Chen Yan

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart
    Chen Yan
    Center for Cardiovascular Research, Aab Institute of Biomedical Science, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circ Res 100:489-501. 2007
  2. ncbi request reprint Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loop
    Chen Yan
    Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circ Res 100:510-9. 2007
  3. ncbi request reprint GIT1 is a scaffold for ERK1/2 activation in focal adhesions
    Guoyong Yin
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 280:27705-12. 2005
  4. ncbi request reprint ERK1/2 associates with the c-Met-binding domain of growth factor receptor-bound protein 2 (Grb2)-associated binder-1 (Gab1): role in ERK1/2 and early growth response factor-1 (Egr-1) nuclear accumulation
    Masaki Osawa
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 279:29691-9. 2004
  5. pmc Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: implications for diabetic ventricular dysfunction after myocardial infarction
    Tetsuro Shishido
    Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, West Henrietta, NY 14586, USA
    Circ Res 102:1416-25. 2008
  6. ncbi request reprint GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor
    Judith Haendeler
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 278:49936-44. 2003
  7. pmc GIT1 functions as a scaffold for MEK1-extracellular signal-regulated kinase 1 and 2 activation by angiotensin II and epidermal growth factor
    Guoyong Yin
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Mol Cell Biol 24:875-85. 2004
  8. pmc The hinge-helix 1 region of peroxisome proliferator-activated receptor gamma1 (PPARgamma1) mediates interaction with extracellular signal-regulated kinase 5 and PPARgamma1 transcriptional activation: involvement in flow-induced PPARgamma activation in end
    Masashi Akaike
    Center for Cardiovascular Research, 601 Elmwood Ave, Box 679, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Mol Cell Biol 24:8691-704. 2004
  9. doi request reprint Extracellular signal-regulated kinase 5 SUMOylation antagonizes shear stress-induced antiinflammatory response and endothelial nitric oxide synthase expression in endothelial cells
    Chang Hoon Woo
    Cardiovascular Research Institute, 601 Elmwood Ave, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circ Res 102:538-45. 2008
  10. pmc Phosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 392 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cells
    Jing Wang
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 30:1976-82. 2010

Detail Information

Publications74

  1. ncbi request reprint Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart
    Chen Yan
    Center for Cardiovascular Research, Aab Institute of Biomedical Science, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circ Res 100:489-501. 2007
    ..Hence, strategies that maintain PDE3A function may represent an attractive approach to circumvent myocyte apoptosis and cardiac dysfunction...
  2. ncbi request reprint Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loop
    Chen Yan
    Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circ Res 100:510-9. 2007
    ..These data suggest a new therapeutic paradigm for end stage of heart failure by inhibiting the PDE3A/ICER feedback loop via activating ERK5...
  3. ncbi request reprint GIT1 is a scaffold for ERK1/2 activation in focal adhesions
    Guoyong Yin
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 280:27705-12. 2005
    ..In summary, the present study further supports a key role for GIT1 (a MEK1-binding protein) as a scaffold for signal transduction in focal adhesions...
  4. ncbi request reprint ERK1/2 associates with the c-Met-binding domain of growth factor receptor-bound protein 2 (Grb2)-associated binder-1 (Gab1): role in ERK1/2 and early growth response factor-1 (Egr-1) nuclear accumulation
    Masaki Osawa
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 279:29691-9. 2004
    ..These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 nuclear accumulation...
  5. pmc Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: implications for diabetic ventricular dysfunction after myocardial infarction
    Tetsuro Shishido
    Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, West Henrietta, NY 14586, USA
    Circ Res 102:1416-25. 2008
    ..These results demonstrated that ERK5 transcriptional activity is subject to downregulation by diabetes-dependent SUMOylation, which resulted in a proapoptotic condition contributing to poor post-MI LV function...
  6. ncbi request reprint GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor
    Judith Haendeler
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 278:49936-44. 2003
    ..We propose that GIT1 is a novel regulator of PLCgamma function that mediates PLCgamma activation by c-Src and integrates signal transduction by GPCRs and TKRs...
  7. pmc GIT1 functions as a scaffold for MEK1-extracellular signal-regulated kinase 1 and 2 activation by angiotensin II and epidermal growth factor
    Guoyong Yin
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Mol Cell Biol 24:875-85. 2004
    ..We propose that GIT1 serves as a scaffold protein to facilitate c-Src-dependent activation of MEK1-ERK1/2 in response to both GPCRs and TKRs...
  8. pmc The hinge-helix 1 region of peroxisome proliferator-activated receptor gamma1 (PPARgamma1) mediates interaction with extracellular signal-regulated kinase 5 and PPARgamma1 transcriptional activation: involvement in flow-induced PPARgamma activation in end
    Masashi Akaike
    Center for Cardiovascular Research, 601 Elmwood Ave, Box 679, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Mol Cell Biol 24:8691-704. 2004
    ..These data suggest that ERK5 mediates flow- and ligand-induced PPARgamma activation via the interaction of ERK5 with the hinge-helix 1 region of PPARgamma...
  9. doi request reprint Extracellular signal-regulated kinase 5 SUMOylation antagonizes shear stress-induced antiinflammatory response and endothelial nitric oxide synthase expression in endothelial cells
    Chang Hoon Woo
    Cardiovascular Research Institute, 601 Elmwood Ave, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circ Res 102:538-45. 2008
    ..These data clearly defined SUMOylation-dependent ERK5 transcriptional repression independent of kinase activity and suggested this process as among the molecular mechanisms of diabetes-mediated endothelial dysfunction...
  10. pmc Phosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 392 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cells
    Jing Wang
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 30:1976-82. 2010
    ..In this study, we identified specific GIT1 tyrosines required for PLCγ activation and podosome formation in vascular smooth muscle cells (VSMC)...
  11. pmc Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice
    Kimio Satoh
    Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Box CVRI, 601 Elmwood Ave, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 31:1116-23. 2011
    ..In this study, we sought to evaluate the role of CyPA in Ang II-induced cardiac hypertrophy...
  12. pmc Tumor suppressor cylindromatosis acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signaling
    Tomoaki Koga
    Department of Microbiology and Immunology and Cardiovascular Research Institute, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 283:12546-54. 2008
    ..pneumoniae infections through the NFAT-dependent mechanism and further identify CYLD as a negative regulator for NFAT signaling, thereby opening up new therapeutic targets for these diseases...
  13. pmc Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation
    Kimio Satoh
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    Circulation 117:3088-98. 2008
    ....
  14. pmc Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent but PDE-independent mechanism
    Kye Im Jeon
    Aab Cardiovascular Research Institute and Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 107:9795-800. 2010
    ..These studies thus identify vinpocetine as a unique antiinflammatory agent that may be repositioned for the treatment of many inflammatory diseases...
  15. pmc p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction
    Nhat Tu Le
    University of Rochester School of Medicine and Dentistry, Aab Cardiovascular Research Institute, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Circ Res 110:536-50. 2012
    ..The regulatory mechanism governing ERK5/CHIP interaction is unknown...
  16. ncbi request reprint Inhibition of tumor necrosis factor-[alpha]-induced SHP-2 phosphatase activity by shear stress: a mechanism to reduce endothelial inflammation
    Nicole Lerner-Marmarosh
    Center for Cardiovascular Research, University of Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 23:1775-81. 2003
    ....
  17. pmc EVI1 acts as an inducible negative-feedback regulator of NF-κB by inhibiting p65 acetylation
    Xiangbin Xu
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 188:6371-80. 2012
    ..Thus, our study provides important insights into the novel role for EVI1 in negatively regulating NF-κB-dependent inflammation, and it may also shed light on the future development of novel anti-inflammatory strategies...
  18. ncbi request reprint Activation of big MAP kinase 1 (BMK1/ERK5) inhibits cardiac injury after myocardial ischemia and reperfusion
    Scott J Cameron
    Department of Pharmacology Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    FEBS Lett 566:255-60. 2004
    ..We propose a novel role for BMK1 in protecting the heart from ischemia/reperfusion-induced cardiac injury...
  19. pmc A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis
    Bo Ding
    Cardiovascular Research Institute, Department of Pathology, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 102:14771-6. 2005
    ..Our findings may provide a therapeutic paradigm to prevent cardiomyocyte apoptosis and the progression of heart failure by inhibiting the PDE3A-ICER feedback loop...
  20. pmc Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy
    Clint L Miller
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Circ Res 105:956-64. 2009
    ..Ca(2+)/calmodulin (CaM)-activated cGMP-hydrolyzing PDE1 family may play a pivotal role in balancing intracellular Ca(2+)/CaM and cGMP signaling; however, its function in cardiomyocytes is unknown...
  21. pmc GIT1 mediates VEGF-induced podosome formation in endothelial cells: critical role for PLCgamma
    Jing Wang
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 29:202-8. 2009
    ..Because GIT1 is a substrate of c-Src, and podosome formation is c-Src dependent, we hypothesized that GIT1 plays an important role in VEGF-induced EC podosome formation and cell migration...
  22. doi request reprint Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart
    Clint L Miller
    Department of Pharmacology and Physiology, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box CVRI, Rochester, NY 14642, USA
    Basic Res Cardiol 106:1023-39. 2011
    ....
  23. ncbi request reprint Big mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis
    Xinchun Pi
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, NY, USA
    Circ Res 94:362-9. 2004
    ..These results suggest that BMK1 activation by steady laminar flow is atheroprotective by inhibiting EC apoptosis via phosphorylation of Bad...
  24. pmc Bcr kinase activation by angiotensin II inhibits peroxisome-proliferator-activated receptor gamma transcriptional activity in vascular smooth muscle cells
    Jeffrey D Alexis
    Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circ Res 104:69-78. 2009
    ....
  25. pmc G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development
    Jinjiang Pang
    Aab Cardiovascular Research Institute and the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circulation 119:1524-32. 2009
    ..However, there have been no in vivo studies of GIT1 function to date...
  26. ncbi request reprint ERK5 activation inhibits inflammatory responses via peroxisome proliferator-activated receptor delta (PPARdelta) stimulation
    Chang Hoon Woo
    Cardiovascular Research Institute, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Biol Chem 281:32164-74. 2006
    ..Based on these data, we propose a new mechanism by which CO and HO-1 mediate anti-inflammatory effects via activating ERK5/PPARdelta, and ERK5 mediates CO and HO-1-induced PPARdelta activation via its interaction with PPARdelta...
  27. doi request reprint Synergistic induction of nuclear factor-kappaB by transforming growth factor-beta and tumour necrosis factor-alpha is mediated by protein kinase A-dependent RelA acetylation
    Hajime Ishinaga
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, U S A
    Biochem J 417:583-91. 2009
    ..Thus the present study reveals a novel role for TGF-beta in inflammatory responses and provides new insight into the regulation of NF-kappaB by TGF-beta signalling...
  28. pmc Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis
    Shin Young Park
    Aab Cardiovascular Research Institute, University of Rochester, 601 Elmwood Ave, Box CVRI, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 33:737-43. 2013
    ..Because VEGFR2 is critical for angiogenesis, we explored the role of TXNIP in VEGF-induced angiogenesis...
  29. ncbi request reprint BMK1/ERK5 is a novel regulator of angiogenesis by destabilizing hypoxia inducible factor 1alpha
    Xinchun Pi
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, NY, USA
    Circ Res 96:1145-51. 2005
    ..In summary, BMK1 is a novel negative regulator of HIF1alpha and angiogenesis by increasing HIF1alpha ubiquitination and inhibiting HIF1alpha activity in endothelial cells...
  30. pmc GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells
    Jinjiang Pang
    Aab Cardiovascular Research Institute and the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Arterioscler Thromb Vasc Biol 28:892-8. 2008
    ..Here we investigated the hypothesis that Ang II-mediated vascular smooth muscle cell (VSMC) gene transcription involves GIT1-CamK II-dependent phosphorylation of HDAC5...
  31. pmc Ca2+/calmodulin-stimulated PDE1 regulates the beta-catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells
    Kye Im Jeon
    Aab Cardiovascular Research Institute, University of Rochester Medical Center, Rochester, NY 14642, USA
    FEBS J 277:5026-39. 2010
    ..Taken together, these findings provide direct evidence for the first time that PP2A B56γ is a critical mediator for PDE1A in the regulation of β-catenin signaling in proliferating VSMCs...
  32. pmc GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass
    Prashanthi Menon
    Department of Medicine and Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Cell Physiol 225:777-85. 2010
    ..These data show that GIT1 is a key regulator of bone mass in vivo by regulating osteoclast function and suggest GIT1 as a potential target for osteoporosis therapy...
  33. ncbi request reprint Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium
    Seigo Itoh
    Cardiovascular Research Institute, University of Rochester, Rochester, NY, USA
    Circulation 113:1787-98. 2006
    ....
  34. pmc Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity
    Zhibo Lu
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circ Res 103:269-78. 2008
    ..These findings indicate that p90RSK activation is critical for reactive oxygen species-mediated inhibition of voltage-gated K+ channel activity and leads to prolongation of cardiac repolarization...
  35. ncbi request reprint Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cells
    Toru Aizawa
    University of Rochester, Center for Cardiovascular Research, 601 Elmwood Ave, Box 679, Rochester, NY 14642, USA
    Circ Res 93:406-13. 2003
    ..These results suggest that SNAP and CNP exert inhibitory effects on NF-kappaB-dependent transcription by activation of PKA via cGMP-dependent inhibition of PDE3 activity. Therefore, PDE3 is a novel mediator of inflammation in VSMCs...
  36. ncbi request reprint 14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function
    Qinlei Zheng
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Aab Institute of Biomedical Sciences, Rochester, New York 14642, USA
    J Biol Chem 279:8787-91. 2004
    ..These data demonstrate an inhibitory function for 14-3-3beta binding to BMK1 and show that serine 486 phosphorylation represents a novel regulatory mechanism for BMK1...
  37. pmc Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells
    Lingli Li
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 706, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 370:159-63. 2008
    ..These results support a key role for the MEK5-BMK1 signaling pathway in the atheroprotective effects of blood flow...
  38. ncbi request reprint Flow antagonizes TNF-alpha signaling in endothelial cells by inhibiting caspase-dependent PKC zeta processing
    Gwenaele Garin
    University of Rochester, Cardiovascular Research Institute, Box 679, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Circ Res 101:97-105. 2007
    ..These results define a novel role for PKCzeta as a shared signaling mediator for flow and TNF-alpha, and important for flow-mediated inhibition of proinflammatory and apoptotic events in ECs...
  39. ncbi request reprint Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation
    Scott J Cameron
    Department of Pharmacology Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 278:18682-8. 2003
    ..These data indicate that BMK1 is more important than ERK1/2 in EGF-mediated Cx43 gap junction uncoupling by association and Cx43 Ser- 255 phosphorylation...
  40. pmc Vinpocetine suppresses pathological vascular remodeling by inhibiting vascular smooth muscle cell proliferation and migration
    Yujun Cai
    Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box CVRI, Rochester, NY 14642, USA
    J Pharmacol Exp Ther 343:479-88. 2012
    ..Given the safety profile of vinpocetine, this study provides insight into the therapeutic potential of vinpocetine in proliferative vascular disorders...
  41. ncbi request reprint Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation
    Seigo Itoh
    Cardiovascular Research Institute, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 280:24135-42. 2005
    ..LY333,531, a specific PKCbeta inhibitor, inhibited both p90RSK and cTnI (Ser(23/24)) phosphorylation by H2O2. Taken together, our data support a new redox-sensitive mechanism regulating cTnI phosphorylation in cardiomyocytes...
  42. doi request reprint Glucocorticoids inhibit nontypeable Haemophilus influenzae-induced MUC5AC mucin expression via MAPK phosphatase-1-dependent inhibition of p38 MAPK
    Kensei Komatsu
    Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 377:763-8. 2008
    ..These studies provide new insight into the molecular mechanism underlying glucocorticoid therapy and may lead to novel therapeutic intervention for inhibiting mucin overproduction in patients with NTHi infections...
  43. ncbi request reprint Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression
    Wenyi Che
    Center for Cardiovascular Research, University of Rochester, Rochester, NY, USA
    Circ Res 90:1222-30. 2002
    ..Furthermore, the IGF-1-mediated downregulation of Gab1 expression represents a novel mechanism to promote vascular inflammation and atherosclerosis...
  44. ncbi request reprint Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure
    Bo Ding
    Center for Cardiovascular Research, University of Rochester School of Medicine and Dentistry, Aab Institute of Biomedical Science, Rochester, NY 14642, USA
    Circulation 111:2469-76. 2005
    ..Although chronic treatment with PDE3 inhibitors increases mortality in patients with heart failure, the contribution of PDE3 expression/activity in heart failure is not well known...
  45. doi request reprint Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells
    Yujun Cai
    Aab Cardiovascular Research Institute, University of Rochester, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 31:616-23. 2011
    ..Herein, we investigate the role and underlying mechanism of cyclic nucleotide phosphodiesterase 1 (PDE1) in regulating collagen I in synthetic VSMCs...
  46. pmc Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor
    Chang Hoon Woo
    Aab Cardiovascular Research Institute, University of Rochester, Rochester, New York 14642, USA
    FASEB J 24:4917-28. 2010
    ..We identified ICER as a novel CHIP substrate and that the ERK5-CHIP complex plays an obligatory role in inhibition of ICER expression, cardiomyocyte apoptosis, and cardiac dysfunction...
  47. pmc Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2
    Xiao Qun Wang
    Aab Cardiovascular Research Institute, 601 Elmwood Avenue, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circ Res 110:560-8. 2012
    ..We previously showed that thioredoxin interacting protein (TXNIP) was required for tumor necrosis factor-mediated expression of vascular cell adhesion molecule-1...
  48. ncbi request reprint Impaired vasorelaxation in inbred mice is associated with alterations in both nitric oxide and super oxide pathways
    Chun Chen
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    J Vasc Res 44:504-12. 2007
    ..In summary, relatively small alterations in redox (SOD-2) and NO pathways (eNOS and PKG) may contribute to significantly impaired vasorelaxation in SJL mice...
  49. pmc Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF
    Yuxian Huang
    Department of Microbiology and Immunology, Box 672, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 359:691-6. 2007
    ..Our studies bring novel insights into our understanding of synergistic regulation of MUC5AC mucin by both pathological and physiological inducers...
  50. ncbi request reprint Fluid shear stress activates proline-rich tyrosine kinase via reactive oxygen species-dependent pathway
    Lung Kuo Tai
    Center for Cardiovascular Research, University of Rochester, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 22:1790-6. 2002
    ..Because flow increases reactive oxygen species (ROS) production in ECs and because H(2)O(2) increases tyrosine phosphorylation of proline-rich tyrosine kinase (PYK2), we hypothesized that flow may activate PYK2 via ROS...
  51. ncbi request reprint NADPH oxidase is involved in angiotensin II-induced apoptosis in H9C2 cardiac muscle cells: effects of apocynin
    Fuzhong Qin
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Free Radic Biol Med 40:236-46. 2006
    ..These results suggest that angiotensin II-induced apoptosis is mediated via NADPH oxidase activation probably through p38 MAPK activation, a decrease in Bcl-2 protein, and caspase activation...
  52. ncbi request reprint Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections
    Jae Hyang Lim
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Immunity 27:349-60. 2007
    ..Thus, CYLD is detrimental for host survival, thereby indicating a mechanism underlying the high early mortality of pneumococcal pneumonia...
  53. pmc TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation
    Hajime Ishinaga
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    EMBO J 26:1150-62. 2007
    ..These studies provide new insights into the novel regulation of NF-kappaB by TGF-beta signaling...
  54. ncbi request reprint Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival
    David J Nagel
    Cardiovascular Research Institute, University of Rochester, New York, USA
    Circ Res 98:777-84. 2006
    ..These suggest that nuclear PDE1A is important in VSMC growth and survival and may contribute to the neointima formation in atherosclerosis and restenosis...
  55. pmc p90 ribosomal S6 kinase regulates activity of the renin-angiotensin system: a pathogenic mechanism for ischemia-reperfusion injury
    Xi Shi
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14620, USA
    J Mol Cell Cardiol 51:272-5. 2011
    ..Thus, renin inhibition may provide an alternative therapeutic strategy under conditions of increased RAS...
  56. pmc Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms
    Kimio Satoh
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Nat Med 15:649-56. 2009
    ..These data define a previously undescribed role for CypA in AAA formation and suggest CypA as a new target for treating cardiovascular disease...
  57. ncbi request reprint Vitamins C and E attenuate apoptosis, beta-adrenergic receptor desensitization, and sarcoplasmic reticular Ca2+ ATPase downregulation after myocardial infarction
    Fuzhong Qin
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Free Radic Biol Med 40:1827-42. 2006
    ..The results suggest that antioxidant therapy may be beneficial in HF...
  58. pmc Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice
    Prashanthi Menon
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Brain Res 1317:218-26. 2010
    ..Thus, our data suggest that GIT1 plays an important role in brain in vivo by regulating spine density involved in synaptic plasticity that is required for processes involved in learning...
  59. ncbi request reprint Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt
    Matthew G Melaragno
    Center for Cardiovascular Research, Department of Medicine, Aab Institute for Biomedical Sciences, University of Rochester, Box MED, Rochester, NY 14642, USA
    J Mol Cell Cardiol 37:881-7. 2004
    ..These findings establish the Gas6-Axl-PI3K-Akt pathway as an anti-apoptotic mechanism for VSMC that may be important in the response to vascular injury...
  60. pmc Targeting cyclic nucleotide phosphodiesterase in the heart: therapeutic implications
    Clint L Miller
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box CVRI, Rochester, NY 14642, USA
    J Cardiovasc Transl Res 3:507-15. 2010
    ..In particular, we will emphasize how these properties influence current and future development of PDE inhibitors for the treatment of pathological cardiac remodeling and dysfunction...
  61. pmc Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5
    Jharon Silva
    Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    J Neuroinflammation 9:253. 2012
    ..This is an important issue because impaired vasoreactivity has been associated with increased risk of ischemic stroke, elevated overall cardiovascular risk and cognitive impairment...
  62. pmc Vinpocetine attenuates lipid accumulation and atherosclerosis formation
    Yujun Cai
    Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 434:439-43. 2013
    ..Given the excellent safety profile of vinpocetine, this study suggests vinpocetine may be a therapeutic candidate for treating atherosclerosis...
  63. pmc PDE1 isozymes, key regulators of pathological vascular remodeling
    Stefan Chan
    Department of Pharmacology and Physiology, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States
    Curr Opin Pharmacol 11:720-4. 2011
    ..This review summarizes the work done to characterize the role and therapeutic potential of PDE1 isozymes in pathological vascular remodeling...
  64. ncbi request reprint Diminished arteriolar responses in nitrate tolerance involve ROS and angiotensin II
    Mary D Frame
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Am J Physiol Heart Circ Physiol 282:H2377-85. 2002
    ..In summary, terminal arterioles are affected by nitrates to a greater extent than the arcade arterioles that feed them, in a process dependent on angiotensin II and ROS...
  65. doi request reprint Thioredoxin-interacting protein mediates nuclear-to-plasma membrane communication: role in vascular endothelial growth factor 2 signaling
    Oded N Spindel
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Aab Cardiovascular Research Institute, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 32:1264-70. 2012
    ..Because TXNIP is an α-arrestin that regulates VEGFR2 signaling, we hypothesized that PARP1 regulates TXNIP localization and function that might affect HUVEC stress-induced apoptosis...
  66. ncbi request reprint Functional interplay between angiotensin II and nitric oxide: cyclic GMP as a key mediator
    Chen Yan
    Center for Cardiovascular Research, University of Rochester, Rochester, NY, USA
    Arterioscler Thromb Vasc Biol 23:26-36. 2003
    ..In this review, we focus on the diverse ways in which Ang II and NO interact and the importance of the balance between the signaling pathways activated by these mediators...
  67. ncbi request reprint Angiotensin II signaling pathways mediated by tyrosine kinases
    Guoyong Yin
    Cardiovascular Research Center, University of Rochester, 601 Elmwood Avenue, P O Box 679, Rochester, NY 14642, USA
    Int J Biochem Cell Biol 35:780-3. 2003
    ..These tyrosine kinases play critical roles in AngII-stimulated cell signal events...
  68. ncbi request reprint The novel role of the C-terminal region of SHP-2. Involvement of Gab1 and SHP-2 phosphatase activity in Elk-1 activation
    Qunhua Huang
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 277:29330-41. 2002
    ..Furthermore, we identified a novel sequence for SHP-2/Gab1 interactions in the C-terminal region of SHP-2...
  69. ncbi request reprint Differential expression of genes from nitrate-tolerant rat aorta
    Xinchun Pi
    Center for Cardiovascular Research, Medical Center, University of Rochester, NY 14642, USA
    J Vasc Res 39:304-10. 2002
    ..These identified genes may play important roles in the development of nitrate tolerance and represent promising candidates to understand the mechanisms of nitrate tolerance and endothelial dysfunction in the vasculature...
  70. ncbi request reprint NAD(P)H oxidase-derived reactive oxygen species regulate angiotensin-II induced adventitial fibroblast phenotypic differentiation
    Wei li Shen
    Joint laboratory of Vascular Biology of Health Science Center and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 225 Chong Qing South Road, Shanghai 200025, China
    Biochem Biophys Res Commun 339:337-43. 2006
    ..These findings demonstrate that angiotensin II induces adventitial fibroblast differentiation to myofibroblast via a pathway that involves NADPH oxidase generation of ROS and activation of p38MAPK and JNK pathways...
  71. ncbi request reprint Cyclic GMP phosphodiesterases and regulation of smooth muscle function
    Sergei D Rybalkin
    Department of Pharmacology, University of Washington, Seattle, Wash 98195, USA
    Circ Res 93:280-91. 2003
    ..In humans, this decrease is caused in large part by induction of another Ca2+/calmodulin-dependent PDE (PDE1C) that allows the brake to be released and proliferation to start...
  72. ncbi request reprint Angiotensin II increases phosphodiesterase 5A expression in vascular smooth muscle cells: a mechanism by which angiotensin II antagonizes cGMP signaling
    Dongsoo Kim
    Departement of cardiology, Yong Dong Severance Hospital, Yonsei University, Seoul, South Korea
    J Mol Cell Cardiol 38:175-84. 2005
    ..These observations establish a new mechanism by which Ang II antagonizes cGMP signaling and stimulates VSMC growth...
  73. ncbi request reprint Expression and function of vascular endothelial growth factor receptors (Flt-1 and Flk-1) in vascular adventitial fibroblasts
    Xin Jin
    Laboratory of Vascular Biology, Institute of Health Science Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Mol Cell Cardiol 43:292-300. 2007
    ..We concluded that functional expression of Flt-1 in adventitial fibroblasts might be an important mediator in the pathogenesis of vascular remodeling after arterial injury...
  74. ncbi request reprint Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3
    James Surapisitchat
    University of Washington, Department of Pharmacology, 1959 NE Pacific St, Seattle, WA 98195 7280, USA
    Circ Res 101:811-8. 2007
    ..These findings suggest that the effect of increasing concentrations of cGMP on endothelial permeability is biphasic, which, in large part, is attributable to the relative amounts of PDE2A and PDE3A in endothelial cells...

Research Grants3

  1. Regulation and Function of Phosphodiesterase in the Heart
    Chen Yan; Fiscal Year: 2009
    ..Significance: The findings will provide novel insights into the molecular mechanisms underlying the development of heart failure, and may lead to the identification of novel therapeutic targets for treating heart failure. ..
  2. Regulation and Function of Phosphodiesterase in the Heart
    Chen Yan; Fiscal Year: 2010
    ..Significance: The findings will provide novel insights into the molecular mechanisms underlying the development of heart failure, and may lead to the identification of novel therapeutic targets for treating heart failure. ..