Michelle L Wynn

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Logic-based models in systems biology: a predictive and parameter-free network analysis method
    Michelle L Wynn
    Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA
    Integr Biol (Camb) 4:1323-37. 2012
  2. pmc Unraveling the complex regulatory relationships between metabolism and signal transduction in cancer
    Michelle L Wynn
    Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA
    Adv Exp Med Biol 736:179-89. 2012
  3. pmc Follow-the-leader cell migration requires biased cell-cell contact and local microenvironmental signals
    Michelle L Wynn
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Phys Biol 10:035003. 2013
  4. pmc Computational modelling of cell chain migration reveals mechanisms that sustain follow-the-leader behaviour
    Michelle L Wynn
    Department of Molecular and Integrative Physiology and Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J R Soc Interface 9:1576-88. 2012
  5. pmc Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity
    Michelle L Wynn
    Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA
    BMC Syst Biol 5:156. 2011

Detail Information

Publications5

  1. pmc Logic-based models in systems biology: a predictive and parameter-free network analysis method
    Michelle L Wynn
    Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA
    Integr Biol (Camb) 4:1323-37. 2012
    ..Here, we address some common concerns and provide a brief tutorial on the use of logic-based models, which we motivate with biological examples...
  2. pmc Unraveling the complex regulatory relationships between metabolism and signal transduction in cancer
    Michelle L Wynn
    Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA
    Adv Exp Med Biol 736:179-89. 2012
    ..Here we discuss computational approaches for modeling protein signal transduction and metabolism as well as how the regulatory relationship between these two important cellular processes can be combined into hybrid models...
  3. pmc Follow-the-leader cell migration requires biased cell-cell contact and local microenvironmental signals
    Michelle L Wynn
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Phys Biol 10:035003. 2013
    ..Together, this integrated modeling and experimental approach suggests new experiments and offers a powerful tool to examine mechanisms that underlie complex cell migration patterns...
  4. pmc Computational modelling of cell chain migration reveals mechanisms that sustain follow-the-leader behaviour
    Michelle L Wynn
    Department of Molecular and Integrative Physiology and Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J R Soc Interface 9:1576-88. 2012
    ..Our results indicate that chain migration persistence depends on the interplay of directional cell movement and biased cell-cell contact...
  5. pmc Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity
    Michelle L Wynn
    Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA
    BMC Syst Biol 5:156. 2011
    ..We hypothesize that targeted therapies such as kinase inhibitors can produce off-target effects as a consequence of retroactivity alone...