Lei Xu

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint GPR56 interacts with extracellular matrix and regulates cancer progression
    Lei Xu
    Department of Biomedical Genetics, 601 Elmwood Ave, University of Rochester Medical Center, Rochester, New York 14642, USA
    Adv Exp Med Biol 706:98-108. 2010
  2. pmc GPR56 plays varying roles in endogenous cancer progression
    Lei Xu
    Howard Hughes Medical Institute and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Clin Exp Metastasis 27:241-9. 2010
  3. ncbi request reprint GPR56 Interacts with Extracellular Matrix and Regulates Cancer Progression
    Lei Xu
    Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, New York, 14642, USA
    Adv Exp Med Biol 706:98-108. 2011
  4. ncbi request reprint GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment
    Lei Xu
    Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cell Cycle 6:160-5. 2007
  5. pmc Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases
    Lei Xu
    Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, MA, USA
    Mol Cancer Res 6:760-9. 2008
  6. pmc GPR56 Regulates VEGF production and angiogenesis during melanoma progression
    Liquan Yang
    Departments of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14612, USA
    Cancer Res 71:5558-68. 2011
  7. doi request reprint GPR56 inhibits melanoma growth by internalizing and degrading its ligand TG2
    Liquan Yang
    Authors Affiliation Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York
    Cancer Res 74:1022-31. 2014
  8. doi request reprint GPR56 in cancer progression: current status and future perspective
    Liquan Yang
    Department of Biomedical Genetics, Department of Dermatology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    Future Oncol 8:431-40. 2012
  9. pmc GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis
    Lei Xu
    Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 103:9023-8. 2006
  10. pmc GPR56 is essential for testis development and male fertility in mice
    Guangchun Chen
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642, USA
    Dev Dyn 239:3358-67. 2010

Collaborators

Detail Information

Publications10

  1. ncbi request reprint GPR56 interacts with extracellular matrix and regulates cancer progression
    Lei Xu
    Department of Biomedical Genetics, 601 Elmwood Ave, University of Rochester Medical Center, Rochester, New York 14642, USA
    Adv Exp Med Biol 706:98-108. 2010
    ..This chapter will give an overview of the primary structures of the Gpr56 gene and its encoded protein and attempt to point out open questions in this research area, with an emphasis on its roles in cancer and signal transduction...
  2. pmc GPR56 plays varying roles in endogenous cancer progression
    Lei Xu
    Howard Hughes Medical Institute and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Clin Exp Metastasis 27:241-9. 2010
    ..These results indicate diverse roles of GPR56 in cancer progression and provide the first genetic evidence for the involvement of an adhesion GPCR in endogenous cancer development...
  3. ncbi request reprint GPR56 Interacts with Extracellular Matrix and Regulates Cancer Progression
    Lei Xu
    Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, New York, 14642, USA
    Adv Exp Med Biol 706:98-108. 2011
    ..This chapter will give an overview of the primary structures of the Gpr56 gene and its encoded protein and attempt to point out open questions in this research area, with an emphasis on its roles in cancer and signal transduction...
  4. ncbi request reprint GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment
    Lei Xu
    Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cell Cycle 6:160-5. 2007
    ..The highly metastatic cells may escape from this inhibition by down-regulation of GPR56. Much future work will be needed to test this hypothesis and further our understanding of metastasis in general...
  5. pmc Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases
    Lei Xu
    Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, MA, USA
    Mol Cancer Res 6:760-9. 2008
    ..Many genes encoding secreted and membrane proteins are included in the signature, suggesting the importance of tumor-microenvironment interactions during metastasis...
  6. pmc GPR56 Regulates VEGF production and angiogenesis during melanoma progression
    Liquan Yang
    Departments of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14612, USA
    Cancer Res 71:5558-68. 2011
    ..We propose that components of the GPR56-mediated signaling pathway may serve as new targets for antiangiogenic treatment of melanoma...
  7. doi request reprint GPR56 inhibits melanoma growth by internalizing and degrading its ligand TG2
    Liquan Yang
    Authors Affiliation Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York
    Cancer Res 74:1022-31. 2014
    ..The uncovered antagonistic relationship between GPR56 and TG2 proposes a mechanism by which ECM accumulation/crosslinking in tumors may be reversed, and thus could have therapeutic potential for cancer control and treatment...
  8. doi request reprint GPR56 in cancer progression: current status and future perspective
    Liquan Yang
    Department of Biomedical Genetics, Department of Dermatology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    Future Oncol 8:431-40. 2012
    ..Tissue transglutaminase plays pleiotropic roles in cancer progression. Whether and how it might mediate GPR56-regulated cancer progression awaits further investigation...
  9. pmc GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis
    Lei Xu
    Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 103:9023-8. 2006
    ..We discuss the mechanisms whereby GPR56-TG2 interactions may suppress tumor growth and metastasis...
  10. pmc GPR56 is essential for testis development and male fertility in mice
    Guangchun Chen
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642, USA
    Dev Dyn 239:3358-67. 2010
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