A Wynshaw-Boris

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Inborn errors of development: disruption of pathways critical for normal development
    Anthony Wynshaw-Boris
    Department of Pediatrics, Center for Human Genetics and Genomics, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0627, USA
    Pediatr Clin North Am 53:855-71, viii. 2006
  2. ncbi Lissencephaly and LIS1: insights into the molecular mechanisms of neuronal migration and development
    A Wynshaw-Boris
    Departments of Pediatrics and Medicine, UCSD School of Medicine, University of California San Diego, La Jolla, CA, USA
    Clin Genet 72:296-304. 2007
  3. ncbi Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation
    Jianbo Wang
    Department of Pediatrics and Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0627, La Jolla, CA 92093 0627, USA
    Development 133:1767-78. 2006
  4. pmc ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation
    C Barlow
    The Salk Institute for Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 97:871-6. 2000
  5. ncbi Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis
    Y Wang
    Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, Glycobiology Research and Training Center, 9500 Gilman Drive 0625, University of California San Diego, La Jolla, CA 92093, USA
    Glycobiology 11:1051-70. 2001
  6. ncbi Expanded characterization of the social interaction abnormalities in mice lacking Dvl1
    J M Long
    Department of Pediatrics, University of California, San Diego School of Medicine, La Jolla, CA, USA
    Genes Brain Behav 3:51-62. 2004
  7. ncbi Unraveling human cancer in the mouse: recent refinements to modeling and analysis
    L Resor
    Departments of Pediatrics and Medicine, UCSD Cancer Center, UCSD School of Medicine, 9500 Gilman Drive, Mail Code 0627, La Jolla, CA 92093, USA
    Hum Mol Genet 10:669-75. 2001
  8. ncbi Pitx genes during cardiovascular development
    C Kioussi
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California 92093, USA
    Cold Spring Harb Symp Quant Biol 67:81-7. 2002

Research Grants

  1. Training Program in Basic Clinical Genetics
    Bruce Hamilton; Fiscal Year: 2007

Collaborators

  • Y Wang
  • C Kioussi
  • Michael Rosenfeld
  • C Barlow
  • Bruce Hamilton
  • Jianbo Wang
  • J M Long
  • L Resor
  • Mary E Dickinson
  • Scott E Fraser
  • Natasha S Hamblet
  • John B Wallingford
  • Sharayne Mark
  • Brendan C Brinkman
  • Ping Chen
  • Neil Segil
  • P LaPorte
  • R Paylor
  • T J Bowen

Detail Information

Publications8

  1. ncbi Inborn errors of development: disruption of pathways critical for normal development
    Anthony Wynshaw-Boris
    Department of Pediatrics, Center for Human Genetics and Genomics, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0627, USA
    Pediatr Clin North Am 53:855-71, viii. 2006
    ....
  2. ncbi Lissencephaly and LIS1: insights into the molecular mechanisms of neuronal migration and development
    A Wynshaw-Boris
    Departments of Pediatrics and Medicine, UCSD School of Medicine, University of California San Diego, La Jolla, CA, USA
    Clin Genet 72:296-304. 2007
    ....
  3. ncbi Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation
    Jianbo Wang
    Department of Pediatrics and Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0627, La Jolla, CA 92093 0627, USA
    Development 133:1767-78. 2006
    ..These results are discussed in light of recent models on PCP and convergent extension...
  4. pmc ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation
    C Barlow
    The Salk Institute for Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 97:871-6. 2000
    ..These findings suggest that ATM may be important as a cytoplasmic protein in neurons and that its absence leads to abnormalities of cytoplasmic organelles reflected as an increase in lysosomal numbers...
  5. ncbi Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis
    Y Wang
    Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, Glycobiology Research and Training Center, 9500 Gilman Drive 0625, University of California San Diego, La Jolla, CA 92093, USA
    Glycobiology 11:1051-70. 2001
    ..Our findings indicate that human genetic disease due to aberrant protein glycosylation can be modeled in the mouse to gain insights into N-glycan-dependent physiology and the pathogenesis of CDG-IIa...
  6. ncbi Expanded characterization of the social interaction abnormalities in mice lacking Dvl1
    J M Long
    Department of Pediatrics, University of California, San Diego School of Medicine, La Jolla, CA, USA
    Genes Brain Behav 3:51-62. 2004
    ..The specificity of observed social interaction deficits also suggests that lack of Dvl1 is associated with deficits in the recognition of social hierarchy and dominance...
  7. ncbi Unraveling human cancer in the mouse: recent refinements to modeling and analysis
    L Resor
    Departments of Pediatrics and Medicine, UCSD Cancer Center, UCSD School of Medicine, 9500 Gilman Drive, Mail Code 0627, La Jolla, CA 92093, USA
    Hum Mol Genet 10:669-75. 2001
    ..Finally, global patterns of gene expression can be determined by microarray analysis to decipher complex gene patterns which occur in cancers. Several of these advances in mouse modeling of human cancer are discussed in this review...
  8. ncbi Pitx genes during cardiovascular development
    C Kioussi
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California 92093, USA
    Cold Spring Harb Symp Quant Biol 67:81-7. 2002

Research Grants1

  1. Training Program in Basic Clinical Genetics
    Bruce Hamilton; Fiscal Year: 2007
    ..Thus, we are requesting financial support for 20 trainees in the first year phasing into 26 trainees after four years to be educated in genetics laboratories at UCSD and the Salk Institute. ..