Affiliation: University of Colorado Health Sciences Center
- Cholesterol domains in cationic lipid/DNA complexes improve transfectionLong Xu
School of Pharmacy, University of Colorado Denver, 4200 E Ninth Avenue, Denver, Colorado, USA
Biochim Biophys Acta 1778:2177-81. 2008..Additional studies quantifying albumin binding suggest that cholesterol domains in the lipid/DNA complex do not bind protein, and this may enable these moieties to enhance transfection by facilitating membrane fusion...
- Ligands located within a cholesterol domain enhance gene delivery to the target tissueLong Xu
School of Pharmacy, University of Colorado Denver, 12850 Montview Blvd, Aurora, CO, United States
J Control Release 160:57-63. 2012..These results demonstrate that the microenvironment of the ligand can affect gene delivery to tumors, and show that ligand-mediated delivery can be enhanced by locating targeting ligands within a cholesterol domain...
- The effect of cholesterol domains on PEGylated liposomal gene delivery in vitroLong Xu
School of Pharmacy, University of Colorado Denver, 12850 E Montview Blvd, Aurora, CO 80045, USA
Ther Deliv 2:451-60. 2011..e., within or excluded from the domain)...
- Effect of cholesterol nanodomains on the targeting of lipid-based gene delivery in cultured cellsLong Xu
School of Pharmacy, University of Colorado Denver, 12700 East 19th Avenue, Aurora, Colorado 80045, USA
Mol Pharm 7:1311-7. 2010....