HIROMI contact YANAGISAWA

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Targeted deletion of a branchial arch-specific enhancer reveals a role of dHAND in craniofacial development
    Hiromi Yanagisawa
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, TX 75390 9148, USA
    Development 130:1069-78. 2003
  2. pmc Dysregulation of protease and protease inhibitors in a mouse model of human pelvic organ prolapse
    Madhusudhan Budatha
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    PLoS ONE 8:e56376. 2013
  3. pmc Unraveling the mechanism of elastic fiber assembly: The roles of short fibulins
    Hiromi Yanagisawa
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Int J Biochem Cell Biol 42:1084-93. 2010
  4. pmc Fibulin-2 and fibulin-5 cooperatively function to form the internal elastic lamina and protect from vascular injury
    Shelby L Chapman
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9148
    Arterioscler Thromb Vasc Biol 30:68-74. 2010
  5. pmc Molecular analysis of fibulin-5 function during de novo synthesis of elastic fibers
    Qian Zheng
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9148, USA
    Mol Cell Biol 27:1083-95. 2007
  6. pmc Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression
    Jianbin Huang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Circ Res 106:583-92. 2010
  7. ncbi request reprint Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo
    Hiromi Yanagisawa
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Texas 75390, USA
    Nature 415:168-71. 2002
  8. pmc Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration
    Jeffrey A Spencer
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 102:2946-51. 2005
  9. ncbi request reprint Normal wound healing in mice deficient for fibulin-5, an elastin binding protein essential for dermal elastic fiber assembly
    Qian Zheng
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Invest Dermatol 126:2707-14. 2006
  10. pmc Pelvic organ prolapse in fibulin-5 knockout mice: pregnancy-induced changes in elastic fiber homeostasis in mouse vagina
    Peter G Drewes
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9032, USA
    Am J Pathol 170:578-89. 2007

Research Grants

Collaborators

  • E N Olson
  • RUTH WORD
  • Zhi Ping Liu
  • Ning Liu
  • Takashi Suzuki
  • Lihua Y Marmorstein
  • Barry Starcher
  • D Y Li
  • Elaine C Davis
  • James A Richardson
  • Shelby L Chapman
  • Madhusudhan Budatha
  • Qian Zheng
  • Jianbin Huang
  • Masashi Yanagisawa
  • Peter G Drewes
  • Yaz Y Kisanuki
  • Marie K Schluterman
  • Cecilia K Wieslander
  • Ana C Barbosa
  • Robert E Hammer
  • Robert D Gerard
  • Jeffrey A Spencer
  • Louis Bruno Ruest
  • Sheena Shah-Simpson
  • Cecilia Karin Wieslander
  • Teodoro Ignacio Montoya
  • Simone Silva
  • Ayako Suzuki
  • F X Sicot
  • Kiyoshi Ozumi
  • Tohru Fukai
  • S Clay Williams
  • Keiko Yagi
  • Noriaki Emoto
  • Grzegorz Korpanty
  • Bambang Widyantoro
  • Mon Li Chu
  • Kazuhiko Nakayama
  • Takako Sasaki
  • Rafal M Kedzierski
  • Rolf A Brekken
  • Takashi Ohuchi
  • Jesus F Acevedo
  • David D Rahn
  • Donald D McIntire
  • Shelby Chapman
  • Spyridon I Marinis
  • Marc D McKee
  • Tiansen Li
  • Katalin Csiszar
  • Noriko Funato
  • Ian Hornstra
  • Patrick Keller
  • Richard L Leask
  • Jiwon Choi
  • Leonie Rouleau
  • Shelby L Hacker
  • Russ H Knutsen
  • Robert P Mecham
  • Jeroen Charité
  • David E Clouthier
  • Marcus Dager

Detail Information

Publications18

  1. ncbi request reprint Targeted deletion of a branchial arch-specific enhancer reveals a role of dHAND in craniofacial development
    Hiromi Yanagisawa
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, TX 75390 9148, USA
    Development 130:1069-78. 2003
    ....
  2. pmc Dysregulation of protease and protease inhibitors in a mouse model of human pelvic organ prolapse
    Madhusudhan Budatha
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    PLoS ONE 8:e56376. 2013
    ..These data collectively suggest that the balance between proteases and their inhibitors contributes to support of the pelvic organs in humans and mice...
  3. pmc Unraveling the mechanism of elastic fiber assembly: The roles of short fibulins
    Hiromi Yanagisawa
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Int J Biochem Cell Biol 42:1084-93. 2010
    ..We review recent findings on the elastogenic functions of short fibulins and discuss the molecular mechanism underlying their activity in vitro and in vivo...
  4. pmc Fibulin-2 and fibulin-5 cooperatively function to form the internal elastic lamina and protect from vascular injury
    Shelby L Chapman
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9148
    Arterioscler Thromb Vasc Biol 30:68-74. 2010
    ..Here, we generated double knockout mice for Fbln5 and Fbln2 (termed DKO) and examined the role of fibulins-2 and -5 in development and injury response of the blood vessel wall...
  5. pmc Molecular analysis of fibulin-5 function during de novo synthesis of elastic fibers
    Qian Zheng
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9148, USA
    Mol Cell Biol 27:1083-95. 2007
    ..These results also support the potential use of fibulin-5 as a therapeutic agent for the treatment of elastinopathies...
  6. pmc Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression
    Jianbin Huang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Circ Res 106:583-92. 2010
    ..However, aneurysms are never seen in mice deficient for elastin, or for fibulin-5, which absence also leads to compromised elastic fibers...
  7. ncbi request reprint Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo
    Hiromi Yanagisawa
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Texas 75390, USA
    Nature 415:168-71. 2002
    ..This function may be mediated by the RGD motif in fibulin-5, which binds to cell surface integrins, and the Ca2+-binding epidermal growth factor (EGF) repeats, which bind elastin...
  8. pmc Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration
    Jeffrey A Spencer
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 102:2946-51. 2005
    ..These findings demonstrate the importance of the elastic laminae in vascular injury, and reveal an unexpected role of fbln-5 as an inhibitor of vascular smooth muscle cell proliferation and migration...
  9. ncbi request reprint Normal wound healing in mice deficient for fibulin-5, an elastin binding protein essential for dermal elastic fiber assembly
    Qian Zheng
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Invest Dermatol 126:2707-14. 2006
    ..Clearly, the long-term effect of the absence of fibulin-5 on the function and integrity of regenerated skin needs to be further addressed...
  10. pmc Pelvic organ prolapse in fibulin-5 knockout mice: pregnancy-induced changes in elastic fiber homeostasis in mouse vagina
    Peter G Drewes
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9032, USA
    Am J Pathol 170:578-89. 2007
    ....
  11. ncbi request reprint Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin
    Zhi Ping Liu
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Dev Cell 9:261-70. 2005
    ..We conclude that signal-dependent interaction of Foxo4 with myocardin couples extracellular signals with the transcriptional program for SMC differentiation...
  12. pmc Quantification of pelvic organ prolapse in mice: vaginal protease activity precedes increased MOPQ scores in fibulin 5 knockout mice
    Cecilia K Wieslander
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Biol Reprod 80:407-14. 2009
    ..The results indicate that >90% of Fbln5(-/-) mice develop prolapse by 6 mo of age, even in the absence of vaginal delivery, and that increased vaginal protease activity precedes the development of prolapse...
  13. pmc Loss of fibulin-5 binding to beta1 integrins inhibits tumor growth by increasing the level of ROS
    Marie K Schluterman
    Hamon Center for Therapeutic Oncology Research, and Departments of Surgery and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dis Model Mech 3:333-42. 2010
    ....
  14. doi request reprint Low blood pressure in endothelial cell-specific endothelin 1 knockout mice
    Yaz Y Kisanuki
    Departments of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Tex75390 8584, USA
    Hypertension 56:121-8. 2010
    ..Taken in conjunction with other lines of genetically altered mice, our results provide evidence for a paracrine vasoregulatory pathway mediated by endothelial cell-derived ET-1 acting on the vascular smooth muscle ET(A) receptor...
  15. pmc DNA binding-dependent and -independent functions of the Hand2 transcription factor during mouse embryogenesis
    Ning Liu
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Development 136:933-42. 2009
    ..These findings suggest that Hand2 regulates tissue growth and development in vivo through DNA binding-dependent and -independent mechanisms...
  16. pmc Hand transcription factors cooperatively regulate development of the distal midline mesenchyme
    Ana C Barbosa
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Dev Biol 310:154-68. 2007
    ..These findings demonstrate the importance of Hand transcription factors in the transcriptional circuitry of craniofacial and tooth development...
  17. pmc dHAND-Cre transgenic mice reveal specific potential functions of dHAND during craniofacial development
    Louis Bruno Ruest
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville, Louisville, KY 40292, USA
    Dev Biol 257:263-77. 2003
    ..Moreover, dHAND-Cre mice will provide a valuable tool for tissue-specific inactivation of gene expression in multiple tissue types of neural crest origin...

Research Grants7

  1. The Role of Fibulin-5 in Cardiovascular Remodeling
    Hiromi Yanagisawa; Fiscal Year: 2007
    ..abstract_text> ..
  2. Protease regulation and integrity of connective tissues of the pelvic floor
    HIROMI contact YANAGISAWA; Fiscal Year: 2010
    ....
  3. Loss of Matrix Regulation and Aortic Aneurysm Development in vivo
    Hiromi Yanagisawa; Fiscal Year: 2011
    ..We will study how this protein functions to prevent the development of aortic aneurysms. ..