Nan Yan

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi SAMHD1 does it again, now in resting T cells
    Nan Yan
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Nat Med 18:1611-2. 2012
  2. ncbi Intrinsic antiviral immunity
    Nan Yan
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Immunol 13:214-22. 2012
  3. ncbi HIV DNA is heavily uracilated, which protects it from autointegration
    Nan Yan
    Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:9244-9. 2011
  4. ncbi The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
    Nan Yan
    Immune Disease Institute and Program in Cellular and Molecular Medicine, Children s Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:1005-13. 2010
  5. ncbi Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes
    Maroof Hasan
    Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA
    Nat Immunol 14:61-71. 2013
  6. ncbi The SET complex acts as a barrier to autointegration of HIV-1
    Nan Yan
    Department of Pediatrics, Immune Disease Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 5:e1000327. 2009
  7. ncbi Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity
    Ming Chieh Shun
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute and Division of AIDS, Harvard Medical School, Boston, MA 02115, USA
    J Virol 82:11555-67. 2008
  8. ncbi Identification of host proteins required for HIV infection through a functional genomic screen
    Abraham L Brass
    Department of Genetics, Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 319:921-6. 2008
  9. ncbi miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements
    Ashish Lal
    Immune Disease Institute, Children s Hospital Boston, Department of Pediatrics, Harvard Medical School, MA 02115, USA
    Mol Cell 35:610-25. 2009
  10. ncbi Gaining a foothold: how HIV avoids innate immune recognition
    Nan Yan
    Immune Disease Institute and Program in Cellular and Molecular Medicine, Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, United States
    Curr Opin Immunol 23:21-8. 2011

Collaborators

Detail Information

Publications10

  1. ncbi SAMHD1 does it again, now in resting T cells
    Nan Yan
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Nat Med 18:1611-2. 2012
    ....
  2. ncbi Intrinsic antiviral immunity
    Nan Yan
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Immunol 13:214-22. 2012
    ..This review focuses on recent advances in understanding of the roles of intrinsic antiviral factors that restrict infection by human immunodeficiency virus and influenza virus...
  3. ncbi HIV DNA is heavily uracilated, which protects it from autointegration
    Nan Yan
    Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:9244-9. 2011
    ..Thus, HIV tolerates, or even benefits from, nonmutagenic uracil incorporation during reverse transcription in human immune cells...
  4. ncbi The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
    Nan Yan
    Immune Disease Institute and Program in Cellular and Molecular Medicine, Children s Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:1005-13. 2010
    ..HIV-stimulated interferon production in cells deficient in TREX1 did not involve known nucleic acid sensors...
  5. ncbi Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes
    Maroof Hasan
    Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA
    Nat Immunol 14:61-71. 2013
    ..Together our data identify Trex1 as a regulator of lysosomal biogenesis and interferon-independent activation of antiviral genes and show that dysregulation of lysosomes can elicit innate immune responses...
  6. ncbi The SET complex acts as a barrier to autointegration of HIV-1
    Nan Yan
    Department of Pediatrics, Immune Disease Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 5:e1000327. 2009
    ..Therefore, the SET complex facilitates HIV-1 infection by preventing suicidal autointegration...
  7. ncbi Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity
    Ming Chieh Shun
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute and Division of AIDS, Harvard Medical School, Boston, MA 02115, USA
    J Virol 82:11555-67. 2008
    ..This initial systematic mutagenesis of a PWWP domain identifies amino acid residues critical for chromatin binding function and the consequences of their changes on HIV-1 integration and infection...
  8. ncbi Identification of host proteins required for HIV infection through a functional genomic screen
    Abraham L Brass
    Department of Genetics, Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 319:921-6. 2008
    ..This effort illustrates the power with which RNA interference and forward genetics can be used to expose the dependencies of human pathogens such as HIV, and in so doing identify potential targets for therapy...
  9. ncbi miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements
    Ashish Lal
    Immune Disease Institute, Children s Hospital Boston, Department of Pediatrics, Harvard Medical School, MA 02115, USA
    Mol Cell 35:610-25. 2009
    ..The E2F2 3'UTR lacks a predicted miR-24 recognition element. In fact, miR-24 regulates expression of E2F2, MYC, AURKB, CCNA2, CDC2, CDK4, and FEN1 by recognizing seedless but highly complementary sequences...
  10. ncbi Gaining a foothold: how HIV avoids innate immune recognition
    Nan Yan
    Immune Disease Institute and Program in Cellular and Molecular Medicine, Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, United States
    Curr Opin Immunol 23:21-8. 2011
    ....