Lianping Xing

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Regulation of apoptosis in osteoclasts and osteoblastic cells
    Lianping Xing
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, NY, USA
    Biochem Biophys Res Commun 328:709-20. 2005
  2. ncbi request reprint Regulation of osteoclast precursors in inflammatory bone loss
    Lianping Xing
    University of Rochester Medical Center, Department of Pathology and Laboratory Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Curr Opin Investig Drugs 10:1195-203. 2009
  3. ncbi request reprint Lymphangiogenesis, myeloid cells and inflammation
    Lianping Xing
    Department of Pathology and Laboratory Medicine, 601 Elmwood Avenue, Box 626, Rochester, NY 14642, USA
    Expert Rev Clin Immunol 4:599-613. 2008
  4. ncbi request reprint Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice
    Ping Li
    University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 50:265-76. 2004
  5. ncbi request reprint Osteoclast precursors, RANKL/RANK, and immunology
    Lianping Xing
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Immunol Rev 208:19-29. 2005
  6. pmc The role of bone marrow edema and lymphangiogenesis in inflammatory-erosive arthritis
    Edward M Schwarz
    The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Adv Exp Med Biol 658:1-10. 2010
  7. pmc Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins
    Ruolin Guo
    Department of Pathology and Laboratory Medicine, and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 283:23084-92. 2008
  8. ncbi request reprint Expression of either NF-kappaB p50 or p52 in osteoclast precursors is required for IL-1-induced bone resorption
    Lianping Xing
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Bone Miner Res 18:260-9. 2003
  9. ncbi request reprint NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1
    Teruhito Yamashita
    Department of Pathology and Laboratory Medicine and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 282:18245-53. 2007
  10. pmc Smurf1 inhibits mesenchymal stem cell proliferation and differentiation into osteoblasts through JunB degradation
    Lan Zhao
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Bone Miner Res 25:1246-56. 2010

Research Grants

Collaborators

Detail Information

Publications68

  1. ncbi request reprint Regulation of apoptosis in osteoclasts and osteoblastic cells
    Lianping Xing
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, NY, USA
    Biochem Biophys Res Commun 328:709-20. 2005
    ..Understanding the mechanisms and regulation of bone cell apoptosis will enhance our knowledge of bone cell function and help us to develop better therapeutics for the management of osteoporosis and other bone diseases...
  2. ncbi request reprint Regulation of osteoclast precursors in inflammatory bone loss
    Lianping Xing
    University of Rochester Medical Center, Department of Pathology and Laboratory Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Curr Opin Investig Drugs 10:1195-203. 2009
    ..Thus, the regulation of OCP mobilization among bone marrow, blood and inflamed sites may be an important factor in the pathogenesis of inflammatory bone disorders, and represents a new therapeutic strategy...
  3. ncbi request reprint Lymphangiogenesis, myeloid cells and inflammation
    Lianping Xing
    Department of Pathology and Laboratory Medicine, 601 Elmwood Avenue, Box 626, Rochester, NY 14642, USA
    Expert Rev Clin Immunol 4:599-613. 2008
    ..The current review will focus on the recent progress made in studies of lymphatics in inflammatory disorders...
  4. ncbi request reprint Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice
    Ping Li
    University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 50:265-76. 2004
    ..To investigate the mechanisms whereby tumor necrosis factor alpha (TNFalpha) increases osteoclastogenesis in vivo...
  5. ncbi request reprint Osteoclast precursors, RANKL/RANK, and immunology
    Lianping Xing
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Immunol Rev 208:19-29. 2005
    ..Disruption of this cycle could provide a new strategy for the development of drugs to treat inflammatory arthritis and other disorders associated with elevated OCP/myeloid progenitors...
  6. pmc The role of bone marrow edema and lymphangiogenesis in inflammatory-erosive arthritis
    Edward M Schwarz
    The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Adv Exp Med Biol 658:1-10. 2010
    ....
  7. pmc Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins
    Ruolin Guo
    Department of Pathology and Laboratory Medicine, and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 283:23084-92. 2008
    ..Inhibition of ubiquitin-mediated Smad1 and Runx2 degradation in osteoblasts could help to treat inflammation-induced osteoporosis...
  8. ncbi request reprint Expression of either NF-kappaB p50 or p52 in osteoclast precursors is required for IL-1-induced bone resorption
    Lianping Xing
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Bone Miner Res 18:260-9. 2003
    ..Thus, expression of either NF-kappaB p50 or p52 is required in osteoclasts and their precursors, rather than osteoblasts, for IL-1-mediated bone resorption...
  9. ncbi request reprint NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1
    Teruhito Yamashita
    Department of Pathology and Laboratory Medicine and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 282:18245-53. 2007
    ..Inhibition of NF-kappaB should prevent RANKL- and TNF-induced bone resorption...
  10. pmc Smurf1 inhibits mesenchymal stem cell proliferation and differentiation into osteoblasts through JunB degradation
    Lan Zhao
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Bone Miner Res 25:1246-56. 2010
    ..In conclusion, our results suggest that Smurf1 negatively regulates MSC proliferation and differentiation by controlling JunB turnover through an ubiquitin-proteasome pathway...
  11. pmc TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY 14642, USA
    Arthritis Res Ther 10:R37. 2008
    ..The objective of the present study was to investigate the role of the stromal cell-derived factor 1 (SDF-1)/CXCR4 axis in TNF-induced mobilization of osteoclast precursors (OCPs) from bone marrow...
  12. pmc Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts
    Hiroyuki Kaneki
    Department of Pathology and Laboratory Medicine, University of Rochester, School of Medicine and Dentistry, NY 14642, USA
    J Biol Chem 281:4326-33. 2006
    ..We propose that one of the mechanisms by which TNF inhibits bone formation in inflammatory bone disorders is by promoting Runx2 proteasomal degradation through up-regulation of Smurf1 and Smurf2 expression...
  13. pmc Increased lymphangiogenesis in joints of mice with inflammatory arthritis
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Res Ther 9:R118. 2007
    ..The lymphatic system may play an important role in the pathogenesis of inflammatory arthritis...
  14. pmc Inhibition of lymphangiogenesis and lymphatic drainage via vascular endothelial growth factor receptor 3 blockade increases the severity of inflammation in a mouse model of chronic inflammatory arthritis
    Ruolin Guo
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Rheum 60:2666-76. 2009
    ..This study was undertaken to investigate the effect of lymphatic inhibition on joint and draining lymph node (LN) pathology during the course of arthritis progression in mice...
  15. ncbi request reprint Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression
    Zhenqiang Yao
    Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 281:11846-55. 2006
    ..Therefore, the first step of TNF-induced osteoclastogenesis is at the level of OCP genesis in the bone marrow, which represents another layer of regulation to control erosive disease...
  16. pmc Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomography
    Steven T Proulx
    Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Rheum 56:4024-37. 2007
    ....
  17. pmc VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanism
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 283:13491-9. 2008
    ....
  18. pmc Elucidating bone marrow edema and myelopoiesis in murine arthritis using contrast-enhanced magnetic resonance imaging
    Steven T Proulx
    University of Rochester, Rochester, New York 14642, USA
    Arthritis Rheum 58:2019-29. 2008
    ..In this study, MRI of murine arthritis was used to elucidate its cellular composition and vascular involvement...
  19. pmc Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism
    Zhenqiang Yao
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Biol Chem 283:9917-24. 2008
    ..TNF could induce c-Fos expression in OCPs at sites of inflammation in bone to promote this autocrine mechanism and thus amplify bone loss...
  20. ncbi request reprint NF-kappaB p50 and p52 expression is not required for RANK-expressing osteoclast progenitor formation but is essential for RANK- and cytokine-mediated osteoclastogenesis
    Lianping Xing
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, New York 14642, USA
    J Bone Miner Res 17:1200-10. 2002
    ....
  21. pmc NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism
    Zhenqiang Yao
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Clin Invest 119:3024-34. 2009
    ..These findings suggest that upregulation of TRAF3 or NF-kappaB p100 expression or inhibition of NF-kappaB p100 degradation in OCPs could limit bone destruction and inflammation-induced bone loss in common bone diseases...
  22. ncbi request reprint RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis
    Ping Li
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Bone Miner Res 19:207-13. 2004
    ..RANK signaling is not required for the TNFalpha-stimulated increase in CD11b(hi) osteoclast precursors but is essential for mature osteoclast formation...
  23. ncbi request reprint SRC inhibitors in metastatic bone disease
    Brendan F Boyce
    University of Rochester Medical Center, Rochester, New York 14642, USA
    Clin Cancer Res 12:6291s-6295s. 2006
    ....
  24. pmc Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flow
    Jie Li
    University of Rochester School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 65:130-8. 2013
    ..The aim of this study was to examine whether the efficacy of B cell depletion therapy is associated with restoration of lymphatic drainage due to removal of obstructing nodal B cells...
  25. pmc Noncanonical NF-κB signaling regulates hematopoietic stem cell self-renewal and microenvironment interactions
    Chen Zhao
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Stem Cells 30:709-18. 2012
    ....
  26. pmc Expanded CD23(+)/CD21(hi) B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis in TNF-transgenic mice and are targets of anti-CD20 therapy
    Jie Li
    Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 19642, USA
    J Immunol 184:6142-50. 2010
    ..On the basis of these findings, we propose a model whereby B cells contribute to arthritis in mice, and possibly RA, by directly affecting the structure, composition, and function of joint-draining lymph nodes...
  27. pmc Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2
    Michihiko Usui
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Bone Miner Res 23:314-25. 2008
    ..We report that hypertrophic chondrocytes induce osteoclast formation through RANKL production stimulated by BMP2 and Runx2/Smad1 and thus they may regulate resorption of calcified matrix by osteoclasts at growth plates...
  28. ncbi request reprint TNF-alpha and pathologic bone resorption
    Brendan F Boyce
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Keio J Med 54:127-31. 2005
    ..Here we review our current understanding of the mechanisms whereby TNFa increases osteoclastogenesis in vitro and in vivo...
  29. pmc Power Doppler ultrasound phenotyping of expanding versus collapsed popliteal lymph nodes in murine inflammatory arthritis
    Echoe M Bouta
    Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America Department of Biomedical Engineering, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America
    PLoS ONE 8:e73766. 2013
    ....
  30. pmc Tumor necrosis factor inhibits mesenchymal stem cell differentiation into osteoblasts via the ubiquitin E3 ligase Wwp1
    Lan Zhao
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Stem Cells 29:1601-10. 2011
    ....
  31. pmc CD23(+)/CD21(hi) B-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic flare in TNF-Tg mice
    Jie Li
    Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Res Ther 13:R138. 2011
    ....
  32. pmc Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia
    Benjamin J Frisch
    Endocrine Metabolism Division, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Blood 119:540-50. 2012
    ..Based on these results, we propose that therapeutic mitigation of leukemia-induced uncoupling of osteoblastic and osteoclastic cells may represent a novel approach to promote normal hematopoiesis in patients with myeloid neoplasms...
  33. ncbi request reprint Autoimmunity and bone
    Edward M Schwarz
    Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    Ann N Y Acad Sci 1068:275-83. 2006
    ..Thus, systemic factors produced by autoimmunity have a dramatic impact on active myelopoiesis and bone homeostasis...
  34. pmc Functions of nuclear factor kappaB in bone
    Brendan F Boyce
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Ann N Y Acad Sci 1192:367-75. 2010
    ..NF-kappaB inhibitors have been developed, but none have made it to clinical trials for the treatment of common bone diseases. Here we review the roles for NF-kappaB in bone and in common bone diseases...
  35. pmc Mediation of nonerosive arthritis in a mouse model of lupus by interferon-alpha-stimulated monocyte differentiation that is nonpermissive of osteoclastogenesis
    Kofi A Mensah
    University of Rochester Medical Center and University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Arthritis Rheum 62:1127-37. 2010
    ..This study was undertaken to examine the effects of IFNalpha and lupus on osteoclasts and erosion in the (NZB x NZW)F(1) mouse model of SLE with K/BxN serum-induced arthritis...
  36. ncbi request reprint In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis
    Lisa M Childs
    Department of Microbiology and Immunology, University of Rochester Medical Center, New York 14642, USA
    J Bone Miner Res 17:192-9. 2002
    ..These studies indicate that osteoclast depletion via RANK blockade is an effective method to prevent and reverse wear debris-induced osteolysis without jeopardizing osteogenesis...
  37. pmc Osteoclasts have multiple roles in bone in addition to bone resorption
    Brendan F Boyce
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Crit Rev Eukaryot Gene Expr 19:171-80. 2009
    ..Here, we review these findings, which define new roles for osteoclasts and OCPs in the growing field of osteoimmunology and in common pathologic conditions in which bone resorption is increased...
  38. ncbi request reprint New roles for osteoclasts in bone
    Brendan F Boyce
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Ann N Y Acad Sci 1116:245-54. 2007
    ..In this article, we review these findings, which support new roles for osteoclasts and OCPs in the growing field of osteoimmunology and in common pathologic conditions affecting bones and joints...
  39. pmc Ubiquitin E3 ligase Wwp1 negatively regulates osteoblast function by inhibiting osteoblast differentiation and migration
    Lei Shu
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA
    J Bone Miner Res 28:1925-35. 2013
    ..Mechanisms designed to decrease Wwp1 levels in BMSCs may represent a new approach to prevent the decrease in osteoblastic bone formation associated with aging...
  40. pmc Effects of antiresorptive agents on osteomyelitis: novel insights into the pathogenesis of osteonecrosis of the jaw
    Dan Li
    The Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
    Ann N Y Acad Sci 1192:84-94. 2010
    ....
  41. pmc Osteoprotegerin, the bone protector, is a surprising target for beta-catenin signaling
    Brendan F Boyce
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Cell Metab 2:344-5. 2005
  42. pmc Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation
    Run Shen
    Department of Orthopaedics and Department of Pathology, Center for Musculoskeletal Research, University of Rochester, School of Medicine, Rochester, New York 14642, USA
    J Biol Chem 281:3569-76. 2006
    ..Smurf1-induced Runx2 degradation serves as a negative regulatory mechanism for the BMP-Smad-Runx2 signaling pathway...
  43. pmc Ubiquitin E3 ligase Itch negatively regulates osteoclast formation by promoting deubiquitination of tumor necrosis factor (TNF) receptor-associated factor 6
    Hengwei Zhang
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 288:22359-68. 2013
    ..Thus, Itch is a new RANKL target gene that is induced during osteoclastogenesis. Itch interacts with the deubiquitinating enzyme and is required for deubiquitination of TRAF6, thus limiting RANKL-induced osteoclast formation. ..
  44. pmc Measuring intranodal pressure and lymph viscosity to elucidate mechanisms of arthritic flare and therapeutic outcomes
    Echoe M Bouta
    Center for Musculoskeletal Research, Department of Biomedical Engineering, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Ann N Y Acad Sci 1240:47-52. 2011
    ..These results demonstrate the potential of lymph node pressure and lymph viscosity measurements, and future studies to test these outcomes as biomarkers of arthritic flare are warranted...
  45. ncbi request reprint MRI and quantification of draining lymph node function in inflammatory arthritis
    Steven T Proulx
    The Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14642, USA
    Ann N Y Acad Sci 1117:106-23. 2007
    ..63, P = 0.01) between LNcap and synovial volume. TNF-Tg mice with a lower LNcap display an accelerated progression of arthritis. These results indicate a protective function of enhanced lymphatic drainage in inflammatory arthritis...
  46. pmc Troponin T3 expression in skeletal and smooth muscle is required for growth and postnatal survival: characterization of Tnnt3(tm2a(KOMP)Wtsi) mice
    Yawen Ju
    Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York
    Genesis 51:667-75. 2013
    ..Moreover, future studies with this mouse model can explore TnnT3 function in adult muscle function using the conditional-inducible gene deletion approach..
  47. ncbi request reprint Future anti-catabolic therapeutic targets in bone disease
    Brendan F Boyce
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY, 14642, USA
    Ann N Y Acad Sci 1068:447-57. 2006
    ....
  48. pmc Functions of RANKL/RANK/OPG in bone modeling and remodeling
    Brendan F Boyce
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY 14642, USA
    Arch Biochem Biophys 473:139-46. 2008
    ..Thus, the relative concentration of RANKL and OPG in bone is a major determinant of bone mass and strength. Here, we review our current understanding of the role of the RANKL/RANK/OPG system in bone modeling and remodeling...
  49. pmc MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation
    Jian Huang
    Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Stem Cells 28:357-64. 2010
    ..Together, our data demonstrated that miR-204/211 act as important endogenous negative regulators of Runx2, which inhibit osteogenesis and promote adipogenesis of mesenchymal progenitor cells and BMSCs...
  50. pmc Ubiquitin e3 ligase itch negatively regulates osteoblast differentiation from mesenchymal progenitor cells
    Hengwei Zhang
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Stem Cells 31:1574-83. 2013
    ..Itch is a potential new target for bone anabolic drug development to treat patients with bone loss...
  51. ncbi request reprint Osteoclast precursors: cytokine-stimulated immunomodulators of inflammatory bone disease
    Brendan F Boyce
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Curr Opin Rheumatol 18:427-32. 2006
    ..We review the regulation of OCP formation and differentiation, and propose that they are not only sources of bone-resorbing osteoclasts, but also of immune cells that influence the progression of inflammatory bone diseases...
  52. pmc BMP-2 modulates beta-catenin signaling through stimulation of Lrp5 expression and inhibition of beta-TrCP expression in osteoblasts
    Ming Zhang
    Department of Orthopaedics, Center for Musculoskeletal Research, Rochester, New York 14642, USA
    J Cell Biochem 108:896-905. 2009
    ..These findings suggest that BMP-2 may regulate osteoblast function in part through modulation of the beta-catenin signaling...
  53. ncbi request reprint Roles for NF-kappaB and c-Fos in osteoclasts
    Brendan F Boyce
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY 14642, USA
    J Bone Miner Metab 23:11-5. 2005
    ....
  54. doi request reprint Bruton and Tec: new links in osteoimmunology
    Brendan F Boyce
    University of Rochester Medical Center, University of Rochester, Rochester, NY 14534, USA
    Cell Metab 7:283-5. 2008
    ..A new study by Shinohara et al. (2008) shows that protein phosphorylation by the tyrosine kinases Bruton and Tec links immunity and bone as well as two signaling pathways in precursors of osteoclasts, the cells that degrade bone...
  55. pmc The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis
    Kristina Subik
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Bone 50:813-23. 2012
    ....
  56. pmc Smurf control in bone cells
    Lianping Xing
    Department of Pathology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Cell Biochem 110:554-63. 2010
    ..Moreover, we discuss the relevance of targeting the HECT E3s through the development of small-molecule inhibitors as an anticancer therapeutic strategy...
  57. pmc Delayed Fracture Healing and Increased Callus Adiposity in a C57BL/6J Murine Model of Obesity-Associated Type 2 Diabetes Mellitus
    Matthew L Brown
    Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, United States of America School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 9:e99656. 2014
    ..While fracture healing in type 1 DM (T1DM) has been studied using animal models, an investigation into delayed healing in an animal model of T2DM has not yet been performed...
  58. pmc NF-κB RelB negatively regulates osteoblast differentiation and bone formation
    Zhenqiang Yao
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA
    J Bone Miner Res 29:866-77. 2014
    ..Our findings indicate that RelB negatively regulates bone mass as mice age and limits bone formation in healing bone defects, suggesting that inhibition of RelB could reduce age-related bone loss and enhance bone repair...
  59. pmc Osteoclast fusion and regulation by RANKL-dependent and independent factors
    Lianping Xing
    Lianping Xing, Yan Xiu, Brendan F Boyce, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, United States
    World J Orthop 3:212-22. 2012
    ..All of these steps are regulated by multiple factors. In this review, we will discuss osteoclast fusion and regulation...
  60. ncbi request reprint The RANKL/RANK/OPG pathway
    Brendan F Boyce
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY 14642, USA
    Curr Osteoporos Rep 5:98-104. 2007
    ..This article reviews the roles of the RANKL/RANK/OPG system in bone and other tissues...
  61. pmc Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues
    Shuyuan Yeh
    Departments of Urology and Pathology, George H Whipple Lab for Cancer Research, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 99:13498-503. 2002
    ..The cre-lox ARKO mouse provides a much-needed in vivo animal model to study androgen functions in the selective androgen target tissues in female or male mice...
  62. pmc Biology of RANK, RANKL, and osteoprotegerin
    Brendan F Boyce
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Res Ther 9:S1. 2007
    ..Here we review our current understanding of the role of the RANKL/RANK/OPG system in bone and other tissues...
  63. doi request reprint RANKL-based osteoclastogenic assays from murine bone marrow cells
    Lianping Xing
    University of Rochester Medical Center, Rochester, NY, USA
    Methods Mol Biol 1130:307-13. 2014
    ..This protocol describes a procedure for generating osteoclasts from mouse bone marrow cells using macrophage colony stimulating factor and receptor activator of NF-κB ligand. ..
  64. ncbi request reprint NF-kappaB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitro
    Jian Q Feng
    Department of Oral Biology, School of Dentistry, University of Missouri, Kansas City, Missouri 64108, USA
    J Biol Chem 278:29130-5. 2003
    ..Therefore, in postnatal growth plate chondrocytes, expression of BMP-2 is regulated by NF-kappaB, which may play an important role in chondrogenesis...
  65. ncbi request reprint Malignant autosomal recessive osteopetrosis caused by spontaneous mutation of murine Rank
    Raj P Kapur
    Department of Pathology, Children s Hospital and Regional Medical Center, University of Washington, Seattle, Washington, USA
    J Bone Miner Res 19:1689-97. 2004
    ..The phenotype, including a block in RANKL-dependent osteoclast differentiation and lymph node agenesis, copies that of Rank(-/-) mice, which have been produced by targeted recombination...
  66. doi request reprint SAR of carbon-linked, 2-substituted purines: synthesis and characterization of AP23451 as a novel bone-targeted inhibitor of Src tyrosine kinase with in vivo anti-resorptive activity
    William C Shakespeare
    ARIAD Pharmaceuticals, Inc, 26 Landsdowne Street, Cambridge, MA 02139, USA
    Chem Biol Drug Des 71:97-105. 2008
    ....
  67. ncbi request reprint Osteoclasts, no longer osteoblast slaves
    Brendan F Boyce
    Nat Med 12:1356-8. 2006
  68. pmc Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2
    Qing Wang
    Medical College, Nankai University, Tianjin 300071, China
    J Biol Chem 282:10742-8. 2007
    ..Treatment with BMP-2 and transfection of Smad1 abolished Smurf1 binding to the OSE2 site. These results show that Smad1 binding excludes Smurf1 interaction with the OSE2 site and promotes Smad6 gene transcription...

Research Grants9

  1. Role of TNFalpha in Osteoclast-Mediated Bone Loss
    Lianping Xing; Fiscal Year: 2002
    ..abstract_text> ..
  2. Role of TNFalpha in Osteoclast-Mediated Bone Loss
    Lianping Xing; Fiscal Year: 2003
    ..abstract_text> ..
  3. Role of TNFalpha in Osteoclast-Mediated Bone Loss
    Lianping Xing; Fiscal Year: 2004
    ..abstract_text> ..
  4. Role of TNFalpha in Osteoclast-Mediated Bone Loss
    Lianping Xing; Fiscal Year: 2005
    ..abstract_text> ..
  5. Proteasomal regulation of TNF-mediated local bone loss
    Lianping Xing; Fiscal Year: 2007
    ..Results from this study should open up a new field of investigation into the involvement of Smurf E3 ligases in inflammation-mediated osteoblast inhibition in erosive bone diseases. ..
  6. Role of TNFa in Osteoclast-Mediated Bone Loss
    Lianping Xing; Fiscal Year: 2009
    ..The results will enhance our understanding of osteoclast and lymphatic biology and provide new direction for developing a novel therapy to treat arthritis. ..
  7. Role of TNFa in Osteoclast-Mediated Bone Loss
    Lianping Xing; Fiscal Year: 2010
    ..The results will enhance our understanding of osteoclast and lymphatic biology and provide new direction for developing a novel therapy to treat arthritis. ..
  8. Role of TNFa in Osteoclast-Mediated Bone Loss
    Lianping Xing; Fiscal Year: 2009
    ..The results will enhance our understanding of osteoclast and lymphatic biology and provide new direction for developing a novel therapy to treat arthritis. ..