Gutian Xiao

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint Interleukin-6 Prevents the Initiation but Enhances the Progression of Lung Cancer
    Zhaoxia Qu
    University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Cancer Res 75:3209-15. 2015
  2. pmc PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease
    Zhaoxia Qu
    University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Cell Biosci 2:23. 2012
  3. pmc NF-kappaB activation: Tax sumoylation is out, but what about Tax ubiquitination?
    Gutian Xiao
    University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Centers, Pittsburgh, PA 15213, USA
    Retrovirology 9:78. 2012
  4. pmc Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer
    Zhaoxia Qu
    University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, PA, USA
    J Biol Chem 285:11786-92. 2010
  5. pmc Human T-cell leukemia virus type I-mediated repression of PDZ-LIM domain-containing protein 2 involves DNA methylation but independent of the viral oncoprotein tax
    Pengrong Yan
    University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Neoplasia 11:1036-41. 2009
  6. pmc The tumor suppressor gene WWOX links the canonical and noncanonical NF-κB pathways in HTLV-I Tax-mediated tumorigenesis
    Jing Fu
    University of Pittsburgh Cancer Institute, Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, PA 15213, USA
    Blood 117:1652-61. 2011
  7. pmc DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target
    Zhaoxia Qu
    University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Res 70:1766-72. 2010
  8. pmc Angiopoietin-2, an angiogenic regulator, promotes initial growth and survival of breast cancer metastases to the lung through the integrin-linked kinase (ILK)-AKT-B cell lymphoma 2 (Bcl-2) pathway
    Yorihisa Imanishi
    Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 286:29249-60. 2011
  9. pmc Human T-cell lymphotropic virus: a model of NF-κB-associated tumorigenesis
    Zhaoxia Qu
    Cancer Institute, Medical Center, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Viruses 3:714-49. 2011
  10. pmc PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation
    Pengrong Yan
    University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, PA, USA
    Blood 113:4370-80. 2009

Research Grants

Collaborators

Detail Information

Publications11

  1. doi request reprint Interleukin-6 Prevents the Initiation but Enhances the Progression of Lung Cancer
    Zhaoxia Qu
    University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Cancer Res 75:3209-15. 2015
    ..These studies also significantly improve our understanding of lung cancer and provide a molecular basis for designing IL6/STAT3-targeted therapies for this deadliest human cancer...
  2. pmc PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease
    Zhaoxia Qu
    University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Cell Biosci 2:23. 2012
    ..abstract:..
  3. pmc NF-kappaB activation: Tax sumoylation is out, but what about Tax ubiquitination?
    Gutian Xiao
    University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Centers, Pittsburgh, PA 15213, USA
    Retrovirology 9:78. 2012
    ..Here, we discuss our current understanding of Tax activation of NF-κB, with a focus on the controversies and the challenges that we are facing...
  4. pmc Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer
    Zhaoxia Qu
    University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, PA, USA
    J Biol Chem 285:11786-92. 2010
    ..These studies thus provide important mechanistic insights into breast cancer pathogenesis. These studies also suggest a tumor suppression function of PDLIM2 and a therapeutic strategy for breast cancer...
  5. pmc Human T-cell leukemia virus type I-mediated repression of PDZ-LIM domain-containing protein 2 involves DNA methylation but independent of the viral oncoprotein tax
    Pengrong Yan
    University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Neoplasia 11:1036-41. 2009
    ..Given the efficient antitumor activity with no obvious toxicity of 5-aza-dC, these studies also suggest potential therapeutic strategies for ATL...
  6. pmc The tumor suppressor gene WWOX links the canonical and noncanonical NF-κB pathways in HTLV-I Tax-mediated tumorigenesis
    Jing Fu
    University of Pittsburgh Cancer Institute, Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, PA 15213, USA
    Blood 117:1652-61. 2011
    ..These data provide one important mechanism by which Tax coordinates the 2 NF-κB pathways for tumorigenesis. These data also suggest a novel role of WWOX in NF-κB regulation and viral tumorigenesis...
  7. pmc DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target
    Zhaoxia Qu
    University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Res 70:1766-72. 2010
    ..These studies thus provide new mechanistic insights into colon tumorigenesis by identifying a novel tumor suppressor role for PDLIM2...
  8. pmc Angiopoietin-2, an angiogenic regulator, promotes initial growth and survival of breast cancer metastases to the lung through the integrin-linked kinase (ILK)-AKT-B cell lymphoma 2 (Bcl-2) pathway
    Yorihisa Imanishi
    Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 286:29249-60. 2011
    ....
  9. pmc Human T-cell lymphotropic virus: a model of NF-κB-associated tumorigenesis
    Zhaoxia Qu
    Cancer Institute, Medical Center, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Viruses 3:714-49. 2011
    ..Answers to those questions will greatly advance our understanding of ATL leukemogenesis and other NF-κB-associated tumorigenesis and will help us design personalized cancer therapies...
  10. pmc PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation
    Pengrong Yan
    University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, PA, USA
    Blood 113:4370-80. 2009
    ..These studies also suggest a potential therapeutic strategy for cancers and other diseases associated with HTLV-I infection and/or PDLIM2 deregulation...
  11. doi request reprint Systematic detection of noncanonical NF-κB activation
    Zhaoxia Qu
    Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, 1 18 Hillman Cancer Center, 5117 Centre Avenue, Pittsburgh, PA, 15213, USA
    Methods Mol Biol 1280:121-54. 2015
    ..Noncanonical NF-κB-induced gene expression changes can be determined by gene array analysis and quantitative real-time PCR. ..

Research Grants1

  1. HTLV deregulation of NF-kappaB2 p100 processing in tumor
    Gutian Xiao; Fiscal Year: 2010
    ..The completion of the proposed studies may lead to new therapeutic strategies for p100 processing-associated human diseases. ..