Gutian Xiao

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease
    Zhaoxia Qu
    University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Cell Biosci 2:23. 2012
  2. pmc NF-kappaB activation: Tax sumoylation is out, but what about Tax ubiquitination?
    Gutian Xiao
    University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Centers, Pittsburgh, PA 15213, USA
    Retrovirology 9:78. 2012
  3. pmc Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer
    Zhaoxia Qu
    University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, PA, USA
    J Biol Chem 285:11786-92. 2010
  4. pmc Human T-cell leukemia virus type I-mediated repression of PDZ-LIM domain-containing protein 2 involves DNA methylation but independent of the viral oncoprotein tax
    Pengrong Yan
    University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Neoplasia 11:1036-41. 2009
  5. pmc The tumor suppressor gene WWOX links the canonical and noncanonical NF-κB pathways in HTLV-I Tax-mediated tumorigenesis
    Jing Fu
    University of Pittsburgh Cancer Institute, Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, PA 15213, USA
    Blood 117:1652-61. 2011
  6. pmc DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target
    Zhaoxia Qu
    University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Res 70:1766-72. 2010
  7. pmc Angiopoietin-2, an angiogenic regulator, promotes initial growth and survival of breast cancer metastases to the lung through the integrin-linked kinase (ILK)-AKT-B cell lymphoma 2 (Bcl-2) pathway
    Yorihisa Imanishi
    Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 286:29249-60. 2011
  8. pmc Human T-cell lymphotropic virus: a model of NF-κB-associated tumorigenesis
    Zhaoxia Qu
    Cancer Institute, Medical Center, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Viruses 3:714-49. 2011
  9. pmc PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation
    Pengrong Yan
    University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, PA, USA
    Blood 113:4370-80. 2009

Collaborators

Detail Information

Publications9

  1. pmc PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease
    Zhaoxia Qu
    University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Cell Biosci 2:23. 2012
    ..abstract:..
  2. pmc NF-kappaB activation: Tax sumoylation is out, but what about Tax ubiquitination?
    Gutian Xiao
    University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Centers, Pittsburgh, PA 15213, USA
    Retrovirology 9:78. 2012
    ..Here, we discuss our current understanding of Tax activation of NF-κB, with a focus on the controversies and the challenges that we are facing...
  3. pmc Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer
    Zhaoxia Qu
    University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, PA, USA
    J Biol Chem 285:11786-92. 2010
    ..These studies thus provide important mechanistic insights into breast cancer pathogenesis. These studies also suggest a tumor suppression function of PDLIM2 and a therapeutic strategy for breast cancer...
  4. pmc Human T-cell leukemia virus type I-mediated repression of PDZ-LIM domain-containing protein 2 involves DNA methylation but independent of the viral oncoprotein tax
    Pengrong Yan
    University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Neoplasia 11:1036-41. 2009
    ..Given the efficient antitumor activity with no obvious toxicity of 5-aza-dC, these studies also suggest potential therapeutic strategies for ATL...
  5. pmc The tumor suppressor gene WWOX links the canonical and noncanonical NF-κB pathways in HTLV-I Tax-mediated tumorigenesis
    Jing Fu
    University of Pittsburgh Cancer Institute, Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, PA 15213, USA
    Blood 117:1652-61. 2011
    ..These data provide one important mechanism by which Tax coordinates the 2 NF-κB pathways for tumorigenesis. These data also suggest a novel role of WWOX in NF-κB regulation and viral tumorigenesis...
  6. pmc DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target
    Zhaoxia Qu
    University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Res 70:1766-72. 2010
    ..These studies thus provide new mechanistic insights into colon tumorigenesis by identifying a novel tumor suppressor role for PDLIM2...
  7. pmc Angiopoietin-2, an angiogenic regulator, promotes initial growth and survival of breast cancer metastases to the lung through the integrin-linked kinase (ILK)-AKT-B cell lymphoma 2 (Bcl-2) pathway
    Yorihisa Imanishi
    Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 286:29249-60. 2011
    ....
  8. pmc Human T-cell lymphotropic virus: a model of NF-κB-associated tumorigenesis
    Zhaoxia Qu
    Cancer Institute, Medical Center, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Viruses 3:714-49. 2011
    ..Answers to those questions will greatly advance our understanding of ATL leukemogenesis and other NF-κB-associated tumorigenesis and will help us design personalized cancer therapies...
  9. pmc PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation
    Pengrong Yan
    University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, PA, USA
    Blood 113:4370-80. 2009
    ..These studies also suggest a potential therapeutic strategy for cancers and other diseases associated with HTLV-I infection and/or PDLIM2 deregulation...

Research Grants5

  1. HTLV deregulation of NF-kappaB2 p100 processing in tumor
    Gutian Xiao; Fiscal Year: 2007
    ..The completion of the proposed studies may lead to new therapeutic strategies for p100 processing-associated human diseases. ..
  2. HTLV deregulation of NF-kappaB2 p100 processing in tumor
    Gutian Xiao; Fiscal Year: 2007
    ..The completion of the proposed studies may lead to new therapeutic strategies for p100 processing-associated human diseases. ..
  3. HTLV deregulation of NF-kappaB2 p100 processing in tumor
    Gutian Xiao; Fiscal Year: 2009
    ..The completion of the proposed studies may lead to new therapeutic strategies for p100 processing-associated human diseases. ..
  4. HTLV deregulation of NF-kappaB2 p100 processing in tumor
    Gutian Xiao; Fiscal Year: 2010
    ..The completion of the proposed studies may lead to new therapeutic strategies for p100 processing-associated human diseases. ..