Lan Xu

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus
    Lan Xu
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell 10:271-82. 2002
  2. ncbi request reprint Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import
    Lan Xu
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Biol Chem 278:42569-77. 2003
  3. pmc Mechanism and regulation of nucleocytoplasmic trafficking of smad
    Xiaochu Chen
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA USA
    Cell Biosci 1:40. 2011
  4. pmc Regulation of Smad activities
    Lan Xu
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Rm 308, Worcester, MA 01605, USA
    Biochim Biophys Acta 1759:503-13. 2006
  5. pmc Specific nucleoporin requirement for Smad nuclear translocation
    Xiaochu Chen
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Mol Cell Biol 30:4022-34. 2010
  6. ncbi request reprint Nucleocytoplasmic shuttling of signal transducers
    Lan Xu
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Rev Mol Cell Biol 5:209-19. 2004
  7. pmc Msk is required for nuclear import of TGF-{beta}/BMP-activated Smads
    Lan Xu
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 178:981-94. 2007
  8. pmc Preferential utilization of Imp7/8 in nuclear import of Smads
    Xiaohao Yao
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 283:22867-74. 2008
  9. pmc Smad inhibition by the Ste20 kinase Misshapen
    Satoshi Kaneko
    Program in Molecular Medicine and Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 108:11127-32. 2011
  10. pmc Identification of phosphatases for Smad in the BMP/DPP pathway
    Hong B Chen
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 20:648-53. 2006

Research Grants

Collaborators

  • Lihua J Zhu
  • Junhao Mao
  • Satoshi Kaneko
  • Y Ip
  • Joan Massague
  • Brian C Lewis
  • Erdjan Salih
  • Xiaochu Chen
  • Qing Zhang
  • Mihir Rajurkar
  • Charisa L Cottonham
  • Xiaohao Yao
  • Jinxi Wang
  • Hong B Chen
  • Hong Bing Chen
  • Shu Yun Zhou
  • Sai Juan Chen
  • Xiao Li Liu
  • Chao Niu
  • Jennifer L Cotton
  • Wilfredo E De Jesus-Monge
  • Karl Simin
  • Andrew P McMahon
  • David S Klimstra
  • Victoria A Appleman
  • David R Driscoll
  • He Huang
  • Charisa Cottonham
  • Xuesong Gu
  • Jochen G Hofstaetter
  • Hai Yan Zhou
  • Marie Torres
  • Jiali Shen
  • Livius Wunderlich
  • Melvin J Glimcher
  • Jonathan G Rud
  • Kai Lin

Detail Information

Publications16

  1. ncbi request reprint Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus
    Lan Xu
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell 10:271-82. 2002
    ..Thus, by directly contacting the nuclear pore complex, Smad2 undergoes constant shuttling, providing a dynamic pool that is competitively drawn by cytoplasmic and nuclear signal transduction partners...
  2. ncbi request reprint Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import
    Lan Xu
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Biol Chem 278:42569-77. 2003
    ....
  3. pmc Mechanism and regulation of nucleocytoplasmic trafficking of smad
    Xiaochu Chen
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA USA
    Cell Biosci 1:40. 2011
    ..In this review we will discuss the current understanding of the molecular machinery responsible for nuclear import and export of Smads...
  4. pmc Regulation of Smad activities
    Lan Xu
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Rm 308, Worcester, MA 01605, USA
    Biochim Biophys Acta 1759:503-13. 2006
    ..With recent advance in the knowledge of regulatory factors impinged on Smads, we are beginning to understand the complexity in cellular responses to TGF-beta...
  5. pmc Specific nucleoporin requirement for Smad nuclear translocation
    Xiaochu Chen
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Mol Cell Biol 30:4022-34. 2010
    ..Thus, we have delineated the nucleoporin requirement of MAD nuclear import, reflecting a unique trans-NPC mechanism...
  6. ncbi request reprint Nucleocytoplasmic shuttling of signal transducers
    Lan Xu
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Rev Mol Cell Biol 5:209-19. 2004
  7. pmc Msk is required for nuclear import of TGF-{beta}/BMP-activated Smads
    Lan Xu
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 178:981-94. 2007
    ..We have thus identified new evolutionarily conserved proteins that are important in the signal transduction of TGF-beta and BMP into the nucleus...
  8. pmc Preferential utilization of Imp7/8 in nuclear import of Smads
    Xiaohao Yao
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 283:22867-74. 2008
    ..These observations suggest selective involvement of Imp8/Msk in nuclear import of different Smads under different conditions...
  9. pmc Smad inhibition by the Ste20 kinase Misshapen
    Satoshi Kaneko
    Program in Molecular Medicine and Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 108:11127-32. 2011
    ..Our findings thus reveal a function of Msn independent of its impact on MAP kinase cascades. This Smad inhibition mechanism by Msn likely has important implications for development and disease...
  10. pmc Identification of phosphatases for Smad in the BMP/DPP pathway
    Hong B Chen
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 20:648-53. 2006
    ..We show that the mammalian PDPs are important in dephosphorylation of BMP-activated Smad1 but not TGF-beta-activated Smad2 or Smad3. Thus, PDPs specifically inactivate Smads in the BMP/DPP pathway...
  11. ncbi request reprint Nuclear targeting of transforming growth factor-beta-activated Smad complexes
    Hong Bing Chen
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 280:21329-36. 2005
    ..Indeed tumorigenic mutations in Smad4 that affect its interaction with Smad2 or Smad3 impair nuclear accumulation of Smad4 in response to TGF-beta...
  12. pmc The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis
    Mihir Rajurkar
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 109:E1038-47. 2012
    ....
  13. pmc miR-21 and miR-31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells
    Charisa L Cottonham
    University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 285:35293-302. 2010
    ..Therefore, we have uncovered miR-21 and miR-31 as downstream effectors of TGF-β in facilitating invasion and metastasis of colon carcinoma cells...
  14. ncbi request reprint Site-specific in vivo calcification and osteogenesis stimulated by bone sialoprotein
    Jinxi Wang
    Laboratory for the Study of Skeletal Disorders and Rehabilitation, Department of Orthopedic Surgery, Harvard Medical School, Children s Hospital, Boston, MA 02115, USA
    Calcif Tissue Int 79:179-89. 2006
    ..These results demonstrate that BSP stimulates calcification and osteogenesis in a site-specific manner, and that local environment and the specificities of responding cells may play critical roles in the function of BSP in vivo...
  15. ncbi request reprint [Influence of irradiation on the dynamic three-dimension distribution of abl and bcr genes in the interphase nuclei of IM-9 cell]
    Qing Zhang
    Department of Hematology, Nanfang Hospital, The First Military Medical University, Guangzhou 510515, China
    Zhonghua Xue Ye Xue Za Zhi 24:144-8. 2003
    ..To investigate the material foundation of the fusion of bcr and abl genes, and to explore the pathogenesis of chronic myeloid leukemia...
  16. ncbi request reprint [Role of the three-dimensional distribution of abl and bcr genes in the formation of bcr/abl fusion gene in interphase neucleus]
    Qing Zhang
    Department of Hematology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 22:197-9. 2002
    ..To explore the mechanism of bcr/abl fusion gene formation in view of its biological stereology...

Research Grants8

  1. Nucleocytoplasmic Trafficking of Smads
    Lan Xu; Fiscal Year: 2007
    ..These regulators of subcellular localization of Smad may serve as potential targets for therapeutic interventions aimed at modulating TGF-beta signaling in treatment of diseases such as cancer. ..
  2. Nucleocytoplasmic Trafficking of Smads
    Lan Xu; Fiscal Year: 2007
    ..These regulators of subcellular localization potential targets for therapeutic interventions aimed at modulating TGF-beta signaling diseases such as cancer. ..