Research Topics
Genomes and Genes | Z YanSummaryAffiliation: University at Buffalo Country: USA Publications
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Publications
Histone deacetylase 6 gates the synaptic action of acute stress in prefrontal cortexJanine B Lee
Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14214, USA
J Physiol 590:1535-46. 2012..These findings have identified HDAC6 as a key molecule gating the effects of acute stress on synaptic functions in the PFC...
Recent advances in basic neurosciences and brain disease: from synapses to behaviorGuo Qiang Bi
Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
Mol Pain 2:38. 2006..The second international meeting on Neurons and Brain Disease will be held in Toronto (August 29-31, 2007)...
Regulation of GABAergic inhibition by serotonin signaling in prefrontal cortex: molecular mechanisms and functional implicationsZhen Yan
Department of Physiology and Biophysics, State University of New York at Buffalo, 14214, USA
Mol Neurobiol 26:203-16. 2002....- RGS4 modulates serotonin signaling in prefrontal cortex and links to serotonin dysfunction in a rat model of schizophreniaZhenglin Gu
Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 124 Sherman Hall, Buffalo NY 14214
Mol Pharmacol 71:1030-9. 2007..Thus, our study has revealed an important coupling of RGS4 to serotonin signaling in cortical neurons and provided a molecular and cellular mechanism underlying the potential involvement of RGS4 in the pathophysiology of schizophrenia... - Alzheimer's disease: interactions between cholinergic functions and beta-amyloidZhen Yan
Dept of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
Curr Alzheimer Res 1:241-8. 2004.... - Roscovitine: a novel regulator of P/Q-type calcium channels and transmitter release in central neuronsZhen Yan
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
J Physiol 540:761-70. 2002.... - Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memoryE Y Yuen
Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA
Mol Psychiatry 16:156-70. 2011.... - The novel antipsychotic drug lurasidone enhances N-methyl-D-aspartate receptor-mediated synaptic responsesEunice Y Yuen
Department of Physiology and Biophysics, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
Mol Pharmacol 81:113-9. 2012.... - Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5J A Bibb
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
Nature 410:376-80. 2001..Our results suggest that changes in Cdk5 levels mediated by DeltaFosB, and resulting alterations in signalling involving D1 dopamine receptors, contribute to adaptive changes in the brain related to cocaine addiction... - Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease miceJ A Bibb
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021 6399, USA
Proc Natl Acad Sci U S A 97:6809-14. 2000..HD mice also show defects in dopamine-regulated ion channels and in the D(1) dopamine/DARPP-32 signaling cascade. These presymptomatic defects may contribute to HD pathology... - Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptorsF Liu
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 98:11062-8. 2001..Together these results indicate that a CK1-Cdk5-DARPP-32 cascade may be involved in the regulation by mGluR agonists of Ca(2+) channels... - Serotonin receptors modulate GABA(A) receptor channels through activation of anchored protein kinase C in prefrontal cortical neuronsJ Feng
Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York 14214, USA
J Neurosci 21:6502-11. 2001..The suppression of GABAergic signaling provides a novel mechanism for serotonergic modulation of PFC neuronal activity, which may underlie the actions of many antidepressant drugs... - D(2) dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neuronsZ Yan
Laboratory of Molecular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 96:11607-12. 1999..Our results suggest that MAPK and CREB signaling cascades are involved in the regulation of gene expression and other long-term effects of D(2) receptor activation... - Chronic antidepressant treatment alters serotonergic regulation of GABA transmission in prefrontal cortical pyramidal neuronsP Zhong
Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, 124 Sherman Hall, Buffalo, NY 14214, USA
Neuroscience 129:65-73. 2004..Given the key role of GABAergic inhibitory transmission in controlling PFC functions, its altered regulation by serotonin after chronic fluoxetine treatment may provide a mechanism underlying the therapeutic action of antidepressants... - beta-Amyloid peptides impair PKC-dependent functions of metabotropic glutamate receptors in prefrontal cortical neuronsJoanna P Tyszkiewicz
Dept. of Physiology and Biophysics, State University of New York at Buffalo, 124 Sherman Hall, Buffalo, NY, 14214, USA
J Neurophysiol 93:3102-11. 2005..This study provides a framework within which the role of mGluRs in normal cognitive functions and AD can be better understood... - Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbensGuojun Chen
Department of Physiology and Biophysics, State University of New York, Buffalo, New York 14214, USA
J Neurosci 26:2513-21. 2006..Together, our results suggest that D3 receptor activation suppresses the efficacy of inhibitory synaptic transmission in NAc by increasing the phospho-dependent endocytosis of GABAA receptors... - Serotonin 5-HT1A receptors regulate AMPA receptor channels through inhibiting Ca2+/calmodulin-dependent kinase II in prefrontal cortical pyramidal neuronsXiang Cai
Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
J Biol Chem 277:36553-62. 2002..This modulation demonstrates the critical role of CaMKII in serotonergic regulation of PFC neuronal activity, which may explain the neuropsychiatric behavioral phenotypes seen in CaMKII knockout mice... - Regulation of NMDA receptors by neuregulin signaling in prefrontal cortexZhenglin Gu
Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
J Neurosci 25:4974-84. 2005.... - Serotonin 5-HT1A receptors regulate NMDA receptor channels through a microtubule-dependent mechanismEunice Y Yuen
Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA
J Neurosci 25:5488-501. 2005..The 5-HT(1A)-NMDAR interaction provides a potential mechanism underlying the role of serotonin in controlling emotional and cognitive processes subserved by PFC... - Dopamine D4 receptors modulate GABAergic signaling in pyramidal neurons of prefrontal cortexXun Wang
Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
J Neurosci 22:9185-93. 2002.... - Spinophilin regulates the formation and function of dendritic spinesJ Feng
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 97:9287-92. 2000..In conclusion, spinophilin appears to be required for the regulation of the properties of dendritic spines... - Muscarinic potentiation of GABA(A) receptor currents is gated by insulin signaling in the prefrontal cortexXiao-Hong Ma
Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York 14214, USA
J Neurosci 23:1159-68. 2003..Given the significance of GABAergic transmission in regulating PFC functions, our results provide a novel mechanism for understanding the role of cholinergic systems and insulin signaling in learning and memory... - Activity-dependent bidirectional regulation of GABA(A) receptor channels by the 5-HT(4) receptor-mediated signalling in rat prefrontal cortical pyramidal neuronsXiang Cai
Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
J Physiol 540:743-59. 2002..This modulation provides a unique and flexible mechanism for 5-HT(4) receptors to dynamically regulate synaptic transmission and neuronal excitability in the PFC network... - Dopamine D4 receptors regulate AMPA receptor trafficking and glutamatergic transmission in GABAergic interneurons of prefrontal cortexEunice Y Yuen
Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA
J Neurosci 29:550-62. 2009.... - Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's diseasePing Zhong
Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
J Biol Chem 278:26888-96. 2003..These results show that the muscarinic regulation of GABA transmission is impaired in the AD model, probably due to the Abeta-mediated interference of mAChR activation of PKC... - Corticotropin-releasing factor and acute stress prolongs serotonergic regulation of GABA transmission in prefrontal cortical pyramidal neuronsHuibing Tan
Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
J Neurosci 24:5000-8. 2004..The interaction between CRF and 5-HT may play an important role in psychiatric disorders, in which both are highly implicated... - Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neuronsJ A Bibb
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
Nature 402:669-71. 1999..Thus DARPP-32 is a bifunctional signal transduction molecule which, by distinct mechanisms, controls a serine/threonine kinase and a serine/threonine phosphatase... - Coordinated expression of muscarinic receptor messenger RNAs in striatal medium spiny neuronsZ Yan
Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214-3005, USA
Neuroscience 103:1017-24. 2001..This quantitative difference provides a means of reconciling previous estimates of M4 receptor distribution and function... - Serotonin facilitates long-term depression induction in prefrontal cortex via p38 MAPK/Rab5-mediated enhancement of AMPA receptor internalizationPing Zhong
Department of Physiology and Biophysics, State University of New York at Buffalo, 124 Sherman Hall, Buffalo, NY 14214, USA
J Physiol 586:4465-79. 2008..It provides a potential mechanism underlying the role of serotonin in controlling emotional and cognitive processes that are mediated by synaptic plasticity in PFC neurons... - Activation of 5-HT2A/C receptors counteracts 5-HT1A regulation of n-methyl-D-aspartate receptor channels in pyramidal neurons of prefrontal cortexEunice Y Yuen
Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
J Biol Chem 283:17194-204. 2008..These findings provide a framework for understanding the complex interactions between serotonin and NMDARs in PFC, which could be important for cognitive and emotional control in which both systems are highly involved... - Regulation of the NMDA receptor-mediated synaptic response by acetylcholinesterase inhibitors and its impairment in an animal model of Alzheimer's diseaseGuojun Chen
Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14214, USA
Neurobiol Aging 29:1795-804. 2008..Loss of the regulation of synaptic NMDAR responses by endogenous ACh may contribute to the cognitive deficiency in AD... - Adrenergic modulation of NMDA receptors in prefrontal cortex is differentially regulated by RGS proteins and spinophilinWenhua Liu
Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY 14214, USA
Proc Natl Acad Sci U S A 103:18338-43. 2006..The effect of alpha1-ARs is modified by RGS2/4 that are recruited to the receptor complex by spinophilin, whereas the effect of alpha2-ARs is modified by RGS4 independent of spinophilin... - Prostaglandin E2 receptors EP2 and EP4 are down-regulated in human mononuclear cells after injuryV E Strong
Department of Surgery, New York Presbyterian Hospital-Weill Medical College of Cornell Univerity, New York, NY 10021, USA
Surgery 130:249-55. 2001..Furthermore, PGE(2) mediates EP2 and EP4 down-regulation. These data suggest that specific EP receptor subtypes may provide critical targets for augmenting the immune response after injury in humans... - Resting bold fMRI differentiates dementia with Lewy bodies vs Alzheimer diseaseJ E Galvin
Center of Excellence on Brain Aging, New York University Langone School of Medicine, 145 East 32nd St, Second Floor, New York, NY 10016, USA
Neurology 76:1797-803. 2011..We performed resting state blood oxygen level-dependent (BOLD) functional connectivity MRI (fcMRI) to determine whether there were differences between AD and DLB... - Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memoryEunice Y Yuen
Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
Proc Natl Acad Sci U S A 106:14075-9. 2009.... - Regulation of NMDA receptors by dopamine D4 signaling in prefrontal cortexXun Wang
Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
J Neurosci 23:9852-61. 2003.... - Bidirectional regulation of Ca2+/calmodulin-dependent protein kinase II activity by dopamine D4 receptors in prefrontal cortexZhenglin Gu
Department of Physiology and Biophysics, State University of New York at Buffalo, 14214, USA
Mol Pharmacol 66:948-55. 2004..This modulation provides a unique and flexible mechanism for D4 receptors to regulate CaMKII activity, which could lead to dynamic regulation of many targets of CaMKII by D4 receptors... - Calpain regulation of AMPA receptor channels in cortical pyramidal neuronsEunice Y Yuen
Department of Physiology and Biophysics, State University of New York at Buffalo, 124 Sherman Hall, Buffalo, NY 14214, USA
J Physiol 580:241-54. 2007..The down-regulation of AMPARs by calpain provides a negative feedback to dampen neuronal excitability in excitotoxic conditions like ischaemia and epilepsy... - Potentiation of NMDA receptor currents by dopamine D1 receptors in prefrontal cortexGuojun Chen
Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
Proc Natl Acad Sci U S A 101:2596-600. 2004..These interactions may play an important role in modulating synaptic plasticity and thus in cognitive and emotional processes... - D3 dopamine autoreceptors do not activate G-protein-gated inwardly rectifying potassium channel currents in substantia nigra dopamine neuronsViviana Davila
Department of Neurology, Columbia University, New York, NY 10032, USA
J Neurosci 23:5693-7. 2003..Thus, it appears that D3 activation of GIRK currents in SN neurons does not occur or is exceedingly rare... - Activation of muscarinic receptors inhibits beta-amyloid peptide-induced signaling in cortical slicesZhenglin Gu
Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
J Biol Chem 278:17546-56. 2003..Thus the muscarinic reversal of the Abeta-induced biochemical and physiological changes provides a potential mechanism for the treatment of Alzheimer's disease with cholinergic enhancers... - Activation of dopamine D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neuronsZhenglin Gu
Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA
Mol Pharmacol 69:813-22. 2006.... - Aberrant regulation of NMDA receptors by dopamine D4 signaling in rats after phencyclidine exposureXun Wang
Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, 124 Sherman Hall, Buffalo, NY 14214, USA
Mol Cell Neurosci 31:15-25. 2006.... - Phosphatidylinositol (4,5)-bisphosphate regulation of N-methyl-D-aspartate receptor channels in cortical neuronsMadhuchhanda Mandal
Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, USA
Mol Pharmacol 76:1349-59. 2009..With the actin cytoskeleton no longer intact, NMDARs are internalized via a dynamin/clathrin-dependent mechanism, leading to reduced NMDAR currents... - Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent MechanismNicholas M Graziane
Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14214
J Biol Chem 284:8329-36. 2009.... - Postsynaptic density-95 (PSD-95) and calcineurin control the sensitivity of N-methyl-D-aspartate receptors to calpain cleavage in cortical neuronsEunice Y Yuen
Department of Physiology and Biophysics, State University of New York at Buffalo, 124 Sherman Hall, Buffalo, NY 14214, USA
Mol Pharmacol 74:360-70. 2008..These data suggest that calpain activation suppresses NMDAR function via proteolytic cleavage of NR2 subunits in vitro and in vivo, and the susceptibility of NMDARs to calpain cleavage is controlled by PSD-95 and calcineurin... - The stress hormone corticosterone increases synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors via serum- and glucocorticoid-inducible kinase (SGK) regulation of the GDI-Rab4 complexWenhua Liu
Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
J Biol Chem 285:6101-8. 2010..It provides a potential mechanism underlying the role of corticosteroid stress hormone in up-regulating excitatory synaptic efficacy in cortical neurons... - Group II metabotropic glutamate receptors enhance NMDA receptor currents via a protein kinase C-dependent mechanism in pyramidal neurones of rat prefrontal cortexJoanna P Tyszkiewicz
Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
J Physiol 554:765-77. 2004..This modulation may be relevant for developing novel mGluR-related pharmacological agents for the treatment of mental illnesses... - The phosphorylation state of GluR1 subunits determines the susceptibility of AMPA receptors to calpain cleavageEunice Y Yuen
Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
J Biol Chem 282:16434-40. 2007.... - Regulation of AMPA receptor channels and synaptic plasticity by cofilin phosphatase Slingshot in cortical neuronsEunice Y Yuen
Department of Physiology and Biophysics and New York State Center of Excellence in Bioinformatics and Life Sciences, State University of New York, Buffalo, NY 14214, USA
J Physiol 588:2361-71. 2010..Our data suggest that Slingshot plays a pivotal role in AMPAR trafficking and synaptic transmission by controlling actin cytoskeleton via cofilin activation... - Microtubule regulation of N-methyl-D-aspartate receptor channels in neuronsEunice Y Yuen
Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, 14214, USA
J Biol Chem 280:29420-7. 2005..Taken together, these results suggest that interfering with microtubule assembly suppresses NMDAR function through a mechanism dependent on kinesin-based dendritic transport of NMDA receptors... - Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neuronsQian Jiang
Department of Physiology and Biophysics, State University of New York, Buffalo, New York 14214, USA
J Biol Chem 281:29391-400. 2006..Thus, our results suggest that neurotrophic factors activate the microtubule-associated protein kinase pathway to stabilize microtubules, and this action significantly attenuates rotenone toxicity on dopaminergic neurons... - Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanismQian Jiang
Department of Physiology and Biophysics, State University of New York, Buffalo, New York 14214, USA
J Neurosci 26:4318-28. 2006..These findings may offer a novel neuroprotective approach against rotenone-induced parkinsonism... - {beta}-Amyloid impairs AMPA receptor trafficking and function by reducing Ca2+/calmodulin-dependent protein kinase II synaptic distributionZhenglin Gu
Department of Physiology and Biophysics, State University of New York, School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
J Biol Chem 284:10639-49. 2009..These results suggest that the Abeta-induced change in CaMKII subcellular distribution may underlie the removal of AMPARs from synaptic membrane by Abeta... - Regulation of N-methyl-D-aspartate receptors by calpain in cortical neuronsHai Yan Wu
Department of Physiology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
J Biol Chem 280:21588-93. 2005.... - Modulation of neuronal excitability by serotonin-NMDA interactions in prefrontal cortexPing Zhong
Department of Physiology and Biophysics and New York State Center of Excellence in Bioinformatics and Life Sciences, State University of New York, Buffalo, NY 14214 USA
Mol Cell Neurosci 38:290-9. 2008.... - Cdk5 modulates cocaine reward, motivation, and striatal neuron excitabilityDavid R Benavides
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Neurosci 27:12967-76. 2007..These results suggest that Cdk5 acts as a negative regulator of neuronal excitability in the NAc and that Cdk5 may govern the behavioral effects of cocaine and motivation for reinforcement... - Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2Kathrin Kastning
Department of Membrane Biochemistry, Institute of Chemistry and Biochemistry, Freie Universitat Berlin, Takustrasse 6, 14195 Berlin, Germany
Proc Natl Acad Sci U S A 104:2991-6. 2007..These data suggest that common mechanisms regulate AP-2-dependent internalization of pre- and postsynaptic membrane proteins... - Expression of heat shock protein 70 in the cochlea in experimental autoimmune inner ear diseaseShu-sheng Gong
Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan City, China
Ann Otol Rhinol Laryngol 111:275-80. 2002..The results suggest that the immune response of the inner ear induced the expression of hsp70 in the guinea pig cochleas... - TRPC3 channels confer cellular memory of recent neuromuscular activityPaul Rosenberg
Department of Internal Medicin, Duke University Medical School, Durham, 27710, USA
Proc Natl Acad Sci U S A 101:9387-92. 2004..These data suggest a mechanism for cellular memory in skeletal muscles whereby repeated bouts of contractile activity drive progressively greater remodeling events... - Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmissionJosef T Kittler
Department of Physiology, University College London, Gower Street, London WC1E 6BT, United Kingdom
Proc Natl Acad Sci U S A 102:14871-6. 2005..Therefore phospho-dependent regulation of AP2 binding to GABA(A)Rs provides a mechanism to specify receptor cell surface number and the efficacy of inhibitory synaptic transmission... - Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor gamma2 subunitJosef T Kittler
Department of Physiology, University College London, Gower Street, London WC1E 6BT, United Kingdom
Proc Natl Acad Sci U S A 105:3616-21. 2008..These data define a mechanism for tyrosine kinase regulation of GABA(A)R surface levels and synaptic inhibition...
Research Grants
- Functions of Dopamine D4 Receptors in Prefrontal CortexZhen Yan; Fiscal Year: 2010....
- The Role of Cholinergic Functions in Alzheimer's DiseaseZhen Yan; Fiscal Year: 2007..Such knowledge should offer important insights into the cellular and molecular basis of AD and the development of new pharmacological agents in the treatment of this disease. ..
- Functions of Dopamine D4 Receptors in Prefrontal CortexZhen Yan; Fiscal Year: 2007....
- Neuromodulator Actions in Prefrontal Cortical NeuronsZhen Yan; Fiscal Year: 2006..Knowledge gained from this work would contribute to the development of novel therapeutic strategies for many neurological and mental disorders. ..
- Synaptic Changes by Stress in Prefrontal CortexZhen Yan; Fiscal Year: 2010..Understanding these molecular and cellular mechanisms will provide valuable targets for designing novel therapies that modify the stress response. ..