Genomes and Genes
Hiroshi Y Yamada
Affiliation: University of Oklahoma Health Sciences Center
- Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105H Y Yamada
Oklahoma Medical Research Foundation OMRF, Molecular, Cell and Developmental Biology Research Program, Oklahoma City, OK 73104, USA
Oncogene 25:1330-9. 2006..UbcH6-RING105 may define a novel ubiquitin-proteasome pathway that targets TSSC5 in mammalian cells...
- Inhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisonsHiroshi Y Yamada
Molecular, Cell, and Developmental Biology Research Program, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, MS48, Oklahoma City, 73104 5097, USA
Mol Cancer Ther 5:29-38. 2006..Our results suggest that targeting the ATPase subunits in 19S regulatory complex in the proteasome may enhance the antitumor effects of spindle poisons...
- Spindle checkpoint function and cellular sensitivity to antimitotic drugsHiroshi Y Yamada
Oklahoma Medical Research Foundation, Molecular, Cell, and Developmental Biology Research Program, Oklahoma City, OK 73104, USA
Mol Cancer Ther 5:2963-9. 2006
- Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesisHiroshi Y Yamada
Center for Chemoprevention and Cancer Drug Development, Department of Medicine, Medical Oncology Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Cell Cycle 11:479-88. 2012..Together, these results suggest that haploinsufficiency of SGO1 causes enhanced CIN, colonic preneoplastic lesions and tumorigenesis in mice. SGO1 is essential for the suppression of CIN and tumor formation...
- Genes that modulate the sensitivity for anti-microtubule drug-mediated chemotherapyH Y Yamada
Department of Medicine, Hematology Oncology Section, University of Oklahoma Health Sciences Center OUHSC, Oklahoma City, OK 73104, USA
Curr Cancer Drug Targets 10:623-33. 2010..Understanding signaling pathways involved in drug efficacy will aid to rationally develop synergistic chemotherapy strategy...
- BRD8 is a potential chemosensitizing target for spindle poisons in colorectal cancer therapyHiroshi Y Yamada
Department of Medicine, Hematology Oncology Section, University of Oklahoma Health Sciences Center OUHSC, BRC1207, Oklahoma City, OK 73104, USA
Int J Oncol 35:1101-9. 2009..Conversely, at least one isoform of BRD8 gave growth advantage and resistance to taxol when stably overexpressed in HeLa cells. Targeting BRD8 would improve therapy outcome against aggressive/metastatic colorectal cancers...
- Mitosis-targeting natural products for cancer prevention and therapyChinthalapally V Rao
Center for Cancer Prevention and Drug Development, Medical Oncology, Department of Medicine, Stephenson Oklahoma Cancer Center, University of Oklahoma Health Sciences Center OUHSC, Oklahoma City, 73104, USA
Curr Drug Targets 13:1820-30. 2012..These advances help us to identify and develop potential natural agents for the prevention and treatment of cancer. This review will focus on natural products that target mitotic process and/or proteins involved in mitotic progression...
- Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in miceChinthalapally V Rao
Department of Medicine, Hematology Oncology Section, University of Oklahoma Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Carcinogenesis 30:1469-74. 2009..Further elucidation of molecular mechanisms of the SAC signaling has the potential for identifying new targets for rational anticancer drug design...