Zipora Yablonka-Reuveni

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Defining the transcriptional signature of skeletal muscle stem cells
    Z Yablonka-Reuveni
    Department of Biological Structure, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Anim Sci 86:E207-16. 2008
  2. ncbi request reprint Influence of PDGF-BB on proliferation and transition through the MyoD-myogenin-MEF2A expression program during myogenesis in mouse C2 myoblasts
    Z Yablonka-Reuveni
    Department of Biological Structure, School of Medicine, University of Washington, Seattle 98195, USA
    Growth Factors 15:1-27. 1997
  3. pmc The skeletal muscle satellite cell: still young and fascinating at 50
    Zipora Yablonka-Reuveni
    Department of Biological Structure, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Histochem Cytochem 59:1041-59. 2011
  4. ncbi request reprint Myostatin blockade: a new way to enhance skeletal muscle repair in old age?
    Zipora Yablonka-Reuveni
    Department of Biological Structure, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Mol Ther 15:1407-9. 2007
  5. ncbi request reprint Transitions in cell organization and in expression of contractile and extracellular matrix proteins during development of chicken aortic smooth muscle: evidence for a complex spatial and temporal differentiation program
    Z Yablonka-Reuveni
    Department of Biological Structure, School of Medicine, University of Washington, Seattle 98195, USA
    Anat Embryol (Berl) 197:421-37. 1998
  6. ncbi request reprint MyoD and myogenin expression patterns in cultures of fetal and adult chicken myoblasts
    Z Yablonka-Reuveni
    Department of Biological Structure, School of Medicine, University of Washington, Seattle 98195, USA
    J Histochem Cytochem 49:455-62. 2001
  7. pmc The depletion of skeletal muscle satellite cells with age is concomitant with reduced capacity of single progenitors to produce reserve progeny
    Kenneth Day
    Department of Biological Structure, Box 357420, Warren B Magneson Health Sciences Building, 1959 NE Pacific Street, University of Washington School of Medicine, Seattle, WA 98195, USA
    Dev Biol 340:330-43. 2010
  8. pmc Nestin-GFP reporter expression defines the quiescent state of skeletal muscle satellite cells
    Kenneth Day
    Department of Biological Structure, University of Washington School of Medicine, Seattle, WA 98195, USA
    Dev Biol 304:246-59. 2007
  9. pmc Myogenic reprogramming of retina-derived cells following their spontaneous fusion with myotubes
    Irina Kirillova
    Department of Biological Structure, University of Washington School of Medicine, Magnuson Health Sciences Center, Box 357420, Room I 146, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Dev Biol 311:449-63. 2007
  10. pmc Satellite-cell pool size does matter: defining the myogenic potency of aging skeletal muscle
    Gabi Shefer
    Department of Biological Structure, School of Medicine, University of Washington, Magnuson Health Sciences Center, Room G514, Box 357420, Seattle, WA 98195, USA
    Dev Biol 294:50-66. 2006

Research Grants

  1. Myogenic Stem Cell Function in Aging Skeletal Muscle
    Zipora Yablonka Reuveni; Fiscal Year: 2006
  2. Satellite Cells and Skeletal Muscle Growth Dynamics
    Zipora Yablonka Reuveni; Fiscal Year: 2007
  3. Myogenic stem cells in extraocular muscles
    Zipora Yablonka Reuveni; Fiscal Year: 2009
  4. Myogenic Stem Cell Function in Aging Skeletal Muscle
    Zipora Yablonka Reuveni; Fiscal Year: 2010
  5. Myogenic stem cells in extraocular muscles
    Zipora Yablonka Reuveni; Fiscal Year: 2010
  6. Myogenic Stem Cell Function in Aging Skeletal Muscle
    Zipora Yablonka Reuveni; Fiscal Year: 2002
  7. Myogenic Stem Cell Function in Aging Skeletal Muscle
    Zipora Yablonka Reuveni; Fiscal Year: 2009

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Defining the transcriptional signature of skeletal muscle stem cells
    Z Yablonka-Reuveni
    Department of Biological Structure, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Anim Sci 86:E207-16. 2008
    ..This feature provides us with a novel means of studying satellite cell transcriptional signatures, heterogeneity among muscle groups, and the role of the myogenic niche in directing satellite cell self-renewal...
  2. ncbi request reprint Influence of PDGF-BB on proliferation and transition through the MyoD-myogenin-MEF2A expression program during myogenesis in mouse C2 myoblasts
    Z Yablonka-Reuveni
    Department of Biological Structure, School of Medicine, University of Washington, Seattle 98195, USA
    Growth Factors 15:1-27. 1997
    ..The study raises the possibility that PDGF-BB and FGF-2 might delay the transition of the C2 cells into the MyoD+/myogenin+ state by depressing a paracrine signal that enhances differentiation...
  3. pmc The skeletal muscle satellite cell: still young and fascinating at 50
    Zipora Yablonka-Reuveni
    Department of Biological Structure, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Histochem Cytochem 59:1041-59. 2011
    ..Thus, on the 50th anniversary since its discovery, the satellite cell's indispensable role in muscle repair has been reaffirmed...
  4. ncbi request reprint Myostatin blockade: a new way to enhance skeletal muscle repair in old age?
    Zipora Yablonka-Reuveni
    Department of Biological Structure, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Mol Ther 15:1407-9. 2007
  5. ncbi request reprint Transitions in cell organization and in expression of contractile and extracellular matrix proteins during development of chicken aortic smooth muscle: evidence for a complex spatial and temporal differentiation program
    Z Yablonka-Reuveni
    Department of Biological Structure, School of Medicine, University of Washington, Seattle 98195, USA
    Anat Embryol (Berl) 197:421-37. 1998
    ..This detailed analysis of the ontogeny of chick aortic smooth muscle should provide a sound basis for future studies on the regulatory mechanisms underlying vascular smooth muscle development...
  6. ncbi request reprint MyoD and myogenin expression patterns in cultures of fetal and adult chicken myoblasts
    Z Yablonka-Reuveni
    Department of Biological Structure, School of Medicine, University of Washington, Seattle 98195, USA
    J Histochem Cytochem 49:455-62. 2001
    ..The fetal myoblasts may already be destined for terminal differentiation at the time of their isolation, and the adult myoblasts may represent progenitors that reside in an earlier compartment of the myogenic lineage...
  7. pmc The depletion of skeletal muscle satellite cells with age is concomitant with reduced capacity of single progenitors to produce reserve progeny
    Kenneth Day
    Department of Biological Structure, Box 357420, Warren B Magneson Health Sciences Building, 1959 NE Pacific Street, University of Washington School of Medicine, Seattle, WA 98195, USA
    Dev Biol 340:330-43. 2010
    ..Thus, satellite cell depletion with age could be attributed to a reduced capacity to generate a reserve population...
  8. pmc Nestin-GFP reporter expression defines the quiescent state of skeletal muscle satellite cells
    Kenneth Day
    Department of Biological Structure, University of Washington School of Medicine, Seattle, WA 98195, USA
    Dev Biol 304:246-59. 2007
    ..The NES-GFP model reveals unique transcriptional activity within quiescent satellite cells and permits novel insight into the heterogeneity of their molecular signatures...
  9. pmc Myogenic reprogramming of retina-derived cells following their spontaneous fusion with myotubes
    Irina Kirillova
    Department of Biological Structure, University of Washington School of Medicine, Magnuson Health Sciences Center, Box 357420, Room I 146, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Dev Biol 311:449-63. 2007
    ..This process may support ongoing myofiber maintenance throughout life...
  10. pmc Satellite-cell pool size does matter: defining the myogenic potency of aging skeletal muscle
    Gabi Shefer
    Department of Biological Structure, School of Medicine, University of Washington, Magnuson Health Sciences Center, Room G514, Box 357420, Seattle, WA 98195, USA
    Dev Biol 294:50-66. 2006
    ..This study suggests that the population of satellite cells that participate in myofiber maintenance during routine muscle utilization is not fully replenished throughout life...
  11. pmc Isolation and culture of skeletal muscle myofibers as a means to analyze satellite cells
    Paul Keire
    Department of Biological Structure, School of Medicine, University of Washington, Seattle, WA, USA
    Methods Mol Biol 946:431-68. 2013
    ..The current chapter provides background, procedural, and reagent updates, and step-by-step images of FDB and EDL muscle isolations, not included in our 2005 publication in this series...
  12. ncbi request reprint Skeletal muscle satellite cells can spontaneously enter an alternative mesenchymal pathway
    Gabi Shefer
    Department of Biological Structure, School of Medicine, University of Washington, Seattle, WA 98195, USA
    J Cell Sci 117:5393-404. 2004
    ..We conclude that satellite cells possess mesenchymal plasticity, being able to commit either to myogenesis or to a mesenchymal alternative differentiation (MAD) program...
  13. pmc Skeletal muscle satellite cells: background and methods for isolation and analysis in a primary culture system
    Maria Elena Danoviz
    Department of Biological Structure, School of Medicine, University of Washington, Seattle, WA, USA
    Methods Mol Biol 798:21-52. 2012
    ..Altogether, the basic protocols described are straightforward and facilitate the study of diverse aspects of skeletal muscle stem cells...
  14. pmc Absence of CD34 on murine skeletal muscle satellite cells marks a reversible state of activation during acute injury
    Nicholas Ieronimakis
    Department of Pathology, School of Medicine, University of Washington, Seattle, Washington, USA
    PLoS ONE 5:e10920. 2010
    ..Interestingly, a minority of satellite cells lacking CD34 has been described...
  15. ncbi request reprint Satellite cells from dystrophic (mdx) mice display accelerated differentiation in primary cultures and in isolated myofibers
    Zipora Yablonka-Reuveni
    Department of Biological Structure, School of Medicine, University of Washington, Seattle, Washington, USA
    Dev Dyn 235:203-12. 2006
    ..Furthermore, the study demonstrated that FDB myofibers are an excellent model of the in vivo state of muscle, as they accurately represented the dystrophic phenotype...
  16. pmc A contemporary atlas of the mouse diaphragm: myogenicity, vascularity, and the Pax3 connection
    Pascal Stuelsatz
    Department of Biological Structure, School of Medicine, University of Washington, Seattle, WA 98195, USA
    J Histochem Cytochem 60:638-57. 2012
    ..The novel information in this "contemporary atlas" can be further explored in the context of diaphragm pathology and genetic disorders...
  17. pmc A distinct profile of myogenic regulatory factor detection within Pax7+ cells at S phase supports a unique role of Myf5 during posthatch chicken myogenesis
    Kenneth Day
    Department of Biological Structure, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Dev Dyn 238:1001-9. 2009
    ..Myf5 was detected strictly within Pax7(+) cells and decreased during S phase while MyoD presence persisted in cycling cells. This study provides novel data in support of a unique role for Myf5 during posthatch myogenesis...
  18. pmc FGFR4 and its novel splice form in myogenic cells: Interplay of glycosylation and tyrosine phosphorylation
    Boguslaw A Kwiatkowski
    Department of Biological Structure, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Cell Physiol 215:803-17. 2008
    ..Our findings suggest that FGFR4 functions in a distinctly different manner than the prototype FGFR during myogenic differentiation...
  19. doi request reprint Ancestral Myf5 gene activity in periocular connective tissue identifies a subset of fibro/adipogenic progenitors but does not connote a myogenic origin
    Pascal Stuelsatz
    Department of Biological Structure, University of Washington School of Medicine, Seattle, WA 98195, USA
    Dev Biol 385:366-79. 2014
    ....
  20. pmc Moderate-intensity treadmill running promotes expansion of the satellite cell pool in young and old mice
    Gabi Shefer
    Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    FEBS J 280:4063-73. 2013
    ....
  21. pmc Increased energy expenditure and leptin sensitivity account for low fat mass in myostatin-deficient mice
    Sun Ju Choi
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, Diabetes and Obesity Center of Excellence, Seattle, WA 98109, USA
    Am J Physiol Endocrinol Metab 300:E1031-7. 2011
    ..2 g vs. WT: -1.6 ± 0.1, P < 0.05) were increased in myostatin-deficient mice compared with WT controls. We conclude that increased EE, together with increased leptin sensitivity, contributes to low fat mass in mice lacking myostatin...
  22. pmc Isolation and culture of skeletal muscle myofibers as a means to analyze satellite cells
    Gabi Shefer
    Department of Biological Structure, School of Medicine, University of Washington, Seattle, USA
    Methods Mol Biol 290:281-304. 2005
    ..These protocols allow studies on the interplay between the myofiber and its associated satellite cells...
  23. ncbi request reprint In ovo exposure to monochromatic green light promotes skeletal muscle cell proliferation and affects myofiber growth in posthatch chicks
    Orna Halevy
    Department of Animal Sciences, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Am J Physiol Regul Integr Comp Physiol 290:R1062-70. 2006
    ..We suggest that the stimulatory effect of in ovo illumination on posthatch muscle growth is the result of enhanced proliferation and differentiation of adult myoblasts and myofiber synchronization...
  24. ncbi request reprint The skeletal muscle satellite cell: the stem cell that came in from the cold
    Peter S Zammit
    Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, London, SE1 1UL England
    J Histochem Cytochem 54:1177-91. 2006
    ..This is a fast-moving and dynamic field, however, and in this review we discuss the evidence that we think puts this enigmatic cell firmly back at the center of adult myogenesis...
  25. ncbi request reprint Pattern of Pax7 expression during myogenesis in the posthatch chicken establishes a model for satellite cell differentiation and renewal
    Orna Halevy
    Department of Animal Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
    Dev Dyn 231:489-502. 2004
    ....
  26. pmc Pax7 shows higher satellite cell frequencies and concentrations within intrafusal fibers of muscle spindles
    Lisa J Kirkpatrick
    Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada
    J Histochem Cytochem 56:831-40. 2008
    ..Thus, extrafusal and intrafusal fibers alike should exhibit reduced capacities for growth, regeneration, and repair during maturation...
  27. pmc Pax7 reveals a greater frequency and concentration of satellite cells at the ends of growing skeletal muscle fibers
    Mohammed Z Allouh
    Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Health Science Building, Saskatoon, Saskatchewan S7N 5E5, Canada
    J Histochem Cytochem 56:77-87. 2008
    ..This study suggests that SCs at fiber ends play a key role in the longitudinal growth of muscle fibers, and that fiber profile size may impact SC distribution...
  28. ncbi request reprint C-Met expression and mechanical activation of satellite cells on cultured muscle fibers
    Ashley C Wozniak
    Department of Human Anatomy and Cell Science, Faculty of Medicine, University of Manitoba, 730 William Avenue, Winnipeg, Manitoba R3E 0W3, Canada
    J Histochem Cytochem 51:1437-45. 2003
    ..These methods have a strong potential to further dissect the nature of stretch-induced activation and gene expression among characterized populations of individual quiescent and activated satellite cells...
  29. pmc Reflections on lineage potential of skeletal muscle satellite cells: do they sometimes go MAD?
    Gabi Shefer
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel
    Crit Rev Eukaryot Gene Expr 17:13-29. 2007
    ..Last, we highlight evidence in favor of satellite cell plasticity and emerging hurdles restraining this hypothesis...
  30. ncbi request reprint A proliferative role for Wnt-3a in chick somites
    Lisa M Galli
    Department of Biology, San Francisco State University, San Francisco, CA 94132, USA
    Dev Biol 269:489-504. 2004
    ..Furthermore, our results demonstrate that small changes in proliferation can dramatically influence patterning and morphogenesis...

Research Grants21

  1. Myogenic Stem Cell Function in Aging Skeletal Muscle
    Zipora Yablonka Reuveni; Fiscal Year: 2006
    ..The proposed investigation will contribute new insight into the status of myogenic precursors in the adult and aging muscle and can prove important for muscle rehabilitation strategies during disease and aging. ..
  2. Satellite Cells and Skeletal Muscle Growth Dynamics
    Zipora Yablonka Reuveni; Fiscal Year: 2007
    ..The proposed investigation will contribute to a better understanding of satellite cell dynamics and muscle growth, and can prove important for muscle rehabilitation strategies during disease and aging. ..
  3. Myogenic stem cells in extraocular muscles
    Zipora Yablonka Reuveni; Fiscal Year: 2009
    ....
  4. Myogenic Stem Cell Function in Aging Skeletal Muscle
    Zipora Yablonka Reuveni; Fiscal Year: 2010
    ..The proposed studies will contribute new insight into the regulation of satellite cell function throughout the lifespan and will, therefore, provide important information for muscle rehabilitation strategies during disease and aging. ..
  5. Myogenic stem cells in extraocular muscles
    Zipora Yablonka Reuveni; Fiscal Year: 2010
    ....
  6. Myogenic Stem Cell Function in Aging Skeletal Muscle
    Zipora Yablonka Reuveni; Fiscal Year: 2002
    ..The proposed investigation will contribute new insight into the status of myogenic precursors in the adult and aging muscle and can prove important for muscle rehabilitation strategies during disease and aging. ..
  7. Myogenic Stem Cell Function in Aging Skeletal Muscle
    Zipora Yablonka Reuveni; Fiscal Year: 2009
    ..The proposed studies will contribute new insight into the regulation of satellite cell function throughout the lifespan and will, therefore, provide important information for muscle rehabilitation strategies during disease and aging. ..