Hiroshi Y Yamada

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. ncbi Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105
    H Y Yamada
    Oklahoma Medical Research Foundation OMRF, Molecular, Cell and Developmental Biology Research Program, Oklahoma City, OK 73104, USA
    Oncogene 25:1330-9. 2006
  2. ncbi Inhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisons
    Hiroshi Y Yamada
    Molecular, Cell, and Developmental Biology Research Program, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, MS48, Oklahoma City, 73104 5097, USA
    Mol Cancer Ther 5:29-38. 2006
  3. ncbi Spindle checkpoint function and cellular sensitivity to antimitotic drugs
    Hiroshi Y Yamada
    Oklahoma Medical Research Foundation, Molecular, Cell, and Developmental Biology Research Program, Oklahoma City, OK 73104, USA
    Mol Cancer Ther 5:2963-9. 2006
  4. ncbi Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis
    Hiroshi Y Yamada
    Center for Chemoprevention and Cancer Drug Development, Department of Medicine, Medical Oncology Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Cell Cycle 11:479-88. 2012
  5. ncbi Genes that modulate the sensitivity for anti-microtubule drug-mediated chemotherapy
    H Y Yamada
    Department of Medicine, Hematology Oncology Section, University of Oklahoma Health Sciences Center OUHSC, Oklahoma City, OK 73104, USA
    Curr Cancer Drug Targets 10:623-33. 2010
  6. ncbi BRD8 is a potential chemosensitizing target for spindle poisons in colorectal cancer therapy
    Hiroshi Y Yamada
    Department of Medicine, Hematology Oncology Section, University of Oklahoma Health Sciences Center OUHSC, BRC1207, Oklahoma City, OK 73104, USA
    Int J Oncol 35:1101-9. 2009
  7. ncbi Mitosis-targeting natural products for cancer prevention and therapy
    Chinthalapally V Rao
    Center for Cancer Prevention and Drug Development, Medical Oncology, Department of Medicine, Stephenson Oklahoma Cancer Center, University of Oklahoma Health Sciences Center OUHSC, Oklahoma City, 73104, USA
    Curr Drug Targets 13:1820-30. 2012
  8. ncbi Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice
    Chinthalapally V Rao
    Department of Medicine, Hematology Oncology Section, University of Oklahoma Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Carcinogenesis 30:1469-74. 2009

Detail Information

Publications8

  1. ncbi Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105
    H Y Yamada
    Oklahoma Medical Research Foundation OMRF, Molecular, Cell and Developmental Biology Research Program, Oklahoma City, OK 73104, USA
    Oncogene 25:1330-9. 2006
    ..UbcH6-RING105 may define a novel ubiquitin-proteasome pathway that targets TSSC5 in mammalian cells...
  2. ncbi Inhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisons
    Hiroshi Y Yamada
    Molecular, Cell, and Developmental Biology Research Program, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, MS48, Oklahoma City, 73104 5097, USA
    Mol Cancer Ther 5:29-38. 2006
    ..Our results suggest that targeting the ATPase subunits in 19S regulatory complex in the proteasome may enhance the antitumor effects of spindle poisons...
  3. ncbi Spindle checkpoint function and cellular sensitivity to antimitotic drugs
    Hiroshi Y Yamada
    Oklahoma Medical Research Foundation, Molecular, Cell, and Developmental Biology Research Program, Oklahoma City, OK 73104, USA
    Mol Cancer Ther 5:2963-9. 2006
  4. ncbi Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis
    Hiroshi Y Yamada
    Center for Chemoprevention and Cancer Drug Development, Department of Medicine, Medical Oncology Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Cell Cycle 11:479-88. 2012
    ..Together, these results suggest that haploinsufficiency of SGO1 causes enhanced CIN, colonic preneoplastic lesions and tumorigenesis in mice. SGO1 is essential for the suppression of CIN and tumor formation...
  5. ncbi Genes that modulate the sensitivity for anti-microtubule drug-mediated chemotherapy
    H Y Yamada
    Department of Medicine, Hematology Oncology Section, University of Oklahoma Health Sciences Center OUHSC, Oklahoma City, OK 73104, USA
    Curr Cancer Drug Targets 10:623-33. 2010
    ..Understanding signaling pathways involved in drug efficacy will aid to rationally develop synergistic chemotherapy strategy...
  6. ncbi BRD8 is a potential chemosensitizing target for spindle poisons in colorectal cancer therapy
    Hiroshi Y Yamada
    Department of Medicine, Hematology Oncology Section, University of Oklahoma Health Sciences Center OUHSC, BRC1207, Oklahoma City, OK 73104, USA
    Int J Oncol 35:1101-9. 2009
    ..Conversely, at least one isoform of BRD8 gave growth advantage and resistance to taxol when stably overexpressed in HeLa cells. Targeting BRD8 would improve therapy outcome against aggressive/metastatic colorectal cancers...
  7. ncbi Mitosis-targeting natural products for cancer prevention and therapy
    Chinthalapally V Rao
    Center for Cancer Prevention and Drug Development, Medical Oncology, Department of Medicine, Stephenson Oklahoma Cancer Center, University of Oklahoma Health Sciences Center OUHSC, Oklahoma City, 73104, USA
    Curr Drug Targets 13:1820-30. 2012
    ..These advances help us to identify and develop potential natural agents for the prevention and treatment of cancer. This review will focus on natural products that target mitotic process and/or proteins involved in mitotic progression...
  8. ncbi Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice
    Chinthalapally V Rao
    Department of Medicine, Hematology Oncology Section, University of Oklahoma Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Carcinogenesis 30:1469-74. 2009
    ..Further elucidation of molecular mechanisms of the SAC signaling has the potential for identifying new targets for rational anticancer drug design...