Z Yan

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. pmc Differential regulation of the excitability of prefrontal cortical fast-spiking interneurons and pyramidal neurons by serotonin and fluoxetine
    Ping Zhong
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, United States of America
    PLoS ONE 6:e16970. 2011
  2. pmc Aβ impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortex
    Guo Jun Chen
    Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
    Mol Neurodegener 8:3. 2013
  3. pmc SNARE proteins are essential in the potentiation of NMDA receptors by group II metabotropic glutamate receptors
    Jia Cheng
    Department of Physiology and Biophysics, State University of New York at Buffalo, NY 14214, USA
    J Physiol 591:3935-47. 2013
  4. pmc Histone deacetylase 6 gates the synaptic action of acute stress in prefrontal cortex
    Janine B Lee
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14214, USA
    J Physiol 590:1535-46. 2012
  5. pmc Recent advances in basic neurosciences and brain disease: from synapses to behavior
    Guo Qiang Bi
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
    Mol Pain 2:38. 2006
  6. ncbi request reprint RGS4 modulates serotonin signaling in prefrontal cortex and links to serotonin dysfunction in a rat model of schizophrenia
    Zhenglin Gu
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 124 Sherman Hall, Buffalo NY 14214
    Mol Pharmacol 71:1030-9. 2007
  7. ncbi request reprint Alzheimer's disease: interactions between cholinergic functions and beta-amyloid
    Zhen Yan
    Dept of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
    Curr Alzheimer Res 1:241-8. 2004
  8. ncbi request reprint Regulation of GABAergic inhibition by serotonin signaling in prefrontal cortex: molecular mechanisms and functional implications
    Zhen Yan
    Department of Physiology and Biophysics, State University of New York at Buffalo, 14214, USA
    Mol Neurobiol 26:203-16. 2002
  9. pmc Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory
    E Y Yuen
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Mol Psychiatry 16:156-70. 2011
  10. pmc Roscovitine: a novel regulator of P/Q-type calcium channels and transmitter release in central neurons
    Zhen Yan
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Physiol 540:761-70. 2002

Collaborators

Detail Information

Publications66

  1. pmc Differential regulation of the excitability of prefrontal cortical fast-spiking interneurons and pyramidal neurons by serotonin and fluoxetine
    Ping Zhong
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, United States of America
    PLoS ONE 6:e16970. 2011
    ..It provides a framework for understanding the action of 5-HT and antidepressants in altering PFC network activity...
  2. pmc Aβ impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortex
    Guo Jun Chen
    Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
    Mol Neurodegener 8:3. 2013
    ....
  3. pmc SNARE proteins are essential in the potentiation of NMDA receptors by group II metabotropic glutamate receptors
    Jia Cheng
    Department of Physiology and Biophysics, State University of New York at Buffalo, NY 14214, USA
    J Physiol 591:3935-47. 2013
    ..Taken together, these results have identified key molecules involved in the group II mGluR-induced potentiation of NMDAR exocytosis and function...
  4. pmc Histone deacetylase 6 gates the synaptic action of acute stress in prefrontal cortex
    Janine B Lee
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14214, USA
    J Physiol 590:1535-46. 2012
    ..These findings have identified HDAC6 as a key molecule gating the effects of acute stress on synaptic functions in the PFC...
  5. pmc Recent advances in basic neurosciences and brain disease: from synapses to behavior
    Guo Qiang Bi
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
    Mol Pain 2:38. 2006
    ..The second international meeting on Neurons and Brain Disease will be held in Toronto (August 29-31, 2007)...
  6. ncbi request reprint RGS4 modulates serotonin signaling in prefrontal cortex and links to serotonin dysfunction in a rat model of schizophrenia
    Zhenglin Gu
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 124 Sherman Hall, Buffalo NY 14214
    Mol Pharmacol 71:1030-9. 2007
    ..Thus, our study has revealed an important coupling of RGS4 to serotonin signaling in cortical neurons and provided a molecular and cellular mechanism underlying the potential involvement of RGS4 in the pathophysiology of schizophrenia...
  7. ncbi request reprint Alzheimer's disease: interactions between cholinergic functions and beta-amyloid
    Zhen Yan
    Dept of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
    Curr Alzheimer Res 1:241-8. 2004
    ....
  8. ncbi request reprint Regulation of GABAergic inhibition by serotonin signaling in prefrontal cortex: molecular mechanisms and functional implications
    Zhen Yan
    Department of Physiology and Biophysics, State University of New York at Buffalo, 14214, USA
    Mol Neurobiol 26:203-16. 2002
    ....
  9. pmc Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory
    E Y Yuen
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Mol Psychiatry 16:156-70. 2011
    ....
  10. pmc Roscovitine: a novel regulator of P/Q-type calcium channels and transmitter release in central neurons
    Zhen Yan
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Physiol 540:761-70. 2002
    ....
  11. pmc The novel antipsychotic drug lurasidone enhances N-methyl-D-aspartate receptor-mediated synaptic responses
    Eunice Y Yuen
    Department of Physiology and Biophysics, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
    Mol Pharmacol 81:113-9. 2012
    ....
  12. ncbi request reprint Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5
    J A Bibb
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 410:376-80. 2001
    ..Our results suggest that changes in Cdk5 levels mediated by DeltaFosB, and resulting alterations in signalling involving D1 dopamine receptors, contribute to adaptive changes in the brain related to cocaine addiction...
  13. pmc Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice
    J A Bibb
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 97:6809-14. 2000
    ..HD mice also show defects in dopamine-regulated ion channels and in the D(1) dopamine/DARPP-32 signaling cascade. These presymptomatic defects may contribute to HD pathology...
  14. pmc Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors
    F Liu
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:11062-8. 2001
    ..Together these results indicate that a CK1-Cdk5-DARPP-32 cascade may be involved in the regulation by mGluR agonists of Ca(2+) channels...
  15. ncbi request reprint Serotonin receptors modulate GABA(A) receptor channels through activation of anchored protein kinase C in prefrontal cortical neurons
    J Feng
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York 14214, USA
    J Neurosci 21:6502-11. 2001
    ..The suppression of GABAergic signaling provides a novel mechanism for serotonergic modulation of PFC neuronal activity, which may underlie the actions of many antidepressant drugs...
  16. pmc D(2) dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons
    Z Yan
    Laboratory of Molecular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 96:11607-12. 1999
    ..Our results suggest that MAPK and CREB signaling cascades are involved in the regulation of gene expression and other long-term effects of D(2) receptor activation...
  17. ncbi request reprint Chronic antidepressant treatment alters serotonergic regulation of GABA transmission in prefrontal cortical pyramidal neurons
    P Zhong
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, 124 Sherman Hall, Buffalo, NY 14214, USA
    Neuroscience 129:65-73. 2004
    ..Given the key role of GABAergic inhibitory transmission in controlling PFC functions, its altered regulation by serotonin after chronic fluoxetine treatment may provide a mechanism underlying the therapeutic action of antidepressants...
  18. ncbi request reprint Estrogen protects against the detrimental effects of repeated stress on glutamatergic transmission and cognition
    J Wei
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY, USA
    Mol Psychiatry 19:588-98. 2014
    ..These results suggest that estrogen protects against the detrimental effects of repeated stress on glutamatergic transmission and PFC-dependent cognition, which may underlie the stress resilience of females...
  19. ncbi request reprint beta-Amyloid peptides impair PKC-dependent functions of metabotropic glutamate receptors in prefrontal cortical neurons
    Joanna P Tyszkiewicz
    Dept of Physiology and Biophysics, State University of New York at Buffalo, 124 Sherman Hall, Buffalo, NY, 14214, USA
    J Neurophysiol 93:3102-11. 2005
    ..This study provides a framework within which the role of mGluRs in normal cognitive functions and AD can be better understood...
  20. ncbi request reprint Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens
    Guojun Chen
    Department of Physiology and Biophysics, State University of New York, Buffalo, New York 14214, USA
    J Neurosci 26:2513-21. 2006
    ..Together, our results suggest that D3 receptor activation suppresses the efficacy of inhibitory synaptic transmission in NAc by increasing the phospho-dependent endocytosis of GABAA receptors...
  21. ncbi request reprint Serotonin 5-HT1A receptors regulate AMPA receptor channels through inhibiting Ca2+/calmodulin-dependent kinase II in prefrontal cortical pyramidal neurons
    Xiang Cai
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 277:36553-62. 2002
    ..This modulation demonstrates the critical role of CaMKII in serotonergic regulation of PFC neuronal activity, which may explain the neuropsychiatric behavioral phenotypes seen in CaMKII knockout mice...
  22. ncbi request reprint Serotonin 5-HT1A receptors regulate NMDA receptor channels through a microtubule-dependent mechanism
    Eunice Y Yuen
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA
    J Neurosci 25:5488-501. 2005
    ..The 5-HT(1A)-NMDAR interaction provides a potential mechanism underlying the role of serotonin in controlling emotional and cognitive processes subserved by PFC...
  23. ncbi request reprint Regulation of NMDA receptors by neuregulin signaling in prefrontal cortex
    Zhenglin Gu
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
    J Neurosci 25:4974-84. 2005
    ....
  24. ncbi request reprint Dopamine D4 receptors modulate GABAergic signaling in pyramidal neurons of prefrontal cortex
    Xun Wang
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
    J Neurosci 22:9185-93. 2002
    ....
  25. pmc Spinophilin regulates the formation and function of dendritic spines
    J Feng
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:9287-92. 2000
    ..In conclusion, spinophilin appears to be required for the regulation of the properties of dendritic spines...
  26. pmc Dopamine D4 receptors regulate AMPA receptor trafficking and glutamatergic transmission in GABAergic interneurons of prefrontal cortex
    Eunice Y Yuen
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA
    J Neurosci 29:550-62. 2009
    ....
  27. pmc Activity-dependent bidirectional regulation of GABA(A) receptor channels by the 5-HT(4) receptor-mediated signalling in rat prefrontal cortical pyramidal neurons
    Xiang Cai
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
    J Physiol 540:743-59. 2002
    ..This modulation provides a unique and flexible mechanism for 5-HT(4) receptors to dynamically regulate synaptic transmission and neuronal excitability in the PFC network...
  28. ncbi request reprint Corticotropin-releasing factor and acute stress prolongs serotonergic regulation of GABA transmission in prefrontal cortical pyramidal neurons
    Huibing Tan
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
    J Neurosci 24:5000-8. 2004
    ..The interaction between CRF and 5-HT may play an important role in psychiatric disorders, in which both are highly implicated...
  29. ncbi request reprint Muscarinic potentiation of GABA(A) receptor currents is gated by insulin signaling in the prefrontal cortex
    Xiao Hong Ma
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York 14214, USA
    J Neurosci 23:1159-68. 2003
    ..Given the significance of GABAergic transmission in regulating PFC functions, our results provide a novel mechanism for understanding the role of cholinergic systems and insulin signaling in learning and memory...
  30. ncbi request reprint Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's disease
    Ping Zhong
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
    J Biol Chem 278:26888-96. 2003
    ..These results show that the muscarinic regulation of GABA transmission is impaired in the AD model, probably due to the Abeta-mediated interference of mAChR activation of PKC...
  31. ncbi request reprint Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons
    J A Bibb
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    Nature 402:669-71. 1999
    ..Thus DARPP-32 is a bifunctional signal transduction molecule which, by distinct mechanisms, controls a serine/threonine kinase and a serine/threonine phosphatase...
  32. ncbi request reprint Coordinated expression of muscarinic receptor messenger RNAs in striatal medium spiny neurons
    Z Yan
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214-3005, USA
    Neuroscience 103:1017-24. 2001
    ..This quantitative difference provides a means of reconciling previous estimates of M4 receptor distribution and function...
  33. pmc Adrenergic modulation of NMDA receptors in prefrontal cortex is differentially regulated by RGS proteins and spinophilin
    Wenhua Liu
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY 14214, USA
    Proc Natl Acad Sci U S A 103:18338-43. 2006
    ..The effect of alpha1-ARs is modified by RGS2/4 that are recruited to the receptor complex by spinophilin, whereas the effect of alpha2-ARs is modified by RGS4 independent of spinophilin...
  34. pmc Regulation of the NMDA receptor-mediated synaptic response by acetylcholinesterase inhibitors and its impairment in an animal model of Alzheimer's disease
    Guojun Chen
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Neurobiol Aging 29:1795-804. 2008
    ..Loss of the regulation of synaptic NMDAR responses by endogenous ACh may contribute to the cognitive deficiency in AD...
  35. pmc Activation of 5-HT2A/C receptors counteracts 5-HT1A regulation of n-methyl-D-aspartate receptor channels in pyramidal neurons of prefrontal cortex
    Eunice Y Yuen
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 283:17194-204. 2008
    ..These findings provide a framework for understanding the complex interactions between serotonin and NMDARs in PFC, which could be important for cognitive and emotional control in which both systems are highly involved...
  36. pmc Serotonin facilitates long-term depression induction in prefrontal cortex via p38 MAPK/Rab5-mediated enhancement of AMPA receptor internalization
    Ping Zhong
    Department of Physiology and Biophysics, State University of New York at Buffalo, 124 Sherman Hall, Buffalo, NY 14214, USA
    J Physiol 586:4465-79. 2008
    ..It provides a potential mechanism underlying the role of serotonin in controlling emotional and cognitive processes that are mediated by synaptic plasticity in PFC neurons...
  37. pmc Resting bold fMRI differentiates dementia with Lewy bodies vs Alzheimer disease
    J E Galvin
    Center of Excellence on Brain Aging, New York University Langone School of Medicine, 145 East 32nd St, Second Floor, New York, NY 10016, USA
    Neurology 76:1797-803. 2011
    ..We performed resting state blood oxygen level-dependent (BOLD) functional connectivity MRI (fcMRI) to determine whether there were differences between AD and DLB...
  38. ncbi request reprint Prostaglandin E2 receptors EP2 and EP4 are down-regulated in human mononuclear cells after injury
    V E Strong
    Department of Surgery, New York Presbyterian Hospital-Weill Medical College of Cornell Univerity, New York, NY 10021, USA
    Surgery 130:249-55. 2001
    ..Furthermore, PGE(2) mediates EP2 and EP4 down-regulation. These data suggest that specific EP receptor subtypes may provide critical targets for augmenting the immune response after injury in humans...
  39. pmc Phosphatidylinositol (4,5)-bisphosphate regulation of N-methyl-D-aspartate receptor channels in cortical neurons
    Madhuchhanda Mandal
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, USA
    Mol Pharmacol 76:1349-59. 2009
    ..With the actin cytoskeleton no longer intact, NMDARs are internalized via a dynamin/clathrin-dependent mechanism, leading to reduced NMDAR currents...
  40. pmc Calpain regulation of AMPA receptor channels in cortical pyramidal neurons
    Eunice Y Yuen
    Department of Physiology and Biophysics, State University of New York at Buffalo, 124 Sherman Hall, Buffalo, NY 14214, USA
    J Physiol 580:241-54. 2007
    ..The down-regulation of AMPARs by calpain provides a negative feedback to dampen neuronal excitability in excitotoxic conditions like ischaemia and epilepsy...
  41. pmc Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory
    Eunice Y Yuen
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
    Proc Natl Acad Sci U S A 106:14075-9. 2009
    ....
  42. ncbi request reprint Activation of dopamine D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons
    Zhenglin Gu
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Mol Pharmacol 69:813-22. 2006
    ....
  43. ncbi request reprint Activation of muscarinic receptors inhibits beta-amyloid peptide-induced signaling in cortical slices
    Zhenglin Gu
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
    J Biol Chem 278:17546-56. 2003
    ..Thus the muscarinic reversal of the Abeta-induced biochemical and physiological changes provides a potential mechanism for the treatment of Alzheimer's disease with cholinergic enhancers...
  44. ncbi request reprint D3 dopamine autoreceptors do not activate G-protein-gated inwardly rectifying potassium channel currents in substantia nigra dopamine neurons
    Viviana Davila
    Department of Neurology, Columbia University, New York, NY 10032, USA
    J Neurosci 23:5693-7. 2003
    ..Thus, it appears that D3 activation of GIRK currents in SN neurons does not occur or is exceedingly rare...
  45. ncbi request reprint Regulation of NMDA receptors by dopamine D4 signaling in prefrontal cortex
    Xun Wang
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
    J Neurosci 23:9852-61. 2003
    ....
  46. ncbi request reprint Bidirectional regulation of Ca2+/calmodulin-dependent protein kinase II activity by dopamine D4 receptors in prefrontal cortex
    Zhenglin Gu
    Department of Physiology and Biophysics, State University of New York at Buffalo, 14214, USA
    Mol Pharmacol 66:948-55. 2004
    ..This modulation provides a unique and flexible mechanism for D4 receptors to regulate CaMKII activity, which could lead to dynamic regulation of many targets of CaMKII by D4 receptors...
  47. pmc Potentiation of NMDA receptor currents by dopamine D1 receptors in prefrontal cortex
    Guojun Chen
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
    Proc Natl Acad Sci U S A 101:2596-600. 2004
    ..These interactions may play an important role in modulating synaptic plasticity and thus in cognitive and emotional processes...
  48. ncbi request reprint Aberrant regulation of NMDA receptors by dopamine D4 signaling in rats after phencyclidine exposure
    Xun Wang
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, 124 Sherman Hall, Buffalo, NY 14214, USA
    Mol Cell Neurosci 31:15-25. 2006
    ....
  49. pmc The stress hormone corticosterone increases synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors via serum- and glucocorticoid-inducible kinase (SGK) regulation of the GDI-Rab4 complex
    Wenhua Liu
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 285:6101-8. 2010
    ..It provides a potential mechanism underlying the role of corticosteroid stress hormone in up-regulating excitatory synaptic efficacy in cortical neurons...
  50. pmc Regulation of AMPA receptor channels and synaptic plasticity by cofilin phosphatase Slingshot in cortical neurons
    Eunice Y Yuen
    Department of Physiology and Biophysics and New York State Center of Excellence in Bioinformatics and Life Sciences, State University of New York, Buffalo, NY 14214, USA
    J Physiol 588:2361-71. 2010
    ..Our data suggest that Slingshot plays a pivotal role in AMPAR trafficking and synaptic transmission by controlling actin cytoskeleton via cofilin activation...
  51. ncbi request reprint Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons
    Qian Jiang
    Department of Physiology and Biophysics, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 281:29391-400. 2006
    ..Thus, our results suggest that neurotrophic factors activate the microtubule-associated protein kinase pathway to stabilize microtubules, and this action significantly attenuates rotenone toxicity on dopaminergic neurons...
  52. pmc Group II metabotropic glutamate receptors enhance NMDA receptor currents via a protein kinase C-dependent mechanism in pyramidal neurones of rat prefrontal cortex
    Joanna P Tyszkiewicz
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
    J Physiol 554:765-77. 2004
    ..This modulation may be relevant for developing novel mGluR-related pharmacological agents for the treatment of mental illnesses...
  53. pmc {beta}-Amyloid impairs AMPA receptor trafficking and function by reducing Ca2+/calmodulin-dependent protein kinase II synaptic distribution
    Zhenglin Gu
    Department of Physiology and Biophysics, State University of New York, School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
    J Biol Chem 284:10639-49. 2009
    ..These results suggest that the Abeta-induced change in CaMKII subcellular distribution may underlie the removal of AMPARs from synaptic membrane by Abeta...
  54. pmc Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism
    Nicholas M Graziane
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14214
    J Biol Chem 284:8329-36. 2009
    ....
  55. ncbi request reprint Microtubule regulation of N-methyl-D-aspartate receptor channels in neurons
    Eunice Y Yuen
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, 14214, USA
    J Biol Chem 280:29420-7. 2005
    ..Taken together, these results suggest that interfering with microtubule assembly suppresses NMDAR function through a mechanism dependent on kinesin-based dendritic transport of NMDA receptors...
  56. pmc Postsynaptic density-95 (PSD-95) and calcineurin control the sensitivity of N-methyl-D-aspartate receptors to calpain cleavage in cortical neurons
    Eunice Y Yuen
    Department of Physiology and Biophysics, State University of New York at Buffalo, 124 Sherman Hall, Buffalo, NY 14214, USA
    Mol Pharmacol 74:360-70. 2008
    ..These data suggest that calpain activation suppresses NMDAR function via proteolytic cleavage of NR2 subunits in vitro and in vivo, and the susceptibility of NMDARs to calpain cleavage is controlled by PSD-95 and calcineurin...
  57. ncbi request reprint The phosphorylation state of GluR1 subunits determines the susceptibility of AMPA receptors to calpain cleavage
    Eunice Y Yuen
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
    J Biol Chem 282:16434-40. 2007
    ....
  58. ncbi request reprint Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism
    Qian Jiang
    Department of Physiology and Biophysics, State University of New York, Buffalo, New York 14214, USA
    J Neurosci 26:4318-28. 2006
    ..These findings may offer a novel neuroprotective approach against rotenone-induced parkinsonism...
  59. ncbi request reprint Regulation of N-methyl-D-aspartate receptors by calpain in cortical neurons
    Hai Yan Wu
    Department of Physiology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    J Biol Chem 280:21588-93. 2005
    ....
  60. ncbi request reprint Expression of heat shock protein 70 in the cochlea in experimental autoimmune inner ear disease
    Shu Sheng Gong
    Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan City, China
    Ann Otol Rhinol Laryngol 111:275-80. 2002
    ..The results suggest that the immune response of the inner ear induced the expression of hsp70 in the guinea pig cochleas...
  61. pmc Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2
    Kathrin Kastning
    Department of Membrane Biochemistry, Institute of Chemistry and Biochemistry, Freie Universitat Berlin, Takustrasse 6, 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 104:2991-6. 2007
    ..These data suggest that common mechanisms regulate AP-2-dependent internalization of pre- and postsynaptic membrane proteins...
  62. ncbi request reprint Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability
    David R Benavides
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 27:12967-76. 2007
    ..These results suggest that Cdk5 acts as a negative regulator of neuronal excitability in the NAc and that Cdk5 may govern the behavioral effects of cocaine and motivation for reinforcement...
  63. pmc Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor gamma2 subunit
    Josef T Kittler
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 105:3616-21. 2008
    ..These data define a mechanism for tyrosine kinase regulation of GABA(A)R surface levels and synaptic inhibition...
  64. pmc TRPC3 channels confer cellular memory of recent neuromuscular activity
    Paul Rosenberg
    Department of Internal Medicin, Duke University Medical School, Durham, 27710, USA
    Proc Natl Acad Sci U S A 101:9387-92. 2004
    ..These data suggest a mechanism for cellular memory in skeletal muscles whereby repeated bouts of contractile activity drive progressively greater remodeling events...
  65. pmc Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission
    Josef T Kittler
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 102:14871-6. 2005
    ..Therefore phospho-dependent regulation of AP2 binding to GABA(A)Rs provides a mechanism to specify receptor cell surface number and the efficacy of inhibitory synaptic transmission...
  66. pmc Modulation of neuronal excitability by serotonin-NMDA interactions in prefrontal cortex
    Ping Zhong
    Department of Physiology and Biophysics and New York State Center of Excellence in Bioinformatics and Life Sciences, State University of New York, Buffalo, NY 14214 USA
    Mol Cell Neurosci 38:290-9. 2008
    ....

Research Grants18

  1. Functions of Dopamine D4 Receptors in Prefrontal Cortex
    Zhen Yan; Fiscal Year: 2010
    ....
  2. Neuromodulator Actions in Prefrontal Cortical Neurons
    Zhen Yan; Fiscal Year: 2002
    ..Knowledge gained from this work would contribute to the development of novel therapeutic strategies for many neurological and mental disorders. ..
  3. Functions of Dopamine D4 Receptors in Prefrontal Cortex
    Zhen Yan; Fiscal Year: 2007
    ....
  4. The Role of Cholinergic Functions in Alzheimer's Disease
    Zhen Yan; Fiscal Year: 2006
    ..Such knowledge should offer important insights into the cellular and molecular basis of AD and the development of new pharmacological agents in the treatment of this disease. ..
  5. Functions of Dopamine D4 Receptors in Prefrontal Cortex
    Zhen Yan; Fiscal Year: 2006
    ....
  6. Neuromodulator Actions in Prefrontal Cortical Neurons
    Zhen Yan; Fiscal Year: 2006
    ..Knowledge gained from this work would contribute to the development of novel therapeutic strategies for many neurological and mental disorders. ..
  7. Functions of Dopamine D4 Receptors in Prefrontal Cortex
    Zhen Yan; Fiscal Year: 2005
    ....
  8. Synaptic Changes by Stress in Prefrontal Cortex
    Zhen Yan; Fiscal Year: 2010
    ..Understanding these molecular and cellular mechanisms will provide valuable targets for designing novel therapies that modify the stress response. ..
  9. Neuromodulator Actions in Prefrontal Cortical Neurons
    Zhen Yan; Fiscal Year: 2005
    ..Knowledge gained from this work would contribute to the development of novel therapeutic strategies for many neurological and mental disorders. ..
  10. The Role of Cholinergic Functions in Alzheimer's Disease
    Zhen Yan; Fiscal Year: 2003
    ..Such knowledge should offer important insights into the cellular and molecular basis of AD and the development of new pharmacological agents in the treatment of this disease. ..
  11. Neuromodulator Actions in Prefrontal Cortical Neurons
    Zhen Yan; Fiscal Year: 2003
    ..Knowledge gained from this work would contribute to the development of novel therapeutic strategies for many neurological and mental disorders. ..
  12. Functions of Dopamine D4 Receptors in Prefrontal Cortex
    Zhen Yan; Fiscal Year: 2009
    ....
  13. The Role of Cholinergic Functions in Alzheimer's Disease
    Zhen Yan; Fiscal Year: 2007
    ..Such knowledge should offer important insights into the cellular and molecular basis of AD and the development of new pharmacological agents in the treatment of this disease. ..
  14. Neuromodulator Actions in Prefrontal Cortical Neurons
    Zhen Yan; Fiscal Year: 2004
    ..Knowledge gained from this work would contribute to the development of novel therapeutic strategies for many neurological and mental disorders. ..
  15. The Role of Cholinergic Functions in Alzheimer's Disease
    Zhen Yan; Fiscal Year: 2004
    ..Such knowledge should offer important insights into the cellular and molecular basis of AD and the development of new pharmacological agents in the treatment of this disease. ..
  16. Functions of Dopamine D4 Receptors in Prefrontal Cortex
    Zhen Yan; Fiscal Year: 2004
    ....
  17. The Role of Cholinergic Functions in Alzheimer's Disease
    Zhen Yan; Fiscal Year: 2005
    ..Such knowledge should offer important insights into the cellular and molecular basis of AD and the development of new pharmacological agents in the treatment of this disease. ..