Bin Xu

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesis
    Bin Xu
    Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48109 5678, USA
    Mol Cell Biol 29:1719-34. 2009
  2. ncbi Multiple roles for the non-coding RNA SRA in regulation of adipogenesis and insulin sensitivity
    Bin Xu
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America
    PLoS ONE 5:e14199. 2010
  3. ncbi Dax1 up-regulates Oct4 expression in mouse embryonic stem cells via LRH-1 and SRA
    Victoria R Kelly
    Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Endocrinol 24:2281-91. 2010
  4. ncbi An RNA-binding domain in the thyroid hormone receptor enhances transcriptional activation
    Bin Xu
    Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0678, USA
    J Biol Chem 279:33051-6. 2004
  5. ncbi Regulation of thyroid hormone receptor alpha2 RNA binding and subcellular localization by phosphorylation
    Bin Xu
    Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical Center, 5560 MSRB II, 1150 West Medical Center Dr, Ann Arbor, 48109 0678, USA
    Mol Cell Endocrinol 245:147-57. 2005
  6. ncbi Geochemical processes controlling fate and transport of arsenic in acid mine drainage (AMD) and natural systems
    Hefa Cheng
    State Key Laboratory of Pollution Control and Resources Reuse, School of Environmental Science and Engineering, Tongji University, Shanghai, PR China
    J Hazard Mater 165:13-26. 2009

Research Grants

  1. Post-transcriptional regulation of gene expression by thyroid hormone receptors
    Bin Xu; Fiscal Year: 2007

Detail Information

Publications6

  1. ncbi Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesis
    Bin Xu
    Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48109 5678, USA
    Mol Cell Biol 29:1719-34. 2009
    ..These findings reveal novel functions of SRA and Dax-1 in steroidogenesis and adrenal biology...
  2. ncbi Multiple roles for the non-coding RNA SRA in regulation of adipogenesis and insulin sensitivity
    Bin Xu
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America
    PLoS ONE 5:e14199. 2010
    ..SRA also inhibits the expression of adipocyte-related inflammatory genes and TNFα-induced phosphorylation of c-Jun NH(2)-terminal kinase. In conclusion, SRA enhances adipogenesis and adipocyte function through multiple pathways...
  3. ncbi Dax1 up-regulates Oct4 expression in mouse embryonic stem cells via LRH-1 and SRA
    Victoria R Kelly
    Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Endocrinol 24:2281-91. 2010
    ..Thus, our results indicate that Dax1 plays an important role in the maintenance of pluripotency in mES cells through interaction with LRH-1 and transcriptional activation of Oct4 and other genes...
  4. ncbi An RNA-binding domain in the thyroid hormone receptor enhances transcriptional activation
    Bin Xu
    Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0678, USA
    J Biol Chem 279:33051-6. 2004
    ..We conclude that thyroid hormone receptors bind RNA through a novel domain and that the interaction of this domain with SRA, and perhaps other RNAs, enhances thyroid hormone receptor function...
  5. ncbi Regulation of thyroid hormone receptor alpha2 RNA binding and subcellular localization by phosphorylation
    Bin Xu
    Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical Center, 5560 MSRB II, 1150 West Medical Center Dr, Ann Arbor, 48109 0678, USA
    Mol Cell Endocrinol 245:147-57. 2005
    ..Since RNA binding is a property of unphosphorylated TRalpha2, the TRalpha2-RNA interaction likely represents a nuclear function of TRalpha2...
  6. ncbi Geochemical processes controlling fate and transport of arsenic in acid mine drainage (AMD) and natural systems
    Hefa Cheng
    State Key Laboratory of Pollution Control and Resources Reuse, School of Environmental Science and Engineering, Tongji University, Shanghai, PR China
    J Hazard Mater 165:13-26. 2009
    ....

Research Grants2

  1. Post-transcriptional regulation of gene expression by thyroid hormone receptors
    Bin Xu; Fiscal Year: 2007
    ..The findings of TR targeted mRNAs will reveal novel functions of TR to regulate gene expression at post-transcriptional levels related to the brain function and neurodevelopment.. ..