Michelle L Wynn

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Logic-based models in systems biology: a predictive and parameter-free network analysis method
    Michelle L Wynn
    Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA
    Integr Biol (Camb) 4:1323-37. 2012
  2. ncbi Unraveling the complex regulatory relationships between metabolism and signal transduction in cancer
    Michelle L Wynn
    Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA
    Adv Exp Med Biol 736:179-89. 2012
  3. ncbi Computational modelling of cell chain migration reveals mechanisms that sustain follow-the-leader behaviour
    Michelle L Wynn
    Department of Molecular and Integrative Physiology and Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J R Soc Interface 9:1576-88. 2012
  4. ncbi Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity
    Michelle L Wynn
    Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA
    BMC Syst Biol 5:156. 2011

Detail Information

Publications4

  1. ncbi Logic-based models in systems biology: a predictive and parameter-free network analysis method
    Michelle L Wynn
    Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA
    Integr Biol (Camb) 4:1323-37. 2012
    ..Here, we address some common concerns and provide a brief tutorial on the use of logic-based models, which we motivate with biological examples...
  2. ncbi Unraveling the complex regulatory relationships between metabolism and signal transduction in cancer
    Michelle L Wynn
    Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA
    Adv Exp Med Biol 736:179-89. 2012
    ..Here we discuss computational approaches for modeling protein signal transduction and metabolism as well as how the regulatory relationship between these two important cellular processes can be combined into hybrid models...
  3. ncbi Computational modelling of cell chain migration reveals mechanisms that sustain follow-the-leader behaviour
    Michelle L Wynn
    Department of Molecular and Integrative Physiology and Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J R Soc Interface 9:1576-88. 2012
    ..Our results indicate that chain migration persistence depends on the interplay of directional cell movement and biased cell-cell contact...
  4. ncbi Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity
    Michelle L Wynn
    Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA
    BMC Syst Biol 5:156. 2011
    ..We hypothesize that targeted therapies such as kinase inhibitors can produce off-target effects as a consequence of retroactivity alone...