Munekazu Yamakuchi

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc MicroRNAs in Vascular Biology
    Munekazu Yamakuchi
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box CVRI, Rochester, NY 14642, USA
    Int J Vasc Med 2012:794898. 2012
  2. pmc MicroRNA Regulation of SIRT1
    Munekazu Yamakuchi
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry Rochester, NY, USA
    Front Physiol 3:68. 2012
  3. pmc MicroRNA-22 regulates hypoxia signaling in colon cancer cells
    Munekazu Yamakuchi
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America
    PLoS ONE 6:e20291. 2011
  4. pmc Aldosterone activates endothelial exocytosis
    Youngtae Jeong
    Department of Medicine, Graduate Program in Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:3782-7. 2009
  5. pmc Thioredoxin increases exocytosis by denitrosylating N-ethylmaleimide-sensitive factor
    Takashi Ito
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 286:11179-84. 2011
  6. pmc Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor
    Kenji Matsushita
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 170:73-9. 2005
  7. pmc Epigallocatechin gallate inhibits endothelial exocytosis
    Munekazu Yamakuchi
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biol Chem 389:935-41. 2008
  8. pmc HMG-CoA reductase inhibitors inhibit endothelial exocytosis and decrease myocardial infarct size
    Munekazu Yamakuchi
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Circ Res 96:1185-92. 2005
  9. ncbi MicroRNA-34a regulation of endothelial senescence
    Takashi Ito
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, West Henrietta, NY 14586, USA
    Biochem Biophys Res Commun 398:735-40. 2010
  10. pmc P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis
    Munekazu Yamakuchi
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 107:6334-9. 2010

Collaborators

Detail Information

Publications16

  1. pmc MicroRNAs in Vascular Biology
    Munekazu Yamakuchi
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box CVRI, Rochester, NY 14642, USA
    Int J Vasc Med 2012:794898. 2012
    ..Furthermore, recent studies demonstrate that circulating miRNAs are delivered into certain recipient cells and act as messengers. These studies suggest that miRNAs provide new therapeutic opportunities...
  2. pmc MicroRNA Regulation of SIRT1
    Munekazu Yamakuchi
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry Rochester, NY, USA
    Front Physiol 3:68. 2012
    ..MicroRNA regulation of SIRT1 might affect a wide variety of pathways in humans, from metabolic diseases such as diabetes to cardiovascular diseases and cancer...
  3. pmc MicroRNA-22 regulates hypoxia signaling in colon cancer cells
    Munekazu Yamakuchi
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America
    PLoS ONE 6:e20291. 2011
    ..Taken together, our data suggest that miR-22 might have an anti-angiogenic effect in colon cancer...
  4. pmc Aldosterone activates endothelial exocytosis
    Youngtae Jeong
    Department of Medicine, Graduate Program in Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:3782-7. 2009
    ..Aldosterone antagonism may decrease vascular inflammation and cardiac fibrosis in part by blocking endothelial exocytosis...
  5. pmc Thioredoxin increases exocytosis by denitrosylating N-ethylmaleimide-sensitive factor
    Takashi Ito
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 286:11179-84. 2011
    ..Our findings suggest that TRX1 might regulate exocytosis in a variety of physiological settings, such as vascular inflammation, thrombosis, and insulin release...
  6. pmc Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor
    Kenji Matsushita
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 170:73-9. 2005
    ..Increasing endogenous H(2)O(2) levels in mice decreases exocytosis and platelet rolling on venules in vivo. By inhibiting endothelial cell exocytosis, endogenous H(2)O(2) may protect the vasculature from inflammation and thrombosis...
  7. pmc Epigallocatechin gallate inhibits endothelial exocytosis
    Munekazu Yamakuchi
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biol Chem 389:935-41. 2008
    ..NOS inhibition revealed that NO mediates the anti-inflammatory effects of EGCG. Our data suggest that polyphenols can decrease vascular inflammation by increasing the synthesis of NO, which blocks endothelial exocytosis...
  8. pmc HMG-CoA reductase inhibitors inhibit endothelial exocytosis and decrease myocardial infarct size
    Munekazu Yamakuchi
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Circ Res 96:1185-92. 2005
    ..These findings may explain part of the pleiotropic effects of statin therapy for patients with cardiovascular disease...
  9. ncbi MicroRNA-34a regulation of endothelial senescence
    Takashi Ito
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, West Henrietta, NY 14586, USA
    Biochem Biophys Res Commun 398:735-40. 2010
    ..Our data suggest that miR-34a contributes to endothelial senescence through suppression of SIRT1...
  10. pmc P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis
    Munekazu Yamakuchi
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 107:6334-9. 2010
    ..Finally, in human colon cancer specimens, expression of miR-107 is inversely associated with expression of HIF-1beta. Taken together these data suggest that miR-107 can mediate p53 regulation of hypoxic signaling and tumor angiogenesis...
  11. ncbi Regulation of Weibel-Palade body exocytosis
    Charles J Lowenstein
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Trends Cardiovasc Med 15:302-8. 2005
    ..This review examines the regulation of WPB exocytosis-the exocytic machinery, activators, and inhibitors of exocytosis-and speculates about the development of novel anti-exocytic drugs...
  12. pmc Exocytosis of endothelial cells is regulated by N-ethylmaleimide-sensitive factor
    Munekazu Yamakuchi
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Methods Mol Biol 440:203-15. 2008
    ..Further characterization of the factors that regulate exocytosis will lead to novel treatments for vascular diseases such as myocardial infarction and stroke...
  13. pmc Inhibition of N-ethylmaleimide-sensitive factor protects against myocardial ischemia/reperfusion injury
    John W Calvert
    Department of Medicine, Division of Cardiology and Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    Circ Res 101:1247-54. 2007
    ..These data suggest that drugs targeting endothelial exocytosis may be useful in the treatment of myocardial injury following ischemia/reperfusion...
  14. ncbi MiR-34, SIRT1 and p53: the feedback loop
    Munekazu Yamakuchi
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell Cycle 8:712-5. 2009
    ..Based on this observation, we propose a positive feedback loop, in which p53 induces expression of miR-34a which suppresses SIRT1, increasing p53 activity...
  15. pmc Platelet factor 4 regulation of monocyte KLF4 in experimental cerebral malaria
    Kalyan Srivastava
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America
    PLoS ONE 5:e10413. 2010
    ..PF4(-/-) mice have less cerebral monocyte trafficking and no change in KLF4 expression. These data indicate that PF4 induction of monocyte KLF4 expression may be an important step in the pathogenesis of ECM...
  16. pmc Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosis
    Kenji Matsushita
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Blood 105:207-14. 2005
    ..Thus, VEGF plays a dual role in regulating endothelial exocytosis, triggering pathways that both promote and inhibit endothelial exocytosis. Regulation of endothelial exocytosis may explain part of the proinflammatory effects of VEGF...