Affiliation: University of Nevada
Klukovich R, Nilsson E, Sadler Riggleman I, Beck D, Xie Y, Yan W, et al
. Environmental Toxicant Induced Epigenetic Transgenerational Inheritance of Prostate Pathology and Stromal-Epithelial Cell Epigenome and Transcriptome Alterations: Ancestral Origins of Prostate Disease. Sci Rep. 2019;9:2209 pubmed publisher
Zhang Y, Tang C, Yu T, Zhang R, Zheng H, Yan W. MicroRNAs control mRNA fate by compartmentalization based on 3' UTR length in male germ cells. Genome Biol. 2017;18:105 pubmed publisher
..In contrast, those with shorter 3' UTRs only possess proximal miRNA binding sites, which, therefore, are targeted into RNPs for enrichment and delayed translation. ..
Tang C, Klukovich R, Peng H, Wang Z, Yu T, Zhang Y, et al
. ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells. Proc Natl Acad Sci U S A. 2018;115:E325-E333 pubmed publisher
..Our study identified reversible m6A modification as a critical mechanism of posttranscriptional control of mRNA fate in late meiotic and haploid spermatogenic cells. ..