ALLISON XU

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc AgRP innervation onto POMC neurons increases with age and is accelerated with chronic high-fat feeding in male mice
    A Jamila Newton
    Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Endocrinology 154:172-83. 2013
  2. ncbi Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding
    Allison W Xu
    Department of Genetics, Stanford University School of Medicine, San Francisco, California 94143, USA
    Endocrinology 148:72-80. 2007
  3. pmc Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons
    Merisa L Piper
    Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA
    Mol Endocrinol 22:751-9. 2008
  4. pmc Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis
    Alison S Reed
    Diabetes Center and the Department of Pediatrics, University of California San Francisco, San Francisco, California, USA
    Diabetes 59:894-906. 2010
  5. pmc Functional role of c-Jun-N-terminal kinase in feeding regulation
    Elizabeth K Unger
    UCSF Diabetes Center, Department of Anatomy, University of California, San Francisco, California 94143, USA
    Endocrinology 151:671-82. 2010
  6. pmc De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance
    Andrew A Pierce
    Diabetes Center, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 30:723-30. 2010
  7. pmc Functional requirement of AgRP and NPY neurons in ovarian cycle-dependent regulation of food intake
    Louise E Olofsson
    Diabetes Center, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:15932-7. 2009
  8. pmc The role of insulin receptor substrate 2 in hypothalamic and beta cell function
    Agharul I Choudhury
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
    J Clin Invest 115:940-50. 2005
  9. pmc Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion
    Esther van de Wall
    Departments of Medicine and Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 12461, USA
    Endocrinology 149:1773-85. 2008
  10. pmc AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
    Marc Claret
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
    J Clin Invest 117:2325-36. 2007

Collaborators

Detail Information

Publications14

  1. pmc AgRP innervation onto POMC neurons increases with age and is accelerated with chronic high-fat feeding in male mice
    A Jamila Newton
    Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Endocrinology 154:172-83. 2013
    ....
  2. ncbi Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding
    Allison W Xu
    Department of Genetics, Stanford University School of Medicine, San Francisco, California 94143, USA
    Endocrinology 148:72-80. 2007
    ....
  3. pmc Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons
    Merisa L Piper
    Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA
    Mol Endocrinol 22:751-9. 2008
    ..These results further suggest that leptin's effects on growth and reproduction are mediated by other signaling pathways, and that Stat3-mediated control of these functions is mediated independently of leptin and LepRb neurons...
  4. pmc Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis
    Alison S Reed
    Diabetes Center and the Department of Pediatrics, University of California San Francisco, San Francisco, California, USA
    Diabetes 59:894-906. 2010
    ..This study aims to determine the functional consequence of Socs3 upregulation on leptin signaling and obesity, and to investigate whether Socs3 upregulation affects energy balance in a cell type-specific way...
  5. pmc Functional role of c-Jun-N-terminal kinase in feeding regulation
    Elizabeth K Unger
    UCSF Diabetes Center, Department of Anatomy, University of California, San Francisco, California 94143, USA
    Endocrinology 151:671-82. 2010
    ..Thus, JNK may integrate diverse metabolic signals and differentially regulate feeding under distinct physiological conditions...
  6. pmc De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance
    Andrew A Pierce
    Diabetes Center, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 30:723-30. 2010
    ..It further suggests that de novo neurogenesis might serve as a compensatory mechanism contributing to the plastic control of energy balance in response to environmental and physiologic insults...
  7. pmc Functional requirement of AgRP and NPY neurons in ovarian cycle-dependent regulation of food intake
    Louise E Olofsson
    Diabetes Center, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:15932-7. 2009
    ..This study indicates that neurons coexpressing AgRP and NPY are functionally required for the cyclic changes in feeding across estrous cycle and that AgRP and NPY neurons are essential mediators of estrogen's anorexigenic function...
  8. pmc The role of insulin receptor substrate 2 in hypothalamic and beta cell function
    Agharul I Choudhury
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
    J Clin Invest 115:940-50. 2005
    ..Our findings demonstrate a critical role for IRS2 in beta cell and hypothalamic function and provide insights into the role of RIPCre neurons, a distinct hypothalamic neuronal population, in growth and energy homeostasis...
  9. pmc Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion
    Esther van de Wall
    Departments of Medicine and Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 12461, USA
    Endocrinology 149:1773-85. 2008
    ....
  10. pmc AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
    Marc Claret
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
    J Clin Invest 117:2325-36. 2007
    ....
  11. ncbi Agouti-related peptide-expressing neurons are mandatory for feeding
    Eva Gropp
    Institute for Genetics and Center for Molecular Medicine CMMC, Department of Mouse Genetics and Metabolism, University of Cologne, Z├╝lpicher Str 47, 50674 Koln, Germany
    Nat Neurosci 8:1289-91. 2005
    ....
  12. ncbi GCN5 and p300 share essential functions during early embryogenesis
    Huy M Phan
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Dev Dyn 233:1337-47. 2005
    ..Our data indicate that p300 cooperates specifically with GCN5 to provide essential functions during early embryogenesis...
  13. ncbi Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
    Tadahiro Kitamura
    Department of Medicine, Columbia University Medical Center, 1150 St Nicholas Avenue, New York, New York 10032, USA
    Nat Med 12:534-40. 2006
    ..Thus, FoxO1 represents a shared component of pathways integrating food intake and peripheral metabolism...
  14. ncbi MC4R neurons weigh in differently
    Allison W Xu
    Nat Neurosci 9:15-6. 2006

Research Grants7

  1. Hypothalamic PI3K signaling in regulation of energy balance & glucose homeostasis
    Allison W Xu; Fiscal Year: 2010
    ..It will advance our understanding of the signaling mechanisms by which leptin and insulin regulate energy balance and glucose homeostasis, and provide insight into the etiology of obesity and type 2 diabetes. ..
  2. Neurogenesis as a compensatory mechanism to regulate energy balance
    ALLISON XU; Fiscal Year: 2007
    ..The identification of neuronal substrates critical for body weight regulation will lay the groundwork for future therapeutic interventions designed to target these specific neurons. ..
  3. Hypothalamic PI3K signaling in regulation of energy balance & glucose homeostasis
    ALLISON XU; Fiscal Year: 2009
    ..It will advance our understanding of the signaling mechanisms by which leptin and insulin regulate energy balance and glucose homeostasis, and provide insight into the etiology of obesity and type 2 diabetes. ..
  4. Hypothalamic PI3K signaling in regulation of energy balance & glucose homeostasis
    Allison W Xu; Fiscal Year: 2010
    ..It will advance our understanding of the signaling mechanisms by which leptin and insulin regulate energy balance and glucose homeostasis, and provide insight into the etiology of obesity and type 2 diabetes. ..
  5. Compensatory regulation of energy balance by neurogenesis in adult hypothalamus
    Allison W Xu; Fiscal Year: 2010
    ..It will provide novel insight into therapeutic potential of neural stem cells in treatment of hypothalamic neurodegeneration that are associated with a variety of chronic diseases and brain injuries. ..