Anthony Wynshaw-Boris

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Dishevelled: in vivo roles of a multifunctional gene family during development
    Anthony Wynshaw-Boris
    UCSF School of Medicine, San Francisco, California, USA
    Curr Top Dev Biol 101:213-35. 2012
  2. pmc Lissencephaly: mechanistic insights from animal models and potential therapeutic strategies
    Anthony Wynshaw-Boris
    UCSF School of Medicine, Department of Pediatrics, San Francisco, CA 94143, USA
    Semin Cell Dev Biol 21:823-30. 2010
  3. doi request reprint Elongator bridges tubulin acetylation and neuronal migration
    Anthony Wynshaw-Boris
    Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco, School of Medicine, San Francisco, CA 94143 0794, USA
    Cell 136:393-4. 2009
  4. ncbi request reprint Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure
    Natasha S Hamblet
    Department of Pediatrics, UCSD Comprehensive Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0627, USA
    Development 129:5827-38. 2002
  5. pmc Novel embryonic neuronal migration and proliferation defects in Dcx mutant mice are exacerbated by Lis1 reduction
    Tiziano Pramparo
    Department of Pediatrics, University of California, San Francisco, School of Medicine, San Francisco, California 94143 0794, USA
    J Neurosci 30:3002-12. 2010
  6. pmc Global developmental gene expression and pathway analysis of normal brain development and mouse models of human neuronal migration defects
    Tiziano Pramparo
    Department of Pediatrics and Institute for Human Genetics, School of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 7:e1001331. 2011
  7. pmc Distinct dose-dependent cortical neuronal migration and neurite extension defects in Lis1 and Ndel1 mutant mice
    Yong Ha Youn
    Department of Pediatrics, Institute for Human Genetics, University of California, San Francisco School of Medicine, San Francisco, California 94143 0794, USA
    J Neurosci 29:15520-30. 2009
  8. ncbi request reprint Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice
    Ralf Schubert
    Department of Pediatrics, The Comprehensive Cancer Center, UCSD School of Medicine, La Jolla, CA 92093 0627, USA
    Hum Mol Genet 13:1793-802. 2004
  9. ncbi request reprint Multiple dose-dependent effects of Lis1 on cerebral cortical development
    Michael J Gambello
    Department of Pediatrics and Medicine, University of California, San Diego, La Jolla, California 92093 0627, USA
    J Neurosci 23:1719-29. 2003
  10. ncbi request reprint Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development
    Chrissa Kioussi
    Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, CMM West, Room 345, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 111:673-85. 2002

Research Grants

  1. Dishevelled-Mediated Control of Wnt/PCP Pathways
    ANTHONY J WYNSHAW BORIS; Fiscal Year: 2010
  2. Genetic Analysis of LIS1 Function in the Mouse
    Anthony Wynshaw Boris; Fiscal Year: 2007
  3. Neural Tube Defects in Disheveled Mutant Mice
    Anthony Wynshaw Boris; Fiscal Year: 2007
  4. Genetic Regulation of Neuronal Migration
    Anthony Wynshaw Boris; Fiscal Year: 2009
  5. Genetic Analysis of LIS1 Function in the Mouse
    Anthony Wynshaw Boris; Fiscal Year: 2009
  6. Genetic Analysis of LIS1 Function in the Mouse
    Anthony Wynshaw Boris; Fiscal Year: 2005
  7. Social Interaction Defects in DV1l Mutant Mice
    Anthony Wynshaw Boris; Fiscal Year: 2005

Collaborators

Detail Information

Publications26

  1. doi request reprint Dishevelled: in vivo roles of a multifunctional gene family during development
    Anthony Wynshaw-Boris
    UCSF School of Medicine, San Francisco, California, USA
    Curr Top Dev Biol 101:213-35. 2012
    ..This suggests that the PCP pathway is sensitive to reduction of Dvls, but only one Dvl allele of six may be required for Wnt pathway...
  2. pmc Lissencephaly: mechanistic insights from animal models and potential therapeutic strategies
    Anthony Wynshaw-Boris
    UCSF School of Medicine, Department of Pediatrics, San Francisco, CA 94143, USA
    Semin Cell Dev Biol 21:823-30. 2010
    ....
  3. doi request reprint Elongator bridges tubulin acetylation and neuronal migration
    Anthony Wynshaw-Boris
    Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco, School of Medicine, San Francisco, CA 94143 0794, USA
    Cell 136:393-4. 2009
    ..In this issue, Creppe et al. (2009) now show that the multisubunit histone acetyltransferase Elongator may regulate migration and branch formation of cortical neurons in the developing mouse brain by acetylating alpha-tubulin...
  4. ncbi request reprint Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure
    Natasha S Hamblet
    Department of Pediatrics, UCSD Comprehensive Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0627, USA
    Development 129:5827-38. 2002
    ..Thus, Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure, and there is functional redundancy between Dvl1 and Dvl2 in some phenotypes...
  5. pmc Novel embryonic neuronal migration and proliferation defects in Dcx mutant mice are exacerbated by Lis1 reduction
    Tiziano Pramparo
    Department of Pediatrics, University of California, San Francisco, School of Medicine, San Francisco, California 94143 0794, USA
    J Neurosci 30:3002-12. 2010
    ..Thus, we provide definitive evidence for a critical role for Dcx in neuronal migration and neurogenesis, as well as for the in vivo genetic interaction of the two genes most commonly involved in human neuronal migration defects...
  6. pmc Global developmental gene expression and pathway analysis of normal brain development and mouse models of human neuronal migration defects
    Tiziano Pramparo
    Department of Pediatrics and Institute for Human Genetics, School of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 7:e1001331. 2011
    ..Our analysis suggests that gene expression and pathway analysis in mouse models of a similar disorder or within a common pathway can be used to define novel candidates for related human diseases...
  7. pmc Distinct dose-dependent cortical neuronal migration and neurite extension defects in Lis1 and Ndel1 mutant mice
    Yong Ha Youn
    Department of Pediatrics, Institute for Human Genetics, University of California, San Francisco School of Medicine, San Francisco, California 94143 0794, USA
    J Neurosci 29:15520-30. 2009
    ..Thus, Lis1 and Ndel1 are essential for normal cortical neuronal migration, neurite outgrowth, and function of the MTOC in a dose-dependent manner...
  8. ncbi request reprint Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice
    Ralf Schubert
    Department of Pediatrics, The Comprehensive Cancer Center, UCSD School of Medicine, La Jolla, CA 92093 0627, USA
    Hum Mol Genet 13:1793-802. 2004
    ..Thus, tempol acts as a novel chemopreventative agent in this mouse model of a human cancer prone syndrome, associated with broad antioxidant effects...
  9. ncbi request reprint Multiple dose-dependent effects of Lis1 on cerebral cortical development
    Michael J Gambello
    Department of Pediatrics and Medicine, University of California, San Diego, La Jolla, California 92093 0627, USA
    J Neurosci 23:1719-29. 2003
    ..These studies reveal the importance of LIS1 levels in orderly cerebral cortical morphogenesis and suggest new insights into the pathogenesis of type I lissencephaly...
  10. ncbi request reprint Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development
    Chrissa Kioussi
    Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, CMM West, Room 345, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 111:673-85. 2002
    ....
  11. ncbi request reprint Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome
    Kazuhito Toyo-oka
    Department of Pediatrics, UCSD Cancer Center, University of California, San Diego School of Medicine, La Jolla 92093 0627, USA
    Hum Mol Genet 13:1057-67. 2004
    ..These results demonstrate an important role for Mnt in embryonic development and survival, and suggest that Mnt may play a role in the craniofacial defects displayed by MDS patients...
  12. ncbi request reprint 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome
    Kazuhito Toyo-oka
    Department of Pediatrics, UCSD Cancer Center, University of California, San Diego School of Medicine, 9500 Gilman Drive, Mailstop 0627, La Jolla, California 92093 0627, USA
    Nat Genet 34:274-85. 2003
    ..3 deletions...
  13. pmc Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature ages
    Maggie L Chow
    Department of Neuroscience, NIH UCSD Autism Center of Excellence, School of Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS Genet 8:e1002592. 2012
    ..Our results raise the hypothesis that genetic dysregulation in the developing brain leads to abnormal regional patterning, excess prefrontal neurons, cortical overgrowth, and neural dysfunction in autism...
  14. pmc Preprocessing and Quality Control Strategies for Illumina DASL Assay-Based Brain Gene Expression Studies with Semi-Degraded Samples
    Maggie L Chow
    Department of Neuroscience, UC San Diego Autism Center of Excellence, School of Medicine, National Institutes of Health, University of California San Diego La Jolla, CA, USA
    Front Genet 3:11. 2012
    ....
  15. ncbi request reprint Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation
    Jianbo Wang
    Department of Pediatrics and Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0627, La Jolla, CA 92093 0627, USA
    Development 133:1767-78. 2006
    ..These results are discussed in light of recent models on PCP and convergent extension...
  16. pmc Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration
    Teruyuki Tanaka
    Department of Neurosciences, University of California, San Diego, La Jolla 92093 0624, USA
    J Cell Biol 165:709-21. 2004
    ..These data indicate Lis1 and Dcx function with dynein to mediate N-C coupling during migration, and suggest defects in this coupling may contribute to migration defects in lissencephaly...
  17. pmc Genome-wide expression assay comparison across frozen and fixed postmortem brain tissue samples
    Maggie L Chow
    Department of Neuroscience, NIH UCSD Autism Center of Excellence, School of Medicine, University of California San Diego, 8110 La Jolla Shores Dr Ste 201, La Jolla, CA 92093, USA
    BMC Genomics 12:449. 2011
    ....
  18. ncbi request reprint IKK-beta links inflammation to obesity-induced insulin resistance
    Melek C Arkan
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nat Med 11:191-8. 2005
    ..We suggest that inhibition of IKK-beta, especially in myeloid cells, may be used to treat insulin resistance...
  19. pmc ALLN rescues an in vitro excitatory synaptic transmission deficit in Lis1 mutant mice
    Joy Y Sebe
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurophysiol 109:429-36. 2013
    ....
  20. pmc Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development
    S Leah Etheridge
    Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA
    PLoS Genet 4:e1000259. 2008
    ..Finally, we establish several developmental processes in which the three Dvls are functionally redundant...
  21. ncbi request reprint Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2
    Wenlai Zhou
    Howard Hughes Medical Institute and Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Nat Genet 39:1225-34. 2007
    ..Thus, we propose that transcriptional readout mediated at least in part by a Wnt11 --> ATF/CREB --> TGFbeta2 pathway is critical in regulating morphogenesis in response to noncanonical Wnt signaling...
  22. ncbi request reprint Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor
    Laura Erker
    Department of Pediatrics, UCSD School of Medicine, La Jolla 92093 0627, USA
    Hum Mol Genet 14:1699-708. 2005
    ..These data suggest that the chemopreventative effect of tempol is not solely due to the reduction of oxidative stress and damage but may also be related to redox-mediated signaling functions that include p53 pathway activation...
  23. ncbi request reprint Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpression
    Kazuhito Toyo-oka
    Department of Pediatrics, University of California, San Diego Comprehensive Cancer Center, La Jolla, California, USA
    Cancer Res 66:5565-73. 2006
    ..These results reveal an important role for Mnt in pregnancy-associated mammary gland development and suggest that mammary gland tumorigenesis in the absence of Mnt is analogous to that caused by Myc deregulation...
  24. ncbi request reprint Pten and the brain: sizing up social interaction
    Joy M Greer
    Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California 92093, USA
    Neuron 50:343-5. 2006
    ..Additionally, neuronal hypertrophy, as well as macrocephaly was observed. Based on rare human mutations in PTEN and the PI3K pathway, the authors suggest they have produced a potential animal model of autism with macrocephaly...
  25. ncbi request reprint Role of 14-3-3 proteins in eukaryotic signaling and development
    Dawn L Darling
    Department of Pediatrics, University of California, San Diego, La Jolla, California 92093, USA
    Curr Top Dev Biol 68:281-315. 2005
    ..Here we review what is known about 14-3-3 proteins during eukaryotic development...
  26. ncbi request reprint Behavior of mice with mutations in the conserved region deleted in velocardiofacial/DiGeorge syndrome
    Jeffrey M Long
    Department of Medicine, University of California, San Diego School of Medicine, La Jolla, CA 92093 0627, USA
    Neurogenetics 7:247-57. 2006
    ....

Research Grants24

  1. Dishevelled-Mediated Control of Wnt/PCP Pathways
    ANTHONY J WYNSHAW BORIS; Fiscal Year: 2010
    ....
  2. Genetic Analysis of LIS1 Function in the Mouse
    Anthony Wynshaw Boris; Fiscal Year: 2007
    ....
  3. Neural Tube Defects in Disheveled Mutant Mice
    Anthony Wynshaw Boris; Fiscal Year: 2007
    ..The effect of these mutations on neural tube closure in Dvl -/-Dvl2 -/- mutants will be assessed. ..
  4. Genetic Regulation of Neuronal Migration
    Anthony Wynshaw Boris; Fiscal Year: 2009
    ..Based on our preliminary data, we predict that with LIS1, OCX plays a role in the regulation of dynein motor function, and that regulation of OCX activity via phosphorylation by Cdk5/p35 may be analogous to NUDEL regulation. ..
  5. Genetic Analysis of LIS1 Function in the Mouse
    Anthony Wynshaw Boris; Fiscal Year: 2009
    ....
  6. Genetic Analysis of LIS1 Function in the Mouse
    Anthony Wynshaw Boris; Fiscal Year: 2005
    ....
  7. Social Interaction Defects in DV1l Mutant Mice
    Anthony Wynshaw Boris; Fiscal Year: 2005
    ..abstract_text> ..