Research Topics
Genomes and Genes | Haodong XuSummaryAffiliation: University of Rochester Country: USA Publications
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Publications
High-grade neuroendocrine carcinomas of the lung express K homology domain containing protein overexpressed in cancer but carcinoid tumors do notHaodong Xu
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Hum Pathol 38:555-63. 2007..Our findings of equivalent IGF-II expression in KOC-positive SCLC and LCNEC and KOC-negative carcinoid tumors suggest different regulatory mechanisms involved in the control of IGF-II expression in these tumors...
Diagnostic utility of IMP3 in segregating metastatic melanoma from benign nevi in lymph nodesMark J Mentrikoski
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Mod Pathol 22:1582-7. 2009....- Merkel cell carcinoma expresses K homology domain-containing protein overexpressed in cancer similar to other high-grade neuroendocrine carcinomasJennifer G Pryor
Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Hum Pathol 40:238-43. 2009.... - IMP3 expression is correlated with histologic grade of lung adenocarcinomaJennifer J Findeis-Hosey
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Hum Pathol 41:477-84. 2010..The higher frequency of expression in moderately/poorly differentiated adenocarcinomas suggests that insulin-like growth factor II mRNA binding protein 3 expression may be associated with an aggressive biological behavior... - Combination of napsin A and TTF-1 immunohistochemistry helps in differentiating primary lung adenocarcinoma from metastatic carcinoma in the lungJiqing Ye
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Appl Immunohistochem Mol Morphol 19:313-7. 2011.... - CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickersRochelle A Simon
Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
Hum Pathol 40:252-8. 2009.... - High-grade neuroendocrine carcinomas of the lung highly express enhancer of zeste homolog 2, but carcinoids do notJennifer J Findeis-Hosey
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Hum Pathol 42:867-72. 2011.... - Unusual features of malignant pleural mesothelioma metastatic to the mediastinal lymph nodesDavid Wagner
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Appl Immunohistochem Mol Morphol 16:301-7. 2008..Caution should be used when diagnosing mesothelial cell inclusions in MLNs... - IMP-3 is a novel progression marker in malignant melanomaJennifer G Pryor
Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Mod Pathol 21:431-7. 2008..Additionally, IMP-3 may have diagnostic utility in distinguishing melanoma from benign nevic cells, dysplastic nevi, and Spitz nevi... - S100P, von Hippel-Lindau gene product, and IMP3 serve as a useful immunohistochemical panel in the diagnosis of adenocarcinoma on endoscopic bile duct biopsyMary Levy
Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Hum Pathol 41:1210-9. 2010.... - Use of IMP3, S100P, and pVHL immunopanel to aid in the interpretation of bile duct biopsies with atypical histology or suspicious for malignancyMichael T Schmidt
Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
Appl Immunohistochem Mol Morphol 20:478-87. 2012..However, caution should be exercised when using this immunopanel in the interpretation of challenging bile duct biopsies, because S100P and pVHL stains may give rise to variable patterns that can be difficult to interpret... - Extrapulmonary small cell carcinomas express K homology domain containing protein overexpressed in cancer, but carcinoid tumors do notRochelle Simon
Department of Pathology and Laboratory Medicine, PO Box 626, University of Rochester Medical Center, Rochester, NY 14642, USA
Hum Pathol 38:1178-83. 2007.... - Value of D2-40 in the differential diagnosis of pleural neoplasms with emphasis on its positivity in solitary fibrous tumorYingchuan Hu
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Appl Immunohistochem Mol Morphol 18:411-3. 2010.... - Utility of anti-L523S antibody in the diagnosis of benign and malignant serous effusionsKrisztina Z Hanley
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
Cancer 114:49-56. 2008..Using a mouse monoclonal antibody (L523S) against KOC, KOC expression was investigated in malignant tumors and reactive mesothelial cells in serous effusions... - Expression of RNA-binding protein IMP3 (KOC) in benign urothelium and urothelial tumorsLin Li
Department of Pathology, University of Rochester Medical Center, Box 626, Rochester, NY 14642, USA
Hum Pathol 39:1205-11. 2008..Immunohistochemical detection of the combined expression of IMP3 and p53 is useful in the diagnosis of high-grade urothelial tumors, particularly in small, superficial materials... - Coexpression of c-kit and bcl-2 in small cell carcinoma and large cell neuroendocrine carcinoma of the lungRandi J A LaPoint
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Elmwood 601, Rochester, NY 14642, USA
Appl Immunohistochem Mol Morphol 15:401-6. 2007..Therapeutic targeting on both c-kit and bcl-2 molecules might be beneficial in the management of patients with high grade neuroendocrine carcinomas of the lung in the future... - Small neuroendocrine lesions in intrathoracic lymph nodes of patients with primary lung adenocarcinoma: real metastasis?Faqian Li
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NC, USA
Am J Surg Pathol 34:1701-7. 2010..These findings suggest that neuroendocrine lesion can be incidentally identified in ILNs. Close clinical follow-up is warranted as metastasis from or synchronous lesions in adjacent organs cannot be excluded... 
Canonical Wnt/β-catenin signaling in epicardial fibrosis of failed pediatric heart allografts with diastolic dysfunctionBo Ye
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Cardiovasc Pathol 22:54-7. 2013..In this study, we tested the hypothesis that canonical Wnt/β-catenin signaling is activated in epicardial fibrosis of end-stage dysfunctional pediatric allografts...- MUC16 expression and risk of adenocarcinoma metastases to peritoneum, pleura, leptomeninges, and brainMahlon D Johnson
Department of Pathology, Division of Neuropathology, University of Rochester Medical Center, Rochester, NY 14623, USA
Appl Immunohistochem Mol Morphol 18:250-3. 2010..Our findings suggest that adenocarcinomas with MUC16 expression may have an increased risk for metastases to pleura/peritoneum but not the leptomeninges or brain... - The use of insulin like-growth factor II messenger RNA binding protein-3 in diagnostic pathologyJennifer J Findeis-Hosey
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Hum Pathol 42:303-14. 2011.... - Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loopChen Yan
Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Circ Res 100:510-9. 2007..These data suggest a new therapeutic paradigm for end stage of heart failure by inhibiting the PDE3A/ICER feedback loop via activating ERK5... - Pulmonary metastases from uterine neoplasms after long tumour-free interval: four cases and review of the literatureHiroshi Miyamoto
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
Pathology 41:234-41. 2009..Uncommon cases of lung metastasis from different types of uterine neoplasms with a long tumour-free interval after hysterectomy are reported... - Ectopic (mediastinal) parathyroid adenoma with prominent lymphocytic infiltrationEnzo Fallone
Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
Appl Immunohistochem Mol Morphol 17:82-4. 2009..Immunohistochemical studies were important in making such a diagnosis... - IMP3, NESP55, TTF-1 and CDX2 serve as an immunohistochemical panel in the distinction among small-cell carcinoma, gastrointestinal carcinoid, and pancreatic endocrine tumor metastasized to the liverKristopher S Denby
Department of Dermatology, University of Rochester Medical Center, NY, USA
Appl Immunohistochem Mol Morphol 20:573-9. 2012..No NESP55 immunoreactivity was detected in metastatic SCCs and GICTs. In conclusion, a panel of these 4 markers is useful in segregating among SCC, PET, and GICT to help determine the primary site of hepatic metastasis... - Reactive oxygen species suppress cardiac NaV1.5 expression through Foxo1Weike Mao
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
PLoS ONE 7:e32738. 2012..These studies indicate that Foxo1 negatively regulates Na(V)1.5 expression in cardiomyocytes and reactive oxygen species suppress Na(V)1.5 expression through Foxo1... - Epigenetic modifications of histone h4 in lung neuroendocrine tumorsFaqian Li
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, NY, USA
Appl Immunohistochem Mol Morphol 19:389-94. 2011..These histone modifications may serve as tumor biomarkers that may aid in diagnosis and prediction of clinical outcome... - Yin yang 1 is a novel regulator of pulmonary fibrosisXin Lin
Department of Medicine, University of Rochester Medical School, Rochester, New York 14642, USA
Am J Respir Crit Care Med 183:1689-97. 2011..The transcription factor Yin Yang 1 (YY1) plays a role in the proliferation and differentiation of diverse cell types, but its role in fibrotic lung diseases is not known... - Malignant solitary fibrous tumor: report of 3 cases with unusual featuresYingchuan Hu
Department of Pathology and Laboratory Medicine, University of Rochester School of Medical Center, Rochester, NY 14642, USA
Appl Immunohistochem Mol Morphol 17:451-7. 2009..The histopathologic diagnostic criteria for MSFT, the differential diagnosis with other spindle cell tumors, and the mechanism of MSFT-derived hypoglycemia via insulin-like growth factor-II are discussed... - Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activityZhibo Lu
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Circ Res 103:269-78. 2008..These findings indicate that p90RSK activation is critical for reactive oxygen species-mediated inhibition of voltage-gated K+ channel activity and leads to prolongation of cardiac repolarization... - A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosisBo Ding
Cardiovascular Research Institute, Department of Pathology, University of Rochester, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 102:14771-6. 2005..Our findings may provide a therapeutic paradigm to prevent cardiomyocyte apoptosis and the progression of heart failure by inhibiting the PDE3A-ICER feedback loop... - Expression of glypican-3 in undifferentiated embryonal sarcoma and mesenchymal hamartoma of the liverMary Levy
Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Hum Pathol 43:695-701. 2012..Caution should thus be exercised when evaluating a GPC3-expressing hepatic neoplasm, particularly on a needle biopsy when the differential diagnosis includes poorly differentiated hepatocellular carcinoma or hepatoblastoma... - Malignant pleural mesothelioma with osseous metastases and pathologic fracture of femoral neckTodd Lester
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Appl Immunohistochem Mol Morphol 16:507-9. 2008..This is a case report of malignant pleural mesothelioma metastatic to the femur with a pathologic fracture of femoral neck... - Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophyClint L Miller
Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
Circ Res 105:956-64. 2009..Ca(2+)/calmodulin (CaM)-activated cGMP-hydrolyzing PDE1 family may play a pivotal role in balancing intracellular Ca(2+)/CaM and cGMP signaling; however, its function in cardiomyocytes is unknown... - Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunctionWeinong Guo
Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
Circ Res 97:1342-50. 2005..Taken together, these findings demonstrate not only an essential role for Kv4.2 in the generation of mouse ventricular I(to,f) channels but also that the loss of I(to,f) per se does not have overt pathophysiological consequences... - Metachronous squamous cell carcinomas evolving from independent oropharyngeal and pulmonary squamous papillomas: association with human papillomavirus 11 and lack of aberrant p53, Rb, and p16 protein expressionHaodong Xu
Lauren V. Ackerman Laboratory of Surgical Pathology, Washington University School of Medicine, St. Louis, MO 63110-1093, USA
Hum Pathol 35:1419-22. 2004..These observations indicate that human papillomavirus 11-associated neoplastic transformation and tumor progression in the respiratory tract may not involve aberrant regulation of the p53 and Rb signaling pathways... - Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathyHsiu Chiang Chiu
Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
Circ Res 96:225-33. 2005..Moreover, the MHC-FATP model supports a role for FATPs in FFA import into the heart in vivo...
Research Grants
- Role of Modulation of Ito,f by Kinases in Cardiac DysrhythmiasHaodong Xu; Fiscal Year: 2007..The results of these studies will enhance our knowledge of the molecular basis of these abnormalities and could lead to development of new therapies for their treatment and/or prevention. (End of Abstract) ..