Haodong Xu

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi High-grade neuroendocrine carcinomas of the lung express K homology domain containing protein overexpressed in cancer but carcinoid tumors do not
    Haodong Xu
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Pathol 38:555-63. 2007
  2. doi Diagnostic utility of IMP3 in segregating metastatic melanoma from benign nevi in lymph nodes
    Mark J Mentrikoski
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mod Pathol 22:1582-7. 2009
  3. doi Merkel cell carcinoma expresses K homology domain-containing protein overexpressed in cancer similar to other high-grade neuroendocrine carcinomas
    Jennifer G Pryor
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Hum Pathol 40:238-43. 2009
  4. doi Combination of napsin A and TTF-1 immunohistochemistry helps in differentiating primary lung adenocarcinoma from metastatic carcinoma in the lung
    Jiqing Ye
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Appl Immunohistochem Mol Morphol 19:313-7. 2011
  5. doi IMP3 expression is correlated with histologic grade of lung adenocarcinoma
    Jennifer J Findeis-Hosey
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Pathol 41:477-84. 2010
  6. doi S100P, von Hippel-Lindau gene product, and IMP3 serve as a useful immunohistochemical panel in the diagnosis of adenocarcinoma on endoscopic bile duct biopsy
    Mary Levy
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Pathol 41:1210-9. 2010
  7. doi CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickers
    Rochelle A Simon
    Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Pathol 40:252-8. 2009
  8. doi IMP3, NESP55, TTF-1 and CDX2 serve as an immunohistochemical panel in the distinction among small-cell carcinoma, gastrointestinal carcinoid, and pancreatic endocrine tumor metastasized to the liver
    Kristopher S Denby
    Department of Dermatology, University of Rochester Medical Center, NY, USA
    Appl Immunohistochem Mol Morphol 20:573-9. 2012
  9. doi High-grade neuroendocrine carcinomas of the lung highly express enhancer of zeste homolog 2, but carcinoids do not
    Jennifer J Findeis-Hosey
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Pathol 42:867-72. 2011
  10. doi Unusual features of malignant pleural mesothelioma metastatic to the mediastinal lymph nodes
    David Wagner
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Appl Immunohistochem Mol Morphol 16:301-7. 2008

Research Grants

Collaborators

Detail Information

Publications40

  1. ncbi High-grade neuroendocrine carcinomas of the lung express K homology domain containing protein overexpressed in cancer but carcinoid tumors do not
    Haodong Xu
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Pathol 38:555-63. 2007
    ..Our findings of equivalent IGF-II expression in KOC-positive SCLC and LCNEC and KOC-negative carcinoid tumors suggest different regulatory mechanisms involved in the control of IGF-II expression in these tumors...
  2. doi Diagnostic utility of IMP3 in segregating metastatic melanoma from benign nevi in lymph nodes
    Mark J Mentrikoski
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mod Pathol 22:1582-7. 2009
    ....
  3. doi Merkel cell carcinoma expresses K homology domain-containing protein overexpressed in cancer similar to other high-grade neuroendocrine carcinomas
    Jennifer G Pryor
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Hum Pathol 40:238-43. 2009
    ....
  4. doi Combination of napsin A and TTF-1 immunohistochemistry helps in differentiating primary lung adenocarcinoma from metastatic carcinoma in the lung
    Jiqing Ye
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Appl Immunohistochem Mol Morphol 19:313-7. 2011
    ....
  5. doi IMP3 expression is correlated with histologic grade of lung adenocarcinoma
    Jennifer J Findeis-Hosey
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Pathol 41:477-84. 2010
    ..The higher frequency of expression in moderately/poorly differentiated adenocarcinomas suggests that insulin-like growth factor II mRNA binding protein 3 expression may be associated with an aggressive biological behavior...
  6. doi S100P, von Hippel-Lindau gene product, and IMP3 serve as a useful immunohistochemical panel in the diagnosis of adenocarcinoma on endoscopic bile duct biopsy
    Mary Levy
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Pathol 41:1210-9. 2010
    ....
  7. doi CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickers
    Rochelle A Simon
    Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Pathol 40:252-8. 2009
    ....
  8. doi IMP3, NESP55, TTF-1 and CDX2 serve as an immunohistochemical panel in the distinction among small-cell carcinoma, gastrointestinal carcinoid, and pancreatic endocrine tumor metastasized to the liver
    Kristopher S Denby
    Department of Dermatology, University of Rochester Medical Center, NY, USA
    Appl Immunohistochem Mol Morphol 20:573-9. 2012
    ..No NESP55 immunoreactivity was detected in metastatic SCCs and GICTs. In conclusion, a panel of these 4 markers is useful in segregating among SCC, PET, and GICT to help determine the primary site of hepatic metastasis...
  9. doi High-grade neuroendocrine carcinomas of the lung highly express enhancer of zeste homolog 2, but carcinoids do not
    Jennifer J Findeis-Hosey
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Pathol 42:867-72. 2011
    ....
  10. doi Unusual features of malignant pleural mesothelioma metastatic to the mediastinal lymph nodes
    David Wagner
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Appl Immunohistochem Mol Morphol 16:301-7. 2008
    ..Caution should be used when diagnosing mesothelial cell inclusions in MLNs...
  11. doi IMP-3 is a novel progression marker in malignant melanoma
    Jennifer G Pryor
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Mod Pathol 21:431-7. 2008
    ..Additionally, IMP-3 may have diagnostic utility in distinguishing melanoma from benign nevic cells, dysplastic nevi, and Spitz nevi...
  12. doi Use of IMP3, S100P, and pVHL immunopanel to aid in the interpretation of bile duct biopsies with atypical histology or suspicious for malignancy
    Michael T Schmidt
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Appl Immunohistochem Mol Morphol 20:478-87. 2012
    ..However, caution should be exercised when using this immunopanel in the interpretation of challenging bile duct biopsies, because S100P and pVHL stains may give rise to variable patterns that can be difficult to interpret...
  13. ncbi Utility of anti-L523S antibody in the diagnosis of benign and malignant serous effusions
    Krisztina Z Hanley
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Cancer 114:49-56. 2008
    ..Using a mouse monoclonal antibody (L523S) against KOC, KOC expression was investigated in malignant tumors and reactive mesothelial cells in serous effusions...
  14. ncbi Extrapulmonary small cell carcinomas express K homology domain containing protein overexpressed in cancer, but carcinoid tumors do not
    Rochelle Simon
    Department of Pathology and Laboratory Medicine, PO Box 626, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Pathol 38:1178-83. 2007
    ....
  15. doi Value of D2-40 in the differential diagnosis of pleural neoplasms with emphasis on its positivity in solitary fibrous tumor
    Yingchuan Hu
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Appl Immunohistochem Mol Morphol 18:411-3. 2010
    ....
  16. pmc Canonical Wnt/β-catenin signaling in epicardial fibrosis of failed pediatric heart allografts with diastolic dysfunction
    Bo Ye
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cardiovasc Pathol 22:54-7. 2013
    ..In this study, we tested the hypothesis that canonical Wnt/β-catenin signaling is activated in epicardial fibrosis of end-stage dysfunctional pediatric allografts...
  17. doi Small neuroendocrine lesions in intrathoracic lymph nodes of patients with primary lung adenocarcinoma: real metastasis?
    Faqian Li
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NC, USA
    Am J Surg Pathol 34:1701-7. 2010
    ..These findings suggest that neuroendocrine lesion can be incidentally identified in ILNs. Close clinical follow-up is warranted as metastasis from or synchronous lesions in adjacent organs cannot be excluded...
  18. ncbi Coexpression of c-kit and bcl-2 in small cell carcinoma and large cell neuroendocrine carcinoma of the lung
    Randi J A LaPoint
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Elmwood 601, Rochester, NY 14642, USA
    Appl Immunohistochem Mol Morphol 15:401-6. 2007
    ..Therapeutic targeting on both c-kit and bcl-2 molecules might be beneficial in the management of patients with high grade neuroendocrine carcinomas of the lung in the future...
  19. doi Expression of RNA-binding protein IMP3 (KOC) in benign urothelium and urothelial tumors
    Lin Li
    Department of Pathology, University of Rochester Medical Center, Box 626, Rochester, NY 14642, USA
    Hum Pathol 39:1205-11. 2008
    ..Immunohistochemical detection of the combined expression of IMP3 and p53 is useful in the diagnosis of high-grade urothelial tumors, particularly in small, superficial materials...
  20. pmc High frequency of coexpression of maspin with p63 and p53 in squamous cell carcinoma but not in adenocarcinoma of the lung
    Bonnie Choy
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center Rochester, NY 14642, USA
    Int J Clin Exp Pathol 6:2542-7. 2013
    ..Therapeutic targeting on maspin, p63 and p53 molecules might be beneficial in the management of patients with squamous cell carcinomas of the lung in the future. ..
  21. doi MUC16 expression and risk of adenocarcinoma metastases to peritoneum, pleura, leptomeninges, and brain
    Mahlon D Johnson
    Department of Pathology, Division of Neuropathology, University of Rochester Medical Center, Rochester, NY 14623, USA
    Appl Immunohistochem Mol Morphol 18:250-3. 2010
    ..Our findings suggest that adenocarcinomas with MUC16 expression may have an increased risk for metastases to pleura/peritoneum but not the leptomeninges or brain...
  22. doi The use of insulin like-growth factor II messenger RNA binding protein-3 in diagnostic pathology
    Jennifer J Findeis-Hosey
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Pathol 42:303-14. 2011
    ....
  23. ncbi Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loop
    Chen Yan
    Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circ Res 100:510-9. 2007
    ..These data suggest a new therapeutic paradigm for end stage of heart failure by inhibiting the PDE3A/ICER feedback loop via activating ERK5...
  24. doi Smoothelin expression in the gastrointestinal tract: implication in colonic inertia
    Owen T M Chan
    Department of Pathology and Laboratory Medicine Gastrointestinal Motility Program, Division of Gastroenterology, Cedars Sinai Medical Center Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA Department of Anatomical Pathology, Cleveland Clinic Foundation, Cleveland, OH Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY Department of Pathology, University of Chicago Hospitals, Chicago, IL
    Appl Immunohistochem Mol Morphol 21:452-9. 2013
    ..The data demonstrate that smoothelin is differentially expressed in the MP and MM of the normal GI tract and suggest that defective smoothelin expression may play a role in the pathogenesis of colonic inertia in a subset of patients. ..
  25. doi Pulmonary metastases from uterine neoplasms after long tumour-free interval: four cases and review of the literature
    Hiroshi Miyamoto
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Pathology 41:234-41. 2009
    ..Uncommon cases of lung metastasis from different types of uterine neoplasms with a long tumour-free interval after hysterectomy are reported...
  26. ncbi Ectopic (mediastinal) parathyroid adenoma with prominent lymphocytic infiltration
    Enzo Fallone
    Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Appl Immunohistochem Mol Morphol 17:82-4. 2009
    ..Immunohistochemical studies were important in making such a diagnosis...
  27. doi Epigenetic modifications of histone h4 in lung neuroendocrine tumors
    Faqian Li
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, NY, USA
    Appl Immunohistochem Mol Morphol 19:389-94. 2011
    ..These histone modifications may serve as tumor biomarkers that may aid in diagnosis and prediction of clinical outcome...
  28. pmc Reactive oxygen species suppress cardiac NaV1.5 expression through Foxo1
    Weike Mao
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
    PLoS ONE 7:e32738. 2012
    ..These studies indicate that Foxo1 negatively regulates Na(V)1.5 expression in cardiomyocytes and reactive oxygen species suppress Na(V)1.5 expression through Foxo1...
  29. pmc Yin yang 1 is a novel regulator of pulmonary fibrosis
    Xin Lin
    Department of Medicine, University of Rochester Medical School, Rochester, New York 14642, USA
    Am J Respir Crit Care Med 183:1689-97. 2011
    ..The transcription factor Yin Yang 1 (YY1) plays a role in the proliferation and differentiation of diverse cell types, but its role in fibrotic lung diseases is not known...
  30. doi Malignant solitary fibrous tumor: report of 3 cases with unusual features
    Yingchuan Hu
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medical Center, Rochester, NY 14642, USA
    Appl Immunohistochem Mol Morphol 17:451-7. 2009
    ..The histopathologic diagnostic criteria for MSFT, the differential diagnosis with other spindle cell tumors, and the mechanism of MSFT-derived hypoglycemia via insulin-like growth factor-II are discussed...
  31. pmc Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity
    Zhibo Lu
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circ Res 103:269-78. 2008
    ..These findings indicate that p90RSK activation is critical for reactive oxygen species-mediated inhibition of voltage-gated K+ channel activity and leads to prolongation of cardiac repolarization...
  32. pmc A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis
    Bo Ding
    Cardiovascular Research Institute, Department of Pathology, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 102:14771-6. 2005
    ..Our findings may provide a therapeutic paradigm to prevent cardiomyocyte apoptosis and the progression of heart failure by inhibiting the PDE3A-ICER feedback loop...
  33. doi Expression of MACC1 and MET in inflammatory bowel disease-associated colonic neoplasia
    Noam Harpaz
    Department of Pathology, Mount Sinai Medical Center, New York, New York Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York and Department of Pathology and Laboratory Medicine, UCLA Center for the Health Science, Los Angeles, California
    Inflamm Bowel Dis 20:703-11. 2014
    ..For the first time, we evaluated the expressions of MACC1 and MET in IBD-associated colitis, dysplasia, and adenocarcinoma...
  34. doi Erk/MAP kinase signaling pathway and neuroendocrine differentiation of non-small-cell lung cancer
    Yuhchyau Chen
    Department of Radiation Oncology, University of Rochester Medical Center, James P Wilmot Cancer Center, Rochester, New York Department of Pathology and Laboratory Medicine, Institute of Molecular Medicine, University of California, Los Angeles, California and Department of Pathology and Laboratory Medicine, University of Rochester Medical Center Rochester, New York
    J Thorac Oncol 9:50-8. 2014
    ..Although distinct clinical features and histology of SCLC and carcinoid tumors are well recognized, the clinical significance and the molecular basis of NED in NSCLC remain unclear...
  35. pmc Expression of glypican-3 in undifferentiated embryonal sarcoma and mesenchymal hamartoma of the liver
    Mary Levy
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Pathol 43:695-701. 2012
    ..Caution should thus be exercised when evaluating a GPC3-expressing hepatic neoplasm, particularly on a needle biopsy when the differential diagnosis includes poorly differentiated hepatocellular carcinoma or hepatoblastoma...
  36. doi Malignant pleural mesothelioma with osseous metastases and pathologic fracture of femoral neck
    Todd Lester
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Appl Immunohistochem Mol Morphol 16:507-9. 2008
    ..This is a case report of malignant pleural mesothelioma metastatic to the femur with a pathologic fracture of femoral neck...
  37. pmc Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy
    Clint L Miller
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Circ Res 105:956-64. 2009
    ..Ca(2+)/calmodulin (CaM)-activated cGMP-hydrolyzing PDE1 family may play a pivotal role in balancing intracellular Ca(2+)/CaM and cGMP signaling; however, its function in cardiomyocytes is unknown...
  38. ncbi Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction
    Weinong Guo
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
    Circ Res 97:1342-50. 2005
    ..Taken together, these findings demonstrate not only an essential role for Kv4.2 in the generation of mouse ventricular I(to,f) channels but also that the loss of I(to,f) per se does not have overt pathophysiological consequences...
  39. ncbi Metachronous squamous cell carcinomas evolving from independent oropharyngeal and pulmonary squamous papillomas: association with human papillomavirus 11 and lack of aberrant p53, Rb, and p16 protein expression
    Haodong Xu
    Lauren V Ackerman Laboratory of Surgical Pathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Hum Pathol 35:1419-22. 2004
    ..These observations indicate that human papillomavirus 11-associated neoplastic transformation and tumor progression in the respiratory tract may not involve aberrant regulation of the p53 and Rb signaling pathways...
  40. ncbi Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy
    Hsiu Chiang Chiu
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 96:225-33. 2005
    ..Moreover, the MHC-FATP model supports a role for FATPs in FFA import into the heart in vivo...

Research Grants2

  1. Role of Modulation of Ito,f by Kinases in Cardiac Dysrhythmias
    Haodong Xu; Fiscal Year: 2007
    ..The results of these studies will enhance our knowledge of the molecular basis of these abnormalities and could lead to development of new therapies for their treatment and/or prevention. (End of Abstract) ..