Research Topics
Genomes and GenesSpecies | Chao XingSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
| Collaborators
|
Detail Information
Publications
A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levelsChao Xing
Donald W Reynolds Cardiovascular Clinical Research Center, McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
Am J Hum Genet 86:440-6. 2010..31 mg/dl per minor allele (p value = 2.2 x 10(-11)). This study reveals that there is a cache of less-frequent variants in GWAS arrays that can be identified via analytical approaches accounting for allele frequencies...- Power of selective genotyping in genome-wide association studies of quantitative traitsChao Xing
Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
BMC Proc 3:S23. 2009..In summary, the selective genotyping approach is most suitable for detecting common variants in candidate gene-based studies... - Linkage studies of catechol-O-methyltransferase (COMT) and dopamine-beta-hydroxylase (DBH) cDNA expression levelsChao Xing
Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building 2103, Cornell Drive, Cleveland, Ohio 44106, USA
BMC Proc 1:S95. 2007..We also found that chromosome 19p13 showed both additive and interactive effects with 9q34 on DBH expression level. Furthermore, a potential interaction between COMT and DBH was indicated... - Telomere shortening in familial and sporadic pulmonary fibrosisJennifer T Cronkhite
Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
Am J Respir Crit Care Med 178:729-37. 2008..Heterozygous mutations in the coding regions of the telomerase genes, TERT and TERC, have been found in familial and sporadic cases of idiopathic interstitial pneumonia. All affected patients with mutations have short telomeres... - Subclinical lung disease, macrocytosis, and premature graying in kindreds with telomerase (TERT) mutationsAlberto Diaz de Leon
McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, 75390 8591, USA
Chest 140:753-63. 2011..The subclinical phenotypes of asymptomatic members of these families have not been evaluated with respect to TERT mutation status or telomere length... - Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancerYongyu Wang
Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Am J Hum Genet 84:52-9. 2009..These data are consistent with SFTPA2 germline mutations that interfere with protein trafficking and cause familial IPF and lung cancer... - Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutationsAlberto Diaz de Leon
McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
PLoS ONE 5:e10680. 2010..Here we examine the telomere lengths and pulmonary fibrosis phenotype seen in multiple kindreds with heterozygous TERT mutations... - Comparison of microsatellites, single-nucleotide polymorphisms (SNPs) and composite markers derived from SNPs in linkage analysisChao Xing
Department of Epidemiology and Biostatistics, Wolstein Research Building, Case Western Reserve University, Cleveland, OH 44106, USA
BMC Genet 6:S29. 2005..Considering all factors, such as information content, flexibility of analysis method, map errors, and genotyping errors, a map of clustered SNPs can be an efficient design for a genome-wide linkage scan... - Linkage analysis of alcohol dependence using both affected and discordant sib pairsPei Ying Shih
Department of Epidemiology and Biostatistics, Case Western Reserve University, 2103 Cornell Road, Wolstein Research Building, Cleveland, OH 44106, USA
BMC Genet 6:S36. 2005..Further, it works better than the conventional LOD score ASP linkage method in these data in the sense of avoiding false-positive linkage evidence... 
Homozygosity mapping identifies a bile acid biosynthetic defect in an adult with cirrhosis of unknown etiologyVered Molho-Pessach
University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Hepatology 55:1139-45. 2012..This family illustrates the wide variation in expressivity that occurs in 3β-HSD deficiency and underscores the need to consider a bile acid synthetic defect as a possible cause of liver disease in adults...- Power of genetic association studies with fixed and random genotype frequenciesJulia Kozlitina
Donald W Reynolds Cardiovascular Clinical Research Center, Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
Ann Hum Genet 74:429-38. 2010..We explore the effect of uncertainty in the factors that determine statistical power of association studies and propose a more economical approach to the power analysis... 
Localization and replication of the systemic lupus erythematosus linkage signal at 4p16: interaction with 2p11, 12q24 and 19q13 in European AmericansChao Xing
Division of Genetic and Molecular Epidemiology, Department of Biostatistics and Epidemiology, Case Western Reserve University, Wolstein Research Building Rm 1312, 10900 Euclid Avenue, Cleveland, OH 44106 7281, USA
Hum Genet 120:623-31. 2007..These results provide important additional information about the SLE linkage effect at 4p16 and offer a unique approach to uncovering susceptibility loci involved in complex human diseases...- A logistic mixture model for a family-based association studyGuan Xing
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
BMC Proc 1:S44. 2007..The simplest version of the model only takes monogenic inheritance into account, but analysis of the GAW simulation data shows that even this simple model can be powerful for complex traits... - Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver diseaseStefano Romeo
Donald W Reynolds Cardiovascular Clinical Research Center, Eugene McDermott Center for Human Growth and Development, Dallas, TX 75390, USA
Nat Genet 40:1461-5. 2008..Thus, variation in PNPLA3 contributes to ancestry-related and inter-individual differences in hepatic fat content and susceptibility to NAFLD... - Genetics and bitter taste responses to goitrin, a plant toxin found in vegetablesStephen Wooding
McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 8591, USA
Chem Senses 35:685-92. 2010..16) than for PROP (r(2) = 0.50) and PTC (r(2) = 0.57). These findings suggest that mutations in TAS2R38 play a role in shaping goitrin perception, but the majority of variance must be explained by other factors... - The affected-/discordant-sib-pair design can guarantee validity of multipoint model-free linkage analysis of incomplete pedigrees when there is marker-marker disequilibriumChao Xing
Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH 44106, USA
Am J Hum Genet 79:396-401. 2006..We advocate the ASP/DSP design with appropriate sib-pair statistics that test the difference in allele sharing between ASPs and DSPs... - Refined mapping of X-linked reticulate pigmentary disorder and sequencing of candidate genesLane J Jaeckle Santos
McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390 8591, USA
Hum Genet 123:469-76. 2008..PDR is most likely due to a mutation within the linked interval not affecting currently annotated coding exons... - Blindly using Wald's test can miss rare disease-causal variants in case-control association studiesGuan Xing
Bristol Myers Squibb Company, Pennington, NJ, USA
Ann Hum Genet 76:168-77. 2012..Our results call for caution in using Wald's test in genome-wide case-control association studies and suggest that the LR test is a better alternative in spite of its computational demands... - Adult-onset pulmonary fibrosis caused by mutations in telomeraseKalliopi D Tsakiri
McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 104:7552-7. 2007..Thus, mutations in TERT or TERC that result in telomere shortening over time confer a dramatic increase in susceptibility to adult-onset IPF... - Distribution of model-based multipoint heterogeneity lod scoresChao Xing
Department of Clinical Sciences, McDermott Center of Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Genet Epidemiol 34:912-6. 2010..We further examine the theoretical result by simulation studies... - Distribution and magnitude of type I error of model-based multipoint lod scores: implications for multipoint mod scoresChao Xing
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
Genet Epidemiol 30:447-58. 2006..Therefore, caution should be taken in interpreting results when employing multipoint lod score and mod score approaches, in particular when inferring the level of linkage significance and the mode of inheritance of a trait... - Genetic linkage of systemic lupus erythematosus to 13q32 in African American families with affected male membersChao Xing
Division of Genetic and Molecular Epidemiology, Department of Biostatistics and Epidemiology, Case Western Reserve University, Wolstein Research Building Rm 1312, 10900 Euclid Avenue, Cleveland, OH, 44106-7281, USA
Hum Genet 118:309-21. 2005.... - Comparison of missing data approaches in linkage analysisChao Xing
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
BMC Genet 4:S44. 2003..Therefore, we compare here six methods of imputing missing repeated phenotypes on results from genome-wide linkage analyses of four quantitative traits from the Framingham Heart Study cohort...