ethnicity...
Characteristics and outcomes in African American patients with decompensated heart failureSandeep A Kamath
University of Texas Southwestern Medical Center, Dallas, Texas, USA
Arch Intern Med 168:1152-8. 2008..Therefore, we assessed race-related differences in presentation, treatment, in-patient experiences, and short-term mortality due to ADHF before and after accounting for known covariates...
Race and the natural history of chronic heart failure: a propensity-matched studyGiovanni Gambassi
Universita Cattolica del Sacro Cuore, Rome, Italy
J Card Fail 14:373-8. 2008....
Blacks and whites have a similar prevalence of reduced left ventricular ejection fraction in the general population: the Dallas Heart Study (DHS)David W Markham
Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
Am Heart J 155:876-82. 2008..Because of the higher prevalence of risk factors for heart failure in blacks, including hypertension, obesity, and LV hypertrophy, we hypothesized that LV dysfunction would also be more common in this ethnic group...
Quality of care of and outcomes for African Americans hospitalized with heart failure: findings from the OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients With Heart Failure) registryClyde W Yancy
Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas 75246, USA
J Am Coll Cardiol 51:1675-84. 2008..We sought to examine the characteristics, quality of care, and clinical outcomes for a large cohort of African-American patients hospitalized with heart failure (HF) in centers participating in a quality improvement initiative...
Comparison of clinical features and outcomes of patients hospitalized with heart failure and normal ejection fraction (> or =55%) versus those with mildly reduced (40% to 55%) and moderately to severely reduced (<40%) fractionsNancy K Sweitzer
University of Wisconsin, Madison, Wisconsin, USA
Am J Cardiol 101:1151-6. 2008..These observations may be important considerations in the design of future clinical trials...
Cardiorenal interactions: insights from the ESCAPE trialAnju Nohria
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Am Coll Cardiol 51:1268-74. 2008....
Acutely decompensated heart failure in a county emergency department: a double-blind randomized controlled comparison of nesiritide versus placebo treatmentAdam H Miller
Department of Surgery Division of Emergency Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8579, USA
Ann Emerg Med 51:571-8. 2008..Nesiritide has been demonstrated to relieve symptoms of acutely decompensated congestive heart failure. We examined the effect of an 8-hour infusion of nesiritide on the composite of return to the ED or hospitalization at 30 days...
Temporal trends in clinical characteristics, treatments, and outcomes for heart failure hospitalizations, 2002 to 2004: findings from Acute Decompensated Heart Failure National Registry (ADHERE)Gregg C Fonarow
Ahmanson UCLA Cardiomyopathy Center, Los Angeles, CA 90095, USA
Am Heart J 153:1021-8. 2007..The purpose of this study was to assess temporal trends in clinical characteristics, treatments, quality indicators, and outcomes for heart failure (HF) hospitalizations...
The editor's roundtable: Acute decompensated heart failureVincent E Friedewald
Department of Internal Medicine, The University of Texas Medical School at Houston, Texas, USA
Am J Cardiol 99:1560-7. 2007
Discovering the full spectrum of cardiovascular disease: Minority Health Summit 2003: executive summaryClyde W Yancy
Circulation 111:1339-49. 2005
Risk stratification for in-hospital mortality in acutely decompensated heart failure: classification and regression tree analysisGregg C Fonarow
Ahmanson UCLA Cardiomyopathy Center, University of California, Los Angeles Medical Center, Los Angeles, CA 90095, USA
JAMA 293:572-80. 2005..Estimation of mortality risk in patients hospitalized with acute decompensated heart failure (ADHF) may help clinicians guide care...
BNP Consensus Panel 2004: A clinical approach for the diagnostic, prognostic, screening, treatment monitoring, and therapeutic roles of natriuretic peptides in cardiovascular diseasesMarc A Silver
Department of Medicine and Heart Failure Institute, Advocate Christ Medical Center, Oak Lawn, IL 60453 2600, USA
Congest Heart Fail 10:1-30. 2004..An expert Consensus Panel with basic, methodological, and clinical expertise was convened to summarize current knowledge in these areas and the findings and consensus statements are contained herein...
Advances in the management of acute and chronic decompensated heart failureSandra L Lowery
CCMI Associates, Francestown, NH 03043, USA
Lippincotts Case Manag 9:4-18; quiz 19-20. 2004..To date the typical treatment of acute decompensation has been based in the hospital and woefully inadequate in promoting any long-term medical stability...
African-American Heart Failure Trial (A-HeFT): rationale, design, and methodologyJoseph A Franciosa
Zena and Michael A. Wiener Cardiovascular Institute, Mt. Sinai School of Medicine, New York, New York, USA
J Card Fail 8:128-35. 2002..CONCLUSIONS: In addition to providing additional information on BiDil efficacy in HF, A-HeFT is the first HF trial aimed at a selected subgroup of patients and the first to use a new composite HF score as its primary efficacy endpoint...
Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF): rationale and designGregg C Fonarow
Department of Medicine, UCLA Medical Center, Los Angeles, Calif, USA
Am Heart J 148:43-51. 2004..The ultimate aim of this program is to improve the standard of HF care in the hospital and outpatient settings and increase the use of evidence-based therapeutic strategies to save lives...
Advances in the management of acute and chronic decompensated heart failureSandra L Lowery
CCMI Associates, 1163 New Boston Road, Francestown, NH 03043, USA
Lippincotts Case Manag 9:S1-15; quiz S16-7. 2004..To date the typical treatment of acute decompensation has been based in the hospital and woefully inadequate in promoting any long-term medical stability...
Heart failure in African Americans: pathophysiology and treatmentClyde W Yancy
Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, TX 75390-9047, USA
J Card Fail 9:S210-5. 2003
Gender differences in advanced heart failure: insights from the BEST studyJalal K Ghali
Cardiac Centers of Louisiana, Shreveport, Louisiana 71103, USA
J Am Coll Cardiol 42:2128-34. 2003..The goal of this study was to determine the influence of gender on baseline characteristics, response to treatment, and prognosis in patients with heart failure (HF) and impaired left ventricular ejection fraction (LVEF)...
Treatment of heart failure in African Americans: clinical updateClyde W Yancy
Department of Medicine, University of Texas, Southwestern Medical Center, Dallas 75390, USA
Ethn Dis 12:S1-19-26. 2002
Relation of lower hematocrit to progression from asymptomatic left ventricular dysfunction to symptomatic heart failure (from the Studies of Left Ventricular Dysfunction Prevention trial)Sandeep R Das
Donald W Reynolds Cardiovascular Clinical Research Center, Dallas, Texas, USA
Am J Cardiol 96:827-31. 2005..37 to 2.34), first HF hospitalization (HR 2.35, 95% CI 1.52 to 3.62), and death or the development of HF symptoms (HR 1.60, 95% CI 1.28 to 1.99) compared with patients in the highest hematocrit quartile (hematocrit > 46%)...
Predictors of delivery of hospital-based heart failure patient education: a report from OPTIMIZE-HFNancy M Albert
Division of Nursing and George M and Linda H Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Card Fail 13:189-98. 2007....
Early and sustained benefit on event-free survival and heart failure hospitalization from fixed-dose combination of isosorbide dinitrate/hydralazine: consistency across subgroups in the African-American Heart Failure TrialAnne L Taylor
Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
Circulation 115:1747-53. 2007....
Isosorbide dinitrate-hydralazine combination therapy in African Americans with heart failureMelvin R Echols
University of Texas Southwestern Dallas, TX, USA
Vasc Health Risk Manag 2:423-31. 2006..These findings strongly imply that nitric oxide enhancement and/or oxidative stress reduction may be important new therapeutic directions in the management of heart failure...
Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF registryMihai Gheorghiade
Division of Cardiology, Feinberg School of Medicine, Northwestern University, Galter 10 240, 201 E Huron Street, Chicago, IL 60611, USA
Eur Heart J 28:980-8. 2007..The predictive value of hyponatraemia has not been evaluated in unselected patients hospitalized with heart failure...
Beyond diuretics: management of volume overload in acute heart failure syndromesJames A Hill
Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida, USA
Am J Med 119:S37-44. 2006....
Systolic blood pressure at admission, clinical characteristics, and outcomes in patients hospitalized with acute heart failureMihai Gheorghiade
Division of Cardiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA
JAMA 296:2217-26. 2006..These findings may have important therapeutic implications because characteristics and outcomes differ greatly among patients with heart failure with varying SBP...
Current approaches to monitoring and management of heart failureClyde W Yancy
Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
Rev Cardiovasc Med 7:S25-32. 2006..When combined with clinical assessment, weight monitoring, and symptom assessment, these newer monitoring platforms may yield improvements in the natural history of heart failure...
A taxonomy for disease management: a scientific statement from the American Heart Association Disease Management Taxonomy Writing GroupHarlan M Krumholz
Yale University, USA
Circulation 114:1432-45. 2006....
Utility of impedance cardiography for the identification of short-term risk of clinical decompensation in stable patients with chronic heart failureMilton Packer
University of Texas Southwestern Medical Center, Dallas, Texas 75390 8822, USA
J Am Coll Cardiol 47:2245-52. 2006..This study sought to assess the potential utility of impedance cardiography (ICG) in predicting clinical deterioration in ambulatory patients with heart failure (HF)...
Racial response to angiotensin-converting enzyme therapy in systolic heart failureDaniel J Dries
Donald W Reynolds Cardiovascular Clinical Research Center, Room H8 116, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Congest Heart Fail 10:30-3. 2004..Race is an inadequate model to explain the observed differences. Careful translational research focusing on genetic patterns of disease may help resolve these outstanding questions...
