Xiang Xi Xu

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc Alteration of Differentiation Potentials by Modulating GATA Transcription Factors in Murine Embryonic Stem Cells
    Callinice D Capo-chichi
    Miller School of Medicine, University of Miami, 1550 NW 10th Avenue M877, Miami, FL 33156, USA
    Stem Cells Int 2010:602068. 2010
  2. pmc Loss of GATA4 and GATA6 expression specifies ovarian cancer histological subtypes and precedes neoplastic transformation of ovarian surface epithelia
    Kathy Qi Cai
    Ovarian Cancer Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 4:e6454. 2009
  3. pmc Differential requirement for Dab2 in the development of embryonic and extra-embryonic tissues
    Robert Moore
    Department of Cell Biology, University of Miami Miller School of Medicine, Miami, 33136, FL, USA
    BMC Dev Biol 13:39. 2013
  4. pmc Loss of A-type lamin expression compromises nuclear envelope integrity in breast cancer
    Callinice D Capo-chichi
    Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL 33136, USA
    Chin J Cancer 30:415-25. 2011
  5. pmc Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer
    Callinice D Capo-chichi
    Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    BMC Med 9:28. 2011
  6. pmc Cyclooxygenase-1 inhibition prolongs postnatal ovarian follicle lifespan in mice
    Elizabeth R Smith
    Department of Cell Biology and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida
    Biol Reprod 89:103. 2013
  7. pmc Nuclear entry of activated MAPK is restricted in primary ovarian and mammary epithelial cells
    Elizabeth R Smith
    Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 5:e9295. 2010
  8. pmc White spotting variant mouse as an experimental model for ovarian aging and menopausal biology
    Elizabeth R Smith
    Sylvester Comprehensive Cancer Center, Department ofMedicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Menopause 19:588-96. 2012
  9. pmc Potential of vesicular stomatitis virus as an oncolytic therapy for recurrent and drug-resistant ovarian cancer
    Joshua F Heiber
    University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Chin J Cancer 30:805-14. 2011
  10. pmc Src Inhibition with saracatinib reverses fulvestrant resistance in ER-positive ovarian cancer models in vitro and in vivo
    Fiona Simpkins
    Braman Family Breast Cancer Institute and Division of Biostatistics, Department of Epidemiology and Public Health, University of Miami Sylvester Comprehensive Cancer Center, Miami, Florida 33136, USA
    Clin Cancer Res 18:5911-23. 2012

Research Grants

  1. DAB2 AND RAS REGULATION
    Xiangxi Xu; Fiscal Year: 2001
  2. Epithelial Positioning Organization and Ovarian Cancer
    XIANGXI MIKE XU; Fiscal Year: 2010

Detail Information

Publications20

  1. pmc Alteration of Differentiation Potentials by Modulating GATA Transcription Factors in Murine Embryonic Stem Cells
    Callinice D Capo-chichi
    Miller School of Medicine, University of Miami, 1550 NW 10th Avenue M877, Miami, FL 33156, USA
    Stem Cells Int 2010:602068. 2010
    ..The finding offers a potential approach to produce desirable cell types from ES cells, useful for regenerative cell therapy...
  2. pmc Loss of GATA4 and GATA6 expression specifies ovarian cancer histological subtypes and precedes neoplastic transformation of ovarian surface epithelia
    Kathy Qi Cai
    Ovarian Cancer Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 4:e6454. 2009
    ..GATA4 and GATA6 were found to be frequently lost in ovarian cancer, and the loss is proposed to account for dedifferentiation of the cancer cells...
  3. pmc Differential requirement for Dab2 in the development of embryonic and extra-embryonic tissues
    Robert Moore
    Department of Cell Biology, University of Miami Miller School of Medicine, Miami, 33136, FL, USA
    BMC Dev Biol 13:39. 2013
    ..To further clarify the in vivo roles of Dab2 in development and physiology, we designed a new floxed allele to delete dab2 gene...
  4. pmc Loss of A-type lamin expression compromises nuclear envelope integrity in breast cancer
    Callinice D Capo-chichi
    Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL 33136, USA
    Chin J Cancer 30:415-25. 2011
    ..We conclude that the loss of nuclear envelope structural proteins lamin A/C in breast cancer underlies the two hallmarks of cancer aberrations in nuclear morphology and aneuploidy...
  5. pmc Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer
    Callinice D Capo-chichi
    Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    BMC Med 9:28. 2011
    ..Another common characteristic of human cancer is aneuploidy, but the causes and its role in carcinogenesis are not well established...
  6. pmc Cyclooxygenase-1 inhibition prolongs postnatal ovarian follicle lifespan in mice
    Elizabeth R Smith
    Department of Cell Biology and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida
    Biol Reprod 89:103. 2013
    ..The current study suggests that inhibition of cyclooxygenase-1 may be able to delay ovarian aging and modulate menopausal timing. ..
  7. pmc Nuclear entry of activated MAPK is restricted in primary ovarian and mammary epithelial cells
    Elizabeth R Smith
    Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 5:e9295. 2010
    ..The MAPK/ERK1/2 serine kinases are primary mediators of the Ras mitogenic signaling pathway. Phosphorylation by MEK activates MAPK/ERK in the cytoplasm, and phospho-ERK is thought to enter the nucleus readily to modulate transcription...
  8. pmc White spotting variant mouse as an experimental model for ovarian aging and menopausal biology
    Elizabeth R Smith
    Sylvester Comprehensive Cancer Center, Department ofMedicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Menopause 19:588-96. 2012
    ....
  9. pmc Potential of vesicular stomatitis virus as an oncolytic therapy for recurrent and drug-resistant ovarian cancer
    Joshua F Heiber
    University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Chin J Cancer 30:805-14. 2011
    ..In this article, we review the development of VSV as a potential therapeutic approach for recurrent or drug-resistant ovarian cancer...
  10. pmc Src Inhibition with saracatinib reverses fulvestrant resistance in ER-positive ovarian cancer models in vitro and in vivo
    Fiona Simpkins
    Braman Family Breast Cancer Institute and Division of Biostatistics, Department of Epidemiology and Public Health, University of Miami Sylvester Comprehensive Cancer Center, Miami, Florida 33136, USA
    Clin Cancer Res 18:5911-23. 2012
    ..Because Src is activated in most ovarian cancers, we investigated whether combined Src and ER blockade by saracatinib and fulvestrant would circumvent antiestrogen resistance...
  11. pmc Ectopic expression of GATA6 bypasses requirement for Grb2 in primitive endoderm formation
    Ying Wang
    Cell and Developmental Biology Graduate Program, University of Miami School of Medicine, Miami, Florida Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida
    Dev Dyn 240:566-76. 2011
    ..Developmental Dynamics 240:566-576, 2011. © 2010 Wiley-Liss, Inc...
  12. pmc The primitive endoderm segregates from the epiblast in β1 integrin-deficient early mouse embryos
    Robert Moore
    Department of Cell Biology, University of Miami School of Medicine, Miami, Florida, USA
    Mol Cell Biol 34:560-72. 2014
    ....
  13. pmc Increased expression of Syne1/nesprin-1 facilitates nuclear envelope structure changes in embryonic stem cell differentiation
    Elizabeth R Smith
    Sylvester Comprehensive Cancer Center, Department of Medicine, and Department of Obstetrics and Gynecology, University of Miami School of Medicine, Miami, Florida, USA
    Dev Dyn 240:2245-55. 2011
    ..We conclude that the nuclear envelope structural change accompanying differentiation likely participates in promoting the differential chromatin organization of the differentiated cells...
  14. pmc Hormonal induction and roles of Disabled-2 in lactation and involution
    Wensi Tao
    Sylvester Comprehensive Cancer Center, and Department of Cell Biology, Graduate Program in Molecular Cell and Developmental Biology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 9:e110737. 2014
    ..We conclude that Dab2 expression is induced by hormones and Dab2 plays a role in modulating TGF-beta signaling to enhance apoptotic clearance of mammary epithelial cells during involution. ..
  15. pmc Cell adhesive affinity does not dictate primitive endoderm segregation and positioning during murine embryoid body formation
    Robert Moore
    Department of Medicine, Sylvester Comprehensive Cancer Center, Department of Obstetrics and Gynecology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Genesis 47:579-89. 2009
    ..Thus, the ability to generate epithelial polarity, rather than adhesive affinity, determines the surface positioning of the primitive endoderm cells...
  16. pmc Explicit targeting of transformed cells by VSV in ovarian epithelial tumor-bearing Wv mouse models
    Callinice D Capo-chichi
    Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL 33136, USA
    Gynecol Oncol 116:269-75. 2010
    ..Specifically, we examined the toxicity to hosts and specificity of targeting ovarian tumors using a Wv ovarian tumor model...
  17. pmc Loss of GATA6 leads to nuclear deformation and aneuploidy in ovarian cancer
    Callinice D Capo-chichi
    Sylvester Comprehensive Cancer Center, Department of Medicine, and Department of Obstetrics and Gynecology, University of Miami School of Medicine, Miami, Florida 33136, USA
    Mol Cell Biol 29:4766-77. 2009
    ..The loss of emerin may be the basis of nuclear morphological deformation and subsequently the cause of aneuploidy in ovarian cancer cells...
  18. pmc Ovarian ageing, follicle depletion, and cancer: a hypothesis for the aetiology of epithelial ovarian cancer involving follicle depletion
    Elizabeth R Smith
    Department of Medicine, University of Miami School of Medicine, Miami, FL, USA
    Lancet Oncol 9:1108-11. 2008
    ....

Research Grants2

  1. DAB2 AND RAS REGULATION
    Xiangxi Xu; Fiscal Year: 2001
    ..These mechanistic studies of Dab2 will enhance our understanding of its role in cell growth regulation and the possible involvement in breast and ovary tumorigenicity. ..
  2. Epithelial Positioning Organization and Ovarian Cancer
    XIANGXI MIKE XU; Fiscal Year: 2010
    ..Such studies will lead to a better understanding of cancer etiology and will contribute to public health by providing cancer preventive stratagy and treatment therapy. ..