Research Topics
Genomes and Genes | Wanfen XiongSummaryAffiliation: University of Nebraska Medical Center Country: USA Publications
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Publications
MMP-2 regulates Erk1/2 phosphorylation and aortic dilatation in Marfan syndromeWanfen Xiong
Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 7690, USA
Circ Res 110:e92-e101. 2012..Losartan has been shown to prevent aneurysms in another mouse model of MFS, Fbn1(C1039G/+), through inhibition of the Erk1/2 pathway. However, the role of MMP-2 in MFS and effect of losartan on the lifespan of MFS mice remain unknown...
Membrane-type 1 matrix metalloproteinase regulates macrophage-dependent elastolytic activity and aneurysm formation in vivoWanfen Xiong
Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska, 68198, USA
J Biol Chem 284:1765-71. 2009..These studies demonstrate that destruction of the elastin fiber network during AAA formation is dependent on macrophage-derived MT1-MMP, which unexpectedly serves as a direct-acting regulator of macrophage proteolytic activity...- Inhibition of reactive oxygen species attenuates aneurysm formation in a murine modelWanfen Xiong
Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 7690, USA
Atherosclerosis 202:128-34. 2009..These studies suggest that both NADPH oxidase and iNOS pathways contribute to ROS production and AAA development... 
Effects of tissue inhibitor of metalloproteinase 2 deficiency on aneurysm formationWanfen Xiong
Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 7690, USA
J Vasc Surg 44:1061-6. 2006..At higher concentrations, TIMP-2 becomes an inhibitor of MMP-2. Thus, TIMP-2 could both augment and inhibit matrix degradation. This study was undertaken to define the net effect of TIMP-2 on matrix destruction and aneurysm formation...- Blocking TNF-alpha attenuates aneurysm formation in a murine modelWanfen Xiong
Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
J Immunol 183:2741-6. 2009..This study confirms that a strategy of TNF-alpha antagonism may be an important therapeutic strategy for treating AAA... - Key roles of CD4+ T cells and IFN-gamma in the development of abdominal aortic aneurysms in a murine modelWanfen Xiong
Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
J Immunol 172:2607-12. 2004..This study has important implications for other degenerative diseases associated with matrix destruction... - Doxycycline delays aneurysm rupture in a mouse model of Marfan syndromeWanfen Xiong
Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
J Vasc Surg 47:166-72; discussion 172. 2008..Doxycycline is a nonspecific MMP inhibitor. The objective of the study was to determine whether docycycline can attenuate matrix degradation and prolong the survival of mice with MFS... - Dose-related influence of chronic alcohol consumption on cerebral ischemia/reperfusion injuryHonggang Zhao
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
Alcohol Clin Exp Res 35:1265-9. 2011.... - Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysmsG Matthew Longo
Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 7690, USA
J Clin Invest 110:625-32. 2002..These findings suggest that macrophage-derived MMP-9 and mesenchymal cell MMP-2 are both required and work in concert to produce AAA... - MMP-12 has a role in abdominal aortic aneurysms in miceG Matthew Longo
Department of Surgery, University of Nebraska Medical Center, 8111 Dodge Street, Omaha, NE 68114, USA
Surgery 137:457-62. 2005..Matrix metalloproteinase (MMP)-12 levels are increased in the abdominal aortic aneurysm (AAA), implicating this protease in AAA pathogenesis. The purpose of this study was to assess the role of MMP-12 in aneurysm formation... - MOP3, a component of the molecular clock, regulates the development of B cellsYimin Sun
Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA
Immunology 119:451-60. 2006..This study also showed a connection between a master regular of circadian rhythm with B-cell development in mice... - Mechanism of inhibition of matrix metalloproteinase-2 expression by doxycycline in human aortic smooth muscle cellsJian Liu
Department of Surgery, University of Nebraska Medical Center, 8111 Dodge Street, Suite 220, Omaha, NE 68114, USA
J Vasc Surg 38:1376-83. 2003..Inasmuch as MMP activity contributes to extracellular matrix degradation in AAAs and atherosclerotic plaque, doxycycline may have potential value in treating these diseases... - Xenogeneic skin graft rejection in M-CSF/macrophage deficient osteopetrotic miceYong Zhao
Department of Surgery, University of Nebraska Medical Center, The Lied Transplant Center, Omaha, NE 68198 7690, USA
Xenotransplantation 10:232-9. 2003..The cellular infiltrate in xenografts suggests that macrophages may be involved in xenograft rejection. However, the precise role of macrophages in xenograft rejection has not yet been fully addressed... - Deletion of CCR2 but not CCR5 or CXCR3 inhibits aortic aneurysm formationJason Neal MacTaggart
Surgery Research, University of Nebraska Medical Center, Omaha, Nebr, USA
Surgery 142:284-8. 2007..We hypothesized that genetic deletions of CCR2, CCR5, and CXCR3 would limit leukocyte infiltration and aneurysm formation in a mouse model of AAA... - Genetic dissection of hyperthermia-induced neural tube defects in miceYunxia Wang Lundberg
Boys Town National Research Hospital, Genetics Department, Omaha, Nebraska 68131, USA
Birth Defects Res A Clin Mol Teratol 67:409-13. 2003..Maternal hyperthermia has been shown to induce neural tube defects (NTD) in humans and in experimental animal systems. We report the first genetic dissection of maternal hyperthermia-induced NTD in mice... - Alcohol-induced exacerbation of ischemic brain injury: role of NAD(P)H oxidaseHonggang Zhao
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5850, USA
Alcohol Clin Exp Res 34:1948-55. 2010..Chronic alcohol consumption increases ischemic stroke and exacerbates ischemic brain injury. We determined the role of NAD(P)H oxidase in exacerbated ischemic brain injury during chronic alcohol consumption... - Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in miceJiusong Sun
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 117:3359-68. 2007.... - Elastin degradation and calcification in an abdominal aorta injury model: role of matrix metalloproteinasesDina M Basalyga
Department of Bioengineering, Clemson University, Clemson, SC 29634, USA
Circulation 110:3480-7. 2004..We hypothesized that matrix metalloproteinase (MMP)-mediated vascular remodeling plays a significant role in elastin calcification...