Affiliation: University of Wisconsin
- Effects of stabilizing or increasing respiratory motor outputs on obstructive sleep apneaAiliang Xie
James B Skatrud Laboratory of Pulmonary and Sleep Medicine, William S Middleton Memorial Veterans Affairs Hospital, Madison, WI 53705, USA
J Appl Physiol (1985) 115:22-33. 2013..Reducing chemosensitivity via hyperoxia had a limited and unpredictable effect on OSA. ..
- The heterogeneity of obstructive sleep apnea (predominant obstructive vs pure obstructive apnea)Ailiang Xie
Population Health Sciences, University of Wisconsin, Madison, WI, USA
Sleep 34:745-50. 2011..To compare the breathing instability and upper airway collapsibility between patients with pure OSA (i.e. 100% of apneas are obstructive) and patients with predominant OSA (i.e., coexisting obstructive and central apneas)...
- Influence of cerebrovascular function on the hypercapnic ventilatory response in healthy humansAiliang Xie
Department of Medicine, University of Wisconsin, Madison, WI, USA
J Physiol 577:319-29. 2006....
- Cerebrovascular response to carbon dioxide in patients with congestive heart failureAiliang Xie
Department of Medicine, University of Wisconsin, Madison, 53705, USA
Am J Respir Crit Care Med 172:371-8. 2005..However, there are no studies relating cerebral circulation abnormality to the presence or absence of central sleep apnea in patients with heart failure...
- Influence of cerebral blood flow on breathing stabilityAiliang Xie
Departments of Medicin, University of Wisconsin, Madison, Wisconsin 53705, USA
J Appl Physiol (1985) 106:850-6. 2009..06 +/- 0.10 vs. 1.61 +/- 0.27 l x min(-1) x mmHg(-1), P < 0.05). We conclude that reductions in the normal cerebral vascular response to hypocapnia will increase the susceptibility to apneas and breathing instability during sleep...
- Role of central/peripheral chemoreceptors and their interdependence in the pathophysiology of sleep apneaJerome A Dempsey
Department of Population Health Sciences, University of Wisconsin, Madison, WI, USA
Adv Exp Med Biol 758:343-9. 2012..Finally, we discuss the effects of preventing transient hypocapnia (via selective increases in FICO(2)) on centrally mediated types of periodic breathing and even some varieties of cyclical obstructive sleep apnea...
- Association of obstructive sleep apnea risk with asthma control in adultsMihaela Teodorescu
Medical Service, William S Middleton Memorial Veterans Hospital, Madison, WI, USA
Chest 138:543-50. 2010..Unrecognized obstructive sleep apnea (OSA) may lead to poor asthma control despite optimal therapy. Our objective was to evaluate the relationship between OSA risk and asthma control in adults...
- Influence of arterial O2 on the susceptibility to posthyperventilation apnea during sleepAiliang Xie
Department of Medicine, University of Wisconsin, Madison, USA
J Appl Physiol (1985) 100:171-7. 2006..These findings indicate that posthyperventilation apnea is initiated by the peripheral chemoreceptors and that the varying susceptibility to apnea during hypoxia vs. hyperoxia is influenced by the relative activity of these receptors...
- The ventilatory responsiveness to CO(2) below eupnoea as a determinant of ventilatory stability in sleepJerome A Dempsey
The John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin Madison, Madison, WI, 53726 2368, USA
J Physiol 560:1-11. 2004..Finally, we review growing evidence that chemoreceptor-induced instability in respiratory motor output during sleep contributes significantly to the major clinical problem of cyclical obstructive sleep apnoea...
- Cardiorespiratory effects of added dead space in patients with heart failure and central sleep apneaRami N Khayat
University of Wisconsin, Department of Medicine and the Middleton Memorial Veterans Hospital, Madison 53705, USA
Chest 123:1551-60. 2003..Added dead space (DS) as a form of supplemental CO(2) was effective in eliminating idiopathic CSA. The efficacy and safety of DS has not yet been evaluated in patients with CHF and CSA...
- Apnea-hypopnea threshold for CO2 in patients with congestive heart failureAiliang Xie
Department of Medicine, University of Wisconsin, and the Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA
Am J Respir Crit Care Med 165:1245-50. 2002..The resultant narrowed DeltaPET(CO2) predisposes the patient to the development of apnea and subsequent breathing instability...