Affiliation: University of Wisconsin
- Arousal from sleep shortens sympathetic burst latency in humansA Xie
Department of Medicine, University of Wisconsin and the Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
J Physiol 515:621-8. 1999..If so, the magnitude of arterial pressure perturbations during sleep (e.g. those caused by sleep disordered breathing and periodic leg movements) may be augmented by arousal...
- Influence of arterial O2 on the susceptibility to posthyperventilation apnea during sleepAiliang Xie
Department of Medicine, University of Wisconsin, Madison, USA
J Appl Physiol 100:171-7. 2006..These findings indicate that posthyperventilation apnea is initiated by the peripheral chemoreceptors and that the varying susceptibility to apnea during hypoxia vs. hyperoxia is influenced by the relative activity of these receptors...
- Cerebrovascular response to carbon dioxide in patients with congestive heart failureAiliang Xie
Department of Medicine, University of Wisconsin, Madison, 53705, USA
Am J Respir Crit Care Med 172:371-8. 2005..However, there are no studies relating cerebral circulation abnormality to the presence or absence of central sleep apnea in patients with heart failure...
- Influence of cerebral blood flow on breathing stabilityAiliang Xie
Departments of Medicin, University of Wisconsin, Madison, Wisconsin 53705, USA
J Appl Physiol 106:850-6. 2009..06 +/- 0.10 vs. 1.61 +/- 0.27 l x min(-1) x mmHg(-1), P < 0.05). We conclude that reductions in the normal cerebral vascular response to hypocapnia will increase the susceptibility to apneas and breathing instability during sleep...
- Apnea-hypopnea threshold for CO2 in patients with congestive heart failureAiliang Xie
Department of Medicine, University of Wisconsin, and the Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA
Am J Respir Crit Care Med 165:1245-50. 2002..The resultant narrowed DeltaPET(CO2) predisposes the patient to the development of apnea and subsequent breathing instability...
- Exposure to hypoxia produces long-lasting sympathetic activation in humansA Xie
Department of Medicine, Middleton Memorial Veterans Hospital, University of Wisconsin, 2500 Overlook Terrace, Madison, WI 53705, USA
J Appl Physiol 91:1555-62. 2001..Hypercapnia-evoked sympathetic activation is short-lived, whereas hypoxia-induced sympathetic activation outlasts the chemical stimulus...
- Effect of hypoxia on the hypopnoeic and apnoeic threshold for CO(2) in sleeping humansA Xie
University of Wisconsin, Department of Medicine, Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
J Physiol 535:269-78. 2001..01 for the apnoeic threshold). We concluded that hypoxia causes a narrowing of the difference between the baseline P(ET,CO2) and the hypopnoea/apnoeic threshold P(ET,CO2), which could increase the likelihood of ventilatory instability...
- Neurocirculatory consequences of intermittent asphyxia in humansA Xie
Department of Medicine, University of Wisconsin, Madison 53705, USA
J Appl Physiol 89:1333-9. 2000..This carryover effect provides a potential mechanism whereby intermittent asphyxia during sleep could lead to chronic sympathetic activation in patients with sleep apnea syndrome...
- The ventilatory responsiveness to CO(2) below eupnoea as a determinant of ventilatory stability in sleepJerome A Dempsey
The John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin Madison, Madison, WI, 53726 2368, USA
J Physiol 560:1-11. 2004..Finally, we review growing evidence that chemoreceptor-induced instability in respiratory motor output during sleep contributes significantly to the major clinical problem of cyclical obstructive sleep apnoea...
- Influence of cerebrovascular function on the hypercapnic ventilatory response in healthy humansAiliang Xie
Department of Medicine, University of Wisconsin, Madison, WI, USA
J Physiol 577:319-29. 2006....
- Cerebrovascular response to arousal from NREM and REM sleepMuhammad Fuad Bangash
Department of Medicine, University of Wisconsin Madison, 53706 1532, USA
Sleep 31:321-7. 2008..To determine the effect of arousal from sleep on cerebral blood flow velocity (CBFV) in relation to associated ventilatory and systemic hemodynamic changes...
- Cardiorespiratory effects of added dead space in patients with heart failure and central sleep apneaRami N Khayat
University of Wisconsin, Department of Medicine and the Middleton Memorial Veterans Hospital, Madison 53705, USA
Chest 123:1551-60. 2003..Added dead space (DS) as a form of supplemental CO(2) was effective in eliminating idiopathic CSA. The efficacy and safety of DS has not yet been evaluated in patients with CHF and CSA...
- Measurement of the CO2 apneic thresholdMagdy Younes
Am J Respir Crit Care Med 167:472; author relpy 472-3. 2003