Shi Hua Xiang

Summary

Affiliation: University of Nebraska
Country: USA

Publications

  1. ncbi request reprint Recent advances on the use of structural biology for the design of novel envelope immunogens of HIV-1
    Shi Hua Xiang
    Nebraska Center for Virology, School of Veterinary Medicine and Biomedical Sciences, University of Nebraska Lincoln, Morrison Center 143, 4240 Fair Street, Lincoln, NE 68583 0900, USA
    Curr HIV Res 11:464-72. 2013
  2. pmc Characterization of a dual-tropic human immunodeficiency virus (HIV-1) strain derived from the prototypical X4 isolate HXBc2
    Shi Hua Xiang
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute and Department of Microbiology and Immunobiology, Division of AIDS, Harvard Medical School, Boston, MA 02215, USA
    Virology 438:5-13. 2013
  3. pmc Topological layers in the HIV-1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitions
    Andres Finzi
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Department of Pathology, Division of AIDS, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 37:656-67. 2010
  4. ncbi request reprint Epitope mapping and characterization of a novel CD4-induced human monoclonal antibody capable of neutralizing primary HIV-1 strains
    Shi Hua Xiang
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Virology 315:124-34. 2003
  5. pmc Lineage-specific differences between human and simian immunodeficiency virus regulation of gp120 trimer association and CD4 binding
    Andres Finzi
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    J Virol 86:8974-86. 2012
  6. pmc A V3 loop-dependent gp120 element disrupted by CD4 binding stabilizes the human immunodeficiency virus envelope glycoprotein trimer
    Shi Hua Xiang
    Dana Farber Cancer Institute, 44 Binney Street, CLS 1010, Boston, MA 02115, USA
    J Virol 84:3147-61. 2010
  7. ncbi request reprint Characterization of CD4-induced epitopes on the HIV type 1 gp120 envelope glycoprotein recognized by neutralizing human monoclonal antibodies
    Shi Hua Xiang
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, USA
    AIDS Res Hum Retroviruses 18:1207-17. 2002
  8. ncbi request reprint Conformational changes in env oligomer induced by an antibody dependent on the V3 loop base
    Lisa Cavacini
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    AIDS 17:685-9. 2003
  9. pmc Mutagenic stabilization and/or disruption of a CD4-bound state reveals distinct conformations of the human immunodeficiency virus type 1 gp120 envelope glycoprotein
    Shi Hua Xiang
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute and Harvard Medical School Boston, Massachusetts 02115, USA
    J Virol 76:9888-99. 2002
  10. pmc Subunit organization of the membrane-bound HIV-1 envelope glycoprotein trimer
    Youdong Mao
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Struct Mol Biol 19:893-9. 2012

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Recent advances on the use of structural biology for the design of novel envelope immunogens of HIV-1
    Shi Hua Xiang
    Nebraska Center for Virology, School of Veterinary Medicine and Biomedical Sciences, University of Nebraska Lincoln, Morrison Center 143, 4240 Fair Street, Lincoln, NE 68583 0900, USA
    Curr HIV Res 11:464-72. 2013
    ..According to the basic binding structural relationship of an antigen and an antibody, structure-based antigen design could bring some hope for the development of an effective vaccine against HIV...
  2. pmc Characterization of a dual-tropic human immunodeficiency virus (HIV-1) strain derived from the prototypical X4 isolate HXBc2
    Shi Hua Xiang
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute and Department of Microbiology and Immunobiology, Division of AIDS, Harvard Medical School, Boston, MA 02215, USA
    Virology 438:5-13. 2013
    ..We also found that the stable association of gp120 with the trimeric envelope glycoprotein complex in R5X4 viruses, as in X4 viruses, is less sensitive to V3 loop changes than gp120-trimer association in R5 viruses...
  3. pmc Topological layers in the HIV-1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitions
    Andres Finzi
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Department of Pathology, Division of AIDS, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 37:656-67. 2010
    ..Thus, despite lack of contact with CD4, the gp120 inner-domain layers govern CD4 triggering by participating in conformational transitions within gp120 and regulating the interaction with gp41...
  4. ncbi request reprint Epitope mapping and characterization of a novel CD4-induced human monoclonal antibody capable of neutralizing primary HIV-1 strains
    Shi Hua Xiang
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Virology 315:124-34. 2003
    ..Thus, on primary HIV-1 isolates, this gp120 region, which has been previously implicated in chemokine receptor binding, is accessible to a subset of CD4i antibodies...
  5. pmc Lineage-specific differences between human and simian immunodeficiency virus regulation of gp120 trimer association and CD4 binding
    Andres Finzi
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    J Virol 86:8974-86. 2012
    ..Distinct biological requirements for CD4 usage have resulted in lineage-specific differences in the HIV-1 and SIV gp120 structures that modulate trimer association and CD4 binding...
  6. pmc A V3 loop-dependent gp120 element disrupted by CD4 binding stabilizes the human immunodeficiency virus envelope glycoprotein trimer
    Shi Hua Xiang
    Dana Farber Cancer Institute, 44 Binney Street, CLS 1010, Boston, MA 02115, USA
    J Virol 84:3147-61. 2010
    ..CD4 binding dismantles this element, altering the gp120-gp41 relationship and rendering the hydrophobic patch in the V3 tip available for chemokine receptor binding...
  7. ncbi request reprint Characterization of CD4-induced epitopes on the HIV type 1 gp120 envelope glycoprotein recognized by neutralizing human monoclonal antibodies
    Shi Hua Xiang
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, USA
    AIDS Res Hum Retroviruses 18:1207-17. 2002
    ..Thus, all known CD4i antibodies recognize a common, conserved gp120 element overlapping the binding site for the CCR5 chemokine receptor...
  8. ncbi request reprint Conformational changes in env oligomer induced by an antibody dependent on the V3 loop base
    Lisa Cavacini
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    AIDS 17:685-9. 2003
    ..We have studied the ability of an IgG2 human monoclonal antibody (hmAb), F425 B4e8 (B4e8), dependent upon the base of the V3 loop, to induce conformational changes in the env oligomer...
  9. pmc Mutagenic stabilization and/or disruption of a CD4-bound state reveals distinct conformations of the human immunodeficiency virus type 1 gp120 envelope glycoprotein
    Shi Hua Xiang
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute and Harvard Medical School Boston, Massachusetts 02115, USA
    J Virol 76:9888-99. 2002
    ..These results indicate that CD4BS antibodies recognize conformations of gp120 different from that recognized by CD4 and CD4i antibodies...
  10. pmc Subunit organization of the membrane-bound HIV-1 envelope glycoprotein trimer
    Youdong Mao
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Struct Mol Biol 19:893-9. 2012
    ..The cage-like architecture, which is unique among characterized viral envelope proteins, restricts antibody access, reflecting requirements imposed by HIV-1 persistence in the host...
  11. pmc A twin-cysteine motif in the V2 region of gp120 is associated with SIV envelope trimer stabilization
    Christopher Bohl
    Nebraska Center for Virology, University of Nebraska Lincoln, Lincoln, Nebraska, United States of America
    PLoS ONE 8:e69406. 2013
    ..This implies that HIV-1 lost the twin-cysteines, and may have relatively unstable Env trimers compared to SIV and HIV-2...
  12. pmc Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120
    Navid Madani
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney Street, JFB 824, Boston, MA 02115, USA
    Structure 16:1689-701. 2008
    ....
  13. pmc Functional interplay between the B-box 2 and the B30.2(SPRY) domains of TRIM5alpha
    Xing Li
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, MA 02115, USA
    Virology 366:234-44. 2007
    ..2(SPRY) domain. Thus, some alterations in the TRIM5alpha B-box 2 domain apparently affect the orientation or conformation of the B30.2(SPRY) domain, influencing capsid recognition...
  14. pmc Functional mimicry of a human immunodeficiency virus type 1 coreceptor by a neutralizing monoclonal antibody
    Shi Hua Xiang
    Jimmy Fund Building, Room 824, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    J Virol 79:6068-77. 2005
    ..Sulfation of N-terminal tyrosines contributed to the function of this chimeric receptor. These results emphasize the close mimicry of the CCR5 N terminus by the gp120-interactive region of a naturally elicited CD4i antibody...
  15. pmc Molecular architecture of the uncleaved HIV-1 envelope glycoprotein trimer
    Youdong Mao
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 110:12438-43. 2013
    ..The Env trimer architecture provides mechanistic insights into the metastability of the unliganded state, receptor-induced conformational changes, and quaternary structure-based strategies for immune evasion. ..
  16. pmc Adaptation of the human immunodeficiency virus type 1 envelope glycoproteins to new world monkey receptors
    Beatriz Pacheco
    Dana Farber Cancer Institute, 44 Binney Street, JFB 824, Boston, MA 02115, USA
    J Virol 82:346-57. 2008
    ....
  17. pmc Modulation of retroviral restriction and proteasome inhibitor-resistant turnover by changes in the TRIM5alpha B-box 2 domain
    Felipe Diaz-Griffero
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Virol 81:10362-78. 2007
    ..However, testing of an array of mutants revealed that the rapid turnover and retroviral restriction functions of this B-box 2 region are separable...
  18. pmc Transitions to and from the CD4-bound conformation are modulated by a single-residue change in the human immunodeficiency virus type 1 gp120 inner domain
    Aemro Kassa
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 83:8364-78. 2009
    ..Thus, a single amino acid change in this strategically positioned gp120 inner domain residue influences the propensity of the HIV-1 envelope glycoproteins to negotiate conformational transitions to and from the CD4-bound state...