Chun hong Xia

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The role of Vldlr in intraretinal angiogenesis in mice
    Chun hong Xia
    School of Optometry and Vision Science Program, University of California, Berkeley, USA
    Invest Ophthalmol Vis Sci 52:6572-9. 2011
  2. pmc LRP5 is required for vascular development in deeper layers of the retina
    Chun hong Xia
    School of Optometry and Vision Science Program, University of California, Berkeley, California, USA
    PLoS ONE 5:e11676. 2010
  3. ncbi request reprint Arginine 54 and Tyrosine 118 residues of {alpha}A-crystallin are crucial for lens formation and transparency
    Chun hong Xia
    School of Optometry and Vision Science Program, University of California, Berkeley, Berkeley, California 94720 2020, USA
    Invest Ophthalmol Vis Sci 47:3004-10. 2006
  4. ncbi request reprint Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis
    Chun hong Xia
    School of Optometry and Vision Science Program, University of California at Berkeley, Berkeley, CA 94720, USA
    Development 133:2033-40. 2006
  5. ncbi request reprint Absence of alpha3 (Cx46) and alpha8 (Cx50) connexins leads to cataracts by affecting lens inner fiber cells
    Chun hong Xia
    School of Optometry and Vision Science Program, University of California at Berkeley, 693 Minor Hall, Berkeley, CA 94720 2020, USA
    Exp Eye Res 83:688-96. 2006
  6. pmc Severe retinal degeneration caused by a novel rhodopsin mutation
    Haiquan Liu
    Vision Science Program and School of Optometry, University of California, Berkeley, Berkeley, California 94720 2020, USA
    Invest Ophthalmol Vis Sci 51:1059-65. 2010
  7. pmc Cataracts and microphthalmia caused by a Gja8 mutation in extracellular loop 2
    Chun hong Xia
    School of Optometry and Vision Science Program, University of California, Berkeley, California, United States of America
    PLoS ONE 7:e52894. 2012
  8. ncbi request reprint Characterization of mouse mutants with abnormal RPE cells
    Chun hong Xia
    School of Optometry and Vision Science Program, University of California, Berkeley, Berkeley, CA 94720 2020, USA
    Adv Exp Med Biol 572:95-100. 2006
  9. ncbi request reprint GammaD-crystallin associated protein aggregation and lens fiber cell denucleation
    Kaijun Wang
    Vision Science Program and School of Optometry, University of California, Berkeley, Berkeley, California 94720 2020, USA
    Invest Ophthalmol Vis Sci 48:3719-28. 2007
  10. ncbi request reprint Knock-in of alpha3 connexin prevents severe cataracts caused by an alpha8 point mutation
    Chun hong Xia
    School of Optometry and Vision Science Program, University of California at Berkeley, Berkeley, CA, USA
    J Cell Sci 119:2138-44. 2006

Collaborators

Detail Information

Publications18

  1. pmc The role of Vldlr in intraretinal angiogenesis in mice
    Chun hong Xia
    School of Optometry and Vision Science Program, University of California, Berkeley, USA
    Invest Ophthalmol Vis Sci 52:6572-9. 2011
    ..Thus, the r26 is a loss-of-function Vldlr mutation. Vldlr on the cell surface probably mediates an antiangiogenic signal to prevent retinal endothelial cells from migrating into the photoreceptor cell layer...
  2. pmc LRP5 is required for vascular development in deeper layers of the retina
    Chun hong Xia
    School of Optometry and Vision Science Program, University of California, Berkeley, California, USA
    PLoS ONE 5:e11676. 2010
    ....
  3. ncbi request reprint Arginine 54 and Tyrosine 118 residues of {alpha}A-crystallin are crucial for lens formation and transparency
    Chun hong Xia
    School of Optometry and Vision Science Program, University of California, Berkeley, Berkeley, California 94720 2020, USA
    Invest Ophthalmol Vis Sci 47:3004-10. 2006
    ..To identify new mouse models for studying roles of alphaAlpha-crystallin in vivo and to investigate why and how different mutations of the alphaAlpha-crystallin gene lead to dominant or recessive cataracts...
  4. ncbi request reprint Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis
    Chun hong Xia
    School of Optometry and Vision Science Program, University of California at Berkeley, Berkeley, CA 94720, USA
    Development 133:2033-40. 2006
    ..This explains why and how different connexin mutations lead to a variety of cataracts. The principle of this explanation can also be applied to mutations of other connexin isoforms that cause different diseases in other organs...
  5. ncbi request reprint Absence of alpha3 (Cx46) and alpha8 (Cx50) connexins leads to cataracts by affecting lens inner fiber cells
    Chun hong Xia
    School of Optometry and Vision Science Program, University of California at Berkeley, 693 Minor Hall, Berkeley, CA 94720 2020, USA
    Exp Eye Res 83:688-96. 2006
    ....
  6. pmc Severe retinal degeneration caused by a novel rhodopsin mutation
    Haiquan Liu
    Vision Science Program and School of Optometry, University of California, Berkeley, Berkeley, California 94720 2020, USA
    Invest Ophthalmol Vis Sci 51:1059-65. 2010
    ..To identify a new mouse mutation developing early-onset dominant retinal degeneration, to determine the causative gene mutation, and to investigate the underlying mechanism...
  7. pmc Cataracts and microphthalmia caused by a Gja8 mutation in extracellular loop 2
    Chun hong Xia
    School of Optometry and Vision Science Program, University of California, Berkeley, California, United States of America
    PLoS ONE 7:e52894. 2012
    ..This work provides molecular insights to understand the cataract and microphthalmia/microcornea phenotype caused by Gja8 mutations in mice and humans...
  8. ncbi request reprint Characterization of mouse mutants with abnormal RPE cells
    Chun hong Xia
    School of Optometry and Vision Science Program, University of California, Berkeley, Berkeley, CA 94720 2020, USA
    Adv Exp Med Biol 572:95-100. 2006
  9. ncbi request reprint GammaD-crystallin associated protein aggregation and lens fiber cell denucleation
    Kaijun Wang
    Vision Science Program and School of Optometry, University of California, Berkeley, Berkeley, California 94720 2020, USA
    Invest Ophthalmol Vis Sci 48:3719-28. 2007
    ..To understand the underlying molecular mechanism for a dominant cataract caused by a point mutation in the gammaD-crystallin gene...
  10. ncbi request reprint Knock-in of alpha3 connexin prevents severe cataracts caused by an alpha8 point mutation
    Chun hong Xia
    School of Optometry and Vision Science Program, University of California at Berkeley, Berkeley, CA, USA
    J Cell Sci 119:2138-44. 2006
    ..Thus, knocked-in alpha3 connexin and mutant alpha8-G22R connexin probably form heteromeric gap junction channels that influence lens homeostasis and lens transparency...
  11. doi request reprint Dense nuclear cataract caused by the gammaB-crystallin S11R point mutation
    Lin Li
    Vision Science Program and School of Optometry, University of California Berkeley, Berkeley, CA 94720, USA
    Invest Ophthalmol Vis Sci 49:304-9. 2008
    ..To identify the causative gene mutation for a new dominant cataract in mice and to investigate the molecular basis for how the mutated gene leads to a dense nuclear cataract...
  12. pmc A model for familial exudative vitreoretinopathy caused by LPR5 mutations
    Chun hong Xia
    School of Optometry and Vision Science Program, University of California, Berkeley, Berkeley, CA 94720 2020, USA
    Hum Mol Genet 17:1605-12. 2008
    ..LRP5 mutant mice can be a useful model to explore the clinical manifestations of FEVR...
  13. pmc Altered chaperone-like activity of alpha-crystallins promotes cataractogenesis
    Catherine Cheng
    School of Optometry and Vision Science Program, University of California, Berkeley, California 94720, USA
    J Biol Chem 285:41187-93. 2010
    ..Crystallins with different chaperone-like activities are likely required in the lens cortex and nucleus for maintaining transparency...
  14. ncbi request reprint Connexins in lens development and cataractogenesis
    Xiaohua Gong
    School of Optometry and Vision Science Program, University of California Berkeley, Berkeley, CA 94720, USA
    J Membr Biol 218:9-12. 2007
    ..These findings provide some molecular insights for essential roles of connexins and gap junctions in lens formation and the establishment and maintenance of lifelong lens transparency...
  15. pmc Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles
    Sandra E Encalada
    Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, 92093, USA
    Cell 144:551-65. 2011
    ..Our data suggest a coordination model wherein PrP(C) vesicles maintain a stable population of associated motors whose activity is modulated by regulatory factors instead of by structural changes to motor-cargo associations...
  16. pmc Deletion of LRP5 in VLDLR knockout mice inhibits retinal neovascularization
    Chun hong Xia
    School of Optometry and Vision Science Program, University of California Berkeley, Berkeley, California, United States of America
    PLoS ONE 8:e75186. 2013
    ..Thus, LRP5 signaling is a prerequisite for neovascularization in VLDLR knockout mice. LRP5 may be an effective target for inhibiting intraretinal neovascularization. ..
  17. pmc Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A
    Chun hong Xia
    Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093 0683, USA
    J Cell Biol 161:55-66. 2003
    ..These data support the hypothesis that a conventional kinesin plays a role in the microtubule-dependent slow axonal transport of at least one cargo, the NF proteins...
  18. pmc Gap junction communication influences intercellular protein distribution in the lens
    Catherine Cheng
    UC Berkeley UCSF Joint Graduate Program in Bioengineering, University of California, Berkeley, Berkeley, CA, USA
    Exp Eye Res 86:966-74. 2008
    ..Although the mechanism that drives GFP transport between fiber cells remains unknown, this work reveals that gap junction communication plays a novel role in the regulation of intercellular protein distribution in the lens...