Cui-Wei Xie

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Calcium-regulated signaling pathways: role in amyloid beta-induced synaptic dysfunction
    Cui Wei Xie
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1761, USA
    Neuromolecular Med 6:53-64. 2004
  2. pmc C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity
    Erica A Fradinger
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 105:14175-80. 2008
  3. ncbi request reprint Alzheimer amyloid beta-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus
    Qi Sheng Chen
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    Neurobiol Learn Mem 77:354-71. 2002
  4. ncbi request reprint Amyloid beta prevents activation of calcium/calmodulin-dependent protein kinase II and AMPA receptor phosphorylation during hippocampal long-term potentiation
    Danyun Zhao
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, University of California Los Angeles, Los Angeles, CA 90024, USA
    J Neurophysiol 92:2853-8. 2004
  5. ncbi request reprint Phosphoinositide 3-kinase cascade facilitates mu-opioid desensitization in sensory neurons by altering G-protein-effector interactions
    Miao Tan
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, University of California, Los Angeles, Los Angeles, California 90024 1759, USA
    J Neurosci 23:10292-301. 2003

Collaborators

  • Gal Bitan
  • Xin Liu
  • Bernhard H Monien
  • B Urbanc
  • Miao Tan
  • Erica A Fradinger
  • Danyun Zhao
  • Qi Sheng Chen
  • Luis Cruz
  • Sean M Spring
  • Margaret M Condron
  • Huiyuan Li
  • George B Benedek
  • Aleksey Lomakin
  • Joseph B Watson
  • Matthias Groszer
  • Aiko M Tan
  • Amy Pandya
  • Takeshi Shimahara
  • Wei Zheng Wei

Detail Information

Publications5

  1. ncbi request reprint Calcium-regulated signaling pathways: role in amyloid beta-induced synaptic dysfunction
    Cui Wei Xie
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1761, USA
    Neuromolecular Med 6:53-64. 2004
    ..Thus, multiple Ca2+-regulated signaling pathways are involved in the synaptic action of Abeta, and malfunction of these pathways may underlie the synaptic dysfunction in early AD...
  2. pmc C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity
    Erica A Fradinger
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 105:14175-80. 2008
    ..Thus, Abeta(31-42) and Abeta(39-42) are leads for obtaining mechanism-based drugs for treatment of AD using a systematic structure-activity approach...
  3. ncbi request reprint Alzheimer amyloid beta-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus
    Qi Sheng Chen
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    Neurobiol Learn Mem 77:354-71. 2002
    ..Thus, inhibition of NMDA receptor channels and disruption of protein synthesis were two possible mechanisms contributing to Abeta-induced L-LTP impairment...
  4. ncbi request reprint Amyloid beta prevents activation of calcium/calmodulin-dependent protein kinase II and AMPA receptor phosphorylation during hippocampal long-term potentiation
    Danyun Zhao
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, University of California Los Angeles, Los Angeles, CA 90024, USA
    J Neurophysiol 92:2853-8. 2004
    ..Disruption of such mechanisms could directly contribute to Abeta-induced deficits in hippocampal synaptic plasticity and memory...
  5. ncbi request reprint Phosphoinositide 3-kinase cascade facilitates mu-opioid desensitization in sensory neurons by altering G-protein-effector interactions
    Miao Tan
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, University of California, Los Angeles, Los Angeles, California 90024 1759, USA
    J Neurosci 23:10292-301. 2003
    ..Our data suggest that the PI3Kcascade involving MAPK and Akt enhances micro-opioid desensitization via postreceptor modifications that interfere with G-protein-effector interactions...

Research Grants9

  1. CA2+ SIGNALING-- ROLE IN ABETA-INDUCED MEMORY DEFICITS
    Cui Wei Xie; Fiscal Year: 2003
    ....
  2. Neurotrophin Rescue of Beta Amyloid (AB) -induced Synaptic Dysfunction
    Cui Wei Xie; Fiscal Year: 2007
    ..The results may provide new insights into synaptic mechanisms for Abeta action and the therapeutic potentials of trkB-acting NT for early AD. ..
  3. Neurotrophin Rescue of Beta Amyloid (AB) -induced Synaptic Dysfunction
    Cui Wei Xie; Fiscal Year: 2009
    ..The results may provide new insights into synaptic mechanisms for Abeta action and the therapeutic potentials of trkB-acting NT for early AD. ..
  4. Neurotrophin Rescue of Beta Amyloid (AB) -induced Synaptic Dysfunction
    Cui Wei Xie; Fiscal Year: 2010
    ..The results may provide new insights into synaptic mechanisms for Abeta action and the therapeutic potentials of trkB-acting NT for early AD. ..