Genomes and Genes
Affiliation: University of Texas Southwestern Medical Center
- Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genesMaroof Hasan
Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA
Nat Immunol 14:61-71. 2013..Together our data identify Trex1 as a regulator of lysosomal biogenesis and interferon-independent activation of antiviral genes and show that dysregulation of lysosomes can elicit innate immune responses...
- SAMHD1 does it again, now in resting T cellsNan Yan
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
Nat Med 18:1611-2. 2012....
- Intrinsic antiviral immunityNan Yan
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Nat Immunol 13:214-22. 2012..This review focuses on recent advances in understanding of the roles of intrinsic antiviral factors that restrict infection by human immunodeficiency virus and influenza virus...
- HIV DNA is heavily uracilated, which protects it from autointegrationNan Yan
Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 108:9244-9. 2011..Thus, HIV tolerates, or even benefits from, nonmutagenic uracil incorporation during reverse transcription in human immune cells...
- The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1Nan Yan
Immune Disease Institute and Program in Cellular and Molecular Medicine, Children s Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
Nat Immunol 11:1005-13. 2010..HIV-stimulated interferon production in cells deficient in TREX1 did not involve known nucleic acid sensors...
- The SET complex acts as a barrier to autointegration of HIV-1Nan Yan
Department of Pediatrics, Immune Disease Institute, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Pathog 5:e1000327. 2009..Therefore, the SET complex facilitates HIV-1 infection by preventing suicidal autointegration...
- Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivityMing Chieh Shun
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute and Division of AIDS, Harvard Medical School, Boston, MA 02115, USA
J Virol 82:11555-67. 2008..This initial systematic mutagenesis of a PWWP domain identifies amino acid residues critical for chromatin binding function and the consequences of their changes on HIV-1 integration and infection...
- Identification of host proteins required for HIV infection through a functional genomic screenAbraham L Brass
Department of Genetics, Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
Science 319:921-6. 2008..This effort illustrates the power with which RNA interference and forward genetics can be used to expose the dependencies of human pathogens such as HIV, and in so doing identify potential targets for therapy...
- miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elementsAshish Lal
Immune Disease Institute, Children s Hospital Boston, Department of Pediatrics, Harvard Medical School, MA 02115, USA
Mol Cell 35:610-25. 2009..The E2F2 3'UTR lacks a predicted miR-24 recognition element. In fact, miR-24 regulates expression of E2F2, MYC, AURKB, CCNA2, CDC2, CDK4, and FEN1 by recognizing seedless but highly complementary sequences...
- Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retrovirusesDaxing Gao
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
Science 341:903-6. 2013..These results indicate that cGAS is an innate immune sensor of HIV and other retroviruses. ..
- Gaining a foothold: how HIV avoids innate immune recognitionNan Yan
Immune Disease Institute and Program in Cellular and Molecular Medicine, Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, United States
Curr Opin Immunol 23:21-8. 2011....