Research Topics
Genomes and Genes
| Xian Jin XieSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
| Collaborators
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Detail Information
Publications
Bayesian optimal discovery procedure for simultaneous significance testingJing Cao
Department of Statistical Science, Southern Methodist University, Dallas, Texas, USA
BMC Bioinformatics 10:5. 2009..Several current approaches demonstrate that test statistics with shrinking variance estimates have more power over the traditional t statistic...
Accounting for intraclass correlations and controlling for baseline differences in a cluster-randomised evidence-based practice intervention studyXian Jin Xie
Department of Clinical Sciences Division of Biostatistics and Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Worldviews Evid Based Nurs 5:95-101. 2008..The choice between a mixed model or marginal approach should be dictated by whether the primary interest is a population or individual...
Atypia and DNA methylation in nipple duct lavage in relation to predicted breast cancer riskDavid M Euhus
E6 222, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9155, USA
Cancer Epidemiol Biomarkers Prev 16:1812-21. 2007..It is not known whether TSG methylation or atypia in nipple duct lavage (NDL) samples is related to predicted breast cancer risk...- Role of physical activity in modulating breast cancer risk as defined by APC and RASSF1A promoter hypermethylation in nonmalignant breast tissueYvonne M Coyle
Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9103, USA
Cancer Epidemiol Biomarkers Prev 16:192-6. 2007..34-0.94; P = 0.03). The study provides indirect evidence supporting the hypothesis that physical activity is inversely associated with promoter hypermethylation of tumor suppressor genes, such as APC, in nonmalignant breast tissue... - Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validationPayal Kapur
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
Lancet Oncol 14:159-67. 2013..The aim of this study was to investigate the clinicopathological significance of these molecular subtypes and to determine whether patients with BAP1-mutant and PBRM1-mutant tumours had different overall survival... - Tamoxifen downregulates ets oncogene family members ETV4 and ETV5 in benign breast tissue: implications for durable risk reductionDavid Euhus
Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
Cancer Prev Res (Phila) 4:1852-62. 2011..The human equivalent of murine multipotential progenitor cap cells of terminal end buds may be the primary target... - Influence of surgical technique on mastectomy and reexcision rates in breast-conserving therapy for cancerAlison Unzeitig
Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9155, USA
Int J Surg Oncol 2012:725121. 2012..009). Multivariate analysis revealed CSM, % DCIS, tumor size, and race to influence reexcisions. Conclusions. CSM is a technique that reduces reexcisions and mastectomy rates... - BAP1 loss defines a new class of renal cell carcinomaSamuel Peña-Llopis
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Nat Genet 44:751-9. 2012..0005). Our results establish the foundation for an integrated pathological and molecular genetic classification of RCC, paving the way for subtype-specific treatments exploiting genetic vulnerabilities... - Regulation of TFEB and V-ATPases by mTORC1Samuel Peña-Llopis
Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
EMBO J 30:3242-58. 2011..These data uncover a regulatory network linking an oncogenic transcription factor that is a master regulator of lysosomal biogenesis, TFEB, to mTORC1 and endocytosis... - Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinomaBlanka Kucejova
Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Mol Cancer Res 9:1255-65. 2011..Understanding how ccRCCs become refractory to REDD1-induced mTORC1 inhibition should shed light into the development of ccRCC and may aid in patient selection for molecular-targeted therapies... - Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapyLong Shan Li
Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, Texas 75390, USA
Clin Cancer Res 17:275-85. 2011..Although prior work suggested that β-lapachone (β-lap) could be used for the treatment of pancreatic cancers, the lack of knowledge of the compound's mechanism of action prevented optimal use of this agent... - RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriersBoning Gao
Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390 8593, USA
Cancer Res 68:22-5. 2008..Our results warrant a large-scale study to examine the effect of the A133S polymorphism in the development of breast and other types of cancers... - A validated tumorgraft model reveals activity of dovitinib against renal cell carcinomaSharanya Sivanand
Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Sci Transl Med 4:137ra75. 2012..The routine incorporation of models recapitulating the molecular genetics and drug sensitivities of human tumors into preclinical programs has the potential to improve oncology drug development... - Axillary lymph node dissection for breast cancer utilizing Harmonic Focus®Katherine T Ostapoff
Department of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9155, USA
World J Surg Oncol 9:90. 2011..We hypothesize that ALND performed with the Harmonic Focus® will decrease operative time and reduce post-operative complications... - Impact of routine cavity shave margins on breast cancer re-excision ratesAnne Kobbermann
Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA
Ann Surg Oncol 18:1349-55. 2011..We hypothesized that routine excision of additional cavity shave margins (CSM) at time of initial partial mastectomy reduces the need for additional surgery... - Survival impact of malignant pancreatic neuroendocrine and islet cell neoplasm phenotypesChristina L Roland
Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390 9155, USA
J Surg Oncol 105:595-600. 2012..This study examined the survival impact of malignant pancreatic ICT morphologic subtypes... - Phase I dose-escalation study of stereotactic body radiation therapy for low- and intermediate-risk prostate cancerThomas P Boike
University of Texas Southwestern, Dallas, TX 75390, USA
J Clin Oncol 29:2020-6. 2011..To evaluate the tolerability of escalating doses of stereotactic body radiation therapy in the treatment of localized prostate cancer... - A peptide selected by biopanning identifies the integrin alphavbeta6 as a prognostic biomarker for nonsmall cell lung cancerAnissa N Elayadi
Division of Translational Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Cancer Res 67:5889-95. 2007..Thus, cell-specific peptides isolated from phage biopanning can be used for the discovery of cell surface biomarkers, emphasizing the utility of peptide libraries to probe the surface of a cell... - Progesterone receptor expression is a marker for early stage breast cancer: implications for progesterone receptor as a therapeutic tool and targetYvonne M Coyle
UT Southwestern Medical Center, Department of Medicine, Hamon Center for Therapeutic Oncology Research, 5323 Harry Hines Boulevard, Dallas, TX 75390 9103, USA
Cancer Lett 258:253-61. 2007..88; confidence interval (CI), 0.77-0.99; P=0.03) and not ER expression (OR, 1.04; CI, 0.94-1.16; P=0.45) was inversely associated with stage. PR and not ER expression is a marker for early stage breast cancer... - Synthetic lethal screen identification of chemosensitizer loci in cancer cellsAngelique W Whitehurst
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Nature 446:815-9. 2007.... - A randomised trial of nursing interventions supporting recovery of the postmastectomy patientHo Soon Michelle Cho
Texas Woman s University, Dallas, TX 75235, USA
J Clin Nurs 22:919-29. 2013..This ABC to recovery study evaluated the combined and separate components of preoperative education and the effectiveness of wearing the Papilla Gown... - Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxiaNicholas C Wolff
University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9133, USA
Mol Cell Biol 31:1870-84. 2011..Interestingly, topological differences in mTORC1 regulation by the tumor suppressor proteins Lkb1 and Tsc1/Tsc2 may underlie their tissue specificity of tumor suppressor action... - TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancerShinako Araki
Department of Oncology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390 8807, USA
J Clin Invest 120:290-302. 2010..Identification of Hdm2 as a downstream target of TGF-beta1 represents a critical prosurvival mechanism in cancer progression and provides another point for therapeutic intervention in late-stage cancer... - Prediction of post-operative necrosis after mastectomy: a pilot study utilizing optical diffusion imaging spectroscopyRoshni Rao
Department of Surgery, Division of Surgical Oncology, University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9155, USA
World J Surg Oncol 7:91. 2009..Optical Diffusion Imaging Spectroscopy (ViOptix T.Ox Tissue Oximeter) measures the ratio of oxyhemoglobin to deoxyhemoglobin over a 1 x 1 cm area to obtain a non-invasive measurement of perfusion (StO2)... - Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivationYing Dong
Departments of Pharmacology, Radiation Oncology, Pathology, Biostatistics and Clinical Sciences, and Urology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8807, USA
Cancer Res 70:8088-96. 2010..Our findings offer a rationale for the clinical utilization of β-lap (Arq 501) as a radiosensitizer in prostate cancers that overexpress NQO1, offering a potentially synergistic targeting strategy to exploit PARP-1 hyperactivation... - Upregulation of TRAG3 gene in urothelial carcinoma of the bladderJose A Karam
Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9110, USA
Int J Cancer 128:2823-32. 2011..Knowing the status of TRAG3 expression could help clinicians tailor treatment to a particular patient population that could benefit from treatment, while allocating patients with resistant tumors to new experimental therapies... - DNA methylation in benign breast epithelium in relation to age and breast cancer riskDavid M Euhus
Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Cancer Epidemiol Biomarkers Prev 17:1051-9. 2008..In proliferative epithelium, such as breast, this may provide an individualized cell-based measure of cancer risk... - A gender gap in the dermatology literature? Cross-sectional analysis of manuscript authorship trends in dermatology journals during 3 decadesJamison D Feramisco
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Am Acad Dermatol 60:63-9. 2009.... - Evaluation and characteristics of "dropouts" in a longitudinal clinical studyRonald L Ettinger
Department of Prosthodontics, University of Iowa, Iowa City, IA 52242, USA
Clin Oral Investig 8:18-24. 2004..Health behaviors such as brushing overdenture abutments or fluoride use may be more predictable but are harder to assess until persons have been study participants for some time... - Acute pain treatment for older adults hospitalized with hip fracture: current nursing practices and perceived barriersMarita G Titler
Department of Nursing Services and Patient Care, University of Iowa Hospitals and Clinics, Iowa City, IA 52242 1009, USA
Appl Nurs Res 16:211-27. 2003..Findings from this multi-site study show that active and focused "translation" interventions are needed to promote adoption of evidence-based acute pain management practices by health care providers... - Oral health, nutrient intake and dietary quality in the very oldTeresa A Marshall
J Am Dent Assoc 133:1369-79. 2002..The authors describe relationships between dietary variety, nutrient intake and oral health measures in community-dwelling, rural Iowans aged 79 years and older...