Jonathan K Wynn

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Object substitution masking in schizophrenia: an event-related potential analysis
    Jonathan K Wynn
    Veterans Affairs Greater Los Angeles Healthcare System Los Angeles, CA, USA Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, USA
    Front Psychol 4:30. 2013
  2. doi request reprint Event-related potential examination of facial affect processing in bipolar disorder and schizophrenia
    J K Wynn
    VA Greater Los Angeles Healthcare System, MIRECC, Los Angeles, CA 90073, USA
    Psychol Med 43:109-17. 2013
  3. pmc Increased extent of object-selective cortex in schizophrenia
    Jonathan K Wynn
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA
    Psychiatry Res 164:97-105. 2008
  4. pmc Impaired anticipatory event-related potentials in schizophrenia
    Jonathan K Wynn
    VA Greater Los Angeles Healthcare System, University of California, Los Angeles, USA
    Int J Psychophysiol 77:141-9. 2010
  5. pmc Using event related potentials to explore stages of facial affect recognition deficits in schizophrenia
    Jonathan K Wynn
    VA Greater Los Angeles Healthcare System, MIRECC, Building 210, Los Angeles, CA 90073, USA
    Schizophr Bull 34:679-87. 2008
  6. pmc Effects of olanzapine, risperidone and haloperidol on prepulse inhibition in schizophrenia patients: a double-blind, randomized controlled trial
    Jonathan K Wynn
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
    Schizophr Res 95:134-42. 2007
  7. pmc Mismatch negativity, social cognition, and functioning in schizophrenia patients
    Jonathan K Wynn
    Mental Illness Research, Education and Clinical Center, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA
    Biol Psychiatry 67:940-7. 2010
  8. ncbi request reprint Exploring the short term visual store in schizophrenia using the attentional blink
    Jonathan K Wynn
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, United States
    J Psychiatr Res 40:599-605. 2006
  9. ncbi request reprint Event-related gamma activity in schizophrenia patients during a visual backward-masking task
    Jonathan K Wynn
    Department of Psychology, UCLA, Los Angeles, CA, USA
    Am J Psychiatry 162:2330-6. 2005
  10. ncbi request reprint Sensorimotor gating, orienting and social perception in schizophrenia
    Jonathan K Wynn
    Department of Psychiatry and Biobehavioral Science, Geffen School of Medicine at UCLA, United States
    Schizophr Res 73:319-25. 2005

Detail Information

Publications34

  1. pmc Object substitution masking in schizophrenia: an event-related potential analysis
    Jonathan K Wynn
    Veterans Affairs Greater Los Angeles Healthcare System Los Angeles, CA, USA Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, USA
    Front Psychol 4:30. 2013
    ..Considering that the VAN is thought to reflect reentrant processing, one interpretation of the findings is that patients' lack of VAN response and poorer performance may be related to dysfunctional reentrant processing...
  2. doi request reprint Event-related potential examination of facial affect processing in bipolar disorder and schizophrenia
    J K Wynn
    VA Greater Los Angeles Healthcare System, MIRECC, Los Angeles, CA 90073, USA
    Psychol Med 43:109-17. 2013
    ..Patients with bipolar disorder exhibit consistent deficits in facial affect identification at both behavioral and neural levels. However, little is known about which stages of facial affect processing are dysfunctional...
  3. pmc Increased extent of object-selective cortex in schizophrenia
    Jonathan K Wynn
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA
    Psychiatry Res 164:97-105. 2008
    ..The findings of abnormal spatial organization of LO in schizophrenia patients may converge with behavioral evidence of deficits in schizophrenia patients for object-recognition tasks that are believed to be mediated by LO activity...
  4. pmc Impaired anticipatory event-related potentials in schizophrenia
    Jonathan K Wynn
    VA Greater Los Angeles Healthcare System, University of California, Los Angeles, USA
    Int J Psychophysiol 77:141-9. 2010
    ..Schizophrenia patients demonstrate diminished motor- and non-motor-related anticipatory processing, which may have wide-ranging adverse functional consequences...
  5. pmc Using event related potentials to explore stages of facial affect recognition deficits in schizophrenia
    Jonathan K Wynn
    VA Greater Los Angeles Healthcare System, MIRECC, Building 210, Los Angeles, CA 90073, USA
    Schizophr Bull 34:679-87. 2008
    ..Our results imply that abnormalities in the later stage of feature decoding could potentially underlie emotion identification deficits in schizophrenia...
  6. pmc Effects of olanzapine, risperidone and haloperidol on prepulse inhibition in schizophrenia patients: a double-blind, randomized controlled trial
    Jonathan K Wynn
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
    Schizophr Res 95:134-42. 2007
    ..The results are discussed in terms of animal models, neural substrates, and treatment implications...
  7. pmc Mismatch negativity, social cognition, and functioning in schizophrenia patients
    Jonathan K Wynn
    Mental Illness Research, Education and Clinical Center, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA
    Biol Psychiatry 67:940-7. 2010
    ..Prior studies found associations between mismatch negativity (MMN), an event-related potential response indexing early auditory processing, and functioning in schizophrenia patients...
  8. ncbi request reprint Exploring the short term visual store in schizophrenia using the attentional blink
    Jonathan K Wynn
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, United States
    J Psychiatr Res 40:599-605. 2006
    ..The findings suggest that the enhanced AB effect in schizophrenia reflects an abnormality in their short term visual memory, as opposed to their enhanced susceptibility to visual masking...
  9. ncbi request reprint Event-related gamma activity in schizophrenia patients during a visual backward-masking task
    Jonathan K Wynn
    Department of Psychology, UCLA, Los Angeles, CA, USA
    Am J Psychiatry 162:2330-6. 2005
    ..This study examined event-related gamma range activity during a visual backward-masking task in schizophrenia patients and normal comparison subjects...
  10. ncbi request reprint Sensorimotor gating, orienting and social perception in schizophrenia
    Jonathan K Wynn
    Department of Psychiatry and Biobehavioral Science, Geffen School of Medicine at UCLA, United States
    Schizophr Res 73:319-25. 2005
    ..By showing a link between sensorimotor gating and social perception, this study supports social cognition's potential role as a mediator of the relationship between neurocognition and social functioning in schizophrenia...
  11. ncbi request reprint The functional relationship between visual backward masking and prepulse inhibition
    Jonathan K Wynn
    Department of Psychology, University of Southern California, Los Angeles, California 90089, USA
    Psychophysiology 41:306-12. 2004
    ..The data are consistent with the hypothesis that recovery from backward masking effects is affected by sensory gating acting in part to gate out the interruptive effects of the mask...
  12. pmc Altered dynamic coupling of lateral occipital complex during visual perception in schizophrenia
    Philippe Olivier Harvey
    Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA
    Neuroimage 55:1219-26. 2011
    ..However, the functional connectivity of LO with other brain regions during visual perception has not been directly investigated in schizophrenia...
  13. pmc Regional brain activity during early visual perception in unaffected siblings of schizophrenia patients
    Junghee Lee
    Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90095 6968, USA
    Biol Psychiatry 68:78-85. 2010
    ..We examined the neural substrates of visual backward performance in unaffected sibling of schizophrenia patients using functional magnetic resonance imaging (fMRI)...
  14. pmc Cross-diagnostic comparison of duration mismatch negativity and P3a in bipolar disorder and schizophrenia
    Carol Jahshan
    Mental Illness Research, Education, and Clinical Center MIRECC, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Bipolar Disord 14:239-48. 2012
    ..Furthermore, MMN and P3a have not been examined between diagnostic subgroups of patients with bipolar disorder. We evaluated MMN and P3a in patients with bipolar disorder compared to patients with schizophrenia and healthy controls...
  15. doi request reprint Efficacy and specificity of social cognitive skills training for outpatients with psychotic disorders
    William P Horan
    Department of Veterans Affairs VISN 22 Mental Illness Research, Education, and Clinical Center, Los Angeles, CA, USA
    J Psychiatr Res 45:1113-22. 2011
    ..Findings provide guidance for continued efforts to maximize the benefits of social cognitive interventions...
  16. pmc Functional neuroanatomy of visual masking deficits in schizophrenia
    Michael F Green
    Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA 90095 6968, USA
    Arch Gen Psychiatry 66:1295-303. 2009
    ..Patients with schizophrenia reliably show deficits on visual masking, and these procedures have been used to explore vulnerability to schizophrenia, probe underlying neural circuits, and help explain functional outcome...
  17. pmc Electrophysiological correlates of emotional responding in schizophrenia
    William P Horan
    Department of Psychiatry, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    J Abnorm Psychol 119:18-30. 2010
    ..However, they showed a disruption in a later component associated with sustained attentional processing of emotional stimuli...
  18. pmc Visual masking in schizophrenia: overview and theoretical implications
    Michael F Green
    VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Schizophr Bull 37:700-8. 2011
    ..Finally, we will suggest a possible mechanism that could explain the patterns of masking findings and other visual processing findings in schizophrenia...
  19. doi request reprint An electrophysiological investigation of attentional blink in schizophrenia: separating perceptual and attentional processes
    Kristopher I Mathis
    VA Desert Pacific Mental Illness Research, Education, and Clinical Center MIRECC, VA Greater Los Angeles Healthcare System, West Los Angeles VA Healthcare Center, Los Angeles, CA 90073, USA
    Int J Psychophysiol 86:108-13. 2012
    ..Mean ssVEP amplitude did not differ between the groups, and the differences in P300 remained after controlling for ssVEP. These results suggest that the observed AB deficits were due to attentional, not perceptual, processing deficits...
  20. pmc The attentional blink in schizophrenia: isolating the perception/attention interface
    Kristopher I Mathis
    Mental Illness Research, Education and Clinical Center MIRECC, VA Greater Los Angeles Healthcare System, CA 90073, USA
    J Psychiatr Res 45:1346-51. 2011
    ..This performance pattern on the AB task suggests that patients with schizophrenia exhibit both deficits in visual processing at the interface of perceptual and attentional processing and a general attentional deficit...
  21. pmc Further support for the role of dysfunctional attitudes in models of real-world functioning in schizophrenia
    William P Horan
    VA Greater Los Angeles Healthcare System, University of California, Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90073, USA
    J Psychiatr Res 44:499-505. 2010
    ..These findings support the value of dysfunctional attitudes for understanding the determinants of outcome in schizophrenia and suggest that therapeutic interventions targeting these attitudes may facilitate functional recovery...
  22. pmc Nonconscious and conscious color priming in schizophrenia
    Carol Jahshan
    VISN 22 Mental Illness Research, Education and Clinical Center, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    J Psychiatr Res 46:1312-7. 2012
    ..These results imply that the well-documented visual processing deficits in this illness likely occur at later, percept-dependent stages of processing...
  23. pmc How do schizophrenia patients use visual information to decode facial emotion?
    Junghee Lee
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA 90095 6968, USA
    Schizophr Bull 37:1001-8. 2011
    ..This study provides direct evidence that schizophrenia patients employ an atypical strategy of using visual information to recognize emotional faces...
  24. pmc Relationship between auditory processing and affective prosody in schizophrenia
    Carol Jahshan
    Sierra Pacific Mental Illness Research, Education and Clinical Center MIRECC, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Schizophr Res 143:348-53. 2013
    ..These findings provide support for bottom-up (e.g., perceptually based) cognitive remediation approaches...
  25. ncbi request reprint Prepulse facilitation and prepulse inhibition in schizophrenia patients and their unaffected siblings
    Jonathan K Wynn
    Department of Psychology MED, University of Southern California, Los Angeles, California 90073, USA
    Biol Psychiatry 55:518-23. 2004
    ..It is less clear whether these information processing deficits extend to prepulse facilitation (PPF), which measures a later stage of generalized alerting or orienting...
  26. pmc Intact motivated attention in schizophrenia: evidence from event-related potentials
    William P Horan
    VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, United States
    Schizophr Res 135:95-9. 2012
    ..Emotional stimuli captured attentional resources in people with schizophrenia even when the emotional stimuli were task-irrelevant, suggesting intact motivated attention at the level of early electrophysiological responding...
  27. pmc Impaired implicit learning in schizophrenia
    William P Horan
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA
    Neuropsychology 22:606-17. 2008
    ..Discussion focuses on possible explanations for schizophrenia patients' poor probabilistic classification task performance...
  28. pmc Perception measurement in clinical trials of schizophrenia: promising paradigms from CNTRICS
    Michael F Green
    Semel Institute, UCLA, CA, USA
    Schizophr Bull 35:163-81. 2009
    ..This manuscript describes the ways in which each of these tasks met the criteria used by the breakout group to evaluate and recommend tasks for further development...
  29. pmc Social cognitive skills training in schizophrenia: an initial efficacy study of stabilized outpatients
    William P Horan
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Schizophr Res 107:47-54. 2009
    ....
  30. doi request reprint Cross-diagnostic comparison of visual processing in bipolar disorder and schizophrenia
    Carol Jahshan
    Mental Illness Research, Education and Clinical Center MIRECC, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA Electronic address
    J Psychiatr Res 51:42-8. 2014
    ..These findings suggest that SZ is characterized by a diffuse pathophysiology affecting all stages of visual processing whereas in BD disruption is only at the latest stage involving higher order attentional functions. ..
  31. ncbi request reprint An analysis of categorical perception of facial emotion in schizophrenia
    Kimmy S Kee
    California State University Channel Islands, United States
    Schizophr Res 87:228-37. 2006
    ....
  32. doi request reprint Multisensory integration in schizophrenia: a behavioural and event-related potential study
    Jonathan K Wynn
    a Mental Illness Research, Education and Clinical Center, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Cogn Neuropsychiatry 19:319-36. 2014
    ..Our results suggest that neural processes associated with MSI are not an additional source of impairment in SZ. ..
  33. ncbi request reprint Quantitative EEG and low resolution electromagnetic tomography (LORETA) imaging of patients with persistent auditory hallucinations
    Seung Hwan Lee
    Department of Psychiatry, Ilsanpaik Hospital, Inje University College of Medicine, 2240 Daehwa dong, Ilsan gu, Goyang City, Gyeonggi do 411 706, Korea
    Schizophr Res 83:111-9. 2006
    ..These results imply that AH is reflecting increased beta frequency oscillations with neural generators localized in speech-related areas...
  34. ncbi request reprint Exaggerated affect-modulated startle during unpleasant stimuli in borderline personality disorder
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biol Psychiatry 62:250-5. 2007
    ..The affect-modulated startle response is a reliable indicator of emotional processing of stimuli. The aim of this study was to examine emotional processing in BPD patients (n = 27) and healthy control subjects (n = 21)...