Research Topics
| J M WyssSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
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Publications
Perinatal taurine exposure alters renal potassium excretion mechanisms in adult conscious ratsSanya Roysommuti
Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
J Biomed Sci 17:S29. 2010..The present data indicates that perinatal taurine exposure only mildly influences renal potassium excretion in adult male and female rats...- Adult renal function is modified by perinatal taurine status in conscious male ratsSanya Roysommuti
Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
J Biomed Sci 17:S31. 2010..The present data indicate that in adult male rats, both perinatal supplementation and depletion of taurine can alter renal hemodynamics, and these effects are differentially time-dependent... - High sugar intake via the renin-angiotensin system blunts the baroreceptor reflex in adult rats that were perinatally depleted of taurineAtcharaporn Thaeomor
Department of Physiology Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
J Biomed Sci 17:S30. 2010..The present data indicate that in perinatal taurine depleted female rats, the renin-angiotensin system underlines the ability of high sugar intake to blunt baroreceptor responses... 
Age-related decline in water maze learning and memory in rats: strain differencesJ M Wyss
Department of Cell Biology, University of Alabama at Birmingham, 35294 0019, USA
Neurobiol Aging 21:671-81. 2000..Thus, in these three strains, age-related impairment of spatial memory proceeds at different rates...- Age-related decline in spatial learning and memory: attenuation by captoprilJ Michael Wyss
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0006, USA
Clin Exp Hypertens 25:455-74. 2003..Further, the results indicate that the memory enhancing effects of captopril are not primarily the due to the ability of captopril to lower blood pressure... - Effects of hormone replacement therapy on the sympathetic nervous system and blood pressureJ Michael Wyss
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294 0006, USA
Curr Hypertens Rep 5:241-6. 2003..This review examines the evidence supporting estrogen's ability to modulate sympathetic nervous system tone and thereby decrease arterial pressure... - Antihypertensive and cognitive effects of grape polyphenols in estrogen-depleted, female, spontaneously hypertensive ratsNing Peng
Dept of Cell Biology, University of Alabama at Birmingham, 1900 Univ Blvd THT 950, Birmingham, AL 35294 0006, USA
Am J Physiol Regul Integr Comp Physiol 289:R771-5. 2005..These results indicate that grape seed polyphenols decrease arterial pressure in SHR, probably via an antioxidant mechanism... - Distribution of neurons in the anterior hypothalamic nucleus activated by blood pressure changes in the ratJ M Wyss
Department of Cell Biology, University of Alabama at Birmingham, 35294 0019, USA
Brain Res Bull 49:163-72. 1999..In contrast, elevation in arterial pressure increased Fos labeling throughout the anterior hypothalamic nucleus and to a lesser extent in the paraventricular nucleus... - The role of the nervous system in hypertensionJ M Wyss
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Curr Hypertens Rep 3:255-62. 2001.... - Hepatic denervation chronically elevates arterial pressure in Wistar-Kyoto ratsS H Carlson
Vascular Biology and Hypertension Program of the Department of Medicine, University of Alabama at Birmingham, USA
Hypertension 32:46-51. 1998..These results suggest that in the rat, although hepatic osmoreceptors contribute to long-term arterial pressure regulation, they contribute much less to dietary NaCl-induced changes in arterial pressure... - Estrogen depletion induces NaCl-sensitive hypertension in female spontaneously hypertensive ratsZ Fang
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294-0019, USA
Am J Physiol Regul Integr Comp Physiol 281:R1934-9. 2001..Furthermore, these results demonstrate that dietary phytoestrogens can have a major impact on the interpretation of studies into the physiological role of estrogen in females... - Effects of botanical dietary supplements on cardiovascular, cognitive, and metabolic function in males and femalesScott Carlson
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA
Gend Med 5:S76-90. 2008..After menopause, the rates of these diseases in women eventually approximate those in men. The loss of endogenous estrogen at menopause has been traditionally believed to be the primary factor involved in these changes... - Long-term telemetric recording of arterial pressure and heart rate in mice fed basal and high NaCl dietsS H Carlson
Department of Cell Biology, University of Alabama at Birmingham, AL, USA
Hypertension 35:E1-5. 2000..Thus, the data demonstrate that telemetric recording of long-term arterial pressure and heart rate provides a powerful tool with which to define the mechanisms of cardiovascular control in mice... - Chronic dietary kudzu isoflavones improve components of metabolic syndrome in stroke-prone spontaneously hypertensive ratsNing Peng
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0006, USA
J Agric Food Chem 57:7268-73. 2009..These results indicate that long-term dietary kudzu root extract supplementation can improve glucose, lipid, and blood pressure control in intact and ovariectomized SP-SHR... - Hepatic denervation does not affect plasma vasopressin response to intragastric hypertonic saline in conscious ratsS H Carlson
Vascular Biology and Hypertension Program, Department of Medicine, and Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
Am J Physiol 277:E161-7. 1999.... - Pressor and depressor sites are intermingled in the cingulate cortex of the ratG D Fisk
Department of Psychology, The University of Alabama at Birmingham, USA
Brain Res 754:204-12. 1997.... 
Tissue distribution of puerarin and its conjugated metabolites in rats assessed by liquid chromatography-tandem mass spectrometryJeevan K Prasain
Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Phytomedicine 16:65-71. 2009..This report identifying puerarin in several organs including kidney and pancreas may explain its beneficial effects in diabetes...- The effectiveness of Hering's nerve stimulation in controlling penicillin-induced seizures in the rat is dependent on the amygdalaR Shane Tubbs
Department of Cell Biology, University of Alabama at Birmingham, USA
Pediatr Neurosurg 37:231-4. 2002..This study tests the hypothesis that the ability of Hering's nerve stimulation (HNS) to blunt seizure activity is dependent on the availability of dopamine in the amygdala... - Identification of puerarin and its metabolites in rats by liquid chromatography-tandem mass spectrometryJeevan K Prasain
Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Agric Food Chem 52:3708-12. 2004..Study of these metabolites may provide further understanding of the health beneficial effects of puerarin in kudzu dietary supplements... - Pharmacokinetic study of puerarin in rat serum by liquid chromatography tandem mass spectrometryJeevan K Prasain
Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Biomed Chromatogr 21:410-4. 2007..54 +/- 2.03 mg/L), T(max) (0.68 +/- 0.37 h), AUC(0-t) (7.29 +/- 3.79 mg h/L), AUC(0-infinity) (9.17 +/- 4.87 mg h/L), T(1/2) (1.7 +/- 0.6 h), CL/F (7.24 +/- 4.27 L/h/kg) and V/F (17.88 +/- 13.55 L/h/kg)... - The role of the central nervous system in NaCl-sensitive hypertension in spontaneously hypertensive ratsS H Carlson
Department of Biology, Luther College, Birmingham, Alabama, USA
Am J Hypertens 14:155S-162S. 2001..Finally, our evidence demonstrates that these factors lead to an increased rise in sympathetic nervous system activity during the early wake phase in SHR on a high NaCl diet, contributing to NaCl-sensitive hypertension in SHR... - Estrogen depletion increases blood pressure and hypothalamic norepinephrine in middle-aged spontaneously hypertensive ratsNing Peng
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Ala 35294-0006, USA
Hypertension 41:1164-7. 2003..These data suggest that both dietary NaCl excess and estrogen depletion raise arterial pressure in middle-aged female SHR by a decreasing hypothalamic norepinephrine... - Insulin-exacerbated hypertension in captopril-treated spontaneously hypertensive rats: role of sympathoexcitationSanya Roysommuti
Department of Cell Biology, University of Alabama at Birmingham, 35294-0006, USA
Can J Physiol Pharmacol 81:1036-41. 2003..These data indicate that in SHR, the ability of insulin to increase blood pressure is closely related to sympathoexcitation, which is unresponsive to blockade of angiotensin-converting enzyme... - Flavonoids and age-related disease: risk, benefits and critical windowsJ K Prasain
Department Pharmacology and Toxicology of the University of Alabama at Birmingham, Birmingham, AL 35294, USA
Maturitas 66:163-71. 2010..Thus, as the population ages, it is important to determine the impact of these agents on prevention/attenuation of disease, including optimal exposure (intake, timing/duration) and potential contraindications... - Neurohormonal regulation of the sympathetic nervous system: new insights into central mechanisms of actionScott H Carlson
Department of Cell Biology, University of Alabama at Birmingham, 1900 University Boulevard, THT 950, Birmingham, AL 35294, USA
Curr Hypertens Rep 10:233-40. 2008..The relative importance of these mechanisms to blood pressure control remains to be fully elucidated... - Genistein attenuates the hypertensive effects of dietary NaCl in hypertensive male ratsTaehyeon M Cho
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294 0006, USA
Endocrinology 148:5396-402. 2007..Thus, in male SHR-SP, dietary genistein blunts NaCl-sensitive hypertension, and these effects may be regulated, in part, by the autonomic nervous system and/or metabolic mechanisms... - Enhanced hypotensive, bradycardic, and hypnotic responses to alpha2-adrenergic agonists in spinophilin-null mice are accompanied by increased G protein coupling to the alpha2A-adrenergic receptorR Lu
Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama, USA
Mol Pharmacol 78:279-86. 2010..These findings suggest that eliminating spinophilin expression in native tissues leads to an enhanced receptor/G protein coupling efficiency that contributes to sensitization of receptor mediated responses in vivo... - Neuregulin-1beta modulates in vivo entorhinal-hippocampal synaptic transmission in adult ratsS Roysommuti
Department of Cell Biology, 1900 University Boulevard, THT 950, University of Alabama at Birmingham, 35294-0006, USA
Neuroscience 121:779-85. 2003..These observations indicate that NRG-1 is not only a developmental growth factor, but also modifies synaptic transmission in adult rat brain... - Blood pressure and NaCl-sensitive hypertension are influenced by angiotensin-converting enzyme gene expression in transgenic miceScott H Carlson
Vascular Biology and Hypertension Program of the Department of Medicine, University of Alabama at Birmingham, USA
Hypertension 39:214-8. 2002.... - Alpha2A-adrenergic receptors mediate sympathoinhibitory responses to atrial natriuretic peptide in the mouse anterior hypothalamic nucleusNing Peng
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294 0006, USA
Hypertension 41:571-5. 2003.... - Simultaneous determination of 11 phytoestrogens in human serum using a 2 min liquid chromatography/tandem mass spectrometry methodJeevan K Prasain
Departments of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Chromatogr B Analyt Technol Biomed Life Sci 878:994-1002. 2010..75 mL/min. This LC-MS/MS method is very useful for high-throughput analysis of phytoestrogens and proved to be simple, sensitive, reproducible, and reliable... - Excess dietary glucose alters renal function before increasing arterial pressure and inducing insulin resistanceSanya Roysommuti
Department of Physiology, Faculty of Medicine, Khon Kaen University, Thailand
Am J Hypertens 15:773-9. 2002..CONCLUSIONS: These results indicate that diets high in carbohydrates impair renal function before they increase arterial pressure, and that this effect is dependent on an intact renin-angiotensin system... - Estrogen depletion differentially affects blood pressure depending on age in Long-Evans ratsJohn T Clark
Department of Physiology, Meharry Medical College, Nashville, TN 37208, USA
Endocrine 25:173-86. 2004..We suggest that chronic increases in aldosterone and sympathetic tone underlie the hypertensive effects of estrogen depletion... - Old rats remember old tricks; memories of the water maze persist for 12 monthsThomas van Groen
Department of Neuroscience and Neurology, University of Kuopio, Canthia Building, P O Box 1627, Finland
Behav Brain Res 136:247-55. 2002..Together these data indicate that 24-month-old rats can learn spatial tasks well and that the performance of old rats in spatial tasks can be significantly influenced by prior exposure to that task, even 12 months earlier... - Retrosplenial cortex lesions of area Rgb (but not of area Rga) impair spatial learning and memory in the ratThomas van Groen
Department of Neuroscience and Neurology, University of Kuopio, Kuopio University Hospital, P O Box 1627, FIN 70211 Kuopio, Finland
Behav Brain Res 154:483-91. 2004..The data highlight the unique and complex contribution of each area of the retrosplenial cortex to behavior... - Botanicals for age-related diseases: from field to practiceConnie M Weaver
Foods and Nutrition, Rutgers University, New Brunswick, NJ, USA
Am J Clin Nutr 87:493S-7S. 2008..Botanicals and their relation to bone antiresorptive capacity, cognitive function, vascular effects, and cancer are principal themes in our center... - Increased PI3-kinase in presympathetic brain areas of the spontaneously hypertensive ratShereeni J Veerasingham
Department of Physiology and Functional Genomics, University of Florida, Gainesville 32610, USA
Circ Res 96:277-9. 2005..Furthermore, normalized PI3-kinase p85alpha/p110delta expression within the PVN might contribute to the overall effect of captopril, perhaps attributable to a consequent decrease in NE availability... - The therapeutic potential of hepatocyte growth factor for myocardial infarction and heart failureHongkui Jin
Department of Translational Oncology, Genentech, Inc, South San Francisco, CA 97080, USA
Curr Pharm Des 10:2525-33. 2004..Clinical trials are needed to investigate the therapeutic potential of HGF for postinfarction heart failure in humans... - Age-related decreases in gonadal hormones in Long-Evans rats: relationship to rise in arterial pressureIan H Fentie
Department of Pathology, Meharry Medical College, Nashville, TN 37208, USA
Endocrine 25:15-22. 2004..Thus, by middle age, male and female rats are exposed to less gonadal hormone/altered patterns of availability, exhibit decrements in reproductive function, and display an increase in systolic blood pressure... - Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient miceScott P Heximer
J Clin Invest 111:1259. 2003 - Heightened epithelial Na+ channel-mediated Na+ absorption in a murine polycystic kidney disease model epithelium lacking apical monociliaDragos Olteanu
Department of Physiology, Univ. of Alabama at Birmingham, MCLM 740, 1918 University Blvd, 35294-0005, USA
Am J Physiol Cell Physiol 290:C952-63. 2006..cilium-competent controls. When the genetic lesion causes loss or malformation of the monocilium, ENaC-driven Na(+) hyperabsorption may explain the rapid emergence of severe hypertension in a majority of patients with ARPKD... - Pathways by which dietary salt affects blood pressure and the nervous systemJ Michael Wyss
Hypertension 47:638-9. 2006 - The role of the laterodorsal nucleus of the thalamus in spatial learning and memory in the ratThomas van Groen
Department of Neuroscience and Neurology, University of Kuopio, FIN 70211 Kuopio, Finland
Behav Brain Res 136:329-37. 2002..These findings support the hypothesis that together with the anterior thalamic nuclei, LD plays a role in spatial learning and memory... - Effects of G207, a conditionally replication-competent oncolytic herpes simplex virus, on the developing mammalian brainAndrew E Radbill
Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
J Neurovirol 13:118-29. 2007..Furthermore, patients in such a study will need to be closely monitored for the development of hydrocephalus... - Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient miceScott P Heximer
Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Clin Invest 111:445-52. 2003....
Research Grants
- Birmingham Science Education Partnership: Middle School Inquiry-Based LearningJ Wyss; Fiscal Year: 2007..The proven partnership of UAB, BCS and McWane Center will provide a test of the power, cost-effectiveness and self-sustainability of this inquiry-based model. ..