X Xu

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. doi request reprint Renin-angiotensin-aldosterone system gene polymorphisms and antihypertensive response to irbesartan in Chinese hypertensives
    H Liu
    School of Life Science, University of Science and Technology of China, Hefei, Anhui, China
    Methods Find Exp Clin Pharmacol 30:307-12. 2008
  2. doi request reprint Effects of protein coding polymorphisms in the kallikrein 1 gene on baseline blood pressure and antihypertensive response to irbesartan in Chinese hypertensive patients
    S Jiang
    School of Life Sciences, Anhui University, Hefei, China
    J Hum Hypertens 25:327-33. 2011
  3. ncbi request reprint Genetic polymorphisms of the urea transporter gene are associated with antihypertensive response to nifedipine GITS
    X Hong
    School of Life Sciences, University of Science and Technology of China, Hefei City, Anhui Province, China
    Methods Find Exp Clin Pharmacol 29:3-10. 2007
  4. ncbi request reprint CYP2C9 Ile359Leu polymorphism, plasma irbesartan concentration and acute blood pressure reductions in response to irbesartan treatment in Chinese hypertensive patients
    G Chen
    Institute of Biomedicine, Anhui Medical University, Department of Pharmacology, Anhui College of Traditional Chinese Medicine, Hefei, Anhui, People s Republic of China
    Methods Find Exp Clin Pharmacol 28:19-24. 2006
  5. doi request reprint Effects of MTHFR and MS gene polymorphisms on baseline blood pressure and Benazepril effectiveness in Chinese hypertensive patients
    S Jiang
    School of Life Sciences, Anhui University, Hefei, China
    J Hum Hypertens 25:172-7. 2011
  6. doi request reprint Effect of folic acid intervention on ALT concentration in hypertensives without known hepatic disease: a randomized, double-blind, controlled trial
    X Qin
    Institute of Biomedicine, Anhui Medical University, Hefei, China
    Eur J Clin Nutr 66:541-8. 2012
  7. ncbi request reprint The C677T polymorphism of the methylenetetrahydrofolate reductase gene is associated with the level of decrease on diastolic blood pressure in essential hypertension patients treated by angiotensin-converting enzyme inhibitor
    Shanqun Jiang
    School of Life Sciences, University of Science and Technology of China, Hefei, China
    Thromb Res 113:361-9. 2004
  8. ncbi request reprint D919G polymorphism of methionine synthase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients
    Yan Zhang
    Department of Cardiology, Peking University First Hospital, 100034, Beijing, China
    J Hum Genet 49:296-301. 2004
  9. ncbi request reprint Association between the interleukin-1beta C(-511)T polymorphism and blood pressure in a Chinese hypertensive population
    Guo Huang
    School of Life Sciences, University of Science and Technology of China, Hefei
    Immunol Lett 91:159-62. 2004
  10. ncbi request reprint Association between human atrial natriuretic peptide Val7Met polymorphism and baseline blood pressure, plasma trough irbesartan concentrations, and the antihypertensive efficacy of irbesartan in rural Chinese patients with essential hypertension
    Shanchun Zhang
    School of Life Science, University of Science and Technology of China, Hefei, Anhui, China
    Clin Ther 27:1774-84. 2005

Collaborators

  • Melissa J Perry
  • X Wang
  • S Zhang
  • Tianhua Niu
  • J Li
  • Z Liu
  • J Hu
  • J Ge
  • Y Wang
  • G Chen
  • X Liu
  • Ke Hao
  • Lin Wang
  • Alayne G Ronnenberg
  • Shanqun Jiang
  • Lyle J Palmer
  • H Watanabe
  • Dong Li
  • Li Chen
  • Jing Shen
  • Yan Feng
  • Xiumei Hong
  • Changzhong Chen
  • Houxun Xing
  • Binyan Wang
  • Yan Zhang
  • Yunxian Yu
  • Zhiping Li
  • Genfu Tang
  • Yi Hsiang Hsu
  • Scott A Venners
  • Shaojie Peng
  • Aiqun Huang
  • Tonghua Zang
  • Jianhua Yang
  • Dafang Chen
  • Henry Terwedow
  • Di Wu
  • Guo Huang
  • X Hong
  • Rajesh Kumar
  • Eunhee Ha
  • Joseph D Brain
  • Nan Laird
  • X Qin
  • Wenwei Guang
  • Daijun Ling
  • Louise Ryan
  • H Liu
  • David C Christiani
  • Guoying Wang
  • Y Yu
  • Elissa Wilker
  • H Xing
  • Y Zhang
  • G Tang
  • Pierre A Zalloua
  • Delai Jin
  • Wenbin Zhang
  • Mary L Bouxsein
  • Guangyun Mao
  • Zhian Fang
  • Lope H Barrero
  • Henry A Terwedow
  • Cliff J Rosen
  • Lingling Fu
  • Bill Lasley
  • Jing Liu
  • Xuejun Zhang
  • Yong Huo
  • Guoying Zhu
  • Yadong Yang
  • Sung Il Cho
  • Thomas J Smith
  • Ye A Hu
  • Yu Fu
  • Ruping Xie
  • F Zhang
  • Y Cui
  • Z Zhao
  • D Guan
  • Y Huo
  • G Mao
  • XiaoWei Ren
  • Xueqi Li
  • Jinqui Yang
  • Qiang Li
  • Lirong Sun
  • Weiqing Ma
  • Wei Ma

Detail Information

Publications67

  1. doi request reprint Renin-angiotensin-aldosterone system gene polymorphisms and antihypertensive response to irbesartan in Chinese hypertensives
    H Liu
    School of Life Science, University of Science and Technology of China, Hefei, Anhui, China
    Methods Find Exp Clin Pharmacol 30:307-12. 2008
    ..001). Our findings suggested that SNPs and their reconstructed haplotypes in RAAS genes might be involved in the regulation of BP-lowering response to irbesartan in Chinese hypertensives...
  2. doi request reprint Effects of protein coding polymorphisms in the kallikrein 1 gene on baseline blood pressure and antihypertensive response to irbesartan in Chinese hypertensive patients
    S Jiang
    School of Life Sciences, Anhui University, Hefei, China
    J Hum Hypertens 25:327-33. 2011
    ..06), but DBP response did not differ. This study suggests that rs5516 in the KLK1 gene may be involved in the development of essential hypertension and in the regulation of SBP-lowering response to irbesartan in Chinese hypertensives...
  3. ncbi request reprint Genetic polymorphisms of the urea transporter gene are associated with antihypertensive response to nifedipine GITS
    X Hong
    School of Life Sciences, University of Science and Technology of China, Hefei City, Anhui Province, China
    Methods Find Exp Clin Pharmacol 29:3-10. 2007
    ..Our study supports the conclusion that polymorphisms in the SLC14A2 gene can predict the antihypertensive efficacy of nifedipine GITS...
  4. ncbi request reprint CYP2C9 Ile359Leu polymorphism, plasma irbesartan concentration and acute blood pressure reductions in response to irbesartan treatment in Chinese hypertensive patients
    G Chen
    Institute of Biomedicine, Anhui Medical University, Department of Pharmacology, Anhui College of Traditional Chinese Medicine, Hefei, Anhui, People s Republic of China
    Methods Find Exp Clin Pharmacol 28:19-24. 2006
    ..Our finding suggests that the CYP2C9*3 gene variant significantly alters the plasma concentration and acute DBP response at the 6-h point following irbesartan treatment in Chinese hypertensive patients...
  5. doi request reprint Effects of MTHFR and MS gene polymorphisms on baseline blood pressure and Benazepril effectiveness in Chinese hypertensive patients
    S Jiang
    School of Life Sciences, Anhui University, Hefei, China
    J Hum Hypertens 25:172-7. 2011
    ..Our results suggest that the effects of MTHFR C677T and MS A2756G gene polymorphisms may have pivotal roles in the aetiology of EH and BP response to Benazepril treatment...
  6. doi request reprint Effect of folic acid intervention on ALT concentration in hypertensives without known hepatic disease: a randomized, double-blind, controlled trial
    X Qin
    Institute of Biomedicine, Anhui Medical University, Hefei, China
    Eur J Clin Nutr 66:541-8. 2012
    ..We addressed the question of whether folic acid (FA) supplementation can affect serum alanine aminotransferase (ALT) level in hypertensive Chinese adults...
  7. ncbi request reprint The C677T polymorphism of the methylenetetrahydrofolate reductase gene is associated with the level of decrease on diastolic blood pressure in essential hypertension patients treated by angiotensin-converting enzyme inhibitor
    Shanqun Jiang
    School of Life Sciences, University of Science and Technology of China, Hefei, China
    Thromb Res 113:361-9. 2004
    ..The purpose of this study was to investigate whether short-term blood pressure control by benazepril, an ACE inhibitor, was modulated by C677T MTHFR gene polymorphism...
  8. ncbi request reprint D919G polymorphism of methionine synthase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients
    Yan Zhang
    Department of Cardiology, Peking University First Hospital, 100034, Beijing, China
    J Hum Genet 49:296-301. 2004
    ..Our finding suggests that the D919G polymorphism of the MTR gene may be a useful genetic marker to predict the antihypertensive effect of short-term benazepril therapy in hypertensive patients of Anhui Province, China...
  9. ncbi request reprint Association between the interleukin-1beta C(-511)T polymorphism and blood pressure in a Chinese hypertensive population
    Guo Huang
    School of Life Sciences, University of Science and Technology of China, Hefei
    Immunol Lett 91:159-62. 2004
    ..Our results suggested a significant role of the IL-1beta C(-511)T polymorphism in the control of blood pressure in Chinese hypertensives...
  10. ncbi request reprint Association between human atrial natriuretic peptide Val7Met polymorphism and baseline blood pressure, plasma trough irbesartan concentrations, and the antihypertensive efficacy of irbesartan in rural Chinese patients with essential hypertension
    Shanchun Zhang
    School of Life Science, University of Science and Technology of China, Hefei, Anhui, China
    Clin Ther 27:1774-84. 2005
    ..The ANP gene, which encodes the precursor of atrial natriuretic peptide (ANP), is among the candidate genes for genetic susceptibility to hypertension...
  11. ncbi request reprint CYP2C9*3 allelic variant is associated with metabolism of irbesartan in Chinese population
    Xiumei Hong
    Life Science School, University of Science and Technology of China, Huangshan Road, Hefei City, Anhui Province, China
    Eur J Clin Pharmacol 61:627-34. 2005
    ....
  12. ncbi request reprint Beta2 adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese
    Guo Huang
    School of Life Science, University of Science and Technology of China, Hefei, China
    Clin Exp Hypertens 26:581-92. 2004
    ..This study examined whether the therapeutic efficacy of benazepril on essential hypertension is modified by beta2 adrenergic receptor gene (ADRB2) Arg16Gly (R16G) polymorphism...
  13. ncbi request reprint Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia
    Lin Wang
    Program for Population Genetics, Harvard School of Public Health, Boston, MA, USA
    Am J Obstet Gynecol 195:162-71. 2006
    ..Prolylcarboxypeptidase encodes a lysosomal enzyme and is a regulator for both renin-angiotensin system and the kallikrein-kinin system. There is no published study on prolylcarboxypeptidase gene and preeclampsia...
  14. ncbi request reprint Associations of baseline blood pressure levels and efficacy of Benazepril treatment with interaction of alpha-adducin and ACE gene polymorphisms in hypertensives
    Yunxian Yu
    School of Life Science, University of Science and Technology of China, Hefei, Anhui, China
    Clin Exp Hypertens 27:83-94. 2005
    ..Our results suggested that the interaction effect of alpha-adducin Gly460Trp and ACE I/D polymorphisms might play a significant role in regulating baseline BP but not BP response to Benazepril...
  15. ncbi request reprint Association of cigarette smoking with steady-state plasma concentration of irbesartan in male Chinese with hypertension
    Shanchun Zhang
    School of Life Science, University of Science and Technology of China, Hefei, Anhui, China
    Methods Find Exp Clin Pharmacol 27:173-8. 2005
    ..The metabolic rate of irbesartan in current smokers was slower than those in nonsmokers and former smokers...
  16. ncbi request reprint A common haplotype on methylenetetrahydrofolate reductase gene modifies the effect of angiotensin-converting enzyme inhibitor on blood pressure in essential hypertension patients--a family-based association study
    Shanqun Jiang
    School of Life Sciences, University of Science and Technology of China, Hefei, China
    Clin Exp Hypertens 27:509-21. 2005
    ..009 in an additive model and 0.006 in a dominant model. Our findings suggest that MTHFR 677C-1298C haplotype modulate blood pressure responsiveness to shortterm treatment of ACE inhibitor in Chinese essential hypertensive patients...
  17. ncbi request reprint Individual and joint association of alpha1A-adrenergic receptor Arg347Cys polymorphism and plasma irbesartan concentration with blood pressure therapeutic response in Chinese hypertensive subjects
    Shanqun Jiang
    School of Life Sciences, University of Science and Technology of China, Anhui, Hefei, People s Republic of China
    Clin Pharmacol Ther 78:239-48. 2005
    ....
  18. ncbi request reprint Hypertensive patients from two rural Chinese counties respond differently to benazepril: the Anhui Hypertension Health Care Study
    Dong Li
    School of Life Science, University of Science and Technology in China, Hefei, China
    Ann Epidemiol 14:123-8. 2004
    ..Genetic and environmental factors associated with individual variation in response to anti-hypertensive drug remain largely unknown...
  19. ncbi request reprint Lack of association between rs7566605 and obesity in a Chinese population
    Yan Feng
    Hum Genet 120:743-5. 2007
  20. doi request reprint Familial aggregation of metabolic syndrome and its components in a large Chinese population
    Yan Feng
    Program for Population Genetics, Harvard School of Public Health, Boston, Massachusetts, USA
    Obesity (Silver Spring) 16:125-9. 2008
    ..To investigate the familial aggregation of metabolic syndrome (MetS) and its components in the Chinese...
  21. pmc Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients
    Yan Feng
    Anhui Biomedical Institute, Anhui Medical University, Hefei, China
    Diabetes Care 31:1939-44. 2008
    ..The purpose of this study was to investigate whether genetic variants could influence the antidiabetic efficacy of gliclazide in type 2 diabetic patients...
  22. ncbi request reprint G protein-coupled receptor 154 gene polymorphism is associated with airway hyperresponsiveness to methacholine in a Chinese population
    Yan Feng
    Program for Population Genetics, Harvard School of Public Health, Boston, MA 02115, USA
    J Allergy Clin Immunol 117:612-7. 2006
    ..A new asthma susceptibility gene, the G protein-coupled receptor for asthma susceptibility (GPRA, GPR154), has recently been identified and the association was replicated in 2 white populations, but not in a Korean population...
  23. pmc Short sleep duration and adiposity in Chinese adolescents
    Yunxian Yu
    The Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Northwestern University, Chicago, IL 60614 3394, USA
    Sleep 30:1688-97. 2007
    ..To investigate the relationship between sleep duration and adiposity measurements in rural Chinese adolescents...
  24. ncbi request reprint Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women
    Yi Hsiang Hsu
    Program for Population Genetics, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 83:146-54. 2006
    ..Higher fat mass may be an independent risk factor for osteoporosis and osteoporotic fractures...
  25. ncbi request reprint Monozygotic co-twin analyses of body composition measurements and serum lipids
    Binyan Wang
    Mary Ann J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Prev Med 45:358-65. 2007
    ..To evaluate BMI and direct measures of body fat (BF) and lean body mass (LBM) in relation to fasting serum lipid profiles in a large Chinese population based twin sample using a monozygotic (MZ) co-twin analysis...
  26. ncbi request reprint Heart rate-corrected QT interval duration is significantly associated with blood pressure in Chinese hypertensives
    Shaojie Peng
    Institute of Biomedicine, Anhui Medical University, Hefei 230032, China
    J Electrocardiol 39:206-10. 2006
    ..Many studies demonstrated that a prolonged heart rate-corrected QT interval (QTc) increases the risk of malignant ventricular arrhythmias and sudden death...
  27. pmc Effects of age at menarche, reproductive years, and menopause on metabolic risk factors for cardiovascular diseases
    Yan Feng
    Program for Population Genetics, Harvard School of Public Health, Boston, MA 02115, USA
    Atherosclerosis 196:590-7. 2008
    ..The impact of changes in some metabolic risk factors of cardiovascular disease (CVD) after menopause remains controversial and ageing is an important confounder...
  28. ncbi request reprint Age and gender specific lung function predictive equations provide similar predictions for both a twin population and a general population from age 6 through adolescence
    Yunxian Yu
    Mary Ann and J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital and Children s Memorial Research Center, Chicago, IL 60614, USA
    Pediatr Pulmonol 42:631-9. 2007
    ..We sought to evaluate this in late childhood and adolescent subjects...
  29. ncbi request reprint Bronchodilator responses in Chinese children from asthma index families and the general population
    Rajesh Kumar
    Division of Allergy, Children s Memorial Hospital, Chicago, IL 60612 0064, USA
    J Allergy Clin Immunol 117:1257-63. 2006
    ..Although airway hyperresponsiveness to bronchoconstrictors has been extensively investigated, epidemiologic studies on airway hyperresponsiveness to bronchodilators are limited...
  30. ncbi request reprint Prevalence of metabolic syndrome and its relation to body composition in a Chinese rural population
    Yan Feng
    Program for Population Genetics, Harvard School of Public Health, 665 Huntington Avenue, FXB 101, Boston, MA 02115, USA
    Obesity (Silver Spring) 14:2089-98. 2006
    ..To investigate the prevalence of metabolic syndrome (MetS) with three different working definitions in a rural Chinese population and to examine its relation to body composition...
  31. ncbi request reprint Environmental pyrethroid and organophosphorus insecticide exposures and sperm concentration
    Melissa J Perry
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Reprod Toxicol 23:113-8. 2007
    ....
  32. pmc Association of the methylenetetrahydrofolate reductase C677T polymorphism and fracture risk in Chinese postmenopausal women
    Xiumei Hong
    School of Life Science, University of Science and Technology of China, Huangshan Road, Hefei City, Anhui Province, China
    Bone 40:737-42. 2007
    ..Further study on the mechanistic role that this polymorphism plays in the development of fractures may lead to better understanding of the etiology of osteoporotic fracture...
  33. ncbi request reprint An efficient family-based association test using multiple markers
    Xin Xu
    Program for Population Genetics, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Genet Epidemiol 30:620-6. 2006
    ..However, when both parents are missing, T(MM) is substantially more powerful than T(H). We also apply this new test on a data set from a previous association study on nicotine dependence...
  34. ncbi request reprint CYP19A1 polymorphisms are associated with bone mineral density in Chinese men
    Xiumei Hong
    School of Life Science, University of Science and Technology of China, Huangshan Road, Hefei City, Anhui Province, China
    Hum Genet 121:491-500. 2007
    ..Our finding suggests that genetic variations in the CYP19A1 gene are significantly associated with BMD at different skeletal sites in adult men, but not in women...
  35. ncbi request reprint Impact of seafood and fruit consumption on bone mineral density
    Pierre A Zalloua
    Program for Population Genetics, Harvard School of Public Health, Boston, MA, USA
    Maturitas 56:1-11. 2007
    ..We investigated environmental determinants, specifically dietary habits, of BMD by using multiple regression models in a rural Chinese population...
  36. ncbi request reprint Preconception B-vitamin and homocysteine status, conception, and early pregnancy loss
    Alayne G Ronnenberg
    Department of Nutrition, University of Massachusetts Amherst, Amherst, MA 01003, and Channing Laboratory, Brigham and Women s Hospital, Boston, USA
    Am J Epidemiol 166:304-12. 2007
    ..7, 95% CI: 0.4, 1.1) than did women with vitamin B6 deficiency. Poor vitamin B6 status appears to decrease the probability of conception and to contribute to the risk of early pregnancy loss in this population...
  37. ncbi request reprint Familial aggregation of forearm bone mineral density in Chinese
    Xiumei Hong
    Center for Population Genetics, Division of Epidemiology and Biostatistics, School of Public Health M C 923, University of Illinois at Chicago, 1603 W Taylor, Rm 978B, Chicago, IL 60612, USA
    Eur J Epidemiol 22:335-41. 2007
    ..Our findings showing strong familial aggregation of both proximal and distal forearm BMD values suggest that genetic factors play a significant role in determining both traits...
  38. ncbi request reprint Prevalence and physical determinants of low back pain in a rural Chinese population
    Lope H Barrero
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Spine (Phila Pa 1976) 31:2728-34. 2006
    ..This was a community-based cross-sectional study that is part of an ongoing study of genetics and osteoporosis...
  39. ncbi request reprint Familial aggregation of airway responsiveness: a community-based study
    Ke Hao
    Program for Population Genetics, Harvard School of Public Health, Boston, MA 02115, USA
    Ann Epidemiol 15:737-43. 2005
    ..We investigated the familial aggregation of airway hyper-responsiveness (AHR) to methacoline among randomly chosen families in a rural community in Anqing, China...
  40. ncbi request reprint Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men
    Yi Hsiang Hsu
    Program for Population Genetics, Harvard School of Public Health, 665 Huntington Avenue, FXB 101, Boston, MA, USA
    Hum Genet 118:568-77. 2006
    ..Our findings suggest that genetic variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are strongly associated with BMD at different skeletal sites in adult men, but not in women...
  41. ncbi request reprint Parental exposure to organic solvents and reduced birth weight
    Eunhee Ha
    Department of Preventive Medicine, Ewha Woman s Medical University, Seoul, South Korea
    Arch Environ Health 57:207-14. 2002
    ..Maternal exposure to organic solvents was associated with reduced birth weight in this population, but paternal exposure to organic solvents was not similarly associated...
  42. ncbi request reprint [Association of estrogen receptor gene polymorphism with cerebral infarction, a case-control study]
    Yan Zhang
    Department of Neurology, Third Hospital, Peking University, Beijing 100083, China
    Zhonghua Yi Xue Za Zhi 82:1443-6. 2002
    ..To explore the association between estrogen receptor (ER) gene PvuII and XbaI polymorphisms and cerebral infarction among Chinese Han people...
  43. ncbi request reprint Does standing at work during pregnancy result in reduced infant birth weight?
    Eunhee Ha
    J Occup Environ Med 44:815-21. 2002
    ..After adjusting for potential confounders, maternal standing hours per day at work was found to be significantly associated with reduced birth weight (-17.7 g, P = 0.03)...
  44. ncbi request reprint Association of asthma with beta(2)-adrenergic receptor gene polymorphism and cigarette smoking
    Xiping Xu
    Am J Respir Crit Care Med 166:775. 2002
  45. ncbi request reprint Exposure-response relationship between paternal smoking and children's pulmonary function
    Xiping Xu
    Am J Respir Crit Care Med 166:775. 2002
  46. ncbi request reprint Asthma, rhinitis, and skin test reactivity to aeroallergens in families of asthmatic subjects in Anqing, China
    Xiping Xu
    Am J Respir Crit Care Med 166:774-5. 2002
  47. ncbi request reprint Familial aggregation of bronchodilator response: a community-based study
    Xiping Xu
    Am J Respir Crit Care Med 166:774. 2002
  48. ncbi request reprint Comparison of self-assessment of solvent exposure with measurement and professional assessment for female petrochemical workers in China
    Ye A Hu
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Am J Ind Med 41:483-9. 2002
    ..The primary objective of this paper is to examine the validity of self-assessment of solvent exposure by comparing it with professional assessment and actual measurements...
  49. ncbi request reprint [The distributive features of three kinds of metabolic genes polymorphisms in population of Han nationality in south area of China]
    Jing Shen
    School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, 210029 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19:302-7. 2002
    ..To find out the distributive features of some metabolic genes polymorphisms in Han population of south area of China...
  50. ncbi request reprint [Association between alpha-1-antichymotrypsin gene polymorphism and cerebral hemorrhage]
    Yu Fu
    Department of Neurology, Peking University Third Hospital, Beijing 100083, China
    Zhonghua Yi Xue Za Zhi 82:915-7. 2002
    ..To explore the association between alpha-1-antichymotrypsin (ACT) gene A/T polymorphism and cerebral hemorrhage among Chinese people...
  51. ncbi request reprint Preconception folate and vitamin B(6) status and clinical spontaneous abortion in Chinese women
    Alayne G Ronnenberg
    Department of Environmental Health, Program for Population Genetics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Obstet Gynecol 100:107-13. 2002
    ..To assess the association between preconception homocysteine and B vitamin status and risk of clinical spontaneous abortion in women from Anqing, China...
  52. ncbi request reprint Insertion/deletion polymorphism of the ACE gene is associated with type 2 diabetes
    Yan Feng
    Division of Endocrinology, the Third Affiliated Hospital of Beijing University, Beijing, China
    Diabetes 51:1986-8. 2002
    ..77, P = 0.03), suggesting that the DD genotype is associated with an increased susceptibility to type 2 diabetes in our study population...
  53. pmc Particulate matter, sulfur dioxide, and daily mortality in Chongqing, China
    Scott A Venners
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115 6096, USA
    Environ Health Perspect 111:562-7. 2003
    ..11-1.30). The relative risks of mortality due to cancer and other causes were insignificant on both days. The estimated effects of mean daily SO2 on cardiovascular and respiratory mortality risk remained after controlling for PM2.5...
  54. ncbi request reprint Association between polymorphism of the dopamine transporter gene and early smoking onset: an interaction risk on nicotine dependence
    Daijun Ling
    School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, PR China
    J Hum Genet 49:35-9. 2004
    ....
  55. ncbi request reprint Body mass index and serum 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane in nulliparous Chinese women
    Melissa J Perry
    Department of Environmental Health, Harvard School of Public Health, Room 1413, Building 1, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:2433-8. 2005
    ..We investigated the relationship of BMI with serum DDT/DDE accounting for other determinants of exposure among women with relatively recent environmental exposures to DDT...
  56. ncbi request reprint Preconception serum DDT and pregnancy loss: a prospective study using a biomarker of pregnancy
    Scott A Venners
    Department of Environmental Health, Harvard School of Public Health, and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Epidemiol 162:709-16. 2005
    ..In this population, there was a positive, monotonic, exposure-response association between preconception serum total DDT and the risk of subsequent early pregnancy losses...
  57. ncbi request reprint Preconception hemoglobin and ferritin concentrations are associated with pregnancy outcome in a prospective cohort of Chinese women
    Alayne G Ronnenberg
    Department of Environmental Health, Harvard School of Public Health, Boston, USA
    J Nutr 134:2586-91. 2004
    ..9, 5.7; P = 0.09) and FGR (OR: 2.7; 95% CI: 1.3, 5.6; P = 0.008). Preconception anemia, particularly iron-deficiency anemia, was associated with reduced infant growth and increased risk of adverse pregnancy outcome in Chinese women...
  58. pmc Effect of environmental tobacco smoke on levels of urinary hormone markers
    Changzhong Chen
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 113:412-7. 2005
    ..In conclusion, ETS exposure was associated with significantly lower urinary E1C levels among nonconception cycles, suggesting that the adverse reproductive effect of ETS may act partly through its antiestrogen effects...
  59. ncbi request reprint Single-nucleotide polymorphisms of the KCNS3 gene are significantly associated with airway hyperresponsiveness
    Ke Hao
    Program for Population Genetics, Harvard School of Public Health, 665 Huntington Avenue FXB 101, Boston, MA 02115, USA
    Hum Genet 116:378-83. 2005
    ..Haplotype analysis also detected significant association (P=0.006). Our findings suggest that SNPs located at the 3' downstream region of KCNS3 have a significant role in the etiology of AHR...
  60. ncbi request reprint PON1 polymorphism, diabetes mellitus, obesity, and risk of myocardial infarction: Modifying effect of diabetes mellitus and obesity on the association between PON1 polymorphism and myocardial infarction
    Jianping Li
    Program for Population Genetics, Harvard School of Public Health, Boston, Massachusetts, USA
    Genet Med 7:58-63. 2005
    ..We investigated the association between PON1 Q192R polymorphism and the risk of myocardial infarction (MI) and in particular, whether the association can be modified by diabetes mellitus (DM) and obesity...
  61. ncbi request reprint Genetic variants of the lipoprotein lipase gene and myocardial infarction in the Central Valley of Costa Rica
    Yadong Yang
    Department of Nutrition, Harvard University School of Public Health, Boston, MA, USA
    J Lipid Res 45:2106-9. 2004
    ..The X447 mutant allele of the LPL gene may protect from MI risk, although this effect is small...
  62. pmc A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men
    Yan Feng
    Program for Population Genetics, Harvard School of Public Health, Boston, MA, USA
    Am J Hum Genet 75:112-21. 2004
    ..31, P<.005) or RTQ scores (Z=-2.73, P=.006). Our findings provide strong evidence suggesting a common CHRNA4 haplotype might be protective against vulnerability to nicotine addiction in men...
  63. ncbi request reprint Paternal smoking and pregnancy loss: a prospective study using a biomarker of pregnancy
    Scott A Venners
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 159:993-1001. 2004
    ..93 (95% CI: 0.72, 1.20) and for group 3 was 0.78 (95% CI: 0.55, 1.12). The authors conclude that heavy paternal smoking increased the risk of early pregnancy loss through maternal and/or paternal exposure...
  64. ncbi request reprint A candidate gene association study on preterm delivery: application of high-throughput genotyping technology and advanced statistical methods
    Ke Hao
    Program for Population Genetics, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Mol Genet 13:683-91. 2004
    ....
  65. ncbi request reprint beta(3) Adrenergic receptor polymorphism and obesity-related phenotypes in hypertensive patients
    Ke Hao
    Institute of Biomedicine, Anhui Medical University, Hefei, China
    Obes Res 12:125-30. 2004
    ..The current study assessed the association between the W64R genotype and obesity-related phenotypes, including body weight, BMI, and serum triglycerides, cholesterol, and glucose...
  66. ncbi request reprint Power estimation of multiple SNP association test of case-control study and application
    Ke Hao
    Program for Population Genetics, Harvard School of Public Health, Boston, Massachusetts, USA
    Genet Epidemiol 26:22-30. 2004
    ..0250 by using Cochran-Armitage chi(2)s as "starting" statistics in the procedure. In the following single point analysis, SNPs on IL1RN, IL1R2, ESR1, Factor 5, and OPRM1 genes were identified as possible risk factors in PTD...
  67. pmc Bayesian haplotype inference for multiple linked single-nucleotide polymorphisms
    Tianhua Niu
    Program for Population Genetics, Harvard School of Public Health, Boston, MA, USA
    Am J Hum Genet 70:157-69. 2002
    ....

Research Grants26

  1. ORGANOPHOSPHATE PESTICIDES AND HUMAN REPRODUCTIVE HEALTH
    Xiping Xu; Fiscal Year: 2003
    ..S.; and (9) the population possesses unique characteristics for examining the proposed hypothesis, i.e., a stable workforce, a non-smoking group and excellent compliance rates. ..
  2. GENETIC EPIDIMOLOGY OF OSTEOPOROSIS
    Xiping Xu; Fiscal Year: 2005
    ..OS (Osteoporosis in Men) studies. ..
  3. POSITIONAL CANDIDATE GENE APPROACHES IN ASTHMA GENE DISC
    Xiping Xu; Fiscal Year: 2006
    ..The findings from the proposed study may lead to improved strategies for prevention, diagnosis, and treatment of this disease. (End of Abstract.) ..
  4. Establishing the Precursors of Osteoporosis in Children
    Xiping Xu; Fiscal Year: 2007
    ....
  5. Establishing the Precursors of Osteoporosis in Children
    Xiping Xu; Fiscal Year: 2009
    ....
  6. GENETICS OF AIRWAY RESPONSIVENESS AND LUNG FUNCTION
    Xiping Xu; Fiscal Year: 2001
    ....
  7. GENETICS OF HYPERTENSION AND ITS INTERMEDIATE PHENOTYPES
    Xiping Xu; Fiscal Year: 2001
    ..Thus, the genetic factors contributing to hypertension in this population may be less heterogeneous and more readily detected. ..
  8. Establishing the Precursors of Osteoporosis in Children
    Xiping Xu; Fiscal Year: 2010
    ....