Xian Jin Xie

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Bayesian optimal discovery procedure for simultaneous significance testing
    Jing Cao
    Department of Statistical Science, Southern Methodist University, Dallas, Texas, USA
    BMC Bioinformatics 10:5. 2009
  2. doi request reprint Accounting for intraclass correlations and controlling for baseline differences in a cluster-randomised evidence-based practice intervention study
    Xian Jin Xie
    Department of Clinical Sciences Division of Biostatistics and Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Worldviews Evid Based Nurs 5:95-101. 2008
  3. ncbi request reprint Atypia and DNA methylation in nipple duct lavage in relation to predicted breast cancer risk
    David M Euhus
    E6 222, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9155, USA
    Cancer Epidemiol Biomarkers Prev 16:1812-21. 2007
  4. ncbi request reprint Role of physical activity in modulating breast cancer risk as defined by APC and RASSF1A promoter hypermethylation in nonmalignant breast tissue
    Yvonne M Coyle
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9103, USA
    Cancer Epidemiol Biomarkers Prev 16:192-6. 2007
  5. doi request reprint Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation
    Payal Kapur
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
    Lancet Oncol 14:159-67. 2013
  6. pmc Tamoxifen downregulates ets oncogene family members ETV4 and ETV5 in benign breast tissue: implications for durable risk reduction
    David Euhus
    Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Cancer Prev Res (Phila) 4:1852-62. 2011
  7. pmc Influence of surgical technique on mastectomy and reexcision rates in breast-conserving therapy for cancer
    Alison Unzeitig
    Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9155, USA
    Int J Surg Oncol 2012:725121. 2012
  8. pmc BAP1 loss defines a new class of renal cell carcinoma
    Samuel Peña-Llopis
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Genet 44:751-9. 2012
  9. pmc Regulation of TFEB and V-ATPases by mTORC1
    Samuel Peña-Llopis
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    EMBO J 30:3242-58. 2011
  10. pmc Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma
    Blanka Kucejova
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cancer Res 9:1255-65. 2011

Collaborators

Detail Information

Publications33

  1. pmc Bayesian optimal discovery procedure for simultaneous significance testing
    Jing Cao
    Department of Statistical Science, Southern Methodist University, Dallas, Texas, USA
    BMC Bioinformatics 10:5. 2009
    ..Several current approaches demonstrate that test statistics with shrinking variance estimates have more power over the traditional t statistic...
  2. doi request reprint Accounting for intraclass correlations and controlling for baseline differences in a cluster-randomised evidence-based practice intervention study
    Xian Jin Xie
    Department of Clinical Sciences Division of Biostatistics and Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Worldviews Evid Based Nurs 5:95-101. 2008
    ..One approach involves use of a mixed model via SAS PROC MIXED. The other approach involves use of a marginal model: Generalised estimating equations using SAS PROC GENMOD...
  3. ncbi request reprint Atypia and DNA methylation in nipple duct lavage in relation to predicted breast cancer risk
    David M Euhus
    E6 222, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9155, USA
    Cancer Epidemiol Biomarkers Prev 16:1812-21. 2007
    ..It is not known whether TSG methylation or atypia in nipple duct lavage (NDL) samples is related to predicted breast cancer risk...
  4. ncbi request reprint Role of physical activity in modulating breast cancer risk as defined by APC and RASSF1A promoter hypermethylation in nonmalignant breast tissue
    Yvonne M Coyle
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9103, USA
    Cancer Epidemiol Biomarkers Prev 16:192-6. 2007
    ..34-0.94; P = 0.03). The study provides indirect evidence supporting the hypothesis that physical activity is inversely associated with promoter hypermethylation of tumor suppressor genes, such as APC, in nonmalignant breast tissue...
  5. doi request reprint Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation
    Payal Kapur
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
    Lancet Oncol 14:159-67. 2013
    ..The aim of this study was to investigate the clinicopathological significance of these molecular subtypes and to determine whether patients with BAP1-mutant and PBRM1-mutant tumours had different overall survival...
  6. pmc Tamoxifen downregulates ets oncogene family members ETV4 and ETV5 in benign breast tissue: implications for durable risk reduction
    David Euhus
    Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Cancer Prev Res (Phila) 4:1852-62. 2011
    ..The human equivalent of murine multipotential progenitor cap cells of terminal end buds may be the primary target...
  7. pmc Influence of surgical technique on mastectomy and reexcision rates in breast-conserving therapy for cancer
    Alison Unzeitig
    Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9155, USA
    Int J Surg Oncol 2012:725121. 2012
    ..009). Multivariate analysis revealed CSM, % DCIS, tumor size, and race to influence reexcisions. Conclusions. CSM is a technique that reduces reexcisions and mastectomy rates...
  8. pmc BAP1 loss defines a new class of renal cell carcinoma
    Samuel Peña-Llopis
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Genet 44:751-9. 2012
    ..0005). Our results establish the foundation for an integrated pathological and molecular genetic classification of RCC, paving the way for subtype-specific treatments exploiting genetic vulnerabilities...
  9. pmc Regulation of TFEB and V-ATPases by mTORC1
    Samuel Peña-Llopis
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    EMBO J 30:3242-58. 2011
    ..These data uncover a regulatory network linking an oncogenic transcription factor that is a master regulator of lysosomal biogenesis, TFEB, to mTORC1 and endocytosis...
  10. pmc Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma
    Blanka Kucejova
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cancer Res 9:1255-65. 2011
    ..Understanding how ccRCCs become refractory to REDD1-induced mTORC1 inhibition should shed light into the development of ccRCC and may aid in patient selection for molecular-targeted therapies...
  11. doi request reprint Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapy
    Long Shan Li
    Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, Texas 75390, USA
    Clin Cancer Res 17:275-85. 2011
    ..Although prior work suggested that β-lapachone (β-lap) could be used for the treatment of pancreatic cancers, the lack of knowledge of the compound's mechanism of action prevented optimal use of this agent...
  12. pmc RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers
    Boning Gao
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390 8593, USA
    Cancer Res 68:22-5. 2008
    ..Our results warrant a large-scale study to examine the effect of the A133S polymorphism in the development of breast and other types of cancers...
  13. pmc A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma
    Sharanya Sivanand
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Sci Transl Med 4:137ra75. 2012
    ..The routine incorporation of models recapitulating the molecular genetics and drug sensitivities of human tumors into preclinical programs has the potential to improve oncology drug development...
  14. pmc Axillary lymph node dissection for breast cancer utilizing Harmonic Focus®
    Katherine T Ostapoff
    Department of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9155, USA
    World J Surg Oncol 9:90. 2011
    ..We hypothesize that ALND performed with the Harmonic Focus® will decrease operative time and reduce post-operative complications...
  15. doi request reprint Impact of routine cavity shave margins on breast cancer re-excision rates
    Anne Kobbermann
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Ann Surg Oncol 18:1349-55. 2011
    ..We hypothesized that routine excision of additional cavity shave margins (CSM) at time of initial partial mastectomy reduces the need for additional surgery...
  16. doi request reprint Cooperation and antagonism among cancer genes: the renal cancer paradigm
    Samuel Peña-Llopis
    Departments of Internal Medicine, Developmental Biology, and Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer Res 73:4173-9. 2013
    ..An enhanced understanding of cancer gene dependencies may help to unravel vulnerabilities that can be exploited therapeutically...
  17. doi request reprint Survival impact of malignant pancreatic neuroendocrine and islet cell neoplasm phenotypes
    Christina L Roland
    Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390 9155, USA
    J Surg Oncol 105:595-600. 2012
    ..This study examined the survival impact of malignant pancreatic ICT morphologic subtypes...
  18. ncbi request reprint Progesterone receptor expression is a marker for early stage breast cancer: implications for progesterone receptor as a therapeutic tool and target
    Yvonne M Coyle
    UT Southwestern Medical Center, Department of Medicine, Hamon Center for Therapeutic Oncology Research, 5323 Harry Hines Boulevard, Dallas, TX 75390 9103, USA
    Cancer Lett 258:253-61. 2007
    ..88; confidence interval (CI), 0.77-0.99; P=0.03) and not ER expression (OR, 1.04; CI, 0.94-1.16; P=0.45) was inversely associated with stage. PR and not ER expression is a marker for early stage breast cancer...
  19. ncbi request reprint A peptide selected by biopanning identifies the integrin alphavbeta6 as a prognostic biomarker for nonsmall cell lung cancer
    Anissa N Elayadi
    Division of Translational Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer Res 67:5889-95. 2007
    ..Thus, cell-specific peptides isolated from phage biopanning can be used for the discovery of cell surface biomarkers, emphasizing the utility of peptide libraries to probe the surface of a cell...
  20. ncbi request reprint Synthetic lethal screen identification of chemosensitizer loci in cancer cells
    Angelique W Whitehurst
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nature 446:815-9. 2007
    ....
  21. pmc Phase I dose-escalation study of stereotactic body radiation therapy for low- and intermediate-risk prostate cancer
    Thomas P Boike
    University of Texas Southwestern, Dallas, TX 75390, USA
    J Clin Oncol 29:2020-6. 2011
    ..To evaluate the tolerability of escalating doses of stereotactic body radiation therapy in the treatment of localized prostate cancer...
  22. doi request reprint Phospho-mTOR is not upregulated in metastatic SDHB paragangliomas
    Hans K Ghayee
    Department of Internal Medicine, VA North Texas Health Care System, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Eur J Clin Invest 43:970-7. 2013
    ..Treatment for patients with metastatic tumours is lacking. As new PCC/PGL susceptibility genes are discovered that are associated with the mTOR pathway, treatment targets focusing on this pathway are being intensively explored...
  23. doi request reprint A randomised trial of nursing interventions supporting recovery of the postmastectomy patient
    Ho Soon Michelle Cho
    Texas Woman s University, Dallas, TX 75235, USA
    J Clin Nurs 22:919-29. 2013
    ..This ABC to recovery study evaluated the combined and separate components of preoperative education and the effectiveness of wearing the Papilla Gown...
  24. pmc Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia
    Nicholas C Wolff
    University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9133, USA
    Mol Cell Biol 31:1870-84. 2011
    ..Interestingly, topological differences in mTORC1 regulation by the tumor suppressor proteins Lkb1 and Tsc1/Tsc2 may underlie their tissue specificity of tumor suppressor action...
  25. pmc TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer
    Shinako Araki
    Department of Oncology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390 8807, USA
    J Clin Invest 120:290-302. 2010
    ..Identification of Hdm2 as a downstream target of TGF-beta1 represents a critical prosurvival mechanism in cancer progression and provides another point for therapeutic intervention in late-stage cancer...
  26. pmc Prediction of post-operative necrosis after mastectomy: a pilot study utilizing optical diffusion imaging spectroscopy
    Roshni Rao
    Department of Surgery, Division of Surgical Oncology, University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9155, USA
    World J Surg Oncol 7:91. 2009
    ..Optical Diffusion Imaging Spectroscopy (ViOptix T.Ox Tissue Oximeter) measures the ratio of oxyhemoglobin to deoxyhemoglobin over a 1 x 1 cm area to obtain a non-invasive measurement of perfusion (StO2)...
  27. pmc Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation
    Ying Dong
    Departments of Pharmacology, Radiation Oncology, Pathology, Biostatistics and Clinical Sciences, and Urology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8807, USA
    Cancer Res 70:8088-96. 2010
    ..Our findings offer a rationale for the clinical utilization of β-lap (Arq 501) as a radiosensitizer in prostate cancers that overexpress NQO1, offering a potentially synergistic targeting strategy to exploit PARP-1 hyperactivation...
  28. pmc Upregulation of TRAG3 gene in urothelial carcinoma of the bladder
    Jose A Karam
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9110, USA
    Int J Cancer 128:2823-32. 2011
    ..Knowing the status of TRAG3 expression could help clinicians tailor treatment to a particular patient population that could benefit from treatment, while allocating patients with resistant tumors to new experimental therapies...
  29. doi request reprint DNA methylation in benign breast epithelium in relation to age and breast cancer risk
    David M Euhus
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer Epidemiol Biomarkers Prev 17:1051-9. 2008
    ..In proliferative epithelium, such as breast, this may provide an individualized cell-based measure of cancer risk...
  30. doi request reprint A gender gap in the dermatology literature? Cross-sectional analysis of manuscript authorship trends in dermatology journals during 3 decades
    Jamison D Feramisco
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Am Acad Dermatol 60:63-9. 2009
    ....
  31. ncbi request reprint Evaluation and characteristics of "dropouts" in a longitudinal clinical study
    Ronald L Ettinger
    Department of Prosthodontics, University of Iowa, Iowa City, IA 52242, USA
    Clin Oral Investig 8:18-24. 2004
    ..Health behaviors such as brushing overdenture abutments or fluoride use may be more predictable but are harder to assess until persons have been study participants for some time...
  32. ncbi request reprint Acute pain treatment for older adults hospitalized with hip fracture: current nursing practices and perceived barriers
    Marita G Titler
    Department of Nursing Services and Patient Care, University of Iowa Hospitals and Clinics, Iowa City, IA 52242 1009, USA
    Appl Nurs Res 16:211-27. 2003
    ..Findings from this multi-site study show that active and focused "translation" interventions are needed to promote adoption of evidence-based acute pain management practices by health care providers...
  33. ncbi request reprint Oral health, nutrient intake and dietary quality in the very old
    Teresa A Marshall
    J Am Dent Assoc 133:1369-79. 2002
    ..The authors describe relationships between dietary variety, nutrient intake and oral health measures in community-dwelling, rural Iowans aged 79 years and older...