Wanfen Xiong

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. doi request reprint MMP-2 regulates Erk1/2 phosphorylation and aortic dilatation in Marfan syndrome
    Wanfen Xiong
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 7690, USA
    Circ Res 110:e92-e101. 2012
  2. pmc Membrane-type 1 matrix metalloproteinase regulates macrophage-dependent elastolytic activity and aneurysm formation in vivo
    Wanfen Xiong
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska, 68198, USA
    J Biol Chem 284:1765-71. 2009
  3. pmc Inhibition of reactive oxygen species attenuates aneurysm formation in a murine model
    Wanfen Xiong
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 7690, USA
    Atherosclerosis 202:128-34. 2009
  4. ncbi request reprint Effects of tissue inhibitor of metalloproteinase 2 deficiency on aneurysm formation
    Wanfen Xiong
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 7690, USA
    J Vasc Surg 44:1061-6. 2006
  5. doi request reprint Blocking TNF-alpha attenuates aneurysm formation in a murine model
    Wanfen Xiong
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 183:2741-6. 2009
  6. ncbi request reprint Key roles of CD4+ T cells and IFN-gamma in the development of abdominal aortic aneurysms in a murine model
    Wanfen Xiong
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 172:2607-12. 2004
  7. doi request reprint Doxycycline delays aneurysm rupture in a mouse model of Marfan syndrome
    Wanfen Xiong
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Vasc Surg 47:166-72; discussion 172. 2008
  8. pmc Dose-related influence of chronic alcohol consumption on cerebral ischemia/reperfusion injury
    Honggang Zhao
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Alcohol Clin Exp Res 35:1265-9. 2011
  9. pmc Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms
    G Matthew Longo
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 7690, USA
    J Clin Invest 110:625-32. 2002
  10. ncbi request reprint MMP-12 has a role in abdominal aortic aneurysms in mice
    G Matthew Longo
    Department of Surgery, University of Nebraska Medical Center, 8111 Dodge Street, Omaha, NE 68114, USA
    Surgery 137:457-62. 2005

Collaborators

Detail Information

Publications18

  1. doi request reprint MMP-2 regulates Erk1/2 phosphorylation and aortic dilatation in Marfan syndrome
    Wanfen Xiong
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 7690, USA
    Circ Res 110:e92-e101. 2012
    ..Losartan has been shown to prevent aneurysms in another mouse model of MFS, Fbn1(C1039G/+), through inhibition of the Erk1/2 pathway. However, the role of MMP-2 in MFS and effect of losartan on the lifespan of MFS mice remain unknown...
  2. pmc Membrane-type 1 matrix metalloproteinase regulates macrophage-dependent elastolytic activity and aneurysm formation in vivo
    Wanfen Xiong
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska, 68198, USA
    J Biol Chem 284:1765-71. 2009
    ..These studies demonstrate that destruction of the elastin fiber network during AAA formation is dependent on macrophage-derived MT1-MMP, which unexpectedly serves as a direct-acting regulator of macrophage proteolytic activity...
  3. pmc Inhibition of reactive oxygen species attenuates aneurysm formation in a murine model
    Wanfen Xiong
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 7690, USA
    Atherosclerosis 202:128-34. 2009
    ..These studies suggest that both NADPH oxidase and iNOS pathways contribute to ROS production and AAA development...
  4. ncbi request reprint Effects of tissue inhibitor of metalloproteinase 2 deficiency on aneurysm formation
    Wanfen Xiong
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 7690, USA
    J Vasc Surg 44:1061-6. 2006
    ..At higher concentrations, TIMP-2 becomes an inhibitor of MMP-2. Thus, TIMP-2 could both augment and inhibit matrix degradation. This study was undertaken to define the net effect of TIMP-2 on matrix destruction and aneurysm formation...
  5. doi request reprint Blocking TNF-alpha attenuates aneurysm formation in a murine model
    Wanfen Xiong
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 183:2741-6. 2009
    ..This study confirms that a strategy of TNF-alpha antagonism may be an important therapeutic strategy for treating AAA...
  6. ncbi request reprint Key roles of CD4+ T cells and IFN-gamma in the development of abdominal aortic aneurysms in a murine model
    Wanfen Xiong
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 172:2607-12. 2004
    ..This study has important implications for other degenerative diseases associated with matrix destruction...
  7. doi request reprint Doxycycline delays aneurysm rupture in a mouse model of Marfan syndrome
    Wanfen Xiong
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Vasc Surg 47:166-72; discussion 172. 2008
    ..Doxycycline is a nonspecific MMP inhibitor. The objective of the study was to determine whether docycycline can attenuate matrix degradation and prolong the survival of mice with MFS...
  8. pmc Dose-related influence of chronic alcohol consumption on cerebral ischemia/reperfusion injury
    Honggang Zhao
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Alcohol Clin Exp Res 35:1265-9. 2011
    ....
  9. pmc Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms
    G Matthew Longo
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 7690, USA
    J Clin Invest 110:625-32. 2002
    ..These findings suggest that macrophage-derived MMP-9 and mesenchymal cell MMP-2 are both required and work in concert to produce AAA...
  10. ncbi request reprint MMP-12 has a role in abdominal aortic aneurysms in mice
    G Matthew Longo
    Department of Surgery, University of Nebraska Medical Center, 8111 Dodge Street, Omaha, NE 68114, USA
    Surgery 137:457-62. 2005
    ..Matrix metalloproteinase (MMP)-12 levels are increased in the abdominal aortic aneurysm (AAA), implicating this protease in AAA pathogenesis. The purpose of this study was to assess the role of MMP-12 in aneurysm formation...
  11. pmc MOP3, a component of the molecular clock, regulates the development of B cells
    Yimin Sun
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA
    Immunology 119:451-60. 2006
    ..This study also showed a connection between a master regular of circadian rhythm with B-cell development in mice...
  12. ncbi request reprint Mechanism of inhibition of matrix metalloproteinase-2 expression by doxycycline in human aortic smooth muscle cells
    Jian Liu
    Department of Surgery, University of Nebraska Medical Center, 8111 Dodge Street, Suite 220, Omaha, NE 68114, USA
    J Vasc Surg 38:1376-83. 2003
    ..Inasmuch as MMP activity contributes to extracellular matrix degradation in AAAs and atherosclerotic plaque, doxycycline may have potential value in treating these diseases...
  13. ncbi request reprint Xenogeneic skin graft rejection in M-CSF/macrophage deficient osteopetrotic mice
    Yong Zhao
    Department of Surgery, University of Nebraska Medical Center, The Lied Transplant Center, Omaha, NE 68198 7690, USA
    Xenotransplantation 10:232-9. 2003
    ..The cellular infiltrate in xenografts suggests that macrophages may be involved in xenograft rejection. However, the precise role of macrophages in xenograft rejection has not yet been fully addressed...
  14. ncbi request reprint Deletion of CCR2 but not CCR5 or CXCR3 inhibits aortic aneurysm formation
    Jason Neal MacTaggart
    Surgery Research, University of Nebraska Medical Center, Omaha, Nebr, USA
    Surgery 142:284-8. 2007
    ..We hypothesized that genetic deletions of CCR2, CCR5, and CXCR3 would limit leukocyte infiltration and aneurysm formation in a mouse model of AAA...
  15. ncbi request reprint Genetic dissection of hyperthermia-induced neural tube defects in mice
    Yunxia Wang Lundberg
    Boys Town National Research Hospital, Genetics Department, Omaha, Nebraska 68131, USA
    Birth Defects Res A Clin Mol Teratol 67:409-13. 2003
    ..Maternal hyperthermia has been shown to induce neural tube defects (NTD) in humans and in experimental animal systems. We report the first genetic dissection of maternal hyperthermia-induced NTD in mice...
  16. doi request reprint Alcohol-induced exacerbation of ischemic brain injury: role of NAD(P)H oxidase
    Honggang Zhao
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5850, USA
    Alcohol Clin Exp Res 34:1948-55. 2010
    ..Chronic alcohol consumption increases ischemic stroke and exacerbates ischemic brain injury. We determined the role of NAD(P)H oxidase in exacerbated ischemic brain injury during chronic alcohol consumption...
  17. pmc Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice
    Jiusong Sun
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 117:3359-68. 2007
    ....
  18. pmc Elastin degradation and calcification in an abdominal aorta injury model: role of matrix metalloproteinases
    Dina M Basalyga
    Department of Bioengineering, Clemson University, Clemson, SC 29634, USA
    Circulation 110:3480-7. 2004
    ..We hypothesized that matrix metalloproteinase (MMP)-mediated vascular remodeling plays a significant role in elastin calcification...