Jagjit Yadav

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint Tandem cytochrome P450 monooxygenase genes and splice variants in the white rot fungus Phanerochaete chrysosporium: cloning, sequence analysis, and regulation of differential expression
    Jagjit S Yadav
    Molecular Toxicology Division, Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    Fungal Genet Biol 38:10-21. 2003
  2. pmc Alveolar macrophage innate response to Mycobacterium immunogenum, the etiological agent of hypersensitivity pneumonitis: role of JNK and p38 MAPK pathways
    Harish Chandra
    Microbial Pathogenesis Laboratory, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, The United States of America
    PLoS ONE 8:e83172. 2013
  3. pmc A fungal P450 (CYP5136A3) capable of oxidizing polycyclic aromatic hydrocarbons and endocrine disrupting alkylphenols: role of Trp(129) and Leu(324)
    Khajamohiddin Syed
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e28286. 2011
  4. pmc Susceptibility of Mycobacterium immunogenum and Pseudomonas fluorescens to formaldehyde and non-formaldehyde biocides in semi-synthetic metalworking fluids
    Suresh B Selvaraju
    Environmental Genetics and Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    Int J Mol Sci 12:725-41. 2011
  5. pmc Genome-wide structural and evolutionary analysis of the P450 monooxygenase genes (P450ome) in the white rot fungus Phanerochaete chrysosporium: evidence for gene duplications and extensive gene clustering
    Harshavardhan Doddapaneni
    Environmental Genetics and Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
    BMC Genomics 6:92. 2005
  6. pmc Multigenic control and sex bias in host susceptibility to spore-induced pulmonary anthrax in mice
    Jagjit S Yadav
    Microbial Pathogenesis Laboratory, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
    Infect Immun 79:3204-15. 2011
  7. ncbi request reprint P450ome of the white rot fungus Phanerochaete chrysosporium: structure, evolution and regulation of expression of genomic P450 clusters
    J S Yadav
    Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
    Biochem Soc Trans 34:1165-9. 2006
  8. pmc Role of P450 monooxygenases in the degradation of the endocrine-disrupting chemical nonylphenol by the white rot fungus Phanerochaete chrysosporium
    Venkataramanan Subramanian
    Environmental Genetics and Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
    Appl Environ Microbiol 75:5570-80. 2009
  9. ncbi request reprint Physiological regulation, xenobiotic induction, and heterologous expression of P450 monooxygenase gene pc-3 (CYP63A3), a new member of the CYP63 gene cluster in the white-rot fungus Phanerochaete chrysosporium
    Harshavardhan Doddapaneni
    Environmental Genetics and Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati, College of Medicine, Cincinnati, Ohio, 45267 0056, USA
    Curr Microbiol 50:292-8. 2005
  10. ncbi request reprint Differential regulation and xenobiotic induction of tandem P450 monooxygenase genes pc-1 (CYP63A1) and pc-2 (CYP63A2) in the white-rot fungus Phanerochaete chrysosporium
    Harshavardhan Doddapaneni
    Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati, College of Medicine, OH 45267 0056, USA
    Appl Microbiol Biotechnol 65:559-65. 2004

Collaborators

  • Harshavardhan Doddapaneni
  • Khajamohiddin Syed
  • Izhar U H Khan
  • Venkataramanan Subramanian
  • Suresh B Selvaraju
  • Harish Chandra
  • Ying Wai Lam
  • Ekta Yadav
  • Aleksey Porollo

Detail Information

Publications13

  1. ncbi request reprint Tandem cytochrome P450 monooxygenase genes and splice variants in the white rot fungus Phanerochaete chrysosporium: cloning, sequence analysis, and regulation of differential expression
    Jagjit S Yadav
    Molecular Toxicology Division, Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    Fungal Genet Biol 38:10-21. 2003
    ..Interestingly, the pc-1 gene is expressible in both primary and secondary phases of growth with peak expression occurring with secondary metabolism...
  2. pmc Alveolar macrophage innate response to Mycobacterium immunogenum, the etiological agent of hypersensitivity pneumonitis: role of JNK and p38 MAPK pathways
    Harish Chandra
    Microbial Pathogenesis Laboratory, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, The United States of America
    PLoS ONE 8:e83172. 2013
    ..This is the first report on M. immunogenum interactions with alveolar macrophages and on the identification of JNK- and p38- mediated signaling and its role in mediating the proinflammatory responses during these interactions. ..
  3. pmc A fungal P450 (CYP5136A3) capable of oxidizing polycyclic aromatic hydrocarbons and endocrine disrupting alkylphenols: role of Trp(129) and Leu(324)
    Khajamohiddin Syed
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e28286. 2011
    ..To our knowledge, this is the first report on an AP-oxidizing P450 from fungi and on structure-activity relationship of a eukaryotic P450 for fused-ring PAHs (phenanthrene and pyrene) and AP substrates...
  4. pmc Susceptibility of Mycobacterium immunogenum and Pseudomonas fluorescens to formaldehyde and non-formaldehyde biocides in semi-synthetic metalworking fluids
    Suresh B Selvaraju
    Environmental Genetics and Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    Int J Mol Sci 12:725-41. 2011
    ....
  5. pmc Genome-wide structural and evolutionary analysis of the P450 monooxygenase genes (P450ome) in the white rot fungus Phanerochaete chrysosporium: evidence for gene duplications and extensive gene clustering
    Harshavardhan Doddapaneni
    Environmental Genetics and Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
    BMC Genomics 6:92. 2005
    ..In order to understand the functional diversity and the evolutionary mechanisms and significance of these hemeproteins, here we report a genome-wide structural and evolutionary analysis of the P450ome of this fungus...
  6. pmc Multigenic control and sex bias in host susceptibility to spore-induced pulmonary anthrax in mice
    Jagjit S Yadav
    Microbial Pathogenesis Laboratory, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
    Infect Immun 79:3204-15. 2011
    ..Our data provide the first evidence for a differential sex response to anthrax resistance and further highlight the unlikelihood of a single common genetic contribution for this response across strains...
  7. ncbi request reprint P450ome of the white rot fungus Phanerochaete chrysosporium: structure, evolution and regulation of expression of genomic P450 clusters
    J S Yadav
    Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
    Biochem Soc Trans 34:1165-9. 2006
    ....
  8. pmc Role of P450 monooxygenases in the degradation of the endocrine-disrupting chemical nonylphenol by the white rot fungus Phanerochaete chrysosporium
    Venkataramanan Subramanian
    Environmental Genetics and Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
    Appl Environ Microbiol 75:5570-80. 2009
    ..This study provides the first evidence for the involvement of P450 enzymes in NP degradation by a white rot fungus and the first genome-wide identification of specific P450 genes responsive to an environmentally significant toxicant...
  9. ncbi request reprint Physiological regulation, xenobiotic induction, and heterologous expression of P450 monooxygenase gene pc-3 (CYP63A3), a new member of the CYP63 gene cluster in the white-rot fungus Phanerochaete chrysosporium
    Harshavardhan Doddapaneni
    Environmental Genetics and Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati, College of Medicine, Cincinnati, Ohio, 45267 0056, USA
    Curr Microbiol 50:292-8. 2005
    ..The pc-3 cDNA (1,812 bp) was expressed in E. coli as a His-tagged protein (approximately 74 kDa). This constitutes the first report on heterologous expression of a P450 monooxygenase enzyme from this model white-rot fungus...
  10. ncbi request reprint Differential regulation and xenobiotic induction of tandem P450 monooxygenase genes pc-1 (CYP63A1) and pc-2 (CYP63A2) in the white-rot fungus Phanerochaete chrysosporium
    Harshavardhan Doddapaneni
    Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati, College of Medicine, OH 45267 0056, USA
    Appl Microbiol Biotechnol 65:559-65. 2004
    ..75) respectively. This study constitutes the first report on the identification of P450 genes in a fungus that are responsive to environmentally significant pollutant chemicals (PAHs, DDT, long-chain alkyl phenols) and lignin derivatives...
  11. pmc Genome-to-function characterization of novel fungal P450 monooxygenases oxidizing polycyclic aromatic hydrocarbons (PAHs)
    Khajamohiddin Syed
    Environmental Genetics and Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
    Biochem Biophys Res Commun 399:492-7. 2010
    ..To our knowledge, this is the first report on specific fungal P450 monooxygenases with catalytic activity toward environmentally persistent and highly toxic HMW PAHs...
  12. ncbi request reprint Occurrence and characterization of multiple novel genotypes of Mycobacterium immunogenum and Mycobacterium chelonae in metalworking fluids
    Izhar U H Khan
    Environmental Genetics and Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    FEMS Microbiol Ecol 54:329-38. 2005
    ..immunogenum from metalworking fluids. Both mycobacterial species are prevalent in metalworking fluids and there is a considerable strain-level genetic diversity within them...
  13. ncbi request reprint Real-time PCR assays for genus-specific detection and quantification of culturable and non-culturable mycobacteria and pseudomonads in metalworking fluids
    Izhar U H Khan
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Mol Cell Probes 18:67-73. 2004
    ..This is the first application of real-time PCR protocol to MWF samples for detection and quantification of total (culturable and non-culturable) Mycobacteria and Pseudomonads without culturing...

Research Grants15

  1. FUNGAL P450 SYSTEMS IN BIODEGRADATION OF HIGHER PAHS-R01ES15543-01
    Jagjit S Yadav; Fiscal Year: 2010
    ..This proposal will develop appropriate fungal biocatalysts and strategies for PAH bioremediation. ..
  2. XENOBIOTIC-OXIDIZING P450 SYSTEM IN A WHITE ROT FUNGUS
    Jagjit Yadav; Fiscal Year: 2001
    ..chrysosporium constructed for this purpose, and/or in vitro assays using expressed enzymes. Optimized P450 conditions and strains will be tested in bench top models of bioremediation. ..
  3. FUNGAL P450 SYSTEMS IN BIODEGRADATION OF HIGHER PAHS-R01ES15543-01
    Jagjit Yadav; Fiscal Year: 2009
    ..This proposal will develop appropriate fungal biocatalysts and strategies for PAH bioremediation. ..
  4. Mycobacteria in metalworking fluids
    Jagjit Yadav; Fiscal Year: 2007
    ..abstract_text> ..
  5. Genetic Determinants of Host Susceptibility to Pulmonary Anthrax
    Jagjit Yadav; Fiscal Year: 2007
    ....
  6. Mycobacteria in metalworking fluids
    Jagjit Yadav; Fiscal Year: 2005
    ..abstract_text> ..
  7. Molecular Analysis of Mycobacteria in Cutting Fluids
    Jagjit Yadav; Fiscal Year: 2003
    ..The resulting information will help NORA's objectives by providing practical methods for microbial exposure assessment and database for developing intervention strategies related to MWF exposures. ..
  8. XENOBIOTIC-OXIDIZING P450 SYSTEM IN A WHITE ROT FUNGUS
    Jagjit Yadav; Fiscal Year: 2003
    ..chrysosporium constructed for this purpose, and/or in vitro assays using expressed enzymes. Optimized P450 conditions and strains will be tested in bench top models of bioremediation. ..
  9. Molecular Analysis of Mycobacteria in Cutting Fluids
    Jagjit Yadav; Fiscal Year: 2002
    ..The resulting information will help NORA's objectives by providing practical methods for microbial exposure assessment and database for developing intervention strategies related to MWF exposures. ..
  10. XENOBIOTIC-OXIDIZING P450 SYSTEM IN A WHITE ROT FUNGUS
    Jagjit Yadav; Fiscal Year: 2002
    ..chrysosporium constructed for this purpose, and/or in vitro assays using expressed enzymes. Optimized P450 conditions and strains will be tested in bench top models of bioremediation. ..
  11. Molecular Analysis of Mycobacteria in Cutting Fluids
    Jagjit Yadav; Fiscal Year: 2001
    ..The resulting information will help NORA's objectives by providing practical methods for microbial exposure assessment and database for developing intervention strategies related to MWF exposures. ..
  12. MWF Mycobacteria antigens in occupational hypersensitivity pneumonitis
    Jagjit S Yadav; Fiscal Year: 2010
    ....