Chao Xing

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Genetic variant I148M in PNPLA3 is associated with the ultrasonography-determined steatosis degree in a Chinese population
    Yiling Li
    Department of Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang, China
    BMC Med Genet 13:113. 2012
  2. pmc A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels
    Chao Xing
    Donald W Reynolds Cardiovascular Clinical Research Center, McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
    Am J Hum Genet 86:440-6. 2010
  3. pmc Linkage studies of catechol-O-methyltransferase (COMT) and dopamine-beta-hydroxylase (DBH) cDNA expression levels
    Chao Xing
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building 2103, Cornell Drive, Cleveland, Ohio 44106, USA
    BMC Proc 1:S95. 2007
  4. pmc Power of selective genotyping in genome-wide association studies of quantitative traits
    Chao Xing
    Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    BMC Proc 3:S23. 2009
  5. pmc Telomere shortening in familial and sporadic pulmonary fibrosis
    Jennifer T Cronkhite
    Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
    Am J Respir Crit Care Med 178:729-37. 2008
  6. pmc Subclinical lung disease, macrocytosis, and premature graying in kindreds with telomerase (TERT) mutations
    Alberto Diaz de Leon
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, 75390 8591, USA
    Chest 140:753-63. 2011
  7. pmc Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutations
    Alberto Diaz de Leon
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 5:e10680. 2010
  8. pmc Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer
    Yongyu Wang
    Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Am J Hum Genet 84:52-9. 2009
  9. pmc Comparison of microsatellites, single-nucleotide polymorphisms (SNPs) and composite markers derived from SNPs in linkage analysis
    Chao Xing
    Department of Epidemiology and Biostatistics, Wolstein Research Building, Case Western Reserve University, Cleveland, OH 44106, USA
    BMC Genet 6:S29. 2005
  10. pmc Linkage analysis of alcohol dependence using both affected and discordant sib pairs
    Pei Ying Shih
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 2103 Cornell Road, Wolstein Research Building, Cleveland, OH 44106, USA
    BMC Genet 6:S36. 2005

Collaborators

Detail Information

Publications24

  1. pmc Genetic variant I148M in PNPLA3 is associated with the ultrasonography-determined steatosis degree in a Chinese population
    Yiling Li
    Department of Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang, China
    BMC Med Genet 13:113. 2012
    ..In this study we aim to investigate whether I148M is associated with the ultrasonography-determined steatosis degree in Chinese adults...
  2. pmc A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels
    Chao Xing
    Donald W Reynolds Cardiovascular Clinical Research Center, McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
    Am J Hum Genet 86:440-6. 2010
    ..31 mg/dl per minor allele (p value = 2.2 x 10(-11)). This study reveals that there is a cache of less-frequent variants in GWAS arrays that can be identified via analytical approaches accounting for allele frequencies...
  3. pmc Linkage studies of catechol-O-methyltransferase (COMT) and dopamine-beta-hydroxylase (DBH) cDNA expression levels
    Chao Xing
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building 2103, Cornell Drive, Cleveland, Ohio 44106, USA
    BMC Proc 1:S95. 2007
    ..We also found that chromosome 19p13 showed both additive and interactive effects with 9q34 on DBH expression level. Furthermore, a potential interaction between COMT and DBH was indicated...
  4. pmc Power of selective genotyping in genome-wide association studies of quantitative traits
    Chao Xing
    Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    BMC Proc 3:S23. 2009
    ..In summary, the selective genotyping approach is most suitable for detecting common variants in candidate gene-based studies...
  5. pmc Telomere shortening in familial and sporadic pulmonary fibrosis
    Jennifer T Cronkhite
    Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
    Am J Respir Crit Care Med 178:729-37. 2008
    ..Heterozygous mutations in the coding regions of the telomerase genes, TERT and TERC, have been found in familial and sporadic cases of idiopathic interstitial pneumonia. All affected patients with mutations have short telomeres...
  6. pmc Subclinical lung disease, macrocytosis, and premature graying in kindreds with telomerase (TERT) mutations
    Alberto Diaz de Leon
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, 75390 8591, USA
    Chest 140:753-63. 2011
    ..The subclinical phenotypes of asymptomatic members of these families have not been evaluated with respect to TERT mutation status or telomere length...
  7. pmc Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutations
    Alberto Diaz de Leon
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 5:e10680. 2010
    ..Here we examine the telomere lengths and pulmonary fibrosis phenotype seen in multiple kindreds with heterozygous TERT mutations...
  8. pmc Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer
    Yongyu Wang
    Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Am J Hum Genet 84:52-9. 2009
    ..These data are consistent with SFTPA2 germline mutations that interfere with protein trafficking and cause familial IPF and lung cancer...
  9. pmc Comparison of microsatellites, single-nucleotide polymorphisms (SNPs) and composite markers derived from SNPs in linkage analysis
    Chao Xing
    Department of Epidemiology and Biostatistics, Wolstein Research Building, Case Western Reserve University, Cleveland, OH 44106, USA
    BMC Genet 6:S29. 2005
    ..Considering all factors, such as information content, flexibility of analysis method, map errors, and genotyping errors, a map of clustered SNPs can be an efficient design for a genome-wide linkage scan...
  10. pmc Linkage analysis of alcohol dependence using both affected and discordant sib pairs
    Pei Ying Shih
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 2103 Cornell Road, Wolstein Research Building, Cleveland, OH 44106, USA
    BMC Genet 6:S36. 2005
    ..Further, it works better than the conventional LOD score ASP linkage method in these data in the sense of avoiding false-positive linkage evidence...
  11. pmc Homozygosity mapping identifies a bile acid biosynthetic defect in an adult with cirrhosis of unknown etiology
    Vered Molho-Pessach
    University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Hepatology 55:1139-45. 2012
    ..This family illustrates the wide variation in expressivity that occurs in 3β-HSD deficiency and underscores the need to consider a bile acid synthetic defect as a possible cause of liver disease in adults...
  12. doi Power of genetic association studies with fixed and random genotype frequencies
    Julia Kozlitina
    Donald W Reynolds Cardiovascular Clinical Research Center, Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
    Ann Hum Genet 74:429-38. 2010
    ..We explore the effect of uncertainty in the factors that determine statistical power of association studies and propose a more economical approach to the power analysis...
  13. ncbi Localization and replication of the systemic lupus erythematosus linkage signal at 4p16: interaction with 2p11, 12q24 and 19q13 in European Americans
    Chao Xing
    Division of Genetic and Molecular Epidemiology, Department of Biostatistics and Epidemiology, Case Western Reserve University, Wolstein Research Building Rm 1312, 10900 Euclid Avenue, Cleveland, OH 44106 7281, USA
    Hum Genet 120:623-31. 2007
    ..These results provide important additional information about the SLE linkage effect at 4p16 and offer a unique approach to uncovering susceptibility loci involved in complex human diseases...
  14. pmc A logistic mixture model for a family-based association study
    Guan Xing
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    BMC Proc 1:S44. 2007
    ..The simplest version of the model only takes monogenic inheritance into account, but analysis of the GAW simulation data shows that even this simple model can be powerful for complex traits...
  15. doi Genetics and bitter taste responses to goitrin, a plant toxin found in vegetables
    Stephen Wooding
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 8591, USA
    Chem Senses 35:685-92. 2010
    ..16) than for PROP (r(2) = 0.50) and PTC (r(2) = 0.57). These findings suggest that mutations in TAS2R38 play a role in shaping goitrin perception, but the majority of variance must be explained by other factors...
  16. pmc Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    Stefano Romeo
    Donald W Reynolds Cardiovascular Clinical Research Center, Eugene McDermott Center for Human Growth and Development, Dallas, TX 75390, USA
    Nat Genet 40:1461-5. 2008
    ..Thus, variation in PNPLA3 contributes to ancestry-related and inter-individual differences in hepatic fat content and susceptibility to NAFLD...
  17. pmc Refined mapping of X-linked reticulate pigmentary disorder and sequencing of candidate genes
    Lane J Jaeckle Santos
    McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390 8591, USA
    Hum Genet 123:469-76. 2008
    ..PDR is most likely due to a mutation within the linked interval not affecting currently annotated coding exons...
  18. pmc The affected-/discordant-sib-pair design can guarantee validity of multipoint model-free linkage analysis of incomplete pedigrees when there is marker-marker disequilibrium
    Chao Xing
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH 44106, USA
    Am J Hum Genet 79:396-401. 2006
    ..We advocate the ASP/DSP design with appropriate sib-pair statistics that test the difference in allele sharing between ASPs and DSPs...
  19. doi Blindly using Wald's test can miss rare disease-causal variants in case-control association studies
    Guan Xing
    Bristol Myers Squibb Company, Pennington, NJ, USA
    Ann Hum Genet 76:168-77. 2012
    ..Our results call for caution in using Wald's test in genome-wide case-control association studies and suggest that the LR test is a better alternative in spite of its computational demands...
  20. pmc Adult-onset pulmonary fibrosis caused by mutations in telomerase
    Kalliopi D Tsakiri
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:7552-7. 2007
    ..Thus, mutations in TERT or TERC that result in telomere shortening over time confer a dramatic increase in susceptibility to adult-onset IPF...
  21. pmc Distribution of model-based multipoint heterogeneity lod scores
    Chao Xing
    Department of Clinical Sciences, McDermott Center of Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Genet Epidemiol 34:912-6. 2010
    ..We further examine the theoretical result by simulation studies...
  22. ncbi Distribution and magnitude of type I error of model-based multipoint lod scores: implications for multipoint mod scores
    Chao Xing
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Genet Epidemiol 30:447-58. 2006
    ..Therefore, caution should be taken in interpreting results when employing multipoint lod score and mod score approaches, in particular when inferring the level of linkage significance and the mode of inheritance of a trait...
  23. ncbi Genetic linkage of systemic lupus erythematosus to 13q32 in African American families with affected male members
    Chao Xing
    Division of Genetic and Molecular Epidemiology, Department of Biostatistics and Epidemiology, Case Western Reserve University, Wolstein Research Building Rm 1312, 10900 Euclid Avenue, Cleveland, OH, 44106 7281, USA
    Hum Genet 118:309-21. 2005
    ....
  24. pmc Comparison of missing data approaches in linkage analysis
    Chao Xing
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    BMC Genet 4:S44. 2003
    ..Therefore, we compare here six methods of imputing missing repeated phenotypes on results from genome-wide linkage analyses of four quantitative traits from the Framingham Heart Study cohort...