Research Topics
Species | Sharon X XieSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Detail Information
Publications
Building an integrated neurodegenerative disease database at an academic health centerSharon X Xie
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Alzheimers Dement 7:e84-93. 2011..These comparative studies rely on powerful database tools to quickly generate data sets that match diverse and complementary criteria set by them...- Longitudinal patterns of semantic and episodic memory in frontotemporal lobar degeneration and Alzheimer's diseaseSharon X Xie
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
J Int Neuropsychol Soc 16:278-86. 2010..These data suggest the presence of specific longitudinal patterns of impairment for episodic and semantic memory in AD and FTLD patients suggesting that all forms of dementia do not necessarily converge into a single phenotype... - Neuropathologic substrates of Parkinson disease dementiaDavid J Irwin
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Morris K Udall Parkinson s Disease Center of Excellence, Institute on Aging, Philadelphia, PA, USA
Ann Neurol 72:587-98. 2012..A study was undertaken to examine the neuropathological substrates of cognitive dysfunction and dementia in Parkinson disease (PD)... - Clinical and pathological continuum of multisystem TDP-43 proteinopathiesFelix Geser
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Arch Neurol 66:180-9. 2009.... - The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic miceBin Zhang
Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 32:3601-11. 2012..These data reveal that brain-penetrant MT-stabilizing drugs hold promise for the treatment of AD and related tauopathies, and that EpoD could be a candidate for clinical testing... - Neuropsychological decline in frontotemporal lobar degeneration: a longitudinal analysisDavid J Libon
Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
Neuropsychology 23:337-46. 2009..These data indicate that distinct patterns of neuropsychological impairment are maintained longitudinally, reflecting the unique anatomic distribution of relative disease burden in AD and FTLD... - Genetic influences on cognitive decline in Parkinson's diseaseJames F Morley
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvalia, USA
Mov Disord 27:512-8. 2012..Clinically, these results suggest that genotyping can provide information about the risk of future cognitive decline for PD patients... - CSF biomarkers cutoffs: the importance of coincident neuropathological diseasesJon B Toledo
Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, CNDR, University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA
Acta Neuropathol 124:23-35. 2012.... - Alzheimer's disease pattern of brain atrophy predicts cognitive decline in Parkinson's diseaseDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3339, USA
Brain 135:170-80. 2012..In addition, an Alzheimer's disease pattern of brain atrophy may be a preclinical biomarker of cognitive decline in Parkinson's disease... - Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementiasMark Yarchoan
3615 Chestnut Street, Philadelphia, PA 19104, USA
Brain 135:3749-56. 2012.... - Prevalence and risk factors for insomnia among breast cancer patients on aromatase inhibitorsKrupali Desai
Department of Family Medicine and Community Health, University of Pennsylvania, 3400 Spruce Street, 2 Gates Building, Philadelphia, PA 19104, USA
Support Care Cancer 21:43-51. 2013.... - Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosisJohannes Brettschneider
Center for Neurodegenerative Disease Research CNDR, University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA
Acta Neuropathol 123:395-407. 2012..In contrast, AD pathology in ALS is primarily related to increasing age and associated with a poorer performance on the MMSE... 
Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosisFelix Geser
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Alzheimer s Disease Core Center, Institute on Aging, Philadelphia, USA
Arch Neurol 65:636-41. 2008....- Ethnoracial differences in the clinical characteristics of Alzheimer's disease at initial presentation at an urban Alzheimer's disease centerMelissa Gartenberg Livney
From the Penn Memory Center, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Geriatr Psychiatry 19:430-9. 2011.... - Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathiesDavid J Irwin
Centre for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Alzheimer s Disease Core Centre, Institute on Ageing, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Brain 135:807-18. 2012..Thus, inhibiting tau acetylation could be a disease-modifying target for drug discovery target in tauopathies... - Neurodegeneration across stages of cognitive decline in Parkinson diseaseDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, 3615 Chestnut St, Ste 330, Philadelphia, PA 19104, USA
Arch Neurol 68:1562-8. 2011..To assess regions and patterns of brain atrophy in patients with Parkinson disease (PD) with normal cognition (PD-NC), mild cognitive impairment (PD-MCI), and dementia-level cognitive deficits (PDD)... - Plasma epidermal growth factor levels predict cognitive decline in Parkinson diseaseAlice S Chen-Plotkin
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Ann Neurol 69:655-63. 2011..Most people with Parkinson disease (PD) eventually develop cognitive impairment (CI). However, neither the timing of onset nor the severity of cognitive symptoms can be accurately predicted. We sought plasma-based biomarkers for CI in PD... - The Philadelphia Brief Assessment of Cognition (PBAC): a validated screening measure for dementiaDavid J Libon
Department of Neurology, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, USA
Clin Neuropsychol 25:1314-30. 2011..The PBAC is a valid tool and able to assesses differential patterns neuropsychological/behavioral impairment in a broad range of neurodegenerative conditions... 
Symptom burden among cancer survivors: impact of age and comorbidityJun J Mao
Department of Family Medicine and Community Health, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
J Am Board Fam Med 20:434-43. 2007....- The organization and anatomy of narrative comprehension and expression in Lewy body spectrum disordersSharon Ash
University of Pennsylvania, Philadelphia, PA, USA
Neuropsychology 26:368-84. 2012..We predicted that comprehension and expression of narrative would be similarly affected and that deficits in both expression and comprehension of narrative would be related to the same anatomic distribution of prefrontal disease... - Patient-physician communication about complementary and alternative medicine in a radiation oncology settingJin Ge
Perelman School of Medicine at the University of Pennsylvania, Department of Radiation Oncology, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
Int J Radiat Oncol Biol Phys 85:e1-6. 2013..This study quantified the extent of patient-physician communication about CAM and identified factors associated with its discussion in radiation therapy (RT) settings... - Phosphorylated tau/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalusSunil Patel
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Fluids Barriers CNS 9:7. 2012..abstract:.. - Would caregivers of Alzheimer disease patients involve their relative in a decision to use an AD-slowing medication?Karen B Hirschman
Division of Biobehavioral and Health Sciences, The Univ of Pennsylvania, School of Nursing, Philadelphia, PA, USA
Am J Geriatr Psychiatry 13:1014-21. 2005.... - Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without severe mental illnessFelix Geser
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Arch Neurol 67:1238-50. 2010.... - Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathologyRoy Hamilton
Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
Ann Neurol 68:535-40. 2010.... - Rate of decline in Alzheimer disease measured by a Dementia Severity Rating ScaleSharon X Xie
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
Alzheimer Dis Assoc Disord 23:268-74. 2009..To measure clinically relevant change in Alzheimer disease (AD) using a family member-completed Dementia Severity Rating Scale (DSRS) questionnaire... - Motor neuron disease clinically limited to the lower motor neuron is a diffuse TDP-43 proteinopathyFelix Geser
Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Alzheimer s Disease Core Center, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Acta Neuropathol 121:509-17. 2011.... - Frequency and clinicopathological characteristics of presenilin 1 Gly206Ala mutation in Puerto Rican Hispanics with dementiaSteven E Arnold
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
J Alzheimers Dis 33:1089-95. 2013..Considered together with the increased prevalence and mortality of AD reported in Puerto Rico, these high rates may reflect hereditary risk concentrated in the island which warrants further study... - Design of comprehensive Alzheimer's disease centers to address unmet national needsJohn Q Trojanowski
Institute on Aging, Philadelphia, PA, USA
Alzheimers Dement 6:150-5. 2010..The intent of this position paper is to stimulate thinking and foster the development of other or alternative models for a systematic approach to the study of dementia and movement disorders... - Uncovering the expectancy effect: the validation of the acupuncture expectancy scaleJun J Mao
Department of Family Medicine and Community Health, University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, Philadelphia, USA
Altern Ther Health Med 16:22-7. 2010..We sought to validate a previously developed Acupuncture Expectancy Scale (AES) as an instrument to measure patients' expected responses to acupuncture... - Do Alzheimer's disease patients want to participate in a treatment decision, and would their caregivers let them?Karen B Hirschman
Institute on Aging, 3615 Chestnut Street, Philadelphia, PA 19104, USA
Gerontologist 45:381-8. 2005.... - How do patients with Alzheimer disease rate their overall quality of life?Bryan D James
Department of Medicine, Institute on Aging, 3615 Chestnut Street, Philadelphia, PA 19104, USA
Am J Geriatr Psychiatry 13:484-90. 2005..The authors asked how Alzheimer disease (AD) patients assess their overall quality of life (QOL) and sought to determine the characteristics associated with this assessment... - Odor identification deficits are associated with increased risk of neuropsychiatric complications in patients with Parkinson's diseaseRandolph Stephenson
Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA
Mov Disord 25:2099-104. 2010..These findings suggest that severity of olfactory impairment early in the disease course may be a useful marker for the risk of neuropsychiatric complications of PD... - Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating ScaleDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 2676, USA
Mov Disord 27:242-7. 2012..Preliminary results suggest that it can be used to support a diagnosis of these disorders, as well as to monitor changes in symptom severity over time... - Co-morbidity of TDP-43 proteinopathy in Lewy body related diseasesHanae Nakashima Yasuda
Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, HUP Maloney 3rd Floor, Philadelphia, PA 19104 4283, USA
Acta Neuropathol 114:221-9. 2007..This study expands the concept of TDP-43 proteinopathies by implicating TDP-43 lesions in mechanisms of neurodegeneration in LB disorders... - The development of a rapid screen for caregiver burdenKaren B Hirschman
School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Am Geriatr Soc 52:1724-9. 2004..To develop a shortened screen for burden associated with caring for a patient with Alzheimer's disease (AD)... - Comparisons of telomere lengths in peripheral blood and cerebellum in Alzheimer's diseaseJ Nicholas Lukens
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
Alzheimers Dement 5:463-9. 2009..We examined the correlation between PBL and cerebellum telomere length in AD patients, and compared telomere lengths in cerebella from individuals with AD versus age-matched control subjects... - The heterogeneity of mild cognitive impairment: a neuropsychological analysisDavid J Libon
Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
J Int Neuropsychol Soc 16:84-93. 2010..In summary, multi-domain MCI is quite common. These data suggest that MCI is a highly nuanced and complex clinical entity... - Cognitive therapy for the prevention of suicide attempts: a randomized controlled trialGregory K Brown
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
JAMA 294:563-70. 2005..Suicide attempts constitute a major risk factor for completed suicide, yet few interventions specifically designed to prevent suicide attempts have been evaluated... - Factors affecting Aβ plasma levels and their utility as biomarkers in ADNIJon B Toledo
Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, HUP, Maloney 3rd JQT or 7th LMS Floor, 36th and Spruce Streets, Philadelphia, PA, 19104 4283, USA
Acta Neuropathol 122:401-13. 2011..Our study emphasizes the need for a better understanding of the biology and dynamics of plasma Aβ as well as the need for longer term studies to determine the clinical utility of measuring plasma Aβ... - Predictors of emergent feeding tubes and tracheostomies in amyotrophic lateral sclerosis (ALS)Amy Y Tsou
Robert Wood Johnson Foundation Veterans Affairs Clinical Scholars Program, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Amyotroph Lateral Scler 13:318-25. 2012..Academic hospital affiliation decreased odds of emergent gastrostomy or tracheostomy. After Medicare changes broadening access, while gastrostomy use increased, the proportion of emergent procedures decreased... - Simulated brain biopsy for diagnosing neurodegeneration using autopsy-confirmed casesSriram Venneti
Division of Neuropathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
Acta Neuropathol 122:737-45. 2011.... - Long-term effects of bilateral subthalamic nucleus stimulation on health-related quality of life in advanced Parkinson's diseaseAndrew Siderowf
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA
Mov Disord 21:746-53. 2006..01). In this selected group of patients, many of the short-term gains in HRQL persist beyond 18 months after STN implantation. Benefits in nonmotor aspects of HRQL such as bodily discomfort and stigma appear to be among the most durable... - Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathyKurt R Brunden
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 30:13861-6. 2010..These results suggest that certain brain-penetrant MT-stabilizing agents might provide a viable therapeutic strategy for the treatment of AD and FTDs... - Genetic testing and Parkinson disease: assessment of patient knowledge, attitudes, and interestDana Clay Falcone
Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA 19104, USA
J Genet Couns 20:384-95. 2011..Genetic education and counseling tools to address these needs were developed to provide patients with the ability to make informed and knowledgeable genetic testing decisions... - Feasibility trial of electroacupuncture for aromatase inhibitor--related arthralgia in breast cancer survivorsJames J Mao
Department of Family Medicine and Community Health, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
Integr Cancer Ther 8:123-9. 2009..Given the existing evidence for electroacupuncture (EA) for treatment of osteoarthritis in the general population, this study aims to establish the feasibility of studying EA for treating AI-related arthralgia... - Development of and psychometric testing for the Brief Pain Inventory-Facial in patients with facial pain syndromesJohn Y K Lee
Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19107, USA
J Neurosurg 113:516-23. 2010..The complete 18-item instrument is referred to as the BPI-Facial... - Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of GuamFelix Geser
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Alzheimer s Disease Core Center, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104 4283, USA
Acta Neuropathol 115:133-45. 2008..Finally, we conclude that the spectrum of TDP-43 proteinopathies should be expanded to include neurodegenerative cognitive and motor diseases, affecting the Chamorro population of Guam... - Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy modelBin Zhang
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 102:227-31. 2005..Thus, MT-stabilizing drugs could have therapeutic potential for treating neurodegenerative tauopathies by offsetting losses of tau function that result from the sequestration of this MT-stabilizing protein into filamentous inclusions... - Prenatal healthcare providers' Gaucher disease carrier screening practicesDana Falcone
Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Genet Med 14:844-51. 2012..Gaucher disease carrier screening is controversial in the medical community. The goal of this study was to explore current Gaucher disease carrier screening practices of prenatal healthcare providers... - Development and Validation of an Instrument for Measuring Attitudes and Beliefs about Complementary and Alternative Medicine (CAM) Use among Cancer PatientsJun J Mao
Department of Family Medicine and Community Health, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
Evid Based Complement Alternat Med 2012:798098. 2012..001) than those who did not use CAM. Our study provides the initial evidence that the ABCAM instrument produced reliable and valid scores that measured attitudes and beliefs related to CAM use among cancer patients... - Use of complementary and alternative medicine and prayer among a national sample of cancer survivors compared to other populations without cancerJun J Mao
Department of Family Medicine and Community Health, University of Pennsylvania School of Medicine, 2 Gates Building 3400 Spruce Street, Philadelphia, PA 19104, USA
Complement Ther Med 15:21-9. 2007..Extensive use of complementary and alternative medicine (CAM) among cancer survivors has been described in literature, but the rate has not previously been compared to other groups in a true population sample... - Longitudinal reproducibility and accuracy of pseudo-continuous arterial spin-labeled perfusion MR imaging in typically developing childrenVarsha Jain
Department of Radiology and Biostatistics, University of Pennsylvania Medical Center, Philadelphia, PA, USA
Radiology 263:527-36. 2012..To evaluate the longitudinal repeatability and accuracy of cerebral blood flow (CBF) measurements by using pseudo-continuous arterial spin-labeled (pCASL) perfusion magnetic resonance (MR) imaging in typically developing children... - How does an Alzheimer's disease patient's role in medical decision making change over time?Karen B Hirschman
Department of Medicine, School of Social Work, University of Pennsylvania, 3615 Chestnut Street, Philadelphia, PA 19104, USA
J Geriatr Psychiatry Neurol 17:55-60. 2004..These results provide clinicians with prognostic information that can help caregivers understand how their role in decision making will change over the course of a patient's dementing illness... - Risk factors for death of patients with cystic fibrosis awaiting lung transplantationRichard A Belkin
Division of Pulmonary, Allergy, and Critical Care, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Medical Center, Philadelphia, PA, USA
Am J Respir Crit Care Med 173:659-66. 2006..The optimal timing for listing of cystic fibrosis patients for lung transplantation is controversial...