Nan Yan

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes
    Maroof Hasan
    Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA
    Nat Immunol 14:61-71. 2013
  2. doi request reprint SAMHD1 does it again, now in resting T cells
    Nan Yan
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Nat Med 18:1611-2. 2012
  3. pmc Intrinsic antiviral immunity
    Nan Yan
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Immunol 13:214-22. 2012
  4. pmc HIV DNA is heavily uracilated, which protects it from autointegration
    Nan Yan
    Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:9244-9. 2011
  5. pmc The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
    Nan Yan
    Immune Disease Institute and Program in Cellular and Molecular Medicine, Children s Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:1005-13. 2010
  6. pmc The SET complex acts as a barrier to autointegration of HIV-1
    Nan Yan
    Department of Pediatrics, Immune Disease Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 5:e1000327. 2009
  7. pmc Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity
    Ming Chieh Shun
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute and Division of AIDS, Harvard Medical School, Boston, MA 02115, USA
    J Virol 82:11555-67. 2008
  8. doi request reprint Identification of host proteins required for HIV infection through a functional genomic screen
    Abraham L Brass
    Department of Genetics, Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 319:921-6. 2008
  9. pmc miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements
    Ashish Lal
    Immune Disease Institute, Children s Hospital Boston, Department of Pediatrics, Harvard Medical School, MA 02115, USA
    Mol Cell 35:610-25. 2009
  10. pmc Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses
    Daxing Gao
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Science 341:903-6. 2013

Collaborators

Detail Information

Publications11

  1. pmc Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes
    Maroof Hasan
    Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA
    Nat Immunol 14:61-71. 2013
    ..Together our data identify Trex1 as a regulator of lysosomal biogenesis and interferon-independent activation of antiviral genes and show that dysregulation of lysosomes can elicit innate immune responses...
  2. doi request reprint SAMHD1 does it again, now in resting T cells
    Nan Yan
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Nat Med 18:1611-2. 2012
    ....
  3. pmc Intrinsic antiviral immunity
    Nan Yan
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Immunol 13:214-22. 2012
    ..This review focuses on recent advances in understanding of the roles of intrinsic antiviral factors that restrict infection by human immunodeficiency virus and influenza virus...
  4. pmc HIV DNA is heavily uracilated, which protects it from autointegration
    Nan Yan
    Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:9244-9. 2011
    ..Thus, HIV tolerates, or even benefits from, nonmutagenic uracil incorporation during reverse transcription in human immune cells...
  5. pmc The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
    Nan Yan
    Immune Disease Institute and Program in Cellular and Molecular Medicine, Children s Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:1005-13. 2010
    ..HIV-stimulated interferon production in cells deficient in TREX1 did not involve known nucleic acid sensors...
  6. pmc The SET complex acts as a barrier to autointegration of HIV-1
    Nan Yan
    Department of Pediatrics, Immune Disease Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 5:e1000327. 2009
    ..Therefore, the SET complex facilitates HIV-1 infection by preventing suicidal autointegration...
  7. pmc Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity
    Ming Chieh Shun
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute and Division of AIDS, Harvard Medical School, Boston, MA 02115, USA
    J Virol 82:11555-67. 2008
    ..This initial systematic mutagenesis of a PWWP domain identifies amino acid residues critical for chromatin binding function and the consequences of their changes on HIV-1 integration and infection...
  8. doi request reprint Identification of host proteins required for HIV infection through a functional genomic screen
    Abraham L Brass
    Department of Genetics, Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 319:921-6. 2008
    ..This effort illustrates the power with which RNA interference and forward genetics can be used to expose the dependencies of human pathogens such as HIV, and in so doing identify potential targets for therapy...
  9. pmc miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements
    Ashish Lal
    Immune Disease Institute, Children s Hospital Boston, Department of Pediatrics, Harvard Medical School, MA 02115, USA
    Mol Cell 35:610-25. 2009
    ..The E2F2 3'UTR lacks a predicted miR-24 recognition element. In fact, miR-24 regulates expression of E2F2, MYC, AURKB, CCNA2, CDC2, CDK4, and FEN1 by recognizing seedless but highly complementary sequences...
  10. pmc Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses
    Daxing Gao
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Science 341:903-6. 2013
    ..These results indicate that cGAS is an innate immune sensor of HIV and other retroviruses. ..
  11. pmc Gaining a foothold: how HIV avoids innate immune recognition
    Nan Yan
    Immune Disease Institute and Program in Cellular and Molecular Medicine, Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, United States
    Curr Opin Immunol 23:21-8. 2011
    ....