Michael Yaffe

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Mdm12p, a component required for mitochondrial inheritance that is conserved between budding and fission yeast
    K H Berger
    Department of Biology, University of California, San Diego, La Jolla 92093 0347, USA
    J Cell Biol 136:545-53. 1997
  2. ncbi Mitochondrial morphogenesis: fusion factor for fly fertility
    M P Yaffe
    Department of Biology, University of California, San Diego, La Jolla, California 92093 0347, USA
    Curr Biol 7:R782-3. 1997
  3. ncbi The machinery of mitochondrial inheritance and behavior
    M P Yaffe
    Department of Biology, University of California, San Diego, La Jolla, CA 92093 0347, USA
    Science 283:1493-7. 1999
  4. pmc Gag3p, an outer membrane protein required for fission of mitochondrial tubules
    P Fekkes
    University of California, San Diego, Division of Biology, Section of Cell and Developmental Biology, La Jolla, California 92093, USA
    J Cell Biol 151:333-40. 2000
  5. ncbi The major 45-kDa protein of the yeast mitochondrial outer membrane is not essential for cell growth or mitochondrial function
    M P Yaffe
    Department of Biology, University of California, San Diego, La Jolla 92093
    J Biol Chem 264:21091-6. 1989
  6. ncbi Intermediate filament formation by a yeast protein essential for organelle inheritance
    S J McConnell
    Department of Biology, University of California, San Diego, La Jolla 92093
    Science 260:687-9. 1993
  7. pmc Prohibitin family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiae
    K H Berger
    Department of Biology, University of California, San Diego, La Jolla, California, USA
    Mol Cell Biol 18:4043-52. 1998
  8. pmc A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae
    H A Fisk
    University of California, San Diego, Department of Biology, La Jolla, California 92093, USA
    J Cell Biol 145:1199-208. 1999
  9. pmc Nuclear and mitochondrial inheritance in yeast depends on novel cytoplasmic structures defined by the MDM1 protein
    S J McConnell
    University of California, San Diego, Department of Biology, La Jolla 92093
    J Cell Biol 118:385-95. 1992
  10. pmc Mutational analysis of Mdm1p function in nuclear and mitochondrial inheritance
    H A Fisk
    Department of Biology, University of California, San Diego, La Jolla, California 92093, USA
    J Cell Biol 138:485-94. 1997

Collaborators

  • F Verde
  • Hiromi Sesaki
  • Nikolaus Pfanner
  • P L Gourley
  • Robert E Jensen
  • T Toda
  • Stephane Chiron
  • H A Fisk
  • K H Berger
  • Chris Meisinger
  • Barbara A Weir
  • P Fekkes
  • Haowen Zhou
  • Alyona Bobkova
  • Nils Wiedemann
  • Helmut E Meyer
  • Agnieszka Chacinska
  • Bernard Guiard
  • Birgit Schönfisch
  • Luiza K Sanjuán Szklarz
  • Christiane Lohaus
  • Michael Rissler
  • Vera Kozjak
  • Dusanka Milenkovic
  • M E Nickas
  • S J McConnell
  • K A Shepard
  • L F Sogo
  • D P Atencio
  • L C Stewart
  • B J Smith

Detail Information

Publications23

  1. pmc Mdm12p, a component required for mitochondrial inheritance that is conserved between budding and fission yeast
    K H Berger
    Department of Biology, University of California, San Diego, La Jolla 92093 0347, USA
    J Cell Biol 136:545-53. 1997
    ..cerevisiae and the first such mitochondrial component that is conserved between two different species...
  2. ncbi Mitochondrial morphogenesis: fusion factor for fly fertility
    M P Yaffe
    Department of Biology, University of California, San Diego, La Jolla, California 92093 0347, USA
    Curr Biol 7:R782-3. 1997
    ..The Drosophila Fzo protein is required for mitochondrial fusion during a key step in sperm formation. This novel, membrane-bound GTPase defines a family of proteins that may mediate mitochondrial fusion in a variety of eukaryotic cells...
  3. ncbi The machinery of mitochondrial inheritance and behavior
    M P Yaffe
    Department of Biology, University of California, San Diego, La Jolla, CA 92093 0347, USA
    Science 283:1493-7. 1999
    ..Characterization of the underlying molecular components of this machinery is providing insight into mechanisms regulating mitochondrial morphology and distribution...
  4. pmc Gag3p, an outer membrane protein required for fission of mitochondrial tubules
    P Fekkes
    University of California, San Diego, Division of Biology, Section of Cell and Developmental Biology, La Jolla, California 92093, USA
    J Cell Biol 151:333-40. 2000
    ..These results indicate that Gag3p plays a distinct role on the mitochondrial surface to mediate the fission of mitochondrial tubules...
  5. ncbi The major 45-kDa protein of the yeast mitochondrial outer membrane is not essential for cell growth or mitochondrial function
    M P Yaffe
    Department of Biology, University of California, San Diego, La Jolla 92093
    J Biol Chem 264:21091-6. 1989
    ..6-kDa. Disruption of the OM45 gene in haploid yeast cells eliminated the expression of OM45. The mutant strain showed no apparent defect in cell viability, growth, mitochondrial function, or mitochondrial protein import...
  6. ncbi Intermediate filament formation by a yeast protein essential for organelle inheritance
    S J McConnell
    Department of Biology, University of California, San Diego, La Jolla 92093
    Science 260:687-9. 1993
    ..In contrast, the purified, mutant protein forms filaments at 4 degrees C but fails to form such structures at 37 degrees C. These results suggest that intermediate filament proteins are universal components of eukaryotic cells...
  7. pmc Prohibitin family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiae
    K H Berger
    Department of Biology, University of California, San Diego, La Jolla, California, USA
    Mol Cell Biol 18:4043-52. 1998
    ..These results provide the first evidence of a role for prohibitin in mitochondrial inheritance and in the regulation of mitochondrial morphology...
  8. pmc A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae
    H A Fisk
    University of California, San Diego, Department of Biology, La Jolla, California 92093, USA
    J Cell Biol 145:1199-208. 1999
    ..These results indicate that protein ubiquitination mediated by Rsp5p plays an essential role in mitochondrial inheritance, and reveal a novel function for protein ubiquitination...
  9. pmc Nuclear and mitochondrial inheritance in yeast depends on novel cytoplasmic structures defined by the MDM1 protein
    S J McConnell
    University of California, San Diego, Department of Biology, La Jolla 92093
    J Cell Biol 118:385-95. 1992
    ..These results suggest that novel cytoplasmic structures containing the MDM1 protein mediate organelle inheritance in yeast...
  10. pmc Mutational analysis of Mdm1p function in nuclear and mitochondrial inheritance
    H A Fisk
    Department of Biology, University of California, San Diego, La Jolla, California 92093, USA
    J Cell Biol 138:485-94. 1997
    ..These results support a model of Mdm1p function in which a network comprised of multimeric assemblies of the protein mediates two distinct cellular processes...
  11. pmc Microtubules mediate mitochondrial distribution in fission yeast
    M P Yaffe
    Department of Biology, University of California at San Diego, La Jolla 92093, USA
    Proc Natl Acad Sci U S A 93:11664-8. 1996
    ..These results indicate that microtubules mediate mitochondrial distribution in fission yeast and provide the first genetic evidence for the role of microtubules in mitochondrial movement...
  12. pmc BRO1, a novel gene that interacts with components of the Pkc1p-mitogen-activated protein kinase pathway in Saccharomyces cerevisiae
    M E Nickas
    Department of Biology, University of California, San Diego, La Jolla 92093, USA
    Mol Cell Biol 16:2585-93. 1996
    ..Analysis of the isolated BRO1 gene revealed that it encodes a novel, 97-kDa polypeptide which contains a putative SH3 domain-binding motif and is homologous to a protein of unknown function in Caenorhabditis elegans...
  13. pmc Import of proteins into yeast mitochondria: the nuclear MAS2 gene encodes a component of the processing protease that is homologous to the MAS1-encoded subunit
    R E Jensen
    Department of Biology, University of California, San Diego, La Jolla 92093
    EMBO J 7:3863-71. 1988
    ..The activity of this enzyme is temperature sensitive in mas2 cells. Together with the results of the accompanying study these results show that MAS2 and MAS1 encode the two subunits of the processing protease...
  14. pmc A mutation in the yeast heat-shock factor gene causes temperature-sensitive defects in both mitochondrial protein import and the cell cycle
    B J Smith
    Department of Biology, University of California, San Diego, La Jolla 92093
    Mol Cell Biol 11:2647-55. 1991
    ..The properties of the mas3 mutant cells indicate that HSF mediates the response to stress of two basic cellular processes: mitochondrial protein import and cell cycle progression...
  15. pmc A role for unsaturated fatty acids in mitochondrial movement and inheritance
    L C Stewart
    University of California, Department of Biology, San Diego, La Jolla 92093
    J Cell Biol 115:1249-57. 1991
    ..These results indicate that mdm2 is a temperature-sensitive allele of OLE1 and demonstrate an essential role for unsaturated fatty acids in mitochondrial movement and inheritance...
  16. pmc MAS5, a yeast homolog of DnaJ involved in mitochondrial protein import
    D P Atencio
    Department of Biology, University of California, San Diego, La Jolla 92093
    Mol Cell Biol 12:283-91. 1992
    ..The deletion mutant also displayed a modest import defect at 23 degrees C and a substantial import defect at 37 degrees C. These results indicate a role for a DnaJ cognate protein in mitochondrial protein import...
  17. ncbi The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane
    Chris Meisinger
    Institut fur Biochemie und Molekularbiologie, Universitat Freiburg, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
    Dev Cell 7:61-71. 2004
    ..We conclude that Mdm10 plays a specific role in the biogenesis of the TOM complex, indicating a connection between the mitochondrial protein assembly apparatus and the machinery for maintenance of mitochondrial morphology...
  18. pmc Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane
    Hiromi Sesaki
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Biol Cell 14:2342-56. 2003
    ..Our results raise the possibility that Mgm1p regulates fusion of the mitochondrial outer membrane through its interactions with Fzo1p and Ugo1p...
  19. ncbi The cutting edge of mitochondrial fusion
    Michael P Yaffe
    Nat Cell Biol 5:497-9. 2003
  20. pmc Mmd1p, a novel, conserved protein essential for normal mitochondrial morphology and distribution in the fission yeast Schizosaccharomyces pombe
    Barbara A Weir
    University of California, San Diego, Division of Biological Sciences, Section of Cell and Developmental Biology, La Jolla, California 92093, USA
    Mol Biol Cell 15:1656-65. 2004
    ..cerevisiae gene complemented the S. pombe mutation. Mmd1p was localized to the cytosol. Mmd1p is the first identified component required for the alignment of mitochondria along microtubules in fission yeast...
  21. pmc Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p
    Hiromi Sesaki
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 173:651-8. 2006
    ..Moreover, the human homologue of Ups1p, PRELI, can fully replace Ups1p in yeast cells. Together, our findings provide a conserved mechanism for the alternative topogenesis of Mgm1p and control of mitochondrial morphology...
  22. ncbi Reactive biomolecular divergence in genetically altered yeast cells and isolated mitochondria as measured by biocavity laser spectroscopy: rapid diagnostic method for studying cellular responses to stress and disease
    Paul L Gourley
    Sandia National Laboratories, Department 8331, MS 1413, Albuquerque, New Mexico 87185, USA
    J Biomed Opt 12:054003. 2007
    ..These features reflect a new state of stressed or diseased cells that we call a reactive biomolecular divergence (RBD) that reflects the vital interdependence of mitochondria and the nucleus...
  23. pmc CLASP regulates mitochondrial distribution in Schizosaccharomyces pombe
    Stephane Chiron
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 182:41-9. 2008
    ..Peg1p is the first identified microtubule plus end-binding protein required for mitochondrial distribution and likely functions as a molecular link between mitochondria and microtubules...

Research Grants12

  1. MECHANISMS OF MITOCHONDRIAL DIVISION AND INHERITANCE
    Michael Yaffe; Fiscal Year: 2004
    ....
  2. MECHANISMS OF MITOCHONDRIAL DIVISION AND INHERITANCE
    Michael Yaffe; Fiscal Year: 2002
    ....
  3. MECHANICS OF MITOCHONDRIAL DIVISION AND INHERITANCE
    Michael Yaffe; Fiscal Year: 1999
    ..These studies of mitochondrial inheritance will reveal new details of cellular organization and cell division, and provide a foundation for understanding changes in cell structure and function asssociated with numerous disease states. ..
  4. MECHANICS OF MITOCHONDRIAL DIVISION AND INHERITANCE
    Michael Yaffe; Fiscal Year: 2000
    ..These studies of mitochondrial inheritance will reveal new details of cellular organization and cell division, and provide a foundation for understanding changes in cell structure and function asssociated with numerous disease states. ..
  5. MECHANISMS OF MITOCHONDRIAL DIVISION AND INHERITANCE
    Michael Yaffe; Fiscal Year: 2003
    ....
  6. MECHANISMS OF MITOCHONDRIAL DIVISION AND INHERITANCE
    Michael Yaffe; Fiscal Year: 2001
    ....
  7. MECHANISMS OF MITOCHONDRIAL DIVISION AND INHERITANCE
    Michael Yaffe; Fiscal Year: 1993
    ....