Y Xia

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. ncbi request reprint The beta-glucan-binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cells
    Y Xia
    Division of Experimental Immunology and Immunopathology, Department of Pathology, University of Louisville, KY 40292, USA
    J Immunol 162:2281-90. 1999
  2. ncbi request reprint Generation of recombinant fragments of CD11b expressing the functional beta-glucan-binding lectin site of CR3 (CD11b/CD18)
    Y Xia
    Division of Experimental Immunology and Immunopathology, Department of Pathology, University of Louisville, KY 40292, USA
    J Immunol 162:7285-93. 1999
  3. ncbi request reprint Beta-glucan, a "specific" biologic response modifier that uses antibodies to target tumors for cytotoxic recognition by leukocyte complement receptor type 3 (CD11b/CD18)
    J Yan
    Division of Experimental Immunology, Department of Pathology, University of Louisville, KY 40292, USA
    J Immunol 163:3045-52. 1999
  4. ncbi request reprint Therapeutic intervention with complement and beta-glucan in cancer
    G D Ross
    Department of Pathology, University of Louisville, KY 40292, USA
    Immunopharmacology 42:61-74. 1999
  5. pmc A mixed population of immature and mature leucocytes in umbilical cord blood results in a reduced expression and function of CR3 (CD11b/CD18)
    R K Reddy
    Division of Neonatal Medicine, Department of Pediatrics, University of Louisville, KY 40292, USA
    Clin Exp Immunol 114:462-7. 1998

Collaborators

  • J Yan
  • G D Ross
  • R K Reddy
  • V Vetvicka
  • J Vetvickova
  • M Hanikýrová

Detail Information

Publications5

  1. ncbi request reprint The beta-glucan-binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cells
    Y Xia
    Division of Experimental Immunology and Immunopathology, Department of Pathology, University of Louisville, KY 40292, USA
    J Immunol 162:2281-90. 1999
    ..The similarity of mouse and human CR3 in response to beta-glucans highlights the utility of mouse tumor models for development of therapeutic beta-glucans...
  2. ncbi request reprint Generation of recombinant fragments of CD11b expressing the functional beta-glucan-binding lectin site of CR3 (CD11b/CD18)
    Y Xia
    Division of Experimental Immunology and Immunopathology, Department of Pathology, University of Louisville, KY 40292, USA
    J Immunol 162:7285-93. 1999
    ..These data suggest that the lectin site may be located entirely within CD11b, although lectin site-dependent signaling through CD18 probably occurs with the heterodimer...
  3. ncbi request reprint Beta-glucan, a "specific" biologic response modifier that uses antibodies to target tumors for cytotoxic recognition by leukocyte complement receptor type 3 (CD11b/CD18)
    J Yan
    Division of Experimental Immunology, Department of Pathology, University of Louisville, KY 40292, USA
    J Immunol 163:3045-52. 1999
    ..Therapy fails when tumors lack iC3b, but can be restored by tumor-specific Abs that deposit iC3b onto the tumors...
  4. ncbi request reprint Therapeutic intervention with complement and beta-glucan in cancer
    G D Ross
    Department of Pathology, University of Louisville, KY 40292, USA
    Immunopharmacology 42:61-74. 1999
    ..Moreover, the cytotoxic activation of beta-glucan-primed NK cell CR3 by iC3b-opsonized tumors is shown to be accompanied by a tumor-localized secretion of the cytokines TNFalpha, IFNalpha, IFNgamma, and IL-6...
  5. pmc A mixed population of immature and mature leucocytes in umbilical cord blood results in a reduced expression and function of CR3 (CD11b/CD18)
    R K Reddy
    Division of Neonatal Medicine, Department of Pediatrics, University of Louisville, KY 40292, USA
    Clin Exp Immunol 114:462-7. 1998
    ..The typical neutrophilia of cord blood may compensate for this apparent deficiency by providing adult concentrations of mature neutrophils...