Kenshi Yamasaki

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The molecular pathology of rosacea
    Kenshi Yamasaki
    Division of Dermatology, University of California, San Diego, CA 92161, USA
    J Dermatol Sci 55:77-81. 2009
  2. pmc Staphylococcus epidermidis antimicrobial delta-toxin (phenol-soluble modulin-gamma) cooperates with host antimicrobial peptides to kill group A Streptococcus
    Anna L Cogen
    Division of Dermatology, University of California San Diego, San Diego, California, United States of America
    PLoS ONE 5:e8557. 2010
  3. ncbi request reprint Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea
    Kenshi Yamasaki
    Division of Dermatology, University of California, San Diego, and VA San Diego Health Care System, 3350 La Jolla Village Drive, San Diego, California 92161, USA
    Nat Med 13:975-80. 2007
  4. pmc TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes
    Kenshi Yamasaki
    Division of Dermatology, Department of Medicine, University of California, San Diego, VA San Diego Health Care System, San Diego, California, USA
    J Invest Dermatol 131:688-97. 2011
  5. pmc Cathelicidin antimicrobial peptides inhibit hyaluronan-induced cytokine release and modulate chronic allergic dermatitis
    Yasuhide Morioka
    Division of Dermatology, University of California, San Diego, and Veterans Affairs San Diego Health Care System, San Diego, California 92161, USA
    J Immunol 181:3915-22. 2008
  6. pmc NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury
    Kenshi Yamasaki
    Division of Dermatology, University of California, and Veterans Affairs San Diego Health Care System, San Diego, CA 92161, USA
    J Biol Chem 284:12762-71. 2009
  7. pmc Engagement of CD44 by hyaluronan suppresses TLR4 signaling and the septic response to LPS
    Jun Muto
    Division of Dermatology, University of California, San Diego and VA San Diego Health Care System, San Diego, CA 92161, USA
    Mol Immunol 47:449-56. 2009
  8. pmc Cathelicidin antimicrobial peptide LL-37 in psoriasis enables keratinocyte reactivity against TLR9 ligands
    Shin Morizane
    Division of Dermatology, Department of Medicine, University of California, San Diego and VA San Diego Healthcare System, San Diego, California, USA
    J Invest Dermatol 132:135-43. 2012
  9. pmc Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin
    Anna L Cogen
    Division of Dermatology, Department of Medicine, University of California San Diego, VA San Diego Health Care System, San Diego, California, USA
    J Invest Dermatol 130:192-200. 2010
  10. pmc HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection
    Daniel T MacLeod
    Division of Dermatology, Department of Medicine, University of California San Diego, La Jolla, California 92093, USA
    Nat Commun 4:1963. 2013

Collaborators

Detail Information

Publications19

  1. pmc The molecular pathology of rosacea
    Kenshi Yamasaki
    Division of Dermatology, University of California, San Diego, CA 92161, USA
    J Dermatol Sci 55:77-81. 2009
    ..This article discusses the possible molecular mechanisms for the pathogenesis of rosacea from current clinical observations and laboratory research...
  2. pmc Staphylococcus epidermidis antimicrobial delta-toxin (phenol-soluble modulin-gamma) cooperates with host antimicrobial peptides to kill group A Streptococcus
    Anna L Cogen
    Division of Dermatology, University of California San Diego, San Diego, California, United States of America
    PLoS ONE 5:e8557. 2010
    ..Thus, these data suggest that S. epidermidis-derived delta-toxin cooperates with the host-derived antimicrobial peptides in the innate immune system to reduce survival of an important human bacterial pathogen...
  3. ncbi request reprint Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea
    Kenshi Yamasaki
    Division of Dermatology, University of California, San Diego, and VA San Diego Health Care System, 3350 La Jolla Village Drive, San Diego, California 92161, USA
    Nat Med 13:975-80. 2007
    ..These findings confirm the role of cathelicidin in skin inflammatory responses and suggest an explanation for the pathogenesis of rosacea by demonstrating that an exacerbated innate immune response can reproduce elements of this disease...
  4. pmc TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes
    Kenshi Yamasaki
    Division of Dermatology, Department of Medicine, University of California, San Diego, VA San Diego Health Care System, San Diego, California, USA
    J Invest Dermatol 131:688-97. 2011
    ..These observations show that abnormal TLR2 function may explain enhanced inflammatory responses to environmental stimuli and can act as a critical element in the pathogenesis of rosacea...
  5. pmc Cathelicidin antimicrobial peptides inhibit hyaluronan-induced cytokine release and modulate chronic allergic dermatitis
    Yasuhide Morioka
    Division of Dermatology, University of California, San Diego, and Veterans Affairs San Diego Health Care System, San Diego, California 92161, USA
    J Immunol 181:3915-22. 2008
    ..These results suggest that cathelicidin has anti-inflammatory activity in skin that may be mediated in part by inhibition of HA-mediated processes...
  6. pmc NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury
    Kenshi Yamasaki
    Division of Dermatology, University of California, and Veterans Affairs San Diego Health Care System, San Diego, CA 92161, USA
    J Biol Chem 284:12762-71. 2009
    ..These findings support the hypothesis that hyaluronan works through IL-1beta and the cryopyrin system to signal sterile inflammation...
  7. pmc Engagement of CD44 by hyaluronan suppresses TLR4 signaling and the septic response to LPS
    Jun Muto
    Division of Dermatology, University of California, San Diego and VA San Diego Health Care System, San Diego, CA 92161, USA
    Mol Immunol 47:449-56. 2009
    ..Therefore, our results show that hyaluronan acts through TLR4, CD44 and A20 to stimulate a unique cellular response that can protect against the septic response to LPS...
  8. pmc Cathelicidin antimicrobial peptide LL-37 in psoriasis enables keratinocyte reactivity against TLR9 ligands
    Shin Morizane
    Division of Dermatology, Department of Medicine, University of California, San Diego and VA San Diego Healthcare System, San Diego, California, USA
    J Invest Dermatol 132:135-43. 2012
    ..These findings suggest that keratinocytes recognize and respond to DNA and can actively participate in contributing to the immunological environment that characterizes psoriasis...
  9. pmc Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin
    Anna L Cogen
    Division of Dermatology, Department of Medicine, University of California San Diego, VA San Diego Health Care System, San Diego, California, USA
    J Invest Dermatol 130:192-200. 2010
    ..Thus, these data suggest that the production of PSMgamma and PSMdelta by S. epidermidis can benefit cutaneous immune defense by selectively inhibiting the survival of skin pathogens while maintaining the normal skin microbiome...
  10. pmc HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection
    Daniel T MacLeod
    Division of Dermatology, Department of Medicine, University of California San Diego, La Jolla, California 92093, USA
    Nat Commun 4:1963. 2013
    ..These findings demonstrate that herpes simplex virus type 1 binds to MARCO to enhance its capacity for disease, and suggests a new therapeutic target to alter pathogenicity of herpes simplex virus type 1 in skin infection...
  11. pmc Mast cell cathelicidin antimicrobial peptide prevents invasive group A Streptococcus infection of the skin
    Anna Di Nardo
    Department of Medicine, Division of Dermatology, University of California, San Diego and Veteran s Affairs Medical Center San Diego, CA 92161, USA
    J Immunol 180:7565-73. 2008
    ..Combined, these results show that MC confer defense against Gram-positive bacterial infection in the skin, a function mediated in part by the expression of a unique cathelicidin peptide...
  12. pmc Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid
    Shin Morizane
    Division of Dermatology, Department of Medicine, University of California, San Diego, San Diego, CA, USA
    J Invest Dermatol 130:1297-306. 2010
    ..Thus, these variables may further control the functions of antimicrobial peptides in the skin...
  13. pmc Cathelicidin, kallikrein 5, and serine protease activity is inhibited during treatment of rosacea with azelaic acid 15% gel
    Alvin B Coda
    Division of Dermatology, Department of Medicine, University of California San Diego, San Diego, California
    J Am Acad Dermatol 69:570-7. 2013
    ..Excess cathelicidin and kallikrein 5 (KLK5) have been hypothesized to play a role in the pathophysiology of rosacea...
  14. ncbi request reprint Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin
    Kenshi Yamasaki
    Division of Dermatology, University of California, San Diego, and VA San Diego Health Care System, San Diego, California, USA
    FASEB J 20:2068-80. 2006
    ..These observations demonstrate that the balance of proteolytic activity at an epithelial interface will control innate immune defense...
  15. pmc CC chemokine ligand 3 overcomes the bacteriocidal and phagocytic defect of macrophages and hastens recovery from experimental otitis media in TNF-/- mice
    Anke Leichtle
    Division of Otolaryngology, Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA
    J Immunol 184:3087-97. 2010
    ..Manipulation of CCL3 and/or TNF may prove to be effective therapeutic approaches in OM or other conditions associated with defective TNF generation...
  16. pmc Exogenous addition of a C-xylopyranoside derivative stimulates keratinocyte dermatan sulfate synthesis and promotes migration
    Jun Muto
    Division of Dermatology, University of California, San Diego and Veterans Affairs San Diego Health Care System, San Diego, California, United States of America
    PLoS ONE 6:e25480. 2011
    ..These results indicate that C-Xyloside may enhance epithelial repair by serving as an initiator of DS synthesis...
  17. pmc Antimicrobial peptides in human skin disease
    Kenshi Yamasaki
    Division of Dermatology, University of California, San Diego MC 9111B, San Diego, California 92161, USA
    Eur J Dermatol 18:11-21. 2008
    ....
  18. ncbi request reprint Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2
    Kristen R Taylor
    Division of Dermatology, University of California, San Diego and Veterans Affairs Medical Center, San Diego, California 92161, USA
    J Biol Chem 282:18265-75. 2007
    ..Taken together, our results define a previously unknown mechanism for initiation of sterile inflammation that involves recognition of released hyaluronan fragments as an endogenous signal of tissue injury...
  19. pmc Control of the innate epithelial antimicrobial response is cell-type specific and dependent on relevant microenvironmental stimuli
    Jürgen Schauber
    Division of Dermatology, University of California, San Diego and VA San Diego Healthcare System, San Diego, CA, USA
    Immunology 118:509-19. 2006
    ....