Research Topics
Genomes and Genes
| Anthony Wynshaw-BorisSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Dishevelled: in vivo roles of a multifunctional gene family during developmentAnthony Wynshaw-Boris
UCSF School of Medicine, San Francisco, California, USA
Curr Top Dev Biol 101:213-35. 2012..This suggests that the PCP pathway is sensitive to reduction of Dvls, but only one Dvl allele of six may be required for Wnt pathway...
Lissencephaly: mechanistic insights from animal models and potential therapeutic strategiesAnthony Wynshaw-Boris
UCSF School of Medicine, Department of Pediatrics, San Francisco, CA 94143, USA
Semin Cell Dev Biol 21:823-30. 2010....- Elongator bridges tubulin acetylation and neuronal migrationAnthony Wynshaw-Boris
Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco, School of Medicine, San Francisco, CA 94143 0794, USA
Cell 136:393-4. 2009..In this issue, Creppe et al. (2009) now show that the multisubunit histone acetyltransferase Elongator may regulate migration and branch formation of cortical neurons in the developing mouse brain by acetylating alpha-tubulin... 
Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closureNatasha S Hamblet
Department of Pediatrics, UCSD Comprehensive Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0627, USA
Development 129:5827-38. 2002..Thus, Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure, and there is functional redundancy between Dvl1 and Dvl2 in some phenotypes...- Novel embryonic neuronal migration and proliferation defects in Dcx mutant mice are exacerbated by Lis1 reductionTiziano Pramparo
Department of Pediatrics, University of California, San Francisco, School of Medicine, San Francisco, California 94143 0794, USA
J Neurosci 30:3002-12. 2010..Thus, we provide definitive evidence for a critical role for Dcx in neuronal migration and neurogenesis, as well as for the in vivo genetic interaction of the two genes most commonly involved in human neuronal migration defects... - Global developmental gene expression and pathway analysis of normal brain development and mouse models of human neuronal migration defectsTiziano Pramparo
Department of Pediatrics and Institute for Human Genetics, School of Medicine, University of California San Francisco, San Francisco, California, United States of America
PLoS Genet 7:e1001331. 2011..Our analysis suggests that gene expression and pathway analysis in mouse models of a similar disorder or within a common pathway can be used to define novel candidates for related human diseases... - Distinct dose-dependent cortical neuronal migration and neurite extension defects in Lis1 and Ndel1 mutant miceYong Ha Youn
Department of Pediatrics, Institute for Human Genetics, University of California, San Francisco School of Medicine, San Francisco, California 94143 0794, USA
J Neurosci 29:15520-30. 2009..Thus, Lis1 and Ndel1 are essential for normal cortical neuronal migration, neurite outgrowth, and function of the MTOC in a dose-dependent manner... - Cancer chemoprevention by the antioxidant tempol in Atm-deficient miceRalf Schubert
Department of Pediatrics, The Comprehensive Cancer Center, UCSD School of Medicine, La Jolla, CA 92093 0627, USA
Hum Mol Genet 13:1793-802. 2004..Thus, tempol acts as a novel chemopreventative agent in this mouse model of a human cancer prone syndrome, associated with broad antioxidant effects... - Multiple dose-dependent effects of Lis1 on cerebral cortical developmentMichael J Gambello
Department of Pediatrics and Medicine, University of California, San Diego, La Jolla, California 92093 0627, USA
J Neurosci 23:1719-29. 2003..These studies reveal the importance of LIS1 levels in orderly cerebral cortical morphogenesis and suggest new insights into the pathogenesis of type I lissencephaly... - Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during developmentChrissa Kioussi
Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, CMM West, Room 345, 9500 Gilman Drive, La Jolla, CA 92093, USA
Cell 111:673-85. 2002.... - Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndromeKazuhito Toyo-oka
Department of Pediatrics, UCSD Cancer Center, University of California, San Diego School of Medicine, La Jolla 92093 0627, USA
Hum Mol Genet 13:1057-67. 2004..These results demonstrate an important role for Mnt in embryonic development and survival, and suggest that Mnt may play a role in the craniofacial defects displayed by MDS patients... - 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndromeKazuhito Toyo-oka
Department of Pediatrics, UCSD Cancer Center, University of California, San Diego School of Medicine, 9500 Gilman Drive, Mailstop 0627, La Jolla, California 92093 0627, USA
Nat Genet 34:274-85. 2003..3 deletions... - Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature agesMaggie L Chow
Department of Neuroscience, NIH UCSD Autism Center of Excellence, School of Medicine, University of California San Diego, La Jolla, California, United States of America
PLoS Genet 8:e1002592. 2012..Our results raise the hypothesis that genetic dysregulation in the developing brain leads to abnormal regional patterning, excess prefrontal neurons, cortical overgrowth, and neural dysfunction in autism... - Preprocessing and Quality Control Strategies for Illumina DASL Assay-Based Brain Gene Expression Studies with Semi-Degraded SamplesMaggie L Chow
Department of Neuroscience, UC San Diego Autism Center of Excellence, School of Medicine, National Institutes of Health, University of California San Diego La Jolla, CA, USA
Front Genet 3:11. 2012.... - Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulationJianbo Wang
Department of Pediatrics and Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0627, La Jolla, CA 92093 0627, USA
Development 133:1767-78. 2006..These results are discussed in light of recent models on PCP and convergent extension... - Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migrationTeruyuki Tanaka
Department of Neurosciences, University of California, San Diego, La Jolla 92093 0624, USA
J Cell Biol 165:709-21. 2004..These data indicate Lis1 and Dcx function with dynein to mediate N-C coupling during migration, and suggest defects in this coupling may contribute to migration defects in lissencephaly... - IKK-beta links inflammation to obesity-induced insulin resistanceMelek C Arkan
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Nat Med 11:191-8. 2005..We suggest that inhibition of IKK-beta, especially in myeloid cells, may be used to treat insulin resistance... - Genome-wide expression assay comparison across frozen and fixed postmortem brain tissue samplesMaggie L Chow
Department of Neuroscience, NIH UCSD Autism Center of Excellence, School of Medicine, University of California San Diego, 8110 La Jolla Shores Dr Ste 201, La Jolla, CA 92093, USA
BMC Genomics 12:449. 2011.... - Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube developmentS Leah Etheridge
Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA
PLoS Genet 4:e1000259. 2008..Finally, we establish several developmental processes in which the three Dvls are functionally redundant... - Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2Wenlai Zhou
Howard Hughes Medical Institute and Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Nat Genet 39:1225-34. 2007..Thus, we propose that transcriptional readout mediated at least in part by a Wnt11 --> ATF/CREB --> TGFbeta2 pathway is critical in regulating morphogenesis in response to noncanonical Wnt signaling... - Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressorLaura Erker
Department of Pediatrics, UCSD School of Medicine, La Jolla 92093 0627, USA
Hum Mol Genet 14:1699-708. 2005..These data suggest that the chemopreventative effect of tempol is not solely due to the reduction of oxidative stress and damage but may also be related to redox-mediated signaling functions that include p53 pathway activation... - Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpressionKazuhito Toyo-oka
Department of Pediatrics, University of California, San Diego Comprehensive Cancer Center, La Jolla, California, USA
Cancer Res 66:5565-73. 2006..These results reveal an important role for Mnt in pregnancy-associated mammary gland development and suggest that mammary gland tumorigenesis in the absence of Mnt is analogous to that caused by Myc deregulation... - ALLN rescues an in vitro excitatory synaptic transmission deficit in Lis1 mutant miceJoy Y Sebe
Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
J Neurophysiol 109:429-36. 2013.... - Pten and the brain: sizing up social interactionJoy M Greer
Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California 92093, USA
Neuron 50:343-5. 2006..Additionally, neuronal hypertrophy, as well as macrocephaly was observed. Based on rare human mutations in PTEN and the PI3K pathway, the authors suggest they have produced a potential animal model of autism with macrocephaly... - Role of 14-3-3 proteins in eukaryotic signaling and developmentDawn L Darling
Department of Pediatrics, University of California, San Diego, La Jolla, California 92093, USA
Curr Top Dev Biol 68:281-315. 2005..Here we review what is known about 14-3-3 proteins during eukaryotic development... - Behavior of mice with mutations in the conserved region deleted in velocardiofacial/DiGeorge syndromeJeffrey M Long
Department of Medicine, University of California, San Diego School of Medicine, La Jolla, CA 92093-0627, USA
Neurogenetics 7:247-57. 2006....
Research Grants
- Dishevelled-Mediated Control of Wnt/PCP PathwaysANTHONY J WYNSHAW BORIS; Fiscal Year: 2010....
- Genetic Analysis of LIS1 Function in the MouseAnthony Wynshaw Boris; Fiscal Year: 2007....
- Neural Tube Defects in Disheveled Mutant MiceAnthony Wynshaw Boris; Fiscal Year: 2007..The effect of these mutations on neural tube closure in Dvl -/-Dvl2 -/- mutants will be assessed. ..
- Genetic Regulation of Neuronal MigrationAnthony Wynshaw Boris; Fiscal Year: 2009..Based on our preliminary data, we predict that with LIS1, OCX plays a role in the regulation of dynein motor function, and that regulation of OCX activity via phosphorylation by Cdk5/p35 may be analogous to NUDEL regulation. ..
- Genetic Analysis of LIS1 Function in the MouseAnthony Wynshaw Boris; Fiscal Year: 2009....
- Genetic Analysis of LIS1 Function in the MouseAnthony Wynshaw Boris; Fiscal Year: 2005....
- Social Interaction Defects in DV1l Mutant MiceAnthony Wynshaw Boris; Fiscal Year: 2005..abstract_text> ..