J Xie

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. pmc Activation of the hedgehog pathway in advanced prostate cancer
    Tao Sheng
    Sealy Centers for Cancer Cell Biology and Environmental Health, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555 1048, USA
    Mol Cancer 3:29. 2004
  2. ncbi Hedgehog signaling in prostate cancer
    Jingwu Xie
    University of Texas Medical Branch at Galveston, Sealy Centers for Cancer Cell Biology and Environmental Health, Department of Pharmacology and Toxicology, 301 University Blvd, Galveston, TX 77555 1048, USA
    Future Oncol 1:331-8. 2005
  3. doi Molecular biology of basal and squamous cell carcinomas
    Jingwu Xie
    Department of Pharmacology and Toxicology, Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1048, USA
    Adv Exp Med Biol 624:241-51. 2008
  4. ncbi Hedgehog signaling pathway: development of antagonists for cancer therapy
    Jingwu Xie
    Sealy Center for Cancer Cell Biology, Department of Pharmacology and Toxicology, University of Texas at Galveston, 301 University Boulevard, Galveston, TX 77555, USA
    Curr Oncol Rep 10:107-13. 2008
  5. pmc A role of PDGFRalpha in basal cell carcinoma proliferation
    J Xie
    Cancer Research Institute, and Department of Dermatology, University of California, San Francisco, CA 94115, USA
    Proc Natl Acad Sci U S A 98:9255-9. 2001
  6. pmc Implications of hedgehog signaling antagonists for cancer therapy
    Jingwu Xie
    Department of Pharmacology and Toxicology, Sealy Center for Cancer Cell Biology, University of Texas at Galveston, Galveston, Texas 77555 1048, USA
    Acta Biochim Biophys Sin (Shanghai) 40:670-80. 2008
  7. ncbi Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome
    M Aszterbaum
    Department of Dermatology, University of California, San Francisco, USA
    J Invest Dermatol 110:885-8. 1998
  8. ncbi Activation of the hedgehog pathway in a subset of lung cancers
    Sumin Chi
    Department of Pharmacology, Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1048, USA
    Cancer Lett 244:53-60. 2006
  9. ncbi Activating Smoothened mutations in sporadic basal-cell carcinoma
    J Xie
    Department of Dermatology, San Francisco General Hospital, University of California, 94110, USA
    Nature 391:90-2. 1998
  10. ncbi Expression of the L-type Ca(2+) channel in AtT-20 cells is regulated by cyclic AMP
    J Xie
    Department of Anatomy, University of Texas Medical Branch at Galveston, Galveston, Tex, USA
    Neuroendocrinology 70:1-9. 1999

Collaborators

Detail Information

Publications29

  1. pmc Activation of the hedgehog pathway in advanced prostate cancer
    Tao Sheng
    Sealy Centers for Cancer Cell Biology and Environmental Health, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555 1048, USA
    Mol Cancer 3:29. 2004
    ..Prostate cancer is the second most prevalent cause of cancer death in American men. Therefore, identification of novel therapeutic targets for prostate cancer has significant clinical implications...
  2. ncbi Hedgehog signaling in prostate cancer
    Jingwu Xie
    University of Texas Medical Branch at Galveston, Sealy Centers for Cancer Cell Biology and Environmental Health, Department of Pharmacology and Toxicology, 301 University Blvd, Galveston, TX 77555 1048, USA
    Future Oncol 1:331-8. 2005
    ..With small molecule inhibitors available to analyze the hedgehog signaling pathway, a novel rationale for prostate cancer therapy can be devised...
  3. doi Molecular biology of basal and squamous cell carcinomas
    Jingwu Xie
    Department of Pharmacology and Toxicology, Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1048, USA
    Adv Exp Med Biol 624:241-51. 2008
    ..In this chapter, we will focus on major recent developments in our understanding of basal cell carcinomas and squamous cell carcinomas at the molecular levels and their clinical implications...
  4. ncbi Hedgehog signaling pathway: development of antagonists for cancer therapy
    Jingwu Xie
    Sealy Center for Cancer Cell Biology, Department of Pharmacology and Toxicology, University of Texas at Galveston, 301 University Boulevard, Galveston, TX 77555, USA
    Curr Oncol Rep 10:107-13. 2008
    ..This review discusses the current understanding of the hedgehog signaling pathway and its activation in human cancers. It also discusses putative and confirmed signaling antagonists and their perspectives in therapeutic applications...
  5. pmc A role of PDGFRalpha in basal cell carcinoma proliferation
    J Xie
    Cancer Research Institute, and Department of Dermatology, University of California, San Francisco, CA 94115, USA
    Proc Natl Acad Sci U S A 98:9255-9. 2001
    ..Therefore, we conclude that increased expression of PDGFRalpha may be an important mechanism by which mutations in the hedgehog pathway cause BCCs...
  6. pmc Implications of hedgehog signaling antagonists for cancer therapy
    Jingwu Xie
    Department of Pharmacology and Toxicology, Sealy Center for Cancer Cell Biology, University of Texas at Galveston, Galveston, Texas 77555 1048, USA
    Acta Biochim Biophys Sin (Shanghai) 40:670-80. 2008
    ....
  7. ncbi Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome
    M Aszterbaum
    Department of Dermatology, University of California, San Francisco, USA
    J Invest Dermatol 110:885-8. 1998
    ..The most common mutations were frameshifts resulting in premature chain termination. These results provide further evidence for the crucial role of PTC as a tumor suppressor in human keratinocytes...
  8. ncbi Activation of the hedgehog pathway in a subset of lung cancers
    Sumin Chi
    Department of Pharmacology, Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1048, USA
    Cancer Lett 244:53-60. 2006
    ..These data indicate that activation of the hedgehog pathway is activated through Shh over-expression or Su(Fu) inactivation in only a subset of lung cancers...
  9. ncbi Activating Smoothened mutations in sporadic basal-cell carcinoma
    J Xie
    Department of Dermatology, San Francisco General Hospital, University of California, 94110, USA
    Nature 391:90-2. 1998
    ..These findings support the role of SMO as a signalling component of the SHH-receptor complex and provide direct evidence that mutated SMO can function as an oncogene in BCCs...
  10. ncbi Expression of the L-type Ca(2+) channel in AtT-20 cells is regulated by cyclic AMP
    J Xie
    Department of Anatomy, University of Texas Medical Branch at Galveston, Galveston, Tex, USA
    Neuroendocrinology 70:1-9. 1999
    ..2 fmol/mg protein in control vs. 47.4 +/- 3.2 fmol/mg protein in 8Br-cAMP-treated cells) but did not change the K(d). These studies show that both alpha(1C) mRNA and L-type Ca(2+) channel protein are increased in AtT-20 cells by cAMP...
  11. ncbi Cold stress and corticotropin-releasing hormone induced changes in messenger ribonucleic acid for the alpha(1)-subunit of the L-type Ca(2+) channel in the rat anterior pituitary and enriched populations of corticotropes
    J Xie
    Department of Anatomy, University of Texas Medical Branch at Galveston, Galveston, Tex, USA
    Neuroendocrinology 70:10-9. 1999
    ....
  12. ncbi CYP2E1 polymorphism, cigarette smoking, p53 expression, and survival in non-small cell lung cancer: a long term follow-up study
    Abida K Haque
    Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA
    Appl Immunohistochem Mol Morphol 12:315-22. 2004
    ..The significant association of long duration of smoking (>40 years) with loss of p53 expression and poor survival suggests inactivation of the protective p53 pathway in those who had a history of more than 40 years of smoking...
  13. ncbi Detoxification of olefinic epoxides and nucleotide excision repair of epoxide-mediated DNA damage: Insights from animal models examining human sensitivity to 1,3-butadiene
    Jeffrey K Wickliffe
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555, USA
    Chem Biol Interact 166:226-31. 2007
    ....
  14. ncbi Activation of the hedgehog pathway in human hepatocellular carcinomas
    Shuhong Huang
    Department of Pharmacology and Toxicology, Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1048, USA
    Carcinogenesis 27:1334-40. 2006
    ..Thus, our data indicate that hedgehog signaling activation is an important event for development of human HCCs...
  15. ncbi Differential expression of alpha1-adrenoceptor subtype mRNAs in the dorsal root ganglion after spinal nerve ligation
    J Xie
    Marine Biomedical Institute, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-1069, USA
    Brain Res Mol Brain Res 93:164-72. 2001
    ....
  16. ncbi IFNalpha induces Fas expression and apoptosis in hedgehog pathway activated BCC cells through inhibiting Ras-Erk signaling
    Chengxin Li
    Sealy Center for Cancer Cell Biology, Department of Pharmacology and Toxicology, University of Texas Medical Branch at Galveston, TX 77555, USA
    Oncogene 23:1608-17. 2004
    ..Thus, our data indicate that IFNalpha-based BCC therapy induces Fas expression and apoptosis through interfering with Mek function...
  17. ncbi Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells
    Zhenyu Ji
    Department of Pharmacology and Toxicology, Sealy Center for Cancer Cell Biology, School of Medicine, The University of Texas Medical Branch, Galveston, TX 77555, USA
    J Biol Chem 282:14048-55. 2007
    ....
  18. ncbi 3,4-Epoxy-1-butene, a reactive metabolite of 1,3-butadiene, induces somatic mutations in Xpc-null mice
    J K Wickliffe
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, Texas, USA
    Environ Mol Mutagen 47:67-70. 2006
    ..Furthermore, it is likely that alternative DNA repair pathways also are involved in restoring genomic integrity compromised by BD-epoxide DNA damage. Collaborative studies are currently underway to address these critical issues...
  19. ncbi Energy transfer cassettes for facile labeling of sequencing and PCR primers
    L Berti
    Department of Chemistry, University of California, Berkeley 94720, USA
    Anal Biochem 292:188-97. 2001
    ....
  20. pmc Identification of a large Myc-binding protein that contains RCC1-like repeats
    Q Guo
    G W Hooper Foundation, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 95:9172-7. 1998
    ..The region in Myc required for binding to Pam includes a domain that is essential for the function of Myc and that is frequently mutated in Burkitt's lymphomas. PAM is located within a 300-kb region on chromosome 13q22...
  21. ncbi Suppressing Wnt signaling by the hedgehog pathway through sFRP-1
    Jing He
    Sealy Center for Cancer Cell Biology, Department of Pharmacology and Biochemistry, University of Texas Medical Branch, Galveston, Texas 77555 1048, USA
    J Biol Chem 281:35598-602. 2006
    ..These data indicate that sFRP-1, a target gene of the hedgehog pathway, is involved in cross-talk between the hedgehog pathway and the Wnt pathway...
  22. ncbi Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal
    Tao Sheng
    Sealy Center for Cancer Cell Biology and Department of Pharmacology, University of Texas Medical Branch, Galveston, Texas 7555 1048, USA
    J Biol Chem 281:9-12. 2006
    ..These data provide evidence to support a model that PKA regulates Gli1 localization and its transcriptional activity, in part, through modulating the NLS function...
  23. ncbi A mechanism of hyperthermia-induced apoptosis in ras-transformed lung cells
    Roger A Vertrees
    Department of Surgery, Medical Branch, The University of Texas at Galveston, Galveston, TX 77555 0528, USA
    Mol Carcinog 44:111-21. 2005
    ..In summary, these data suggest that hyperthermia could become an additional modality in the multidisciplinary approach to the treatment of lung cancer...
  24. pmc Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1
    Ranajoy Chattopadhyay
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 1079, USA
    Mol Cell Biol 28:7066-80. 2008
    ..Thus, our study has established the novel role of the acetylation-mediated transcriptional regulatory function of APE1, making it a potential target for the drug sensitization of tumor cells...
  25. ncbi Regulation of lung cancer cell growth and invasiveness by beta-TRCP
    Nonggao He
    Sealy Center for Cancer Cell Biology and Environmental Medicine, University of Texas Medical Branch at Galveston, Texas 77555, USA
    Mol Carcinog 42:18-28. 2005
    ..Cells treated with CDC25A inhibitors become less invasive. Thus, loss of beta-TRCP1 may promote both growth and cell motility of lung cancer cells, possibly through regulation of CDC25A and the MMP11 level...
  26. ncbi Hedgehog signaling is activated in subsets of esophageal cancers
    Xiaoli Ma
    Institute of Developmental Biology, School of Life Sciences, Shandong University, Jinan, China
    Int J Cancer 118:139-48. 2006
    ..Our data also indicate that downregulation of Gli1 expression may be an important mechanism by which KAAD-cyclopamine inhibits growth and induces apoptosis in esophageal cancer cells...
  27. ncbi Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis
    Mohammad Athar
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Cancer Res 64:7545-52. 2004
    ....
  28. ncbi Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas
    Xiaoli Ma
    Institute of Developmental Biology, School of Life Sciences, Shandong University, Jinan, PR China
    Carcinogenesis 26:1698-705. 2005
    ..These data predict that targeted inhibition of the hedgehog pathway may be effective in the prevention and treatment of advanced gastric adenocarcinomas...
  29. ncbi Novel mutations in the PATCHED gene in basal cell nevus syndrome
    Ching Wan Lam
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Mol Genet Metab 76:57-61. 2002
    ..All the mutations cause a shift of the open reading frames and lead to premature termination of PTCH protein translation. Our results showed that mutational inactivation of the PTCH gene causes BCNS in Chinese...