Yan Q Xiong

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Real-time in vivo bioluminescent imaging for evaluating the efficacy of antibiotics in a rat Staphylococcus aureus endocarditis model
    Yan Q Xiong
    Division of Infectious Diseases, St John s Cardiovascular Research Center, Harbor UCLA Research and Education Institute, 1124 W Carson St, Torrance, CA 90502, USA
    Antimicrob Agents Chemother 49:380-7. 2005
  2. pmc Efficacy of NZ2114, a novel plectasin-derived cationic antimicrobial peptide antibiotic, in experimental endocarditis due to methicillin-resistant Staphylococcus aureus
    Yan Q Xiong
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Antimicrob Agents Chemother 55:5325-30. 2011
  3. pmc Phenotypic and genotypic characteristics of persistent methicillin-resistant Staphylococcus aureus bacteremia in vitro and in an experimental endocarditis model
    Yan Q Xiong
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA
    J Infect Dis 199:201-8. 2009
  4. pmc A synthetic congener modeled on a microbicidal domain of thrombin- induced platelet microbicidal protein 1 recapitulates staphylocidal mechanisms of the native molecule
    Yan Q Xiong
    Department of Medicine, Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, RB 2, Room 231, Torrance, CA 90502, USA
    Antimicrob Agents Chemother 50:3786-92. 2006
  5. pmc Functional interrelationships between cell membrane and cell wall in antimicrobial peptide-mediated killing of Staphylococcus aureus
    Yan Q Xiong
    LA Biomedical Research Institute at Harbor UCLA St John s Cardiovascular Research Center, RB 2, 1124 West Carson Street, Torrance, CA 90502, USA
    Antimicrob Agents Chemother 49:3114-21. 2005
  6. pmc Role of the LytSR two-component regulatory system in adaptation to cationic antimicrobial peptides in Staphylococcus aureus
    Soo Jin Yang
    Division of Infectious Diseases, St John s Cardiovascular Research Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
    Antimicrob Agents Chemother 57:3875-82. 2013
  7. pmc Enhanced expression of dltABCD is associated with the development of daptomycin nonsusceptibility in a clinical endocarditis isolate of Staphylococcus aureus
    Soo Jin Yang
    Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA
    J Infect Dis 200:1916-20. 2009
  8. pmc Failures in clinical treatment of Staphylococcus aureus Infection with daptomycin are associated with alterations in surface charge, membrane phospholipid asymmetry, and drug binding
    Tiffanny Jones
    Los Angeles Biomedical Research Institute at Harbor UCLA, 1124 West Carson Street, Bldg RB2, Room 225, Torrance, CA 90502, USA
    Antimicrob Agents Chemother 52:269-78. 2008
  9. pmc Telavancin in therapy of experimental aortic valve endocarditis in rabbits due to daptomycin-nonsusceptible methicillin-resistant Staphylococcus aureus
    Yan Q Xiong
    Los Angeles Biomedical Research Institute, Torrance, California, USA
    Antimicrob Agents Chemother 56:5528-33. 2012
  10. pmc Relationship of agr expression and function with virulence and vancomycin treatment outcomes in experimental endocarditis due to methicillin-resistant Staphylococcus aureus
    Kati Seidl
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Antimicrob Agents Chemother 55:5631-9. 2011

Detail Information

Publications24

  1. pmc Real-time in vivo bioluminescent imaging for evaluating the efficacy of antibiotics in a rat Staphylococcus aureus endocarditis model
    Yan Q Xiong
    Division of Infectious Diseases, St John s Cardiovascular Research Center, Harbor UCLA Research and Education Institute, 1124 W Carson St, Torrance, CA 90502, USA
    Antimicrob Agents Chemother 49:380-7. 2005
    ..These data suggest that bioluminescent imaging provides a substantial advance in the real-time monitoring of the efficacy of therapy of invasive S. aureus infections in live animals...
  2. pmc Efficacy of NZ2114, a novel plectasin-derived cationic antimicrobial peptide antibiotic, in experimental endocarditis due to methicillin-resistant Staphylococcus aureus
    Yan Q Xiong
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Antimicrob Agents Chemother 55:5325-30. 2011
    ..69). The superior efficacy of NZ2114 in this MRSA IE model suggests the potential for further development of this compound for treating serious MRSA infections...
  3. pmc Phenotypic and genotypic characteristics of persistent methicillin-resistant Staphylococcus aureus bacteremia in vitro and in an experimental endocarditis model
    Yan Q Xiong
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA
    J Infect Dis 199:201-8. 2009
    ..Persistent MRSA bacteremia (PB) represents an important subset of Staphylococcus aureus infections and correlates with poor clinical outcomes...
  4. pmc A synthetic congener modeled on a microbicidal domain of thrombin- induced platelet microbicidal protein 1 recapitulates staphylocidal mechanisms of the native molecule
    Yan Q Xiong
    Department of Medicine, Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, RB 2, Room 231, Torrance, CA 90502, USA
    Antimicrob Agents Chemother 50:3786-92. 2006
    ....
  5. pmc Functional interrelationships between cell membrane and cell wall in antimicrobial peptide-mediated killing of Staphylococcus aureus
    Yan Q Xiong
    LA Biomedical Research Institute at Harbor UCLA St John s Cardiovascular Research Center, RB 2, 1124 West Carson Street, Torrance, CA 90502, USA
    Antimicrob Agents Chemother 49:3114-21. 2005
    ....
  6. pmc Role of the LytSR two-component regulatory system in adaptation to cationic antimicrobial peptides in Staphylococcus aureus
    Soo Jin Yang
    Division of Infectious Diseases, St John s Cardiovascular Research Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
    Antimicrob Agents Chemother 57:3875-82. 2013
    ..Collectively, these results suggest that the lytSR TCRS plays an important role in adaptive responses of S. aureus to CM-perturbing HDPs/CAPs, likely by functioning as a sense-response system for detecting subtle changes in ΔΨ. ..
  7. pmc Enhanced expression of dltABCD is associated with the development of daptomycin nonsusceptibility in a clinical endocarditis isolate of Staphylococcus aureus
    Soo Jin Yang
    Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA
    J Infect Dis 200:1916-20. 2009
    ..In contrast, we demonstrated enhanced dlt expression coincident with increased positive surface charge and reduced daptomycin binding...
  8. pmc Failures in clinical treatment of Staphylococcus aureus Infection with daptomycin are associated with alterations in surface charge, membrane phospholipid asymmetry, and drug binding
    Tiffanny Jones
    Los Angeles Biomedical Research Institute at Harbor UCLA, 1124 West Carson Street, Bldg RB2, Room 225, Torrance, CA 90502, USA
    Antimicrob Agents Chemother 52:269-78. 2008
    ..aureus. Moreover, the cross-resistance to hNP-1 and tPMP-1 may also impact the capacity of these daptomycin-resistant organisms to be cleared from sites of infection, particularly endovascular foci...
  9. pmc Telavancin in therapy of experimental aortic valve endocarditis in rabbits due to daptomycin-nonsusceptible methicillin-resistant Staphylococcus aureus
    Yan Q Xiong
    Los Angeles Biomedical Research Institute, Torrance, California, USA
    Antimicrob Agents Chemother 56:5528-33. 2012
    ..0001). Together, these results demonstrate that TLV has potent bactericidal activity in vitro and in vivo against DAP-R MRSA isolates...
  10. pmc Relationship of agr expression and function with virulence and vancomycin treatment outcomes in experimental endocarditis due to methicillin-resistant Staphylococcus aureus
    Kati Seidl
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Antimicrob Agents Chemother 55:5631-9. 2011
    ..Our findings suggest that agr dysfunction does not correlate with vancomycin treatment failures in this experimental IE model in two distinct MRSA genetic backgrounds...
  11. pmc Regulation of mprF in daptomycin-nonsusceptible Staphylococcus aureus strains
    Soo Jin Yang
    LA Biomedical Research Institute at Harbor UCLA, 1124 West Carson Street, RB 2, Rm 230, Torrance, CA 90502, USA
    Antimicrob Agents Chemother 53:2636-7. 2009
    ..We observed a correlation between increased expression of a mutant mprF gene and reduced in vitro DAP susceptibility. There were no detectable fitness differences between strains in experimental infective endocarditis...
  12. pmc Daptomycin-oxacillin combinations in treatment of experimental endocarditis caused by daptomycin-nonsusceptible strains of methicillin-resistant Staphylococcus aureus with evolving oxacillin susceptibility (the "seesaw effect")
    Soo Jin Yang
    LA Biomedical Research Institute at Harbor UCLA, 1124 West Carson Street, RB 2, Rm 230, Torrance, CA 90502, USA
    Antimicrob Agents Chemother 54:3161-9. 2010
    ..The mechanism(s) of the seesaw effect remains to be defined but does not appear to involve excision of the staphylococcal cassette chromosome mec (SCCmec) that carries mecA...
  13. pmc Reduced vancomycin susceptibility in an in vitro catheter-related biofilm model correlates with poor therapeutic outcomes in experimental endocarditis due to methicillin-resistant Staphylococcus aureus
    Wessam Abdelhady
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    Antimicrob Agents Chemother 57:1447-54. 2013
    ....
  14. pmc Combinatorial phenotypic signatures distinguish persistent from resolving methicillin-resistant Staphylococcus aureus bacteremia isolates
    Kati Seidl
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Antimicrob Agents Chemother 55:575-82. 2011
    ..These combinatorial mosaics can be defined and used to prospectively distinguish PB from RB strains in advance and potentially to predict ultimate clinical outcomes...
  15. pmc In vitro endothelial cell damage is positively correlated with enhanced virulence and poor vancomycin responsiveness in experimental endocarditis due to methicillin-resistant Staphylococcus aureus
    Kati Seidl
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    Cell Microbiol 13:1530-41. 2011
    ....
  16. pmc Divergent responses of different endothelial cell types to infection with Candida albicans and Staphylococcus aureus
    Kati Seidl
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, United States of America
    PLoS ONE 7:e39633. 2012
    ..Thus, C. albicans and S. aureus interact with HMEC-1 cells in a substantially different manner than with HUVECs, and data obtained with one type of endothelial cell cannot necessarily be extrapolated to other types...
  17. pmc The Staphylococcus aureus two-component regulatory system, GraRS, senses and confers resistance to selected cationic antimicrobial peptides
    Soo Jin Yang
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
    Infect Immun 80:74-81. 2012
    ..Collectively, these data support an important role of the graRS and vraFG loci in the sensing of and response to specific CAPs involved in innate host defenses...
  18. pmc Platelet antistaphylococcal responses occur through P2X1 and P2Y12 receptor-induced activation and kinocidin release
    Darin A Trier
    Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Infect Immun 76:5706-13. 2008
    ....
  19. ncbi request reprint In vitro susceptibility of Staphylococcus aureus to thrombin-induced platelet microbicidal protein-1 (tPMP-1) is influenced by cell membrane phospholipid composition and asymmetry
    Kasturi Mukhopadhyay
    The L A Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    Microbiology 153:1187-97. 2007
    ..These findings offer new insights into mechanisms of antimicrobial peptide susceptibility and resistance in S. aureus...
  20. ncbi request reprint Regulation of Staphylococcus aureus alpha-toxin gene (hla) expression by agr, sarA, and sae in vitro and in experimental infective endocarditis
    Yan Q Xiong
    Department of Medicine, Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles Medical Center, Torrance, CA, USA
    J Infect Dis 194:1267-75. 2006
    ..However, their relative in vivo contributions to hla expression, particularly in endovascular infections, have not been defined...
  21. pmc Role of the serine-rich surface glycoprotein GspB of Streptococcus gordonii in the pathogenesis of infective endocarditis
    Yan Q Xiong
    Department of Medicine, Harbor UCLA Medical Center, 1000W Carson Street, Building RB2, Torrance, CA 90502, USA
    Microb Pathog 45:297-301. 2008
    ..62, 5.07 and 4.18, respectively) PS846 was not detected within these tissues. Thus, platelet binding by GspB appears to be a major interaction in the pathogenesis of endocarditis due to S. gordonii...
  22. ncbi request reprint Advances in antimicrobial peptide immunobiology
    Nannette Y Yount
    Division of Infectious Diseases, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Biopolymers 84:435-58. 2006
    ..The following discussion highlights such recent developments in antimicrobial peptide immunobiology, with an emphasis on the biophysical aspects of host-defense polypeptide action and mechanisms of microbial resistance...
  23. pmc gC1qR/p33 blockade reduces Staphylococcus aureus colonization of target tissues in an animal model of infective endocarditis
    Ellinor I B Peerschke
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Infect Immun 74:4418-23. 2006
    ..aureus binding to fibrinogen. Such impacts may include direct modulation of complement (MAb 60.11) and kinin cascades (MAb 74.5.2) and/or activation of immune and inflammatory responses via localized immune complex formation...