Research Topics
Genomes and Genes | Xiang Xi XuSummaryAffiliation: University of Miami Country: USA Publications
Research Grants
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Detail Information
Publications
Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancerCallinice D Capo-chichi
Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
BMC Med 9:28. 2011..Another common characteristic of human cancer is aneuploidy, but the causes and its role in carcinogenesis are not well established...- Nuclear entry of activated MAPK is restricted in primary ovarian and mammary epithelial cellsElizabeth R Smith
Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, United States of America
PLoS ONE 5:e9295. 2010..The MAPK/ERK1/2 serine kinases are primary mediators of the Ras mitogenic signaling pathway. Phosphorylation by MEK activates MAPK/ERK in the cytoplasm, and phospho-ERK is thought to enter the nucleus readily to modulate transcription... - Loss of GATA6 leads to nuclear deformation and aneuploidy in ovarian cancerCallinice D Capo-chichi
Sylvester Comprehensive Cancer Center, Department of Medicine, and Department of Obstetrics and Gynecology, University of Miami School of Medicine, Miami, Florida 33136, USA
Mol Cell Biol 29:4766-77. 2009..The loss of emerin may be the basis of nuclear morphological deformation and subsequently the cause of aneuploidy in ovarian cancer cells... - Increased expression of Syne1/nesprin-1 facilitates nuclear envelope structure changes in embryonic stem cell differentiationElizabeth R Smith
Sylvester Comprehensive Cancer Center, Department of Medicine, and Department of Obstetrics and Gynecology, University of Miami School of Medicine, Miami, Florida, USA
Dev Dyn 240:2245-55. 2011..We conclude that the nuclear envelope structural change accompanying differentiation likely participates in promoting the differential chromatin organization of the differentiated cells... 
Loss of A-type lamin expression compromises nuclear envelope integrity in breast cancerCallinice D Capo-chichi
Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL 33136, USA
Chin J Cancer 30:415-25. 2011..We conclude that the loss of nuclear envelope structural proteins lamin A/C in breast cancer underlies the two hallmarks of cancer aberrations in nuclear morphology and aneuploidy...- Ectopic expression of GATA6 bypasses requirement for Grb2 in primitive endoderm formationYing Wang
Cell and Developmental Biology Graduate Program, University of Miami School of Medicine, Miami, Florida Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida
Dev Dyn 240:566-76. 2011..Developmental Dynamics 240:566-576, 2011. © 2010 Wiley-Liss, Inc... - Cell adhesive affinity does not dictate primitive endoderm segregation and positioning during murine embryoid body formationRobert Moore
Department of Medicine, Sylvester Comprehensive Cancer Center, Department of Obstetrics and Gynecology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Genesis 47:579-89. 2009..Thus, the ability to generate epithelial polarity, rather than adhesive affinity, determines the surface positioning of the primitive endoderm cells... - Explicit targeting of transformed cells by VSV in ovarian epithelial tumor-bearing Wv mouse modelsCallinice D Capo-chichi
Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL 33136, USA
Gynecol Oncol 116:269-75. 2010..Specifically, we examined the toxicity to hosts and specificity of targeting ovarian tumors using a Wv ovarian tumor model... - Alteration of Differentiation Potentials by Modulating GATA Transcription Factors in Murine Embryonic Stem CellsCallinice D Capo-chichi
Miller School of Medicine, University of Miami, 1550 NW 10th Avenue M877, Miami, FL 33156, USA
Stem Cells Int 2010:602068. 2010..The finding offers a potential approach to produce desirable cell types from ES cells, useful for regenerative cell therapy... 
Potential of vesicular stomatitis virus as an oncolytic therapy for recurrent and drug-resistant ovarian cancerJoshua F Heiber
University of Miami Miller School of Medicine, Miami, FL 33136, USA
Chin J Cancer 30:805-14. 2011..In this article, we review the development of VSV as a potential therapeutic approach for recurrent or drug-resistant ovarian cancer...- Ovarian ageing, follicle depletion, and cancer: a hypothesis for the aetiology of epithelial ovarian cancer involving follicle depletionElizabeth R Smith
Department of Medicine, University of Miami School of Medicine, Miami, FL, USA
Lancet Oncol 9:1108-11. 2008....
Research Grants
- Gonadotropins & Cox-2 in Ovarian Cancer PreventionXIANGXI MIKE XU; Fiscal Year: 2007..These studies will help to understand the etiology of ovarian cancer related to gonadotropins, and provide a mechanism(s) for the chemopreventive activity of Cox-2 inhibitors. ..
- Ovarian Cancer: Epithelial DedifferentiationXIANGXI MIKE XU; Fiscal Year: 2007..Such analysis may lead to new understanding of the tumor biology and etiology of ovarian cancer. ..
- Epithelial Positioning Organization and Ovarian CancerXIANGXI MIKE XU; Fiscal Year: 2007..Such studies will lead to a better understanding of cancer etiology and will contribute to public health by providing cancer preventive stratagy and treatment therapy. ..
- Epithelial Positioning Organization and Ovarian CancerXIANGXI MIKE XU; Fiscal Year: 2010..Such studies will lead to a better understanding of cancer etiology and will contribute to public health by providing cancer preventive stratagy and treatment therapy. ..
- Epithelial Positioning Organization and Ovarian CancerXIANGXI MIKE XU; Fiscal Year: 2009..Such studies will lead to a better understanding of cancer etiology and will contribute to public health by providing cancer preventive stratagy and treatment therapy. ..
- Gonadotropins & Cox-2 in Ovarian Cancer PreventionXIANGXI MIKE XU; Fiscal Year: 2010..Also, the studies will test if Cox and uPA pathways may be useful as targets for prevention of ovarian cancer targets, and provide an understanding of their mechanisms. ..
- DAB2 AND RAS REGULATIONXiangxi Xu; Fiscal Year: 2001..These mechanistic studies of Dab2 will enhance our understanding of its role in cell growth regulation and the possible involvement in breast and ovary tumorigenicity. ..
- Epithelial Positioning Organization and Ovarian CancerXiangxi Xu; Fiscal Year: 2002..abstract_text> ..
- OVARIAN CANCERXiangxi Xu; Fiscal Year: 2003..The results will clarify the role of Dab2 loss in the tumorigenicity of breast and ovarian cancers. ..
- Ovarian Cancer: Epithelial DedifferentiationXIANGXI MIKE XU; Fiscal Year: 2011....