K Yaffe

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Endogenous sex hormone levels and risk of cognitive decline in an older biracial cohort
    K Yaffe
    Department of Psychiatry, University of California, San Francisco, CA 94121, USA
    Neurobiol Aging 28:171-8. 2007
  2. ncbi Retinopathy and Cognitive Impairment in Adults With CKD
    Kristine Yaffe
    Department of Psychiatry, University of California, San Francisco, CA Department of Neurology, University of California, San Francisco, CA Department of Epidemiology, University of California, San Francisco, CA San Francisco Veterans Affairs Medical Center, San Francisco, CA Electronic address
    Am J Kidney Dis 61:219-27. 2013
  3. ncbi Diabetes, glucose control, and 9-year cognitive decline among older adults without dementia
    Kristine Yaffe
    Departments of Psychiatry, University of California, San Francisco, and San Francisco, VA, USA
    Arch Neurol 69:1170-5. 2012
  4. ncbi Postmenopausal hormones and sleep quality in the elderly: a population based study
    Gregory J Tranah
    CPMC Research Institute, San Francisco, CA, USA
    BMC Womens Health 10:15. 2010
  5. ncbi Estrogen receptor genotype and risk of cognitive impairment in elders: findings from the Health ABC study
    Kristine Yaffe
    Department of Psychiatry and Neurology, School of Medicine, San Francisco, CA 94121, USA
    Neurobiol Aging 30:607-14. 2009
  6. ncbi The effect of maintaining cognition on risk of disability and death
    Kristine Yaffe
    Department of Psychiatry, University of California at San Francisco, San Francisco, California 94121, USA
    J Am Geriatr Soc 58:889-94. 2010
  7. ncbi Metabolic syndrome and cognitive decline in elderly Latinos: findings from the Sacramento Area Latino Study of Aging study
    Kristine Yaffe
    Department of Psychiatry, University of California at San Francisco, San Francisco VA Medical Center, San Francisco, CA, USA
    J Am Geriatr Soc 55:758-62. 2007
  8. ncbi Chronic kidney disease and cognitive function in older adults: findings from the chronic renal insufficiency cohort cognitive study
    Kristine Yaffe
    Department of Psychiatry, School of Medicine, University of California at San Francisco, San Francisco, California, USA
    J Am Geriatr Soc 58:338-45. 2010
  9. ncbi Telomere length and cognitive function in community-dwelling elders: findings from the Health ABC Study
    Kristine Yaffe
    Department of Psychiatry, School of Medicine, University of California, San Francisco, CA 94143, USA
    Neurobiol Aging 32:2055-60. 2011
  10. ncbi The metabolic syndrome and development of cognitive impairment among older women
    Kristine Yaffe
    Department of Psychiatry, University of California, San Francisco, The San Francisco Veterans Affairs Medical Center, 94121, USA
    Arch Neurol 66:324-8. 2009

Research Grants

  1. ESTROGEN COMPOUNDS, COGNITION & DEMENTIA IN OLDER WOMEN
    Kristine Yaffe; Fiscal Year: 2002
  2. Cognitive Decline in Chronic Renal Insufficiency
    Kristine Yaffe; Fiscal Year: 2009
  3. Predictors & Outcomes of Cognitive Trajectories in the Oldest Old
    Kristine Yaffe; Fiscal Year: 2007
  4. Cognitive Decline in Chronic Renal Insufficiency
    Kristine Yaffe; Fiscal Year: 2007
  5. Sex Hormones, Related Polymorphisms & Cognitive Decline
    Kristine Yaffe; Fiscal Year: 2006
  6. Metabolic Syndrome and Cognitive Impairment
    Kristine Yaffe; Fiscal Year: 2005
  7. Long Term Depressive Symptom Course & Adverse Health Outcomes among Older Women
    Kristine Yaffe; Fiscal Year: 2010

Collaborators

Detail Information

Publications120 found, 100 shown here

  1. ncbi Endogenous sex hormone levels and risk of cognitive decline in an older biracial cohort
    K Yaffe
    Department of Psychiatry, University of California, San Francisco, CA 94121, USA
    Neurobiol Aging 28:171-8. 2007
    ..Older women treated with conjugated estrogens may have an increased risk of dementia, but the effect of naturally occurring sex hormones on cognition is not certain...
  2. ncbi Retinopathy and Cognitive Impairment in Adults With CKD
    Kristine Yaffe
    Department of Psychiatry, University of California, San Francisco, CA Department of Neurology, University of California, San Francisco, CA Department of Epidemiology, University of California, San Francisco, CA San Francisco Veterans Affairs Medical Center, San Francisco, CA Electronic address
    Am J Kidney Dis 61:219-27. 2013
    ..This relationship has not been evaluated in persons with chronic kidney disease (CKD), a condition associated with increased risk of both retinal pathology and cognitive impairment...
  3. ncbi Diabetes, glucose control, and 9-year cognitive decline among older adults without dementia
    Kristine Yaffe
    Departments of Psychiatry, University of California, San Francisco, and San Francisco, VA, USA
    Arch Neurol 69:1170-5. 2012
    ..To determine if prevalent and incident diabetes mellitus (DM) increase risk of cognitive decline and if, among elderly adults with DM, poor glucose control is related to worse cognitive performance. DESIGN Prospective cohort study...
  4. ncbi Postmenopausal hormones and sleep quality in the elderly: a population based study
    Gregory J Tranah
    CPMC Research Institute, San Francisco, CA, USA
    BMC Womens Health 10:15. 2010
    ..Using data from the multicenter Study of Osteoporotic Fractures (SOF), we tested the relationship between HT and sleep-wake estimated from actigraphy...
  5. ncbi Estrogen receptor genotype and risk of cognitive impairment in elders: findings from the Health ABC study
    Kristine Yaffe
    Department of Psychiatry and Neurology, School of Medicine, San Francisco, CA 94121, USA
    Neurobiol Aging 30:607-14. 2009
    ..To determine whether variants in the estrogen receptors 1 (alpha) and 2 (beta) (ESR1 and ESR2) genes are associated with cognitive impairment in non-demented elderly men and women...
  6. ncbi The effect of maintaining cognition on risk of disability and death
    Kristine Yaffe
    Department of Psychiatry, University of California at San Francisco, San Francisco, California 94121, USA
    J Am Geriatr Soc 58:889-94. 2010
    ..To determine whether long-term maintenance of cognition is associated with health advantages such as lower mortality or incident disability in older adults...
  7. ncbi Metabolic syndrome and cognitive decline in elderly Latinos: findings from the Sacramento Area Latino Study of Aging study
    Kristine Yaffe
    Department of Psychiatry, University of California at San Francisco, San Francisco VA Medical Center, San Francisco, CA, USA
    J Am Geriatr Soc 55:758-62. 2007
    ..To investigate the effect of metabolic syndrome on cognitive function in an elderly Latino population and to determine whether inflammation modifies this association...
  8. ncbi Chronic kidney disease and cognitive function in older adults: findings from the chronic renal insufficiency cohort cognitive study
    Kristine Yaffe
    Department of Psychiatry, School of Medicine, University of California at San Francisco, San Francisco, California, USA
    J Am Geriatr Soc 58:338-45. 2010
    ....
  9. ncbi Telomere length and cognitive function in community-dwelling elders: findings from the Health ABC Study
    Kristine Yaffe
    Department of Psychiatry, School of Medicine, University of California, San Francisco, CA 94143, USA
    Neurobiol Aging 32:2055-60. 2011
    ..There was a borderline statistically significant interaction for telomere length and APOE e4 on 3MS change score (p=0.06). Thus, telomere length may serve as a biomarker for cognitive aging...
  10. ncbi The metabolic syndrome and development of cognitive impairment among older women
    Kristine Yaffe
    Department of Psychiatry, University of California, San Francisco, The San Francisco Veterans Affairs Medical Center, 94121, USA
    Arch Neurol 66:324-8. 2009
    ..The metabolic syndrome, a constellation of cardiovascular risk factors, is common in elderly people. A growing but conflicting body of literature suggests that the metabolic syndrome may be associated with cognitive impairment...
  11. ncbi Metabolic syndrome and cognitive disorders: is the sum greater than its parts?
    Kristine Yaffe
    Department of Psychiatry, University of California, San Francisco VA Medical Center, San Francisco, CA 94121, USA
    Alzheimer Dis Assoc Disord 21:167-71. 2007
    ..If metabolic syndrome is associated with increased risk of developing cognitive impairment, regardless of mechanism, then early identification and treatment of these individuals might offer avenues for disease course modification...
  12. ncbi Glycosylated hemoglobin level and development of mild cognitive impairment or dementia in older women
    K Yaffe
    University of California, San Francisco, Box 181, 4150 Clement St, San Francisco, CA 94121, USA
    J Nutr Health Aging 10:293-5. 2006
    ..We determined the association between HbA1C level and risk of developing cognitive impairment in older women, mostly without diabetes...
  13. ncbi Posttraumatic stress disorder and risk of dementia among US veterans
    Kristine Yaffe
    San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Arch Gen Psychiatry 67:608-13. 2010
    ..Posttraumatic stress disorder (PTSD) is highly prevalent among US veterans because of combat and may impair cognition...
  14. ncbi Metabolic syndrome and cognitive decline
    Kristine Yaffe
    Department of Psychiatry, University of California, San Francisco, San Francisco VA Medical Center, San Francisco, CA, USA
    Curr Alzheimer Res 4:123-6. 2007
    ..If metabolic syndrome is associated with increased risk of developing cognitive impairment, regardless of mechanism, then early identification and treatment of these individuals might offer avenues for disease course modification...
  15. ncbi Association of plasma beta-amyloid level and cognitive reserve with subsequent cognitive decline
    Kristine Yaffe
    Department of Psychiatry, University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    JAMA 305:261-6. 2011
    ..Lower plasma β-amyloid 42 and 42/40 levels have been associated with incident dementia, but results are conflicting and few have investigated cognitive decline among elders without dementia...
  16. ncbi Effects of ultra-low-dose transdermal estradiol on cognition and health-related quality of life
    Kristine Yaffe
    Department of Psychiatry, University of California, San Francisco, CA 94121, USA
    Arch Neurol 63:945-50. 2006
    ..The effect of an ultra-low- dose of unopposed transdermal estradiol on cognition and health-related quality of life is unknown...
  17. ncbi Subtype of mild cognitive impairment and progression to dementia and death
    Kristine Yaffe
    Department of Psychiatry, University of California, San Francisco, CA 94121, USA
    Dement Geriatr Cogn Disord 22:312-9. 2006
    ..We determined the longitudinal course of subtypes of MCI and assessed the rate of progression to dementia and to death...
  18. ncbi PPAR-gamma Pro12Ala genotype and risk of cognitive decline in elders
    K Yaffe
    Department of Psychiatry and Neurology, University of California, San Francisco, CA 94121, United States
    Neurobiol Aging 29:78-83. 2008
    ..We tested whether this polymorphism is associated with cognition...
  19. ncbi Cystatin C as a marker of cognitive function in elders: findings from the health ABC study
    Kristine Yaffe
    Department of Psychiatry, School of Medicine, University of California, San Francisco, CA 94121, USA
    Ann Neurol 63:798-802. 2008
    ..92; 95% confidence interval, 1.37-2.69; Digit Symbol Substitution: 38 vs 26%; odds ratio, 1.54; 95% confidence interval, 1.10-2.15)...
  20. ncbi Advanced glycation end product level, diabetes, and accelerated cognitive aging
    Kristine Yaffe
    Department of Psychiatry, University of California, San Francisco, CA 94121, USA
    Neurology 77:1351-6. 2011
    ..AGEs are cross-linked products that result from reactions between glucose and proteins. Little is known about the association between peripheral AGE concentration and cognitive aging...
  21. ncbi Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women
    Kristine Yaffe
    Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94121, USA
    JAMA 306:613-9. 2011
    ..Cross-sectional studies have linked sleep-disordered breathing to poor cognition; however, it remains unclear whether sleep-disordered breathing precedes cognitive impairment in older adults...
  22. ncbi Mild cognitive impairment, dementia, and their subtypes in oldest old women
    Kristine Yaffe
    Department of Psychiatry, University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Arch Neurol 68:631-6. 2011
    ..The population of oldest old is increasing, but the prevalence of cognitive impairment is not well characterized in this group...
  23. ncbi Preclinical cognitive decline and subsequent sleep disturbance in older women
    K Yaffe
    Department of Psychiatry, University of California, San Francisco, and the San Francisco VA Medical Center, San Francisco, CA, USA
    Neurology 69:237-42. 2007
    ..To determine whether longitudinal cognitive decline is associated with increased risk of sleep disturbance in older, nondemented, community-dwelling women...
  24. ncbi COMT genotype and cognitive function: an 8-year longitudinal study in white and black elders
    A J Fiocco
    Department of Psychiatry, School of Medicine, University of California, San Francisco, CA 94121, USA
    Neurology 74:1296-302. 2010
    ..Few studies have examined the prospective association between COMT (val(158)met) genotype and cognition in older adults...
  25. ncbi Predictors of maintaining cognitive function in older adults: the Health ABC study
    K Yaffe
    Department of Psychiatry, School of Medicine, University of California, San Francisco, 4150 Clement St, San Francisco, CA 94117, USA
    Neurology 72:2029-35. 2009
    ..Although several risk factors for cognitive decline have been identified, much less is known about factors that predict maintenance of cognitive function in advanced age...
  26. ncbi Association of sleep characteristics and cognition in older community-dwelling men: the MrOS sleep study
    Terri Blackwell
    Research Institute, California Pacific Medical Center, San Francisco, CA 94107, USA
    Sleep 34:1347-56. 2011
    ..To examine the association of objectively and subjectively measured sleep characteristics with cognition in older men...
  27. ncbi Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patients
    L L Chao
    Magnetic Resonance Unit, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, 116R, San Francisco, CA 94121, USA
    Neurology 64:282-9. 2005
    ..Because NAA is considered a marker of neuronal integrity, reduced medial temporal and parietal lobe NAA could be an early indication of dementia-related pathology in elderly individuals...
  28. ncbi Higher atrophy rate of entorhinal cortex than hippocampus in AD
    A T Du
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Neurology 62:422-7. 2004
    ..CONCLUSION: The finding in AD that the atrophy rate in the entorhinal cortex is higher than in the hippocampus is consistent with the view that AD pathology begins in the entorhinal cortex...
  29. ncbi Inflammatory markers and cognition in well-functioning African-American and white elders
    K Yaffe
    Department of Psychiatry, University of California, San Francisco 94121, USA
    Neurology 61:76-80. 2003
    ..Several lines of evidence suggest that inflammatory mechanisms contribute to AD...
  30. ncbi The association between physical function and lifestyle activity and exercise in the health, aging and body composition study
    Jennifer S Brach
    Department of Physical Therapy, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvannia 15260, USA
    J Am Geriatr Soc 52:502-9. 2004
    ..To determine whether older adults who exercise demonstrate higher levels of physical function than those who do not exercise but are physically active throughout the day...
  31. ncbi Race/ethnic differences in AD survival in US Alzheimer's Disease Centers
    K M Mehta
    Division of Geriatrics, University of California, San Francisco, 4150 Clement St, Box 181G, San Francisco, CA 94121, USA
    Neurology 70:1163-70. 2008
    ..We examined whether nonwhite AD patients (African American, Latino, Asian, American Indian) had different rates of survival compared with white AD patients...
  32. ncbi Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease
    A T Du
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center (114M, University of California, San Francisco 94121, USA
    J Neurol Neurosurg Psychiatry 71:441-7. 2001
    ..CONCLUSIONS: Volume reductions in the ERC and hippocampus may be early signs of AD pathology that can be measured using MRI...
  33. ncbi Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD
    N Schuff
    Magnetic Resonance Unit, DVA Medical Center San Francisco, CA 94121, USA
    Neurology 61:358-64. 2003
    ....
  34. ncbi Plasma F2-isoprostane level and cognitive function over eight years in non-demented older adults: Findings from the Health ABC Study
    A J Fiocco
    Department of Psychiatry, School of Medicine, University of California, San Francisco, CA, USA
    Prostaglandins Leukot Essent Fatty Acids 84:57-61. 2011
    ..No association was found between F2-IsoP tertile and baseline or change (slope) in cognitive function over eight years. Plasma F2-IsoP is not a valuable biomarker in predicting cognitive change over years in non-demented older adults...
  35. ncbi Atrophy rates of entorhinal cortex in AD and normal aging
    A T Du
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco 94121, USA
    Neurology 60:481-6. 2003
    ..93. CONCLUSION: ERC volume loss over time may be a better indicator for AD than cross-sectional measurements...
  36. ncbi Diabetes, impaired fasting glucose, and development of cognitive impairment in older women
    K Yaffe
    Department of Psychiatry, University of California, San Francisco, Box 181 4150 Clement St, San Francisco, CA 94121, USA
    Neurology 63:658-63. 2004
    ..To investigate the association between diabetes and impaired fasting glucose (IFG) and cognition and risk of developing both dementia and mild cognitive impairment (MCI) in older women...
  37. ncbi Brain atrophy associated with baseline and longitudinal measures of cognition
    V A Cardenas
    San Francisco Veterans Affairs Medical Center, USA
    Neurobiol Aging 32:572-80. 2011
    ..These findings suggest that baseline volumes of prefrontal and temporal regions may underlie continuing cognitive decline due to aging, pathology, or both in non-demented elderly individuals...
  38. ncbi Clinical profile and course of cognitively normal patients evaluated in memory disorders clinics
    Emily R Edwards
    Department of Psychiatry, University of California, San Francisco, USA
    Neurology 62:1639-42. 2004
    ..Thirty-six percent returned for follow-up, and of those, 65% received a diagnosis of dementia or mild cognitive impairment. Patients evaluated at memory clinics who are considered cognitively normal may merit periodic re-evaluation...
  39. ncbi Frontotemporal dementia progresses to death faster than Alzheimer disease
    E D Roberson
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA
    Neurology 65:719-25. 2005
    ..Frontotemporal lobar degeneration (FTLD) is a common cause of non-Alzheimer dementia, but its natural history and the factors related to mortality in affected patients are not well understood...
  40. ncbi Predicting risk of dementia in older adults: The late-life dementia risk index
    D E Barnes
    Department of Psychiatry, University of California, San Francisco, CA 94121, USA
    Neurology 73:173-9. 2009
    ..To develop a late-life dementia risk index that can accurately stratify older adults into those with a low, moderate, or high risk of developing dementia within 6 years...
  41. ncbi Estrogen therapy in postmenopausal women: effects on cognitive function and dementia
    K Yaffe
    Department of Psychiatry, University of California, San Francisco 94121, USA
    JAMA 279:688-95. 1998
    ....
  42. ncbi Factors that may influence the classification of sleep-wake by wrist actigraphy: the MrOS Sleep Study
    Terri Blackwell
    California Pacific Medical Center Research Institute, San Francisco, CA, USA
    J Clin Sleep Med 7:357-67. 2011
    ..Associations of measurement error for TST (PSG-actigraphy) with demographics, medical history, exam data, and sleep characteristics were examined...
  43. ncbi Cognitive function in postmenopausal women treated with raloxifene
    K Yaffe
    Department of Psychiatry, University of California at San Francisco, 94121, USA
    N Engl J Med 344:1207-13. 2001
    ..CONCLUSIONS: Raloxifene treatment for three years does not affect overall cognitive scores in postmenopausal women with osteoporosis...
  44. ncbi Cognitive decline in women in relation to non-protein-bound oestradiol concentrations
    K Yaffe
    Department of Psychiatry, University of California, San Francisco 94121, USA
    Lancet 356:708-12. 2000
    ..We tested the hypothesis that concentrations of non-protein-bound (free) and loosely bound (bioavailable) sex hormones are associated with cognitive function in older women...
  45. ncbi Hormone therapy in menopausal women with cognitive complaints: a randomized, double-blind trial
    P M Maki
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
    Neurology 69:1322-30. 2007
    ..To evaluate the effects of hormone therapy (HT) on cognition and subjective quality of life (QoL) in recently postmenopausal women with cognitive complaints...
  46. ncbi Cognitive impairment in chronic kidney disease
    Manjula Kurella
    Divison of Nephrology, University of California at San Francisco, San Francisco, CA 94143, USA
    J Am Geriatr Soc 52:1863-9. 2004
    ..CONCLUSION: Cognitive impairment is associated with the severity of kidney disease. Further studies are needed to determine the reasons for cognitive impairment in subjects with CKD and ESRD...
  47. ncbi A prospective study of physical activity and cognitive decline in elderly women: women who walk
    K Yaffe
    University of California, San Francisco, Campus Box 111G, 4150 Clement St, San Francisco, CA 94121, USA
    Arch Intern Med 161:1703-8. 2001
    ..We determined whether physical activity is associated with cognitive decline in a prospective study of older women...
  48. ncbi Donepezil delays progression to AD in MCI subjects with depressive symptoms
    P H Lu
    Departments of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Neurology 72:2115-21. 2009
    ..To determine whether the presence of depression predicts higher rate of progression to Alzheimer disease (AD) in patients with amnestic mild cognitive impairment (aMCI) and whether donepezil treatment beneficially affect this relationship...
  49. ncbi Cognitive screening predicts magnitude of functional recovery from admission to 3 months after discharge in hospitalized elders
    Laura P Sands
    UCSF Mt Zion Center on Aging and Department of Medicine, University of California, San Francisco, USA
    J Gerontol A Biol Sci Med Sci 58:37-45. 2003
    ..We sought to determine whether performance on a cognitive screen at the time of hospital admission predicted the magnitude of functional recovery after hospitalization...
  50. ncbi Serum leptin level and cognition in the elderly: Findings from the Health ABC Study
    Karen F Holden
    Department of Psychiatry, University of California San Francisco, 94143, USA
    Neurobiol Aging 30:1483-9. 2009
    ..66 (95% CI 0.48-0.91). We conclude that in elderly individuals, higher serum leptin appears to protect against cognitive decline, independent of comorbidites and body fat...
  51. ncbi Depressed mood is not a risk factor for incident dementia in a community-based cohort
    James T Becker
    Department of Psychiatry, School of Medicine, Graduate School of Public Health, University of Pittsburgh, 3501 Forbes Avenue, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 17:653-63. 2009
    ..To determine the relationship between depressed mood and the development of Alzheimer disease in cognitively normal individuals...
  52. ncbi Caregiver characteristics are associated with neuropsychiatric symptoms of dementia
    Kaycee M Sink
    Section on Gerontology and Geriatric Medicine, School of Medicine, Wake Forest University, Winston Salem, NC 27157, USA
    J Am Geriatr Soc 54:796-803. 2006
    ..To determine whether caregiver characteristics are independently associated with neuropsychiatric symptoms of dementia (NPS) after accounting for patient characteristics...
  53. ncbi Endogenous estrogen levels affect sexual function in elderly post-menopausal women
    Katharina Modelska
    UCSF Coordinating Center, Department of Medicine, Prevention Sciences Group, University of California, San Francisco, San Francisco, CA, USA
    Maturitas 49:124-33. 2004
    ..The objective of this study was to determine if there is an association between endogenous serum concentration of estradiol (E2) and changes in sexual function in post-menopausal women over 3 years...
  54. ncbi Estrogen receptor 1 polymorphisms and risk of cognitive impairment in older women
    Kristine Yaffe
    Department of Psychiatry, University of California San Francisco, Box 111G, 4150 Clement Street, San Francisco, CA 94121, USA
    Biol Psychiatry 51:677-82. 2002
    ..We investigated whether estrogen receptor 1 (ESR1) polymorphisms are associated with risk of developing cognitive impairment in older women...
  55. ncbi Cognitive function predicts first-time stroke and heart disease
    Jacob S Elkins
    University of California, San Francisco, CA 94143, USA
    Neurology 64:1750-5. 2005
    ..To investigate whether impaired cognitive function is an early manifestation of vascular injury in the brain and therefore predicts risk of subsequent cardiovascular disease...
  56. ncbi Evidence of neurodegeneration in brains of older adults who do not yet fulfill MCI criteria
    L L Chao
    Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, San Francisco, CA 94121, USA
    Neurobiol Aging 31:368-77. 2010
    ....
  57. ncbi Methylenetetrahydrofolate reductase C677T polymorphism and cognitive function in older women
    Jacob S Elkins
    Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Am J Epidemiol 166:672-8. 2007
    ..035). Although the strength of the observed associations was modest, these results lend some support to the theory that an elevated homocysteine level contributes to cognitive decline...
  58. ncbi Treatment practices of mild cognitive impairment in California Alzheimer's Disease Centers
    Andrea M Weinstein
    San Francisco Veterans Affairs Medical Center, San Francisco, California, USA
    J Am Geriatr Soc 57:686-90. 2009
    ..To examine "real world" treatments for patients with mild cognitive impairment (MCI)...
  59. ncbi Urinary incontinence in older community-dwelling women: the role of cognitive and physical function decline
    Alison J Huang
    Veterans Affairs Medical Center, San Francisco, and University of California San Francisco, San Francisco, California 94121, USA
    Obstet Gynecol 109:909-16. 2007
    ..To examine the association between cognitive decline, physical function decline, and urinary incontinence in older community-dwelling women...
  60. ncbi Limited literacy in older people and disparities in health and healthcare access
    Rebecca L Sudore
    Department of Medicine, Division of Geriatrics, University of California San Francisco, San Francisco, CA, USA
    J Am Geriatr Soc 54:770-6. 2006
    ..To determine the relationship between health literacy, demographics, and access to health care...
  61. ncbi Estrogens, selective estrogen receptor modulators, and dementia: what is the evidence?
    K Yaffe
    Department of Psychiatry, University of California, San Francisco and the San Francisco VA Medical Center, 94121, USA
    Ann N Y Acad Sci 949:215-22. 2001
    ..In addition, the status of ongoing and recently completed trials of estrogen and SERMs on cognitive function or on Alzheimer's disease severity will be summarized...
  62. ncbi Neuropsychiatric symptoms in mild cognitive impairment: differences by subtype and progression to dementia
    Emily R Edwards
    Department of Psychiatry, University of California, San Francisco, CA, USA
    Int J Geriatr Psychiatry 24:716-22. 2009
    ..In addition, it is unclear whether NPS increase risk of progression to dementia. We investigated the distribution of NPS across MCI subtypes and determined whether NPS increase risk of progression to dementia...
  63. ncbi Hippocampal volume is associated with memory but not monmemory cognitive performance in patients with mild cognitive impairment
    Michael Grundman
    Department of Neurosciences, University of California, San Diego, La Jolla 92093 0949, USA
    J Mol Neurosci 20:241-8. 2003
    ..We conclude that the relationship between hippocampal volume and risk of AD is likely tied to reduced memory performance and not associated with impairment in nonmemory cognitive domains...
  64. ncbi Poor sleep is associated with impaired cognitive function in older women: the study of osteoporotic fractures
    Terri Blackwell
    San Francisco Coordinating Center and California Pacific Medical Center Research Institute, 185 Berry Street, Lobby 4, Suite 5700, San Francisco, CA 94107, USA
    J Gerontol A Biol Sci Med Sci 61:405-10. 2006
    ..The association between objectively measured sleep and cognition among community-dwelling elderly persons remains understudied. This observational, cross-sectional analysis examined this association...
  65. ncbi Donepezil treatment and Alzheimer disease: can the results of randomized clinical trials be applied to Alzheimer disease patients in clinical practice?
    Jared R Tinklenberg
    Sierra Pacific Mental Illness, Research, Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA
    Am J Geriatr Psychiatry 15:953-60. 2007
    ....
  66. ncbi Promising strategies for the prevention of dementia
    Laura E Middleton
    Department of Psychiatry, School of Medicine, University of California, San Francisco, San Francisco, CA 94121, USA
    Arch Neurol 66:1210-5. 2009
    ..Future studies should continue to examine the implication of risk factor modification in controlled trials, with particular focus on whether several simultaneous interventions may have additive or multiplicative effects...
  67. ncbi Validation of the Kidney Disease Quality of Life (KDQOL) cognitive function subscale
    Manjula Kurella
    Division of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, California 94118-1211, USA
    Kidney Int 66:2361-7. 2004
    ..KDQOL-CF screening followed by 3MS testing in selected individuals may prove to be an effective and efficient strategy for identifying cognitive impairment in patients with kidney disease...
  68. ncbi Comparisons between global and focal brain atrophy rates in normal aging and Alzheimer disease: Boundary Shift Integral versus tracing of the entorhinal cortex and hippocampus
    Frank Ezekiel
    Magnetic Resonance Unit, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Alzheimer Dis Assoc Disord 18:196-201. 2004
    ..Logistic regression analysis revealed that combined rates of ERC and ventricular BSI were the best explanatory variables for classifying AD from controls...
  69. ncbi Limited literacy and mortality in the elderly: the health, aging, and body composition study
    Rebecca L Sudore
    University of California, San Francisco, CA 94121, USA
    J Gen Intern Med 21:806-12. 2006
    ..While limited literacy is common and its prevalence increases with age, no prospective study has assessed whether limited literacy is associated with mortality in older adults...
  70. ncbi Midlife obesity and long-term risk of nursing home admission
    Jacob S Elkins
    Department of Neurology, University of California, 505 Parnassus Avenue, Box 0114, San Francisco, CA 94143, USA
    Obesity (Silver Spring) 14:1472-8. 2006
    ..We investigated whether obesity in middle-aged individuals influences the need for future nursing home care and whether the risk of nursing home admission associated with obesity is greater in whites than in blacks...
  71. ncbi Cognitive function and retinal and ischemic brain changes: the Women's Health Initiative
    M Haan
    Departments of Epidemiology and Biostatistics, University of California, San Francisco, USA
    Neurology 78:942-9. 2012
    ..To examine the association between retinopathy and cognitive decline or brain lesions and volumes in older women...
  72. ncbi Reduced employment in caregivers of frail elders: impact of ethnicity, patient clinical characteristics, and caregiver characteristics
    K E Covinsky
    Division of Geriatrics, San Francisco VA Medical Center and the University of California, San Francisco 94121, USA
    J Gerontol A Biol Sci Med Sci 56:M707-13. 2001
    ..Our goal was to determine the patient and caregiver characteristics associated with the reduction of employment hours in caregivers of frail elders...
  73. ncbi Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD
    N Schuff
    Magnetic Resonance Unit, DVA Medical Center San Francisco, CA 94121, USA
    Neurology 58:928-35. 2002
    ..MRS imaging (MRSI) measures the neuronal marker N-acetylaspartate (NAA), which could help assess brain change in AD and aging...
  74. ncbi Effect of postmenopausal hormone therapy on cognitive function: the Heart and Estrogen/progestin Replacement Study
    Deborah Grady
    Department of Epidemiology and Biostatistics, University of California San Francisco, 1635 Divisidero Street, Suite 600, San Francisco, CA 94115, USA
    Am J Med 113:543-8. 2002
    ..To determine if hormone therapy results in better cognitive function in older postmenopausal women...
  75. ncbi Evaluation of the diagnosis and management of cognitive impairment in long-term care
    Cynthia Barton
    Department of Neurology, University of California, San Francisco, California, USA
    Alzheimer Dis Assoc Disord 17:72-6. 2003
    ..Further research is needed to identify barriers to diagnosis and management so that greater numbers of patients can benefit from recommended strategies...
  76. ncbi Anxiety symptoms and objectively measured sleep quality in older women
    Adam P Spira
    Division of Geriatrics and Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA
    Am J Geriatr Psychiatry 17:136-43. 2009
    ..Few studies have examined the association between anxiety symptoms and objectively measured sleep quality in older adults. The authors determined this association in a large cohort of very old community-dwelling women...
  77. ncbi Improved evaluation and management of cognitive impairment: results of a comprehensive intervention in long-term care
    Cynthia Barton
    Department of Neurology, University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Am Med Dir Assoc 7:84-9. 2006
    ..We determined whether an intervention could improve the diagnosis and management of patients with cognitive impairment (CI) in long-term care...
  78. ncbi Cognitive impairment, depressive symptoms, and functional decline in older people
    Kala M Mehta
    Division of Geriatrics, Department of Internal Medicine, University of California San Francisco, 4150 Clement Street, Box 181G, San Francisco, CA 94121, USA
    J Am Geriatr Soc 50:1045-50. 2002
    ..The purpose of this study is to determine the relative contributions of cognitive impairment and depressive symptoms on decline in activity of daily living (ADL) function over 2 years in an older cohort...
  79. ncbi ASL perfusion MRI predicts cognitive decline and conversion from MCI to dementia
    Linda L Chao
    Center for Imaging of Neurodegenerative Disease, San Francisco, CA, USA
    Alzheimer Dis Assoc Disord 24:19-27. 2010
    ..03). These results suggest that hypoperfusion as detected by ASL-MRI can predict subsequent clinical, functional, and cognitive decline and may be useful for identifying candidates for future Alzheimer disease treatment trials...
  80. ncbi Age and gender interactions on verbal memory performance
    Joel H Kramer
    University of California, San Francisco Medical Center, 94143, USA
    J Int Neuropsychol Soc 9:97-102. 2003
    ..The role of estrogen on cognition in normal aging warrants further study...
  81. ncbi Predicting 12-month mortality for persons with dementia
    Robert Newcomer
    Departments of Social and Behavioral Science, University of California, San Francisco, CA 94118, USA
    J Gerontol B Psychol Sci Soc Sci 58:S187-98. 2003
    ..We develop and test a model of 12-month mortality among persons (N=3858) with organic dementia...
  82. ncbi Additive effects of cognitive function and depressive symptoms on mortality in elderly community-living adults
    Kala M Mehta
    Division of Geriatrics, University of California at San Francisco, 4150 Clement Street, Box 181G, San Francisco, CA 94121, USA
    J Gerontol A Biol Sci Med Sci 58:M461-7. 2003
    ..Our aim was to examine whether the combination of varying levels of cognitive function and depressive symptoms affect the risk of mortality in community-living elderly adults...
  83. ncbi Chronic kidney disease and cognitive impairment in the elderly: the health, aging, and body composition study
    Manjula Kurella
    Division of Nephrology, University of California San Francisco, Laurel Heights, 3333 California Street, Suite 430, San Francisco, CA 94118 1211, USA
    J Am Soc Nephrol 16:2127-33. 2005
    ..Studies aimed at understanding the mechanism(s) responsible for cognitive impairment in CKD and efforts to interrupt this decline are warranted...
  84. ncbi Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imaging
    Xiaoping Zhu
    Department of Radiology, VA Medical Center, University of California, San Francisco, CA 94121, USA
    Alzheimer Dis Assoc Disord 20:77-85. 2006
    ..However, the NAA and mI changes are not correlated with each other, suggesting that they represent different processes that might help staging of AD...
  85. ncbi Prevalence and correlates of anxiety symptoms in well-functioning older adults: findings from the health aging and body composition study
    Kala M Mehta
    Division of Geriatrics, University of California at San Francisco, San Francisco, California 94121
    J Am Geriatr Soc 51:499-504. 2003
    ..To determine the prevalence and correlates of anxiety symptoms in the absence of depression, in older black and white people...
  86. ncbi Depressive symptoms in middle age and the development of later-life functional limitations: the long-term effect of depressive symptoms
    Kenneth E Covinsky
    Department of Medicine, University of California, San Francisco, San Francisco VA Medical Center 181G, 4150 Clement, San Francisco, CA 94121, USA
    J Am Geriatr Soc 58:551-6. 2010
    ..To determine whether middle-aged persons with depressive symptoms are at higher risk for developing activity of daily living (ADL) and mobility limitations as they advance into older age than those without...
  87. ncbi Total and regional adiposity and cognitive change in older adults: The Health, Aging and Body Composition (ABC) study
    Alka M Kanaya
    Department of Medicine, University of California San Francisco, 94115, USA
    Arch Neurol 66:329-35. 2009
    ....
  88. ncbi The effects of acute illness on ADL decline over 1 year in frail older adults with and without cognitive impairment
    Laura P Sands
    Center on Aging, Division of Geriatrics, University of California, San Francisco 94143 1265, USA
    J Gerontol A Biol Sci Med Sci 57:M449-54. 2002
    ..These relationships have not been described for the frailest of older adults whose high rates of acute illness and cognitive impairment put them at the greatest risk for loss of ADL functioning...
  89. ncbi Serum lipoprotein levels, statin use, and cognitive function in older women
    Kristine Yaffe
    Departments of Psychiatry and Neurology, University of California, San Francisco, 4150 Clement St, Campus Box 111G, San Francisco, CA 94121, USA
    Arch Neurol 59:378-84. 2002
    ..Serum lipoprotein levels may be important predictors of cognitive function, and drugs that lower cholesterol may be effective for the prevention of cognitive impairment...
  90. ncbi Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study
    Deborah E Barnes
    Department of Psychiatry, University of California, San Francisco 94121, USA
    Arch Gen Psychiatry 63:273-9. 2006
    ..It has been hypothesized that depressive symptoms and dementia may be attributable to underlying vascular disease in some older persons...
  91. ncbi Black and white differences in cognitive function test scores: what explains the difference?
    Kala M Mehta
    Division of Geriatrics, University of California at San Francisco, 94121, USA
    J Am Geriatr Soc 52:2120-7. 2004
    ..This study evaluates whether differences in health and socioeconomic indicators, including literacy level, can explain differences in cognitive function test scores between older black and white adults...
  92. ncbi Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly men
    Po H Lu
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, USA
    Arch Neurol 63:177-85. 2006
    ..There is a compelling need for therapies that prevent, defer the onset, slow the progression, or improve the symptoms of Alzheimer disease (AD)...
  93. ncbi Change in cognitive function by glucose tolerance status in older adults: a 4-year prospective study of the Rancho Bernardo study cohort
    Alka M Kanaya
    Division of General Internal Medicine, University of California, San Francisco, USA
    Arch Intern Med 164:1327-33. 2004
    ..A few studies have examined change in cognitive performance by diabetes status with disparate results. We examined the 4-year change in cognitive performance among older adults according to glucose tolerance status...
  94. ncbi Sex hormones and cognitive function in older men
    Kristine Yaffe
    Department of Psychiatry, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 50:707-12. 2002
    ..We investigated whether serum level of testosterone and estradiol is associated with cognition in older community-dwelling men...
  95. ncbi Kidney function and cognitive impairment in US adults: the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study
    Manjula Kurella Tamura
    Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Am J Kidney Dis 52:227-34. 2008
    ..The association between kidney function and cognitive impairment has not been assessed in a national sample with a wide spectrum of kidney disease severity...
  96. ncbi Patient and caregiver characteristics associated with depression in caregivers of patients with dementia
    Kenneth E Covinsky
    Department of Medicine, University of California, San Francisco and the San Francisco VA Medical Center, San Francisco, CA 94121, USA
    J Gen Intern Med 18:1006-14. 2003
    ..The goal of this study was to determine the patient and caregiver characteristics associated with depression among caregivers of patients with dementia...
  97. ncbi Baseline predictors of clinical progression among patients with dysexecutive mild cognitive impairment
    Julene K Johnson
    Institute for Health and Aging, University of California, San Francisco, USA
    Dement Geriatr Cogn Disord 30:344-51. 2010
    ..The purpose of this study was to evaluate baseline predictors of clinical progression after 2 years for patients with dysexecutive MCI (dMCI), a single-domain non-amnestic MCI subgroup...
  98. ncbi Physical activity and dementia: The need for prevention trials
    Deborah E Barnes
    Department of Psychiatry, University of California, San Francisco, CA 94121, USA
    Exerc Sport Sci Rev 35:24-9. 2007
    ..This review summarizes the evidence that physical activity is associated with a reduced risk of dementia in older adults and recommends that prevention trials be performed to determine whether this association is causal...
  99. ncbi The last 2 years of life: functional trajectories of frail older people
    Kenneth E Covinsky
    Division of Geriatrics, San Francisco VA Medical Center and the University ofCalifornia at San Francisco, San Francisco, California 94121, USA
    J Am Geriatr Soc 51:492-8. 2003
    ....
  100. ncbi DHEA treatment of Alzheimer's disease: a randomized, double-blind, placebo-controlled study
    O M Wolkowitz
    Department of Psychiatry, Center for Neurobiology and Psychiatry, University of California San Francisco UCSF School of Medicine, USA
    Neurology 60:1071-6. 2003
    ..To compare the efficacy and tolerability of dehydroepiandrosterone (DHEA) vs placebo in AD...
  101. ncbi Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease
    Y Zhang
    MR Unit 114M, VA Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
    Neurology 68:13-9. 2007
    ..However, it is unclear whether these abnormalities also impact the cingulum fibers, which connect the medial temporal lobe and the posterior cingulate regions...

Research Grants14

  1. ESTROGEN COMPOUNDS, COGNITION & DEMENTIA IN OLDER WOMEN
    Kristine Yaffe; Fiscal Year: 2002
    ..This award will foster the applicant's development towards becoming an independent investigator in aging research. ..
  2. Cognitive Decline in Chronic Renal Insufficiency
    Kristine Yaffe; Fiscal Year: 2009
    ..Moreover, understandingthese relations may help to identify potential modifiable risk factors and to treat cognitive impairment thereby maintaining independence among patients with renal disease. ..
  3. Predictors & Outcomes of Cognitive Trajectories in the Oldest Old
    Kristine Yaffe; Fiscal Year: 2007
    ..This award will be instrumental in advancing the applicant's research in the epidemiology of cognitive aging and in mentoring the "next generation" of investigators committed to cognitive aging patient-oriented research. ..
  4. Cognitive Decline in Chronic Renal Insufficiency
    Kristine Yaffe; Fiscal Year: 2007
    ..Moreover, understanding these relations may help to identify potential modifiable risk factors and to treat cognitive impairment thereby maintaining independence among patients with renal disease ..
  5. Sex Hormones, Related Polymorphisms & Cognitive Decline
    Kristine Yaffe; Fiscal Year: 2006
    ..Further knowledge of the association between sex hormones, hormone-related polymorphisms and cognitive decline may facilitate preventative strategies to maintain independence and to promote optimum brain aging. ..
  6. Metabolic Syndrome and Cognitive Impairment
    Kristine Yaffe; Fiscal Year: 2005
    ..If elders with metabolic syndrome have increased risk of developing cognitive impairment, this would have important clinical and public health significance. ..
  7. Long Term Depressive Symptom Course & Adverse Health Outcomes among Older Women
    Kristine Yaffe; Fiscal Year: 2010
    ..It will shed important insights on both the clinical need for monitoring/treating the elderly with depressive symptoms and on the biological mechanisms that may link depression to cognitive and functional decline. ..